Chlorpropamide

Diabetes Insipidus, Type 2 Diabetes
Treatment
1 FDA approval
20 Active Studies for Chlorpropamide

What is Chlorpropamide

ChlorpropamideThe Generic name of this drug
Treatment SummaryChlorpropamide is a medication used to treat non-insulin dependent diabetes mellitus (NIDDM). It belongs to a family of drugs called sulfonylureas, which increase insulin levels in the body by stimulating the pancreas to release insulin. It can cause weight gain, but usually to a lesser degree than insulin. It can also cause hypoglycemia and must be taken with food to reduce this risk. It is not recommended for patients with high blood pressure or retinopathy. Chlorpropamide is metabolized in the liver and excreted in urine as the drug itself and its metabolites. People
Diabineseis the brand name
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Chlorpropamide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Diabinese
Chlorpropamide
1958
9

Approved as Treatment by the FDA

Chlorpropamide, otherwise called Diabinese, is approved by the FDA for 1 uses including Type 2 Diabetes .
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus

Effectiveness

How Chlorpropamide Affects PatientsChlorpropamide is a type of medicine used to help people with type II diabetes manage their blood sugar levels. It is taken with a special diet and is twice as strong as another medicine for diabetes called glipizide.
How Chlorpropamide works in the bodySulfonylureas like chlorpropamide attach to potassium channels on the outside of pancreas cells. This reduces the flow of potassium into the cell, which causes an electrical imbalance and brings calcium ions into the cell. This increase in calcium ions triggers the release of insulin from the pancreas.

When to interrupt dosage

The prescribed dose of Chlorpropamide relies upon the diagnosed condition. The quantity of dosage fluctuates as per the mode of delivery outlined in the table beneath.
Condition
Dosage
Administration
Diabetes Insipidus
, 250.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral
Type 2 Diabetes
, 250.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Chlorpropamide Contraindications
Condition
Risk Level
Notes
Type 1 Diabetes
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
There are 20 known major drug interactions with Chlorpropamide.
Common Chlorpropamide Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Minor
Chlorpropamide may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Minor
Chlorpropamide may increase the anticoagulant activities of (S)-Warfarin.
Abacavir
Minor
Chlorpropamide may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abrocitinib
Minor
The metabolism of Abrocitinib can be decreased when combined with Chlorpropamide.
Aclidinium
Minor
Chlorpropamide may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Chlorpropamide Toxicity & Overdose RiskIPN-RAT has an LD50 of 580mg/kg, meaning this is the dose at which 50% of the test subjects die.
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Chlorpropamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Chlorpropamide?

164 active clinical trials are currently being conducted to assess the viability of Chlorpropamide for Diabetes Insipidus treatment.
Condition
Clinical Trials
Trial Phases
Diabetes Insipidus
1 Actively Recruiting
Phase 1
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3

Chlorpropamide Reviews: What are patients saying about Chlorpropamide?

5Patient Review
6/1/2009
Chlorpropamide for Diabetes Insipidus
I've been using this medication for 40 years without any issues. It's always worked well for me as long as I follow the directions and stay on it consistently. I use a generic form which has given me just as great of results.
5Patient Review
7/11/2014
Chlorpropamide for Diabetes Insipidus
This treatment is very effective.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about chlorpropamide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is chlorpropamide a sulfonylurea?

"An oral sulfonylurea drug called chlorpropamide (Diabinese) is used to treat high blood sugar levels in people."

Answered by AI

What is mechanism of action of chlorpropamide?

"Chlorpropamide is used to treat non-insulin-dependent diabetes mellitus (NIDDM) by stimulating the β cells of the pancreas to release insulin."

Answered by AI

Why is chlorpropamide used in diabetes insipidus?

"In four children with vasopressin-sensitive diabetes insipidus, the hypoglycemic agent chlorpropamide caused a decrease in urinary flow rate and free water clearance. There was no change in osmolar clearance."

Answered by AI

Clinical Trials for Chlorpropamide

Have you considered Chlorpropamide clinical trials? We made a collection of clinical trials featuring Chlorpropamide, we think they might fit your search criteria.
Have you considered Chlorpropamide clinical trials? We made a collection of clinical trials featuring Chlorpropamide, we think they might fit your search criteria.
Have you considered Chlorpropamide clinical trials? We made a collection of clinical trials featuring Chlorpropamide, we think they might fit your search criteria.
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