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What is Cardene
NicardipineThe Generic name of this drug
Treatment SummaryNimodipine is a drug used to lower blood pressure and relax the blood vessels. It can also be used to treat angina and coronary spasms without causing harm to the heart. Nimodipine can also be used to treat asthma, and it can increase the effectiveness of certain chemotherapy drugs.
Cardene IVis the brand name
Cardene Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cardene IV
Nicardipine
1992
71
Approved as Treatment by the FDA
Nicardipine, also called Cardene IV, is approved by the FDA for 2 uses which include Hypertensive disease and Chronic Stable Angina Pectoris .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Chronic Stable Angina Pectoris
Helps manage Chronic Stable Angina Pectoris
Effectiveness
How Cardene Affects PatientsNicardipine is a medication used to lower blood pressure, treat chest pain, and Prinzmetal's variant angina (a rare form of chest pain). It works by blocking calcium from entering certain muscles of the heart and blood vessels, which relaxes the muscles and makes it easier for blood to flow. This helps to decrease the workload on the heart, reduce resistance to blood flow, and lower overall blood pressure. Nicardipine is similar to other peripheral vasodilators in that it helps increase oxygen delivery to the heart and relax blood vessels.
How Cardene works in the bodyNicardipine helps to relax blood vessels and reduce blood pressure by blocking calcium from entering cells in the heart and blood vessels. This decreases the amount of calcium available to cause muscle contraction, allowing the arteries to dilate and increase oxygen delivery to the heart. Additionally, it helps to decrease the pressure of the blood flowing through the arteries, reducing the overall strain on the heart.
When to interrