CPT + Memory Enhancement for PTSD
What You Need to Know Before You Apply
What is the purpose of this trial?
Several psychotherapies for posttraumatic stress disorder (PTSD) have a strong evidence base for their efficacy, but nonresponse rates are high, particularly among older Veterans. Accumulating evidence indicates that memory deficits and poor learning of therapy contents adversely affect psychotherapy treatment response in PTSD. However, limited research has examined methods for increasing learning of therapy contents in psychotherapy for PTSD. The proposed study aims to examine the feasibility of integrating an intervention to increase learning and memory of psychotherapy content into the provision of a widely used psychotherapy, cognitive processing therapy (CPT), for older adults with PTSD. The ultimate goal of this line of research is to develop novel rehabilitation interventions to increase functioning for individuals with PTSD.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you use benzodiazepines daily.
How is the treatment CPT + Memory Enhancement for PTSD different from other treatments for PTSD?
What data supports the effectiveness of the treatment Cognitive Processing Therapy (CPT) + Memory Support for PTSD?
Cognitive Processing Therapy (CPT) has been shown to be effective in treating PTSD, including in cases involving combat, assault, and interpersonal violence trauma. Additionally, a modified form of CPT has demonstrated promise in improving PTSD symptoms and related issues, such as heavy alcohol use, in individuals with PTSD. Integrating memory support into CPT may help address cognitive challenges, potentially enhancing treatment outcomes for those with PTSD.12567
Who Is on the Research Team?
James C. Scott, PhD
Principal Investigator
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
Are You a Good Fit for This Trial?
This trial is for veterans over the age of 59 with PTSD diagnosed by a specific scale (CAPS-5). It's not suitable for those with severe brain injury, dementia signs, daily benzodiazepine use, bipolar or psychotic disorders, current serious suicidal thoughts, active substance abuse issues not in remission for at least a month, or other limiting conditions.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Cognitive Processing Therapy (CPT) with or without Memory Support to enhance learning and memory of therapy content
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Cognitive Processing Therapy
- Cognitive Processing Therapy (CPT) + Memory Support
Cognitive Processing Therapy is already approved in United States, European Union for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
VA Office of Research and Development
Lead Sponsor