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OCT + CMR Imaging for Heart Attack (RIO Trial)

Waitlist Available
Led By Harmony Reynolds, MD
Research Sponsored by NYU Langone Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Objective evidence of myocardial infarction (either or both of the following): Elevation of troponin to above the laboratory upper limit of normal (ULN) or ST segment elevation of ≥1mm on 2 contiguous ECG leads
Age ≥ 21 years
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

RIO Trial Summary

This trial is looking at whether or not a certain type of heart attack is related to a specific heart condition.

Who is the study for?
This trial is for adults over 21 with a recent heart attack and non-obstructive coronary artery disease, willing to consent to the study's procedures. It excludes those with other reasons for troponin elevation, significant coronary tortuosity, pregnancy, prior thrombolytic therapy for STEMI, stenosis in major vessels, known obstructive CAD history including PCI or CABG surgery, recent use of vasospastic agents, very low kidney function or MRI contraindications.Check my eligibility
What is being tested?
The study aims to understand plaque disruption in heart attack patients using OCT (a light-based imaging) and CMR (advanced cardiac imaging with Gadolinium contrast). Researchers will compare images from both methods to learn about myocardial infarction causes when arteries are not blocked.See study design
What are the potential side effects?
Potential side effects may include allergic reactions to the Gadolinium contrast used in CMR imaging. There might also be risks associated with OCT such as discomfort or complications related to catheter insertion.

RIO Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I have had a heart attack, confirmed by blood tests or an ECG.
I am 21 years old or older.
I have symptoms like chest pain that suggest a heart attack.

RIO Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The prevalence of plaque disruption
Secondary outcome measures
Dental Plaque
Other outcome measures
Event rate in follow-up: death, MI, heart failure, stroke

RIO Trial Design

1Treatment groups
Experimental Treatment
Group I: MI without obstructive CADExperimental Treatment3 Interventions
MI without obstructive CAD, with OCT and CMR imaging
First Studied
Drug Approval Stage
How many patients have taken this drug
Completed Phase 4

Find a Location

Who is running the clinical trial?

NYU Langone HealthLead Sponsor
1,367 Previous Clinical Trials
839,746 Total Patients Enrolled
Harmony Reynolds, MDPrincipal InvestigatorNYU Langone Medical Center
2 Previous Clinical Trials
30 Total Patients Enrolled

Media Library

Cardiac Magnetic Resonance Imaging (CMR) Clinical Trial Eligibility Overview. Trial Name: NCT02270359 — N/A
Heart Attack Research Study Groups: MI without obstructive CAD
Heart Attack Clinical Trial 2023: Cardiac Magnetic Resonance Imaging (CMR) Highlights & Side Effects. Trial Name: NCT02270359 — N/A
Cardiac Magnetic Resonance Imaging (CMR) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02270359 — N/A
Heart Attack Patient Testimony for trial: Trial Name: NCT02270359 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it possible for me to enroll in this research project?

"To qualify for this medical trial, individuals should have experienced a myocardial infarction and fit into the age range of 21 to 99. A maximum of 15 participants are accepted."

Answered by AI

Does this research accept participants who are beyond the age of forty?

"To be included in this medical experiment, participants must have attained the legal age of majority and not yet reached centenarian status."

Answered by AI

Are participants being admitted to this experiment currently?

"This medical trial is not presently recruiting patients. It was first published on April 1st, 2014 and its information was last modified on December 20th, 2021. For those looking for other trials related to myocardial infarction, there are 360 currently accepting participants while 10 more studies regarding the same treatment option seek out potential candidates."

Answered by AI

What other research initiatives have been undertaken to further explore the efficacy of this treatment?

"Currently, 10 ongoing trials are exploring this intervention with none of them having reached Phase 3. Most studies on the treatment have been conducted in Portland, Oregon but there are 26 other sites involved as well."

Answered by AI

What is the current cohort size for this research trial?

"This medical trial is not currently admitting patients. The study was first published on April 1st 2014 and the info has been updated lastly on December 20th 2021. If you're looking for other trials, there are 360 ongoing studies that involve myocardial infarction as well as 10 ones recruiting people to this particular treatment."

Answered by AI

Who else is applying?

What state do they live in?
New York
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?

Why did patients apply to this trial?

I’m just looking for a solution to my health issues.
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

How long do screaming visits take?
PatientReceived 2+ prior treatments
~2 spots leftby Jun 2025