Cimetidine Hydrochloride

Systemic Mastocytosis, Gastric hypersecretion, NSAID use + 12 more

Treatment

7 FDA approvals

20 Active Studies for Cimetidine Hydrochloride

Treatment for

Systemic Mastocytosis

What is Cimetidine Hydrochloride

CimetidineThe Generic name of this drug

Treatment SummaryCimetidine is a drug used to block the activity of histamine, which is a chemical released in the body when an allergic reaction occurs. It works by blocking the activity of histamine on special receptors in the body and can be used to reduce acid production in the stomach, reduce pepsin and gastrin production, and block the activity of cytochrome P-450. Cimetidine is sometimes used in cancer treatments.

Cimetidineis the brand name

image of different drug pills on a surface

Cimetidine Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Cimetidine

Cimetidine

1994

91

Approved as Treatment by the FDA

Cimetidine, also known as Cimetidine, is approved by the FDA for 7 uses which include Gastric ulcer and Heartburn .

Gastric ulcer

Heartburn

Helps manage Gastro-esophageal Reflux Disease (GERD)

Zollinger-Ellison Syndrome

Helps manage Zollinger-Ellison Syndrome

Duodenal Ulcer

Gastric hypersecretion

Helps manage Gastric hypersecretion

Systemic Mastocytosis

Helps manage Systemic Mastocytosis

Adenoma

Helps manage multiple endocrine adenomas

Effectiveness

How Cimetidine Hydrochloride Affects PatientsCimetidine helps reduce stomach acid and is used to treat gastric and duodenal ulcers, heartburn, and other conditions that involve too much acid secretion. It does this by blocking the histamine H2 receptors in the stomach. Cimetidine also affects certain enzymes in the liver and increases the amount of certain types of bacteria in the stomach.

How Cimetidine Hydrochloride works in the bodyCimetidine works by blocking histamine receptors on the stomach. This stops the body from producing too much stomach acid and reduces the amount of acid in the stomach.

When to interrupt dosage

The recommended measure of Cimetidine Hydrochloride is contingent upon the diagnosed condition, including Acid indigestion, Cystic Fibrosis (CF) and Systemic Mastocytosis. Dosage fluctuates in accordance with the mode of delivery (e.g. Liquid or Intramuscular; Intravenous) delineated in the following table.

Condition

Dosage

Administration

Systemic Mastocytosis

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Gastric hypersecretion

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Cystic Fibrosis (CF)

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Duodenal Ulcer

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Duodenum

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Zollinger-Ellison Syndrome

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Indigestion

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Heartburn

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

NSAID use

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Acid indigestion

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

NSAID Associated Gastric Ulcers

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Adenoma

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Gastrointestinal Symptoms

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Heartburn

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Gastric ulcer

800.0 mg, 6.0 mg/mL, 200.0 mg, 100.0 mg, 150.0 mg/mL, 60.0 mg/mL, 400.0 mg, , 300.0 mg, 600.0 mg, 400.0 mg/mL, 300.0 mg/mL, 0.1 mg/mg, 0.05 mg/mg

Liquid, Intramuscular; Intravenous, Liquid - Intramuscular; Intravenous, , Oral, Liquid - Oral, Gel, Solution, Tablet - Oral, Injection, solution - Intramuscular; Intravenous, Injection, solution, Tablet, film coated, Tablet, Intravenous, Tablet, film coated - Oral, Liquid - Intravenous, Cream, Injection, solution - Intravenous, Cream - Topical, Topical, Solution - Intramuscular; Intravenous, Solution - Oral, Gel - Topical

Warnings

Cimetidine Hydrochloride Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Cimetidine may interact with Toxoplasma Infections

There are 20 known major drug interactions with Cimetidine Hydrochloride.

Common Cimetidine Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Cimetidine.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Cimetidine.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Cimetidine.

Alpelisib

Major

The metabolism of Alpelisib can be decreased when combined with Cimetidine.

Anagrelide

Major

The metabolism of Anagrelide can be decreased when combined with Cimetidine.

Cimetidine Hydrochloride Toxicity & Overdose RiskIf someone takes too much cimetidine, it is important to keep their airway and heart rate stable. The patient should be carefully monitored and given any necessary medical care. If needed, treatments like stomach pumping and activated charcoal may be used.

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Cimetidine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Cimetidine Hydrochloride?

27 active clinical trials are currently assessing the potential of Cimetidine Hydrochloride to relieve Heartburn, Duodenal and Duodenal Ulcer symptoms.

Condition

Clinical Trials

Trial Phases

Gastrointestinal Symptoms

2 Actively Recruiting

Phase 1, Phase 2, Not Applicable

Gastric ulcer

0 Actively Recruiting

Duodenal Ulcer

0 Actively Recruiting

Cystic Fibrosis (CF)

0 Actively Recruiting

Gastric hypersecretion

0 Actively Recruiting

Acid indigestion

0 Actively Recruiting

Heartburn

11 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 4, Early Phase 1

Duodenum

0 Actively Recruiting

NSAID use

0 Actively Recruiting

NSAID Associated Gastric Ulcers

0 Actively Recruiting

Adenoma

0 Actively Recruiting

Indigestion

9 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Phase 1

Zollinger-Ellison Syndrome

0 Actively Recruiting

Systemic Mastocytosis

1 Actively Recruiting

Phase 1

Heartburn

2 Actively Recruiting

Phase 3, Not Applicable

Patient Q&A Section about cimetidine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why was cimetidine taken off the market?

