Colistimethate Sodium

Urinary Tract Infection (UTI)
Treatment
1 FDA approval
20 Active Studies for Colistimethate Sodium

What is Colistimethate Sodium

ColistimethateThe Generic name of this drug
Treatment SummaryColistimethate is an antibiotic used to treat bacterial infections caused by certain types of Pseudomonas aeruginosa. It is effective in killing certain types of aerobic gram-negative bacteria.
Coly-Mycin Mis the brand name
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Colistimethate Sodium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Coly-Mycin M
Colistimethate
1970
12

Approved as Treatment by the FDA

Colistimethate, also known as Coly-Mycin M, is approved by the FDA for 1 uses such as Urinary Tract Infection (UTI) .
Urinary Tract Infection (UTI)

Effectiveness

How Colistimethate Sodium Affects PatientsColistimethate is an antibiotic medicine used to fight bacterial infections. It works by breaking down the cell walls of bacteria, but can be toxic when taken in high doses. In the past, it has been used less commonly than other antibiotics like penicillin and cephalosporin, but recently it has been used more to treat infections caused by certain drug-resistant bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii.
How Colistimethate Sodium works in the bodyColistimethate is a surface active agent. It works by entering a bacterial cell and disrupting its membrane, making it unable to function properly. Colistimethate's polycationic properties allow it to interact with the bacterial cytoplasmic membrane and cause changes in its permeability. This action kills the bacteria. Additionally, colistimethate enters the cell and affects cytoplasmic components, particularly ribosomes, which are essential for cell function.

When to interrupt dosage

The endorsed measure of Colistimethate Sodium is contingent upon the diagnosed state. The amount of dosage fluctuates, as per the technique of delivery (e.g. Powder, for solution - Intramuscular; Intravenous or Intramuscular; Intravenous) outlined in the table beneath.
Condition
Dosage
Administration
Urinary Tract Infection (UTI)
, 150.0 mg/mL, 1662500.0 [iU], 150.0 mg
, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Injection, Injection - Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous

Warnings

There are 20 known major drug interactions with Colistimethate Sodium.
Common Colistimethate Sodium Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Colistimethate is combined with Neomycin.
Tenofovir
Major
Colistimethate may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Colistimethate may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil
Major
Colistimethate may increase the nephrotoxic activities of Tenofovir disoproxil.
Abacavir
Minor
Colistimethate may decrease the excretion rate of Abacavir which could result in a higher serum level.
Colistimethate Sodium Toxicity & Overdose RiskThe lowest toxic dose of colistimethate in rats is 5450 mg/kg. Overdosing on colistimethate can cause nerve and muscle problems such as tingling, fatigue, confusion, dizziness, difficulty walking, rapid eye movement, speech difficulties, and lack of breathing. Severe cases can lead to respiratory failure and even death.
image of a doctor in a lab doing drug, clinical research

Colistimethate Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Colistimethate Sodium?

27 clinical trials are currently in progress to investigate the utilization of Colistimethate Sodium for Urinary Tract Infection (UTI) management.
Condition
Clinical Trials
Trial Phases
Urinary Tract Infection (UTI)
24 Actively Recruiting
Phase 2, Phase 1, Phase 4, Phase 3, Not Applicable

Colistimethate Sodium Reviews: What are patients saying about Colistimethate Sodium?

4.3Patient Review
10/8/2012
Colistimethate Sodium for Cystic Fibrosis and Infection from Pseudomonas Bacteria
Though it's not the quickest or most convenient to prepare, this medication is effective for me. I only have some tingling in my feet as a side effect, which I'll mention to my doctor tomorrow.
4Patient Review
4/14/2010
Colistimethate Sodium for Cystic Fibrosis
Colistimethate can be a little tricky to mix, but it's worth it. The effects can take a little while to kick in, but they're great once they do.
4Patient Review
2/3/2014
Colistimethate Sodium for Infection caused by Pseudomonas Aeruginosa Bacteria
My mother was placed on this medication for Pseudomonas Aeruginosa. While it did effectively treat the infection, we were made aware of nephrotoxicity ahead of time and unfortunately her kidneys shut down as a result. She is now on hemodialysis.
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Patient Q&A Section about colistimethate sodium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is colistin a strong antibiotic?

"Klebsiella pneumoniae: 0.015–0.5 μg/ml. Serratia marcescens: 0.015–0.5 μg/ml Colistin is effective against infections caused by Pseudomonas, Escherichia, and Klebsiella species. The minimum inhibitory concentration (MIC) susceptibility data for a few medically significant microorganisms is as follows: Escherichia coli: 0.12–128 μg/ml. Klebsiella pneumoniae: 0.015–0.5 μg/ml. Serratia marcescens: 0.015–0.5 μg/ml"

Answered by AI

What type of antibiotic is colistimethate?

"These agents bind to lipopolysaccharides in the bacterial outer membrane, which disrupts the integrity of the membrane and causes cell lysis.

Colistin is an antibiotic that is used to treat bacterial infections caused by susceptible Gram negative bacteria. It is a cyclic polypeptide antibiotic that is composed of Polymyxins E1 and E2 (or Colistins A, B, and C). These agents bind to lipopolysaccharides in the bacterial outer membrane, which disrupts the integrity of the membrane and causes cell lysis."

Answered by AI

Why is colistin used?

"As a last-line therapy, colistin is being used increasingly to treat infections caused by MDR Gram-negative bacteria when other options are not available."

Answered by AI

What is colistimethate sodium used for?

"This medication is used to treat infections that are caused by bacteria. It works by killing the bacteria. This medication will not work for viral infections such as colds or the flu."

Answered by AI

Clinical Trials for Colistimethate Sodium

Have you considered Colistimethate Sodium clinical trials? We made a collection of clinical trials featuring Colistimethate Sodium, we think they might fit your search criteria.
Have you considered Colistimethate Sodium clinical trials? We made a collection of clinical trials featuring Colistimethate Sodium, we think they might fit your search criteria.
Have you considered Colistimethate Sodium clinical trials? We made a collection of clinical trials featuring Colistimethate Sodium, we think they might fit your search criteria.
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