30 Participants Needed

CPT + Memory Enhancement for PTSD

JC
RA
Overseen ByRichard A Moore
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: VA Office of Research and Development
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

Several psychotherapies for posttraumatic stress disorder (PTSD) have a strong evidence base for their efficacy, but nonresponse rates are high, particularly among older Veterans. Accumulating evidence indicates that memory deficits and poor learning of therapy contents adversely affect psychotherapy treatment response in PTSD. However, limited research has examined methods for increasing learning of therapy contents in psychotherapy for PTSD. The proposed study aims to examine the feasibility of integrating an intervention to increase learning and memory of psychotherapy content into the provision of a widely used psychotherapy, cognitive processing therapy (CPT), for older adults with PTSD. The ultimate goal of this line of research is to develop novel rehabilitation interventions to increase functioning for individuals with PTSD.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but you cannot participate if you use benzodiazepines daily.

How is the treatment CPT + Memory Enhancement for PTSD different from other treatments for PTSD?

CPT + Memory Enhancement for PTSD is unique because it combines Cognitive Processing Therapy (CPT) with memory support to address the cognitive challenges faced by individuals with PTSD, particularly in verbal memory acquisition, which may limit the effectiveness of standard CPT.12345

What data supports the effectiveness of the treatment Cognitive Processing Therapy (CPT) + Memory Support for PTSD?

Cognitive Processing Therapy (CPT) has been shown to be effective in treating PTSD, including in cases involving combat, assault, and interpersonal violence trauma. Additionally, a modified form of CPT has demonstrated promise in improving PTSD symptoms and related issues, such as heavy alcohol use, in individuals with PTSD. Integrating memory support into CPT may help address cognitive challenges, potentially enhancing treatment outcomes for those with PTSD.12567

Who Is on the Research Team?

JC

James C. Scott, PhD

Principal Investigator

Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA

Are You a Good Fit for This Trial?

This trial is for veterans over the age of 59 with PTSD diagnosed by a specific scale (CAPS-5). It's not suitable for those with severe brain injury, dementia signs, daily benzodiazepine use, bipolar or psychotic disorders, current serious suicidal thoughts, active substance abuse issues not in remission for at least a month, or other limiting conditions.

Inclusion Criteria

Veterans with DSM-5 diagnoses of PTSD via the Clinician Administered PTSD Scale (CAPS-5)
I am 60 years old or older.

Exclusion Criteria

I use benzodiazepines daily.
I have had a severe brain injury.
Current suicidal ideation with plan or intent
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive Cognitive Processing Therapy (CPT) with or without Memory Support to enhance learning and memory of therapy content

12-16 weeks
Weekly therapy sessions

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Cognitive Processing Therapy
  • Cognitive Processing Therapy (CPT) + Memory Support
Trial Overview The study tests whether adding Memory Support to Cognitive Processing Therapy (CPT) can help older adults with PTSD learn and remember therapy content better. The goal is to improve how well they respond to treatment.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive Processing Therapy (CPT) + Memory SupportExperimental Treatment2 Interventions
Group II: Cognitive Processing Therapy (CPT)Active Control1 Intervention

Cognitive Processing Therapy is already approved in United States, European Union for the following indications:

🇺🇸
Approved in United States as Cognitive Processing Therapy for:
🇪🇺
Approved in European Union as Cognitive Processing Therapy for:

Find a Clinic Near You

Who Is Running the Clinical Trial?

VA Office of Research and Development

Lead Sponsor

Trials
1,691
Recruited
3,759,000+

Published Research Related to This Trial

A 12-week course of modified Cognitive Processing Therapy (CPT-C) effectively improved PTSD symptoms and reduced alcohol dependence in a combat veteran, showing promise for treating co-occurring conditions.
The veteran maintained significant improvements in both PTSD and alcohol-related issues 12 weeks after completing the treatment, suggesting the long-term efficacy of this enhanced therapy.
Case report on the use of cognitive processing therapy-cognitive, enhanced to address heavy alcohol use.McCarthy, E., Petrakis, I.[2022]
Cognitive Processing Therapy (CPT) is an effective evidence-based treatment for PTSD, particularly for individuals who have experienced combat, assault, or interpersonal violence, as supported by randomized controlled trials.
The Department of Veterans Affairs has successfully implemented CPT across its healthcare system, with trained clinicians showing good adoption of the therapy and significant improvements in patients' PTSD and depressive symptoms.
Dissemination and experience with cognitive processing therapy.Chard, KM., Ricksecker, EG., Healy, ET., et al.[2022]
The CPTPTSD study will investigate how cognitive functioning affects the response to Cognitive Processing Therapy (CPT) in 105 veterans with PTSD, focusing on memory and cognitive abilities before treatment begins.
By identifying the relationship between cognitive deficits and treatment outcomes, this research aims to develop more personalized and effective PTSD therapies, potentially improving the efficacy of existing psychotherapies.
Neurocognitive Predictors of Treatment Outcomes in Cognitive Processing Therapy for Post-traumatic Stress Disorder: Study Protocol.Cenkner, DP., Asnaani, A., DiChiara, C., et al.[2022]

Citations

Case report on the use of cognitive processing therapy-cognitive, enhanced to address heavy alcohol use. [2022]
Dissemination and experience with cognitive processing therapy. [2022]
Evaluation of a hybrid treatment for Veterans with comorbid traumatic brain injury and posttraumatic stress disorder: Study protocol for a randomized controlled trial. [2018]
Neurocognitive Predictors of Treatment Outcomes in Cognitive Processing Therapy for Post-traumatic Stress Disorder: Study Protocol. [2022]
Cognitive processing therapy for sexual assault victims. [2022]
Effect of Group vs Individual Cognitive Processing Therapy in Active-Duty Military Seeking Treatment for Posttraumatic Stress Disorder: A Randomized Clinical Trial. [2022]
Delivered as Described: A Successful Case of Cognitive Processing Therapy With an Older Woman Veteran With PTSD. [2023]
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