Hyperpolarized Xenon MRI for Respiratory Disorders
(HPXeMR Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, if you have uncontrolled asthma requiring frequent use of a rescue inhaler, you may not be eligible to participate.
Is Hyperpolarized Xenon MRI safe for humans?
Research on Hyperpolarized Xenon MRI, which uses a special type of gas for lung imaging, suggests it is generally safe for humans. It has been used in clinical trials and studies for various lung conditions, and while it is still mainly available in research settings, no major safety concerns have been reported.12345
How does hyperpolarized xenon MRI differ from other treatments for respiratory disorders?
Hyperpolarized xenon MRI is unique because it uses a special form of xenon gas to create detailed images of the lungs, allowing doctors to see both how air moves through the lungs and how well gases are exchanged. This imaging technique is different from other treatments because it provides a non-invasive way to assess lung function and structure, which can help in diagnosing and managing respiratory disorders.13678
What data supports the effectiveness of the treatment Hyperpolarized 129 Xenon MRI for respiratory disorders?
Research shows that Hyperpolarized 129 Xenon MRI is promising for assessing lung function, as it can evaluate both ventilation (airflow) and gas transfer in the lungs. It has been used to study lung diseases and may help identify ventilation issues in conditions like pulmonary embolism and chronic obstructive airway diseases.12378
Who Is on the Research Team?
Jason C. Woods, PhD
Principal Investigator
Children's Hospital Medical Center, Cincinnati
Are You a Good Fit for This Trial?
This trial is for children and adults aged 6 or older who can hold their breath for up to 16 seconds. It's not suitable for pregnant individuals, those with recent respiratory infections, low oxygen levels without support, metal implants that interfere with MRI, heart defects, uncontrolled asthma, or claustrophobia.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging Session
Participants undergo MRI scans using hyperpolarized 129Xe gas to assess lung function
Follow-up
Participants are monitored for safety and effectiveness after imaging
What Are the Treatments Tested in This Trial?
Interventions
- Hyperpolarized 129 Xenon
Find a Clinic Near You
Who Is Running the Clinical Trial?
Children's Hospital Medical Center, Cincinnati
Lead Sponsor