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What is Cimetidine Hydrochloride
CimetidineThe Generic name of this drug
Treatment SummaryCimetidine is a drug used to block the activity of histamine, which is a chemical released in the body when an allergic reaction occurs. It works by blocking the activity of histamine on special receptors in the body and can be used to reduce acid production in the stomach, reduce pepsin and gastrin production, and block the activity of cytochrome P-450. Cimetidine is sometimes used in cancer treatments.
Cimetidineis the brand name
Cimetidine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cimetidine
Cimetidine
1994
91
Approved as Treatment by the FDA
Cimetidine, also known as Cimetidine, is approved by the FDA for 12 uses which include Adenoma and Heartburn .Adenoma
Helps manage multiple endocrine adenomas
Heartburn
Helps manage Gastro-esophageal Reflux Disease (GERD)
active Duodenal ulcer
multiple endocrine adenomas
Helps manage multiple endocrine adenomas
benign gastric ulcers
Zollinger-Ellison Syndrome
Helps manage Zollinger-Ellison Syndrome
Gastric hypersecretion
Helps manage Gastric hypersecretion
Systemic Mastocytosis
Helps manage Systemic Mastocytosis
Gastro-esophageal Reflux Disease (GERD)
Helps manage Gastro-esophageal Reflux Disease (GERD)
Gastric ulcer
Duodenal Ulcer
Mastocytosis, Systemic
Helps manage Systemic Mastocytosis
Effectiveness
How Cimetidine Hydrochloride Affects PatientsCimetidine helps reduce stomach acid and is used to treat gastric and duodenal ulcers, heartburn, and other conditions that involve too much acid secretion. It does this by blocking the histamine H2 receptors in the stomach. Cimetidine also affects certain enzymes in the liver and increases the amount of certain types of bacteria in the stomach.
How Cimetidine Hydrochloride works in the bodyCimetidine works by blocking histamine receptors on the stomach. This stops the body from producing too much stomach acid and reduces the amount of acid in the stomach.
When to interrupt dosage
The recommended measure of Cimetidine Hydrochloride is contingent upon the diagnosed condition, including Acid indigestion, Cystic Fibrosis (CF) and Systemic Mastocytosis. Dosage fluctuates in accordance with the mode of delivery (e.g. Liquid or Intramuscular; Intravenous) delineated in the following table.Condition
Dosage
Administration
Heartburn
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Gastric hypersecretion
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Zollinger-Ellison Syndrome
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Indigestion
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Heartburn
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Duodenal Ulcer
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
NSAID use
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Adenoma
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Cystic Fibrosis
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Gastric ulcer
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Mastocytosis, Systemic
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Gastrointestinal Symptoms
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Duodenum
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Stomach Ulcer
, 300.0 mg, 400.0 mg, 800.0 mg, 200.0 mg, 300.0 mg/mL, 600.0 mg, 100.0 mg, 6.0 mg/mL, 150.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg, 400.0 mg/mL, 60.0 mg/mL
Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, Intravenous, Liquid - Intravenous, Solution - Intramuscular; Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution - Intramuscular; Intravenous, Cream - Topical, Cream, Topical, Gel, Gel - Topical
Warnings
Cimetidine Hydrochloride ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Cimetidine may interact with Pulse Frequency
Common Cimetidine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Cimetidine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Cimetidine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Cimetidine.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Cimetidine.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Cimetidine.
Cimetidine Hydrochloride Toxicity & Overdose RiskIf someone takes too much cimetidine, it is important to keep their airway and heart rate stable. The patient should be carefully monitored and given any necessary medical care. If needed, treatments like stomach pumping and activated charcoal may be used.
Cimetidine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Cimetidine Hydrochloride?
27 active clinical trials are currently assessing the potential of Cimetidine Hydrochloride to relieve Heartburn, Duodenal and Duodenal Ulcer symptoms.Condition
Clinical Trials
Trial Phases
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
Indigestion
7 Actively Recruiting
Phase 3, Early Phase 1, Phase 2, Not Applicable, Phase 4
Gastric ulcer
0 Actively Recruiting
Zollinger-Ellison Syndrome
0 Actively Recruiting
Stomach Ulcer
0 Actively Recruiting
Duodenum
0 Actively Recruiting
NSAID use
0 Actively Recruiting
Duodenal Ulcer
0 Actively Recruiting
Cystic Fibrosis
0 Actively Recruiting
Mastocytosis, Systemic
0 Actively Recruiting
Gastrointestinal Symptoms
3 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Adenoma
0 Actively Recruiting
Heartburn
11 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 1, Phase 4
Gastric hypersecretion
0 Actively Recruiting
Patient Q&A Section about cimetidine hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why was cimetidine taken off the market?
"The FDA has warned that some common heartburn medications may contain NDMA, a substance classified as a probable human carcinogen by the World Health Organization."
Answered by AI
What is the major side effect of cimetidine?
"Headaches, dizziness, drowsiness and diarrhea may occur. If any of these effects persist or worsen, notify your doctor immediately."
Answered by AI
What is cimetidine hydrochloride used for?
"This medicine is an antihistamine that blocks the release of stomach acid. It is used to treat stomach or intestinal ulcers. It can relieve ulcer pain and discomfort, and the heartburn from acid reflux."
Answered by AI
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