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What is Coreg Cr
CarvedilolThe Generic name of this drug
Treatment SummaryCarvedilol is a drug used to treat heart failure, left ventricular dysfunction, and high blood pressure. It is a combination of two different drugs, one that blocks beta adrenaline receptors and one that blocks both beta and alpha-1 adrenaline receptors. Carvedilol is often prescribed in combination with other drugs to treat moderate hypertension because lower doses of two drugs have fewer side effects than higher doses of one drug. The FDA approved Carvedilol in 1995.
Coregis the brand name
Coreg Cr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Coreg
Carvedilol
1997
522
Approved as Treatment by the FDA
Carvedilol, commonly known as Coreg, is approved by the FDA for 6 uses such as Heart failure and Hypesthesia .Heart failure
Helps manage NYHA Class I or II heart failure
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)
Hypesthesia
Helps manage chronic heart failure with reduced ejection fraction (NYHA Class III)
Ventricular Dysfunction, Left
Helps manage LVEF ≤40% Left ventricular dysfunction
Heart Attack
Helps manage Myocardial Infarction
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Coreg Cr Affects PatientsCarvedilol works by blocking two different hormones that regulate heart rate and blood pressure. It is usually taken once daily, and the recommended dose is 10-80mg. It is important to not suddenly stop taking this medication, as it could make coronary artery disease worse.
How Coreg Cr works in the bodyCarvedilol reduces heart rate in response to exercise by blocking the action of beta adrenoceptors. It also relaxes blood vessels and lowers blood pressure. At higher doses, it can block calcium channels and act like an antioxidant, preventing the oxidation of low-density lipoprotein and its buildup in the coronary circulation.
When to interrupt dosage
The recommended measure of Coreg Cr is contingent upon the determined affliction, including Chronic Stable Angina Pectoris, Ventricular Dysfunction, Left and Hypesthesia. The amount of dosage is dependent on the mode of administration featured in the table below.Condition
Dosage
Administration
Hypesthesia
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Ventricular Dysfunction, Left
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Heart failure
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Atrial Fibrillation
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Heart Attack
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Chronic Stable Angina Pectoris
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Hypesthesia
, 10.0 mg, 20.0 mg, 40.0 mg, 80.0 mg, 3.125 mg, 6.25 mg, 12.5 mg, 25.0 mg, 0.125 mg, 50.0 mg
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Tablet, coated, Tablet, coated - Oral
Warnings
Coreg Cr ContraindicationsCondition
Risk Level
Notes
Bronchospasm
Do Not Combine
Bronchial Asthma
Do Not Combine
Sick Sinus Syndrome
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Therapeutic procedure
Do Not Combine
Therapeutic procedure
Do Not Combine
severe bradycardia
Do Not Combine
third degree AV block
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Carvedilol may interact with Pulse Frequency
Common Coreg Cr Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Carvedilol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Carvedilol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Carvedilol.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Carvedilol.
Acepromazine
Major
Carvedilol may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Coreg Cr Toxicity & Overdose RiskAn overdose of Lanoxin can lead to low blood pressure, slow heart rate, heart failure, shock, and even cardiac arrest. Patients should lie down and may be given atropine to increase the heart rate and glucagon and other medications to help support the cardiovascular system.
Coreg Cr Novel Uses: Which Conditions Have a Clinical Trial Featuring Coreg Cr?
253 active clinical trials are currently being conducted to assess the potential of Coreg Cr in alleviating Hypesthesia, Heart Failure and Hypesthesia Disorders.Condition
Clinical Trials
Trial Phases
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Heart Attack
53 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Atrial Fibrillation
145 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Heart failure
0 Actively Recruiting
Hypesthesia
5 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1
Hypesthesia
8 Actively Recruiting
Not Applicable, Phase 1
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable
Ventricular Dysfunction, Left
0 Actively Recruiting
Coreg Cr Reviews: What are patients saying about Coreg Cr?
5Patient Review
10/14/2012 I've been on several different blood pressure medications, but this one has more side effects than the others. I can't sleep, I'm constantly hungry and thirsty, and exhausted all the time. Working now to get off this stuff!
5Patient Review
4/12/20104.3Patient Review
3/14/2011 There was no change in my blood pressure after taking this medication.
4Patient Review
9/8/2010 I was diagnosed with cardiomyopathy eight years ago and my EF (ejection fraction) was only 48%. After starting Coreg, and then switching to Coreg CR two years ago, my EF is now up to 53%! I'm feeling better than ever and have zero side effects.
3.7Patient Review
2/2/2014 I've been on Coreg CR for fifteen years now, and I'm wondering if it could be the cause of my recent joint pain.
3.7Patient Review
3/17/2013 This medication has been effective in lowering my blood pressure and heart rate.
3.3Patient Review
11/24/2010 I've been taking this medication for four years now. I often experience dizziness a couple hours after taking it in the morning, to the point where I have had to leave work early. It's also hard to manage because I'm also taking Synthroid.
3.3Patient Review
3/25/2012 This treatment left me feeling confused.
3Patient Review
5/25/2012 I wake up several times throughout the night and my hair is falling out. I can't handle this medication.
3Patient Review
6/25/20102.7Patient Review
3/5/2012 After my heart attack, I was given Coreg CR 80mg. However, this medication hasn't worked well for me. I experience constant fatigue and dizziness, drowsiness, aching joints, deep sleep, itchy patches of skin, and skipped heartbeats. When discussing these side effects with my doctor, he brushed me off and said this medicine was best for me. In my opinion, the side effects are worse than any good the medicine does.
2.3Patient Review
11/24/2010 The dizziness can be really extreme with this, so I have to plan my days around when I take it.
2.3Patient Review
9/19/2011 I saw no change in my blood pressure, and actually experienced some negative side effects like swollen feet and joint pain. I'm going to discuss this with my doctor at my appointment later this month.
2.3Patient Review
11/26/2010 My blood pressure has been all over the place since I started taking this medication. I'm looking for something a bit more stable.
2Patient Review
8/7/20101Patient Review
2/2/2012 Coreg did nothing to help control my blood pressure, and it caused a lot of unpleasant side effects like dizziness and mental fuzziness. In my opinion, the risks outweigh any potential benefits.
1Patient Review
12/10/2010 I frequently experience beta blocker flush, which is accompanied by sweating.
Patient Q&A Section about coreg cr
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Coreg CR the same as carvedilol?
"Carvedilol is a drug that falls into the category of alpha and beta-blockers. It is sometimes used to treat a heart rhythm disorder called atrial fibrillation. Carvedilol is available under the brand names Coreg and Coreg CR."
Answered by AI
Is there a generic for Coreg CR?
"Coreg Cr is a brand-name prescription drug that is the generic version of Carvedilol ER."
Answered by AI
What is Coreg CR used for?
"Carvedilol is a drug used to manage hypertension and heart failure. It is also administered post-heart attack to increase the likelihood of survival if the heart is not pumping effectively. Reducing high blood pressure decreases the risk of stroke, heart attack, and kidney disease."
Answered by AI
Is Coreg extended-release?
"COREG CR is an extended-release capsule that is taken once a day. Patients who are already taking carvedilol tablets (either alone or with other medications) can switch to COREG CR extended-release capsules, based on the total daily doses in Table 1."
Answered by AI