Colcrys

Postcommissurotomy Syndrome, Pericarditis, Postpericardiotomy Syndrome + 4 more
Treatment
4 FDA approvals
0 Active Studies for Colcrys

What is Colcrys

ColchicineThe Generic name of this drug
Treatment SummaryColchicine is a medication used to treat gout and Familial Mediterranean Fever (FMF). It was first approved by the FDA in 1961 and is derived from the Colchicum autumnale plant. Colchicine is commonly prescribed to reduce the swelling and pain caused by urate crystals in the joints associated with gout and may also help reduce inflammation in FMF.
Probenecid and Colchicineis the brand name
image of different drug pills on a surface
Colcrys Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Probenecid and Colchicine
Colchicine
1982
59

Approved as Treatment by the FDA

Colchicine, commonly known as Probenecid and Colchicine, is approved by the FDA for 4 uses which include Gout Flares and Familial Mediterranean Fever (FMF ) .
Gout Flares
Familial Mediterranean Fever (FMF )
prophylaxis of Gout Flares
Familial Mediterranean Fever

Effectiveness

How Colcrys Affects PatientsColchicine helps to relieve the pain of gout and reduce flare-ups of Familial Mediterranean fever by interrupting the chemical processes that cause inflammation. It is important to be careful with this drug as a very small adjustment in the dose can make a big difference.
How Colcrys works in the bodyWe don't know the exact way colchicine works, but it likely stops inflammation by disrupting the inflammasome complex. This complex is involved in the production of an inflammatory messenger called interleukin-1. Colchicine also prevents neutrophils and other cells from adhering and producing a type of oxidative stress called superoxide. Lastly, it interferes with a type of NF-κΒ pathway that reduces inflammation. On a molecular level, colchicine is an anti-mitotic drug, meaning it stops cells from dividing by binding to tubulin and preventing microtubules from growing

When to interrupt dosage

The proposed dosage of Colcrys is contingent upon the diagnosed condition, including Gout Flares, Pericarditis and Postcommissurotomy Syndrome. The measure of dosage varies, contingent upon the technique of administration featured in the accompanying table.
Condition
Dosage
Administration
Familial Mediterranean Fever
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
prophylaxis of Gout Flares
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Postcommissurotomy Syndrome
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Pericarditis
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Postpericardiotomy Syndrome
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Behcet Syndrome
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release
Gout Flares
0.5 mg, , 0.6 mg, 1.0 mg, 0.6 mg/mL, 0.001 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Tablet, extended release - Oral, Tablet, extended release

Warnings

Colcrys Contraindications
Condition
Risk Level
Notes
Liver Disease
Do Not Combine
Liver Disease
Do Not Combine
There are 20 known major drug interactions with Colcrys.
Common Colcrys Drug Interactions
Drug Name
Risk Level
Description
Choline C 11
Major
The therapeutic efficacy of Choline C 11 can be decreased when used in combination with Colchicine.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Colchicine.
Fentanyl
Major
The metabolism of Fentanyl can be decreased when combined with Colchicine.
Aclidinium
Minor
Colchicine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Colchicine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Colcrys Toxicity & Overdose RiskTests have found that the toxic dose of colchicine for mice is 5.87 mg/kg. In cases of colchicine overdose, people may experience abdominal pain, nausea, vomiting, diarrhea, and dehydration within 24 hours of ingesting the drug. Over the next 24-72 hours, serious complications such as multi-organ failure and respiratory depression may occur, which can lead to death. To treat an overdose, doctors may perform gastric lavage and provide supportive care, though there is no antidote for colchicine. It is important to keep this drug away from children. Dialysis is not an effective way
image of a doctor in a lab doing drug, clinical research

Colcrys Novel Uses: Which Conditions Have a Clinical Trial Featuring Colcrys?

Three active trials are assessing the potential of Colcrys as a prophylactic agent for Gout Flares, Behcet's Syndrome and Postpericardiotomy Syndrome.
Condition
Clinical Trials
Trial Phases
prophylaxis of Gout Flares
0 Actively Recruiting
Behcet Syndrome
0 Actively Recruiting
Gout Flares
0 Actively Recruiting
Pericarditis
0 Actively Recruiting
Familial Mediterranean Fever
0 Actively Recruiting
Postpericardiotomy Syndrome
0 Actively Recruiting
Postcommissurotomy Syndrome
0 Actively Recruiting

Colcrys Reviews: What are patients saying about Colcrys?

5Patient Review
2/2/2015
Colcrys for Gout
I had severe gout pain in my left big toe and this treatment completely alleviated it. I just took three pills within one hour of each other and felt no pain afterwards. No side effects that I could tell, would definitely use again!
5Patient Review
1/25/2019
Colcrys for Gout
Colcrys has been an integral part of my treatment plan and it really helps to manage active attacks in combination with indocin and allopurinol.
5Patient Review
10/19/2014
Colcrys for Gout
4.3Patient Review
11/30/2016
Colcrys for Gout
Colcrys is the only thing that works quickly, and it's not even that expensive if you use the coupon on their website.
4.3Patient Review
4/20/2017
Colcrys for Familial Mediterranean Fever
This alleviated my kidney-related back pain after just a week of use. Additionally, it has helped to lessen the frequency and intensity of attacks.
View All Reviews
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Patient Q&A Section about colcrys

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of the drug Colcrys?

"If you experience any of the following symptoms, you should see a doctor immediately: black or tarry stools, blood in the urine or stools, burning, crawling, or tingling feeling in the skin, difficulty with breathing when exercising, fever with or without chills, large hive-like swellings on the face, eyelids, mouth, lips, or tongue, muscle weakness, or numbness in the fingers or toes."

Answered by AI

How quickly does Colcrys work?

"Colchicine helps reduce inflammation that can lead to symptoms, typically within 30 minutes to 2 hours. However, you may not notice a difference in inflammation or pain for a day or two. If you're taking colchicine to prevent flare-ups of familial Mediterranean fever, you may not feel any different."

Answered by AI

What does Colcrys do for gout?

"If you have too much uric acid in your blood, it can form crystals in your joints, which causes pain. Colchicine helps by reducing swelling and the amount of uric acid crystals."

Answered by AI
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