Dynamic Neural Retraining System for Chronic Fatigue Syndrome
(MILES Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a mind-body program called the Dynamic Neural Retraining System (DNRS) to determine its effectiveness for individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID. The researchers aim to assess whether DNRS can enhance quality of life, reduce fatigue and pain, and improve mental health and physical activity. Participants will be divided into two groups: one will engage in the DNRS program, while the other will continue their regular treatment plan before eventually switching to DNRS. This study suits those diagnosed with ME/CFS for more than six months, who are well enough to participate, and have reliable internet access. As an unphased trial, it offers a unique opportunity to explore a novel approach to managing ME/CFS and Long COVID symptoms.
Do I need to stop my current medications for the trial?
The trial protocol does not specify if you need to stop taking your current medications. However, you cannot start any new treatments, including prescription or over-the-counter medications, during the study period.
What prior data suggests that the Dynamic Neural Retraining System is safe for people with ME/CFS and Long COVID?
Research has shown that mind-body methods, such as the Dynamic Neural Retraining System (DNRS), are generally well-received. DNRS uses brain exercises, visualization, and mindfulness to help manage symptoms of conditions like chronic fatigue syndrome. These techniques aim to change how the brain and body communicate, potentially improving health and well-being.
Regarding safety, strong scientific evidence specifically about DNRS is lacking. However, mind-body programs do not involve surgery or drugs, often resulting in fewer side effects than medications. As this study is in an early stage, safety data specifically for DNRS remains limited. Nonetheless, because DNRS does not use drugs, it is likely safe with minimal risks. Participants should discuss any concerns or side effects with the study team during the trial.12345Why are researchers excited about this trial?
Researchers are excited about the Dynamic Neural Retraining System (DNRS) because it offers a novel approach to managing Chronic Fatigue Syndrome (CFS). Unlike traditional treatments that often focus on symptom management through medications like antivirals or cognitive behavioral therapy, DNRS aims to address the underlying neural pathways contributing to chronic fatigue. This system uses brain retraining techniques to potentially rewire neural circuits, promoting a more sustainable recovery. By targeting the brain's plasticity, DNRS could offer a transformative solution for those who haven't found relief with existing options.
What evidence suggests that the Dynamic Neural Retraining System might be an effective treatment for ME/CFS?
Research has shown that mind-body techniques, such as the Dynamic Neural Retraining System (DNRS), may assist individuals with Chronic Fatigue Syndrome (CFS) and similar conditions. These techniques can improve anxiety, tiredness, depression, quality of life, and physical abilities. DNRS leverages the brain's ability to change, known as neuroplasticity, to potentially enhance health. Some studies have reported significant health improvements in patients with similar chronic illnesses. However, strong evidence specifically for DNRS in ME/CFS is not yet available. This ongoing study will help determine its effectiveness, with participants either receiving the DNRS intervention or joining a wait-list control group.23678
Who Is on the Research Team?
Eleanor Stein, MD FRCPC
Principal Investigator
University of Calgary
Sunita Vohra, MD MSc FRCPC FCAHS
Principal Investigator
University of Alberta
Are You a Good Fit for This Trial?
This trial is for individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) or Long COVID, experiencing symptoms like muscle pain and fatigue. Participants should be interested in a mind-body treatment approach.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants in the DNRS intervention group undergo the mind-body program, while the wait-list control group continues usual care for 4 months
Follow-up
Participants are monitored for changes in physical functioning and other health-related outcomes post-intervention
Open-label extension (optional)
Wait-list control group participants may opt into the DNRS program after the initial 4-month waiting period
What Are the Treatments Tested in This Trial?
Interventions
- Dynamic Neural Retraining System
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alberta
Lead Sponsor
College of Physicians and Surgeons of Alberta
Collaborator