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What is Cilostazol
CilostazolThe Generic name of this drug
Treatment SummaryCilostazol, sold under the brand name Pletal, is a medication used to treat intermittent claudication (pain in the legs due to poor circulation). It works by preventing platelets from sticking together and narrowing the blood vessels, increasing blood flow to the legs. Cilostazol belongs to a group of drugs known as quinolinone derivatives.
Pletalis the brand name
Cilostazol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pletal
Cilostazol
1999
68
Approved as Treatment by the FDA
Cilostazol, also called Pletal, is approved by the FDA for 1 uses which include Intermittent Claudication .Intermittent Claudication
Effectiveness
How Cilostazol Affects PatientsCilostazol helps reduce the pain in the legs caused by reduced blood flow that comes and goes with walking. This is known as intermittent claudication. Taking Cilostazol can help you walk further and reduce the amount of pain you feel.
How Cilostazol works in the bodyCilostazol stops an enzyme from breaking down a compound called cAMP. This leads to increased levels of cAMP in platelets and blood vessels, which in turn helps prevent blood clots and improves blood flow.
When to interrupt dosage
The recommended dosage of Cilostazol is contingent upon the specified condition. The amount of dosage is contingent upon the mode of delivery (e.g. Tablet or Tablet - Oral) detailed in the table underneath.Condition
Dosage
Administration
Intermittent Claudication
50.0 mg, , 100.0 mg
, Oral, Tablet, Tablet - Oral, Tablet - Conjunctival; Oral, Conjunctival; Oral
Warnings
Cilostazol ContraindicationsCondition
Risk Level
Notes
Congestive Heart Failure
Do Not Combine
Common Cilostazol Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Cilostazol is combined with Abrocitinib.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Cilostazol.
Amrinone
Major
The risk or severity of congestive heart failure, bleeding, hypotension, and Tachycardia can be increased when Cilostazol is combined with Amrinone.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Cilostazol.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Cilostazol.
Cilostazol Toxicity & Overdose RiskNot much is known about what happens when someone takes too much cilostazol. However, it is likely that they would experience a severe headache, diarrhea, low blood pressure, rapid heartbeat, and possibly abnormal heart rhythms. Studies have shown that a lethal dose of cilostazol is greater than 5.0 g/kg in mice and rats and greater than 2.0 g/kg in dogs.
Cilostazol Novel Uses: Which Conditions Have a Clinical Trial Featuring Cilostazol?
Nine clinical trials are presently assessing the potential of Cilostazol to manage Intermittent Claudication.Condition
Clinical Trials
Trial Phases
Intermittent Claudication
8 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3
Cilostazol Reviews: What are patients saying about Cilostazol?
5Patient Review
3/5/2014 I had a severe reaction to this medication that included pounding in my chest, headaches, and an all-around feeling of unease. I'm glad I stopped taking the medication when I did, as the symptoms lingered for days afterwards.
5Patient Review
12/25/2019 The only thing I have with this medication, is I needed to take it one hour before or 2 hours after meal. Sometime it is impossible because I am a diabetic.
4.7Patient Review
7/23/2014 This drug has been a huge help when it comes to walking. I can walk much further distances without pain, and even if I do start to feel some pain, a short rest usually does the trick.
4Patient Review
1/3/2017 I'm a 65 year old male who had bypass surgery 18 years ago. I walk an average of 12,000 steps per day and this medication has helped me significantly with the pain in my left leg.
3.7Patient Review
6/13/2014 I've used this medication in the past and it really helped with my leg cramps. I ran out and noticed that the cramps came back sooner than when I was on the medication.
3.3Patient Review
7/23/2022 I started taking this medication about a month ago, and it doesn't seem to be working as well as I'd hoped. I have a follow-up appointment with my doctor in September, but I might need to go back to the emergency room before then if things don't improve.
2.7Patient Review
9/21/20132.3Patient Review
9/24/2015 Of no benefit ..
2.3Patient Review
2/27/2014 I got headaches as a side-effect of this medication.
2.3Patient Review
4/25/2020 There was no change in the amount of pain I felt when walking, and if anything, it seems like the distance I can walk has decreased.
2Patient Review
9/9/2021 I'm still having a lot of pain after two weeks on this medication. I was hoping for more relief by now.
1Patient Review
7/13/2016 I had to stop taking this medication after only two and a half weeks because it caused extreme mood swings, dizziness, nausea, memory loss, and headaches. I was also nonfunctional at times and didn't even know where I was.
1Patient Review
10/21/2013 Every time I take this medication, I feel nauseous and get an instant headache.
Patient Q&A Section about cilostazol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the generic name for cilostazol?
"What is cilostazol?
Cilostazol is a quinolinone derivative used for the treatment of intermittent claudication and peripheral vascular disease. It is available under the brand name Pletal."
Answered by AI
What is cilostazol used for?
"The drug cilostazol improves blood flow through vessels and is used to reduce leg pain from poor circulation. With cilostazol, people can walk further before needing to take a break because of leg pain."
Answered by AI
Is cilostazol a blood thinner?
"No, cilostazol is not a blood thinner. However, it does help prevent platelets from sticking together, which could theoretically increase the risk of bleeding."
Answered by AI
What type of drug is cilostazol?
"Cilostazol belongs to a class of medications known as platelet-aggregation inhibitors, or antiplatelet medications. These drugs work by improving blood flow to the legs."
Answered by AI