Coreg Cr

Atrial Fibrillation, Ventricular Dysfunction, Left, Heart failure + 5 more
Treatment
9 FDA approvals
20 Active Studies for Coreg Cr

What is Coreg Cr

CarvedilolThe Generic name of this drug
Treatment SummaryCarvedilol is a drug used to treat heart failure, left ventricular dysfunction, and high blood pressure. It is a combination of two different drugs, one that blocks beta adrenaline receptors and one that blocks both beta and alpha-1 adrenaline receptors. Carvedilol is often prescribed in combination with other drugs to treat moderate hypertension because lower doses of two drugs have fewer side effects than higher doses of one drug. The FDA approved Carvedilol in 1995.
Coregis the brand name
Coreg Cr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Coreg
Carvedilol
1997
522

Approved as Treatment by the FDA

Carvedilol, commonly known as Coreg, is approved by the FDA for 9 uses such as Heart failure and Ventricular Dysfunction, Left .
Heart failure
Helps manage NYHA Class I or II heart failure
Ventricular Dysfunction, Left
Helps manage LVEF ≤40% Left ventricular dysfunction
chronic heart failure with reduced ejection fraction (NYHA Class IV)
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
NYHA Class I or II heart failure
Helps manage NYHA Class I or II heart failure
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class III)
LVEF ≤40% Left ventricular dysfunction
Helps manage LVEF ≤40% Left ventricular dysfunction
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
Heart Attack
Helps manage Myocardial Infarction

Effectiveness

How Coreg Cr Affects PatientsCarvedilol works by blocking two different hormones that regulate heart rate and blood pressure. It is usually taken once daily, and the recommended dose is 10-80mg. It is important to not suddenly stop taking this medication, as it could make coronary artery disease worse.
How Coreg Cr works in the bodyCarvedilol reduces heart rate in response to exercise by blocking the action of beta adrenoceptors. It also relaxes blood vessels and lowers blood pressure. At higher doses, it can block calcium channels and act like an antioxidant, preventing the oxidation of low-density lipoprotein and its buildup in the coronary circulation.

When to interrupt dosage

The recommended measure of Coreg Cr is contingent upon the determined affliction, including Chronic Stable Angina Pectoris, Ventricular Dysfunction, Left and Hypesthesia. The amount of dosage is dependent on the mode of administration featured in the table below.
Condition
Dosage
Administration
Atrial Fibrillation
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Ventricular Dysfunction, Left
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Heart failure
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Hypesthesia
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Hypesthesia
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Heart Attack
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Angina, Stable
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral

Warnings

Coreg Cr Contraindications
Condition
Risk Level
Notes
Bronchospasm
Do Not Combine
Asthma
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Therapeutic procedure
Do Not Combine
Therapeutic procedure
Do Not Combine
severe bradycardia
Do Not Combine
Atrioventricular Block
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Carvedilol may interact with Pulse Frequency
There are 20 known major drug interactions with Coreg Cr.
Common Coreg Cr Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Carvedilol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Carvedilol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Carvedilol.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Carvedilol.
Acepromazine
Major
Carvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Coreg Cr Toxicity & Overdose RiskAn overdose of Lanoxin can lead to low blood pressure, slow heart rate, heart failure, shock, and even cardiac arrest. Patients should lie down and may be given atropine to increase the heart rate and glucagon and other medications to help support the cardiovascular system.
image of a doctor in a lab doing drug, clinical research

Coreg Cr Novel Uses: Which Conditions Have a Clinical Trial Featuring Coreg Cr?

253 active clinical trials are currently being conducted to assess the potential of Coreg Cr in alleviating Hypesthesia, Heart Failure and Hypesthesia Disorders.
Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
96 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Heart Attack
26 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1, Phase 3
Angina, Stable
1 Actively Recruiting
Not Applicable
Hypesthesia
10 Actively Recruiting
Not Applicable, Phase 1
Heart failure
0 Actively Recruiting
Hypesthesia
7 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
Ventricular Dysfunction, Left
0 Actively Recruiting

Coreg Cr Reviews: What are patients saying about Coreg Cr?

5Patient Review
10/14/2012
Coreg Cr for High Blood Pressure
I've been on several different blood pressure medications, but this one has more side effects than the others. I can't sleep, I'm constantly hungry and thirsty, and exhausted all the time. Working now to get off this stuff!
5Patient Review
4/12/2010
Coreg Cr for Diastolic Heart Failure
4.3Patient Review
3/14/2011
Coreg Cr for High Blood Pressure
There was no change in my blood pressure after taking this medication.
4Patient Review
9/8/2010
Coreg Cr for High Blood Pressure
I was diagnosed with cardiomyopathy eight years ago and my EF (ejection fraction) was only 48%. After starting Coreg, and then switching to Coreg CR two years ago, my EF is now up to 53%! I'm feeling better than ever and have zero side effects.
3.7Patient Review
2/2/2014
Coreg Cr for High Blood Pressure
I've been on Coreg CR for fifteen years now, and I'm wondering if it could be the cause of my recent joint pain.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about coreg cr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Coreg CR the same as carvedilol?

"Carvedilol is a drug that falls into the category of alpha and beta-blockers. It is sometimes used to treat a heart rhythm disorder called atrial fibrillation. Carvedilol is available under the brand names Coreg and Coreg CR."

Answered by AI

Is there a generic for Coreg CR?

"Coreg Cr is a brand-name prescription drug that is the generic version of Carvedilol ER."

Answered by AI

What is Coreg CR used for?

"Carvedilol is a drug used to manage hypertension and heart failure. It is also administered post-heart attack to increase the likelihood of survival if the heart is not pumping effectively. Reducing high blood pressure decreases the risk of stroke, heart attack, and kidney disease."

Answered by AI

Is Coreg extended-release?

"COREG CR is an extended-release capsule that is taken once a day. Patients who are already taking carvedilol tablets (either alone or with other medications) can switch to COREG CR extended-release capsules, based on the total daily doses in Table 1."

Answered by AI

Clinical Trials for Coreg Cr

Have you considered Coreg Cr clinical trials? We made a collection of clinical trials featuring Coreg Cr, we think they might fit your search criteria.
Have you considered Coreg Cr clinical trials? We made a collection of clinical trials featuring Coreg Cr, we think they might fit your search criteria.
Have you considered Coreg Cr clinical trials? We made a collection of clinical trials featuring Coreg Cr, we think they might fit your search criteria.
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