"The FDA has warned that some common heartburn medications may contain NDMA, a substance classified as a probable human carcinogen by the World Health Organization."

Answered by AI

What is the major side effect of cimetidine?

"Headaches, dizziness, drowsiness and diarrhea may occur. If any of these effects persist or worsen, notify your doctor immediately."

Answered by AI

What is cimetidine hydrochloride used for?

"This medicine is an antihistamine that blocks the release of stomach acid. It is used to treat stomach or intestinal ulcers. It can relieve ulcer pain and discomfort, and the heartburn from acid reflux."

Answered by AI

Clinical Trials for Cimetidine Hydrochloride

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Breath Test Evaluation For SIBOfor Acid Reflux

Jacksonville, FL

This trial aims to find out how common gut bacteria imbalance is in people taking acid-reducing medications. #guthealth

Waitlist Available

Mayo Clinic FloridaAndree Koop, MD

Image of Cleveland Clinic Center for Abdominal Core Health in Cleveland, United States.

Mesh-based Crural Reinforcementfor Paraesophageal Hernia

This trial examines whether using mesh during a paraesophageal hernia repair surgery improves results and patient quality of life compared to using sutures alone.

Waitlist Available

Cleveland Clinic Center for Abdominal Core HealthMichael J Rosen, MD

Image of Memphis VA Medical Center, Memphis, TN in Memphis, United States.

Oral Glutaminefor Gulf War Syndrome

This trial will provide a novel treatment for veterans with Gulf War Illness who have chronic GI symptoms, which currently have no specific treatments. It could drastically improve the health of many veterans and reduce negative economic effects.

Waitlist Available

Dietary Supplement

Memphis VA Medical Center, Memphis, TNQiQi Zhou, MD PhD

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Experimentalfor Indigestion

Jacksonville, FL

This trial studies the use of virtual reality to reduce stomach pain & other symptoms caused by functional dyspepsia.

Waitlist Available

Mayo Clinic in FloridaDavid Cangemi

Have you considered Cimetidine Hydrochloride clinical trials? We made a collection of clinical trials featuring Cimetidine Hydrochloride, we think they might fit your search criteria.

Explore trials for Cimetidine Hydrochloride

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Glutamine Groupfor Indigestion

Jacksonville, FL

This trial looks at how glutamine affects patients with functional dyspepsia, comparing it with a placebo. It looks at safety & treatment results.

No Cost For Treatment

Mayo Clinic Florida (+1 Sites)David Cangemi, MD

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Tradipitantfor Indigestion

This trial tests how a drug affects stomach functions, feeling full, and post-meal symptoms in people with stomach issues.

Waitlist Available

Vanda Investigational SiteVanda PharmaceuticalsVanda Pharmaceuticals

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Cognitive Behavioral Therapyfor Behavioral Medicine

This trial tested a therapy to help adults with digestive issues and difficulty eating, due to ARFID, to gain weight.

Massachusetts General HospitalHelen Burton Murray, PhD

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Patients Undergoing Routine Screening Via Upper Endoscopy (EGD)for Barrett's Esophagus

This trial will test a new method for detecting Barrett's esophagus and esophageal cancer in primary care patients. The new method, called Esocheck/Esoguard, is non-endoscopic, meaning it does not require a scope be inserted down the throat. The trial will compare the new method's effectiveness to that of standard endoscopic screening.

Katarina B Greer, MD (+1 Sites)Katarina B Greer, MD/MS

Have you considered Cimetidine Hydrochloride clinical trials? We made a collection of clinical trials featuring Cimetidine Hydrochloride, we think they might fit your search criteria.

Explore trials for Cimetidine Hydrochloride

Image of University of California, Irvine in Irvine, United States.

Combo Transoral Incisionless Fundoplication (CTIF)for Acid Reflux

This trial will compare the effectiveness and safety of two different treatments for GERD in patients with hiatal hernia who are also having hernia repair surgery.

University of California, Irvine (+7 Sites)EndoGastric Solutions

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Overall Studyfor Gastroparesis

Kansas City, MO

This trial program will allow the use of domperidone in children with motility disorders and GERD who have failed standard treatments.

FDA Approved Drug

Children's Mercy Hospitals and ClinicsJose Cocjin, MD

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Flotetuzumabfor Hematologic Malignancy

This trial is studying the best dose and side effects of flotetuzumab for treating patients with relapsed or refractory blood cancers. Flotetuzumab is an antibody that may interfere with cancer cells' ability to grow and spread.

Waitlist Available

FDA Approved Drug

City of Hope Medical CenterIbrahim T Aldoss

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Caffeine Reduction Manualfor Caffeine Withdrawal

This trial will test whether a caffeine reduction program can help people cut back on their intake, and whether it's feasible to do it online.

Waitlist Available

Behavioral Pharmacology Research Unit, Johns Hopkins Bayview Medical CenterMary M Sweeney, PhD

Have you considered Cimetidine Hydrochloride clinical trials? We made a collection of clinical trials featuring Cimetidine Hydrochloride, we think they might fit your search criteria.

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