← Back to Search

Other

Through-flow System for Respiratory Insufficiency (Throughflow Trial)

N/A

Recruiting

Led By Ewan Goligher, MD, PhD

Research Sponsored by University Health Network, Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Oral endotracheal intubation and mechanical ventilation

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24 hours

Awards & highlights

Throughflow Trial Summary

This trial looks at how a new system can reduce diaphragm and lung injury caused by mechanical ventilation.

Who is the study for?

This trial is for patients with a specific type of breathing difficulty due to lung or diaphragm injury, who are already on mechanical ventilation. They must have a certain level of oxygenation issues and visible lung problems on imaging tests. It's not for those with high brain pressure, expected to be off the ventilator within a day, recent upper GI surgery, or intubated due to brain injury or stroke.Check my eligibility

What is being tested?

The study is testing the Throughflow system which aims to reduce respiratory drive without increasing breath size by removing dead space in mechanically ventilated patients. This could potentially prevent further damage to the lungs and diaphragm caused by overworking during artificial ventilation.See study design

What are the potential side effects?

While specific side effects aren't listed, potential risks may include discomfort from the esophageal catheter used in Throughflow and complications related to changes in how the lungs receive air from mechanical ventilation.

Throughflow Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am on a breathing machine through a tube in my mouth.

Throughflow Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Dynamic driving transpulmonary pressure (lung-distending pressure)

Esophageal pressure swing (respiratory effort)

Oxygenation (PaO2/FiO2 ratio)

Secondary outcome measures

Changes in dose of sedative medications achieved during the titration phase

Rate of serious adverse events

Throughflow Trial Design

1Treatment groups

Experimental Treatment

Group I: ThroughflowExperimental Treatment1 Intervention

Throughflow is a novel system that reduces anatomical dead space by providing a constant flow of fresh gas (i.e., gas that is free of CO2) during inspiration in patients receiving invasive mechanical ventilation. By clearing the CO2 that normally remains in the upper airway after exhalation (anatomical dead space), TF can dramatically reduce anatomical dead space without the need to increase the delivered VT, making it a safe strategy in terms of lung protection. This reduction in dead space reduces the ventilatory demands of the patients, reducing respiratory drive.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Unity Health TorontoOTHER

540 Previous Clinical Trials

447,765 Total Patients Enrolled

6 Trials studying Lung Injury

182 Patients Enrolled for Lung Injury

University Health Network, TorontoLead Sponsor

1,476 Previous Clinical Trials

485,165 Total Patients Enrolled

5 Trials studying Lung Injury

509 Patients Enrolled for Lung Injury

Ewan Goligher, MD, PhDPrincipal InvestigatorUniversity Health Network, Toronto

7 Previous Clinical Trials

6,587 Total Patients Enrolled

3 Trials studying Lung Injury

273 Patients Enrolled for Lung Injury

Media Library

Lung Injury Clinical Trial 2023: Throughflow titration phase Highlights & Side Effects. Trial Name: NCT05642832 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies in this medical trial?

"According to clinicaltrials.gov, the current study has stopped enrolling patients as of November 29th 2022. Initially posted on December 1st 2022, this trial no longer seeks participants; however there are still 943 other studies active recruiting at present."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Feasibility of Reducing Respiratory Drive Using the Through-flow System

2024. "Feasibility of Reducing Respiratory Drive Using the Through-flow System". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05642832.