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What is Colcrys
ColchicineThe Generic name of this drug
Treatment SummaryColchicine is a medication used to treat gout and Familial Mediterranean Fever (FMF). It was first approved by the FDA in 1961 and is derived from the Colchicum autumnale plant. Colchicine is commonly prescribed to reduce the swelling and pain caused by urate crystals in the joints associated with gout and may also help reduce inflammation in FMF.
Probenecid and Colchicineis the brand name
Colcrys Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Probenecid and Colchicine
Colchicine
1982
59
Approved as Treatment by the FDA
Colchicine, commonly known as Probenecid and Colchicine, is approved by the FDA for 3 uses which include prophylaxis of Gout Flares and Gout Flares .prophylaxis of Gout Flares
Gout Flares
Familial Mediterranean Fever
Effectiveness
How Colcrys Affects PatientsColchicine helps to relieve the pain of gout and reduce flare-ups of Familial Mediterranean fever by interrupting the chemical processes that cause inflammation. It is important to be careful with this drug as a very small adjustment in the dose can make a big difference.
How Colcrys works in the bodyWe don't know the exact way colchicine works, but it likely stops inflammation by disrupting the inflammasome complex. This complex is involved in the production of an inflammatory messenger called interleukin-1. Colchicine also prevents neutrophils and other cells from adhering and producing a type of oxidative stress called superoxide. Lastly, it interferes with a type of NF-κΒ pathway that reduces inflammation. On a molecular level, colchicine is an anti-mitotic drug, meaning it stops cells from dividing by binding to tubulin and preventing microtubules from growing
When to interrupt dosage
The proposed dosage of Colcrys is contingent upon the diagnosed condition, including Gout Flares, Pericarditis and Postcommissurotomy Syndrome. The measure of dosage varies, contingent upon the technique of administration featured in the accompanying table.Condition
Dosage
Administration
Postcommissurotomy Syndrome
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
prophylaxis of Gout Flares
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Behcet's Syndrome
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Gout Flares
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Familial Mediterranean Fever
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Pericarditis
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Postpericardiotomy Syndrome
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Warnings
Colcrys ContraindicationsCondition
Risk Level
Notes
Liver Disease
Do Not Combine
Liver Disease
Do Not Combine
Common Colcrys Drug Interactions
Drug Name
Risk Level
Description
Choline C 11
Major
The therapeutic efficacy of Choline C 11 can be decreased when used in combination with Colchicine.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Colchicine.
Fentanyl
Major
The metabolism of Fentanyl can be decreased when combined with Colchicine.
Aclidinium
Minor
Colchicine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Colchicine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Colcrys Toxicity & Overdose RiskTests have found that the toxic dose of colchicine for mice is 5.87 mg/kg. In cases of colchicine overdose, people may experience abdominal pain, nausea, vomiting, diarrhea, and dehydration within 24 hours of ingesting the drug. Over the next 24-72 hours, serious complications such as multi-organ failure and respiratory depression may occur, which can lead to death. To treat an overdose, doctors may perform gastric lavage and provide supportive care, though there is no antidote for colchicine. It is important to keep this drug away from children. Dialysis is not an effective way
Colcrys Novel Uses: Which Conditions Have a Clinical Trial Featuring Colcrys?
Three active trials are assessing the potential of Colcrys as a prophylactic agent for Gout Flares, Behcet's Syndrome and Postpericardiotomy Syndrome.Condition
Clinical Trials
Trial Phases
Postcommissurotomy Syndrome
0 Actively Recruiting
Postpericardiotomy Syndrome
0 Actively Recruiting
Gout Flares
0 Actively Recruiting
Behcet's Syndrome
1 Actively Recruiting
Phase 2
Pericarditis
2 Actively Recruiting
Phase 2, Phase 3
Familial Mediterranean Fever
0 Actively Recruiting
prophylaxis of Gout Flares
0 Actively Recruiting
Colcrys Reviews: What are patients saying about Colcrys?
5Patient Review
2/2/2015 I had severe gout pain in my left big toe and this treatment completely alleviated it. I just took three pills within one hour of each other and felt no pain afterwards. No side effects that I could tell, would definitely use again!
5Patient Review
1/25/2019 Colcrys has been an integral part of my treatment plan and it really helps to manage active attacks in combination with indocin and allopurinol.
5Patient Review
10/19/20144.3Patient Review
11/30/2016 Colcrys is the only thing that works quickly, and it's not even that expensive if you use the coupon on their website.
4.3Patient Review
4/20/2017 This alleviated my kidney-related back pain after just a week of use. Additionally, it has helped to lessen the frequency and intensity of attacks.
4Patient Review
9/21/2016 This drug effectively stopped my gout symptoms, but unfortunately caused some diarrhea in the process. I only need to take one pill per day now, and only if the gout tries to come back. Additionally, I stop taking my statin drug when taking colcrys.
3.7Patient Review
5/16/2015 This medication works great, but my insurance company is giving me a hard time about it.
3.3Patient Review
10/28/2015 While I experienced some great results from this treatment, like the disappearance of swelling and pain in various areas of my body, the weight loss came on too quickly for me to feel comfortable. In addition, the cost is prohibitively high.
3.3Patient Review
9/9/2018 I've been taking colchicine for over 30 years and it's really helped me. I'm outraged that my insurance won't cover the cost of the new Colcrys medication, which is 3 times as expensive. This needs to be changed!
3Patient Review
9/7/2016 Worked great, but then I lost my prescription coverage. Now it costs $170 a month, which is really not affordable.
2Patient Review
12/27/20141.7Patient Review
5/17/2015 The old generic version was very effective and only cost 10 cents per tablet. However, it could be a bit hard on the stomach for some people. The new version is much more expensive at $8 per tablet, which is outrageous.
1Patient Review
11/22/2015 I was diagnosed with pericarditis 2 months after my open heart surgery. I was given this medication at the ER and my cardiologist want me to stay on it for 3 months. It's been 6 weeks. I don't have any side effects.
Patient Q&A Section about colcrys
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of the drug Colcrys?
"If you experience any of the following symptoms, you should see a doctor immediately: black or tarry stools, blood in the urine or stools, burning, crawling, or tingling feeling in the skin, difficulty with breathing when exercising, fever with or without chills, large hive-like swellings on the face, eyelids, mouth, lips, or tongue, muscle weakness, or numbness in the fingers or toes."
Answered by AI
How quickly does Colcrys work?
"Colchicine helps reduce inflammation that can lead to symptoms, typically within 30 minutes to 2 hours. However, you may not notice a difference in inflammation or pain for a day or two. If you're taking colchicine to prevent flare-ups of familial Mediterranean fever, you may not feel any different."
Answered by AI
What does Colcrys do for gout?
"If you have too much uric acid in your blood, it can form crystals in your joints, which causes pain. Colchicine helps by reducing swelling and the amount of uric acid crystals."
Answered by AI