Accelerated TMS for Schizophrenia
(ATP Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a faster schedule of Transcranial Magnetic Stimulation (TMS) to determine its effectiveness in treating symptoms of schizophrenia, which affects thinking and perception. It uses repetitive TMS, a non-invasive method where magnetic fields stimulate nerve cells in the brain. Individuals with schizophrenia, or those at high risk and in stable treatment without recent medication changes, may be suitable candidates. The trial aims to assess the method's effectiveness and patient tolerance. As a Phase 1 and Phase 2 trial, the research seeks to understand how the treatment works in people and measure its effectiveness in an initial, smaller group, offering participants a chance to contribute to groundbreaking advancements in schizophrenia treatment.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop your current medications. However, your medications will be reviewed by the study's principal investigator to decide if you can participate, based on your medical history and current treatment.
What prior data suggests that this method is safe for treating schizophrenia?
Studies have shown that repetitive Transcranial Magnetic Stimulation (rTMS) is generally safe and well-tolerated for people with schizophrenia. Research indicates that individuals with schizophrenia do not face a higher risk of serious side effects, such as seizures, when using rTMS. In fact, side effects related to rTMS are usually mild and occurred in about 16.7% of participants. While a seizure is the most serious possible side effect, it remains rare. Overall, rTMS appears to be a safe option for those considering this treatment.12345
Why do researchers think this study treatment might be promising?
Most treatments for schizophrenia, like antipsychotic medications, work by altering neurotransmitter levels in the brain to manage symptoms. But repetitive Transcranial Magnetic Stimulation (rTMS) offers a different approach. It uses magnetic fields to stimulate nerve cells, which researchers believe can lead to quicker and potentially more effective relief, especially when applied in an accelerated protocol. This method targets the brain directly and non-invasively, offering hope for faster symptom improvement without the side effects often associated with medication. Researchers are excited about rTMS because it could revolutionize how we manage schizophrenia, making treatment more accessible and tolerable for patients.
What evidence suggests that repetitive Transcranial Magnetic Stimulation (rTMS) might be an effective treatment for schizophrenia?
Research shows that repetitive Transcranial Magnetic Stimulation (rTMS), which participants in this trial will receive, can help treat symptoms of schizophrenia. Studies have found that rTMS reduces negative symptoms, like a lack of emotion or motivation, and works better than placebo treatments. It also improves thinking skills, such as memory and language. Imaging-guided rTMS safely reduces auditory hallucinations (hearing voices) in people with schizophrenia. Overall, rTMS appears promising in improving both mental and emotional symptoms of this condition.45678
Who Is on the Research Team?
Roscoe O Brady, MD, PhD
Principal Investigator
Beth Israel Deaconess Medical Center
Are You a Good Fit for This Trial?
This trial is for adults aged 18-65 with a diagnosis of schizophrenia, schizoaffective disorder, or at high risk for psychosis. Participants must be stable outpatients, fluent in English, and capable of completing study procedures without recent hospitalizations or medication changes.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive accelerated TMS sessions multiple times per day over 5 days
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- repetitive Transcranial Magnetic Stimulation (rTMS)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Beth Israel Deaconess Medical Center
Lead Sponsor