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Genetic Testing for Depression and Suicide Risk Management

N/A
Recruiting
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
11-18 Years Old?
Be younger than 65 years old
Must not have
You have been diagnosed with Bipolar Disorder
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks
Awards & highlights

Study Summary

This trialstudies biomarkers to understand depression and suicide better, to improve treatment and care in the future. It tests how treatments can improve depressive and suicidal behavior.

Who is the study for?
This trial is for physically healthy adolescents with major depressive disorder (MDD) and a high risk of suicide, who can provide informed consent. It includes those who recently attempted suicide or have severe suicidal thoughts. Participants must not have certain mental health conditions, recent serious physical health issues, or substance use disorders.Check my eligibility
What is being tested?
The study aims to identify new biomarkers in the blood related to depression and suicidality by using genetic testing on exosomes derived from nerve cells. It will also assess how standard treatments for depression affect these potential biomarkers and patient outcomes.See study design
What are the potential side effects?
Since this trial involves genetic testing rather than drug treatment, there are no direct side effects associated with the intervention itself. However, participants may experience discomfort or other minor effects from the blood draw required for the test.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Clinical phenotype analysis

Trial Design

1Treatment groups
Experimental Treatment
Group I: MDD ParticipantExperimental Treatment1 Intervention
Participants with MDD will return at six weeks for a second blood draw and assessments
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Genetic testing
2017
N/A
~5890

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,590 Previous Clinical Trials
2,281,422 Total Patients Enrolled
23 Trials studying Depression
2,389 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,786 Previous Clinical Trials
2,689,469 Total Patients Enrolled
666 Trials studying Depression
251,344 Patients Enrolled for Depression

Media Library

MDD Participant Clinical Trial Eligibility Overview. Trial Name: NCT05437588 — N/A
Depression Research Study Groups: MDD Participant
Depression Clinical Trial 2023: MDD Participant Highlights & Side Effects. Trial Name: NCT05437588 — N/A
MDD Participant 2023 Treatment Timeline for Medical Study. Trial Name: NCT05437588 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the research team currently looking for new participants?

"Affirmative, this investigation is currently soliciting participants. The original advertisement was posted on October 1st and the information has been refreshed as of October 25th."

Answered by AI

What is the aggregate number of individuals participating in this clinical experiment?

"Affirmative. According to clinicaltrials.gov, this medical trial launched on October 1st 2022 is currently recruiting participants across two sites with a total of 240 people needed for the study. The record has been recently updated as of October 25th 2022."

Answered by AI

Does this research necessitate a certain age threshold for participation?

"According to the criteria outlined in this trial, only those between 10 and 24 years of age are eligible. There are an additional 239 trials for minors as well as 1,063 studies for individuals over 65."

Answered by AI

Could I potentially qualify to join this medical experiment?

"This research endeavour seeks to enrol 240 minors aged 10-24 with mental depression. To qualify, individuals must meet physical wellness requirements and provide informed consent (and parental/guardian permission if applicable). Moreover, they need a DSM-5 diagnosis in addition to obtaining a CDRS-R score of 30+ within the two weeks preceding their application; those that have experienced suicidal ideations must also get C-SSRS scores of 4 or higher over this time span, as well as having had an attempt serious enough for medical attention in the last fortnight which displays at least medium intent on SIS. Lastly, no major psychiatric illness excluding specific ph"

Answered by AI

Who else is applying?

What site did they apply to?
University of Alabama at Birmingham
What portion of applicants met pre-screening criteria?
Met criteria

Why did patients apply to this trial?

I never want another person to feel how I have felt.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents
Yogesh Dwivedi, PhD 2022. "Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05437588.
~160 spots leftby Jun 2027
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