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Accelerated TMS for Schizophrenia (ATP Trial)
Phase 1 & 2
Waitlist Available
Led By Roscoe O Brady, MD, PhD
Research Sponsored by Beth Israel Deaconess Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up before treatment (baseline) and 1 week and 3 weeks and 24 weeks post treatment
Awards & highlights
ATP Trial Summary
This trial is to test if a more intense Transcranial Magnetic Stimulation schedule can effectively treat symptoms of psychotic disorders like schizophrenia.
Who is the study for?
This trial is for adults aged 18-65 with a diagnosis of schizophrenia, schizoaffective disorder, or at high risk for psychosis. Participants must be stable outpatients, fluent in English, and capable of completing study procedures without recent hospitalizations or medication changes.Check my eligibility
What is being tested?
The trial tests the safety and effectiveness of an accelerated schedule of repetitive Transcranial Magnetic Stimulation (rTMS) to treat symptoms associated with psychotic disorders like schizophrenia.See study design
What are the potential side effects?
Possible side effects from rTMS may include discomfort at the stimulation site, headache, lightheadedness, seizures in rare cases, and hearing issues if ear protection isn't used during treatment.
ATP Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ before treatment (baseline) and 1 week and 3 weeks and 24 weeks post treatment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~before treatment (baseline) and 1 week and 3 weeks and 24 weeks post treatment
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Tolerability of accelerated TMS
Secondary outcome measures
Change in auditory hallucination severity
Change in cerebellar-cerebral resting-state functional connectivity
Change in information processing speed
+1 moreATP Trial Design
1Treatment groups
Experimental Treatment
Group I: repetitive Transcranial Magnetic Stimulation (rTMS)Experimental Treatment1 Intervention
repetitive Transcranial Magnetic Stimulation (rTMS) in a iTBS pattern to the cerebellum at 100% of resting motor threshold
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
repetitive Transcranial Magnetic Stimulation (rTMS)
2014
N/A
~510
Find a Location
Who is running the clinical trial?
Beth Israel Deaconess Medical CenterLead Sponsor
836 Previous Clinical Trials
13,010,316 Total Patients Enrolled
21 Trials studying Schizophrenia
1,982 Patients Enrolled for Schizophrenia
Roscoe O Brady, MD, PhDPrincipal InvestigatorBeth Israel Deaconess Medical Center
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I don't have conditions that increase risks from rTMS or MRI.I have had a head injury that caused me to lose consciousness for a long time or left me with lasting neurological issues.I have had fainting spells that might be seizures.I have a chronic condition that could lead to a medical emergency if I have a seizure.I have had many seizures or have been diagnosed with epilepsy.I do not have a progressive neurological disorder like MS or Parkinson's.I am able to complete all study-related procedures.I have been diagnosed with schizophrenia or schizoaffective disorder, or I am at high risk for developing a psychotic disorder.I do not have signs of increased pressure in my brain or brain lesions.I am between 18 and 65 years old.I have a known brain disorder, cerebral palsy, had a severe head injury, or significant physical brain abnormalities.My medications and medical history will be reviewed by the study leader.I haven't been hospitalized or changed my medications in the last 30 days.I have been diagnosed with schizophrenia, schizoaffective disorder, or am at high risk for a psychotic disorder.
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Research Study Groups:
This trial has the following groups:- Group 1: repetitive Transcranial Magnetic Stimulation (rTMS)
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is the age criterion for enrolling in this trial above 25 years?
"Candidates for the trial must fall within a specific age range, namely 18 to 65. Separately, there are 93 clinical trials available for those under 18 and 211 studies open to seniors aged over 65 years old."
Answered by AI
Are there any opportunities to participate in this clinical experiment?
"This investigation is enrolling twenty individuals with a diagnosis of schizophrenia or deemed at high risk for psychosis, aged between eighteen and sixty-five. To be eligible, participants must demonstrate fluency in English, the ability to complete study procedures as judged by staff members, and stability within their current outpatient treatment plan without any hospitalisations or changes to medication regimens over the last thirty days."
Answered by AI
Are there any vacancies in this experimental program for participants?
"As per the information published on clinicaltrials.gov, this trial has concluded recruitment and is no longer accepting new participants. The study was put up in October of 2022 but ceased to recruit shortly after; however, there are currently 438 other trials searching for volunteers right now."
Answered by AI
Who else is applying?
What state do they live in?
Texas
What site did they apply to?
Beth Israel Deaconess Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
3+
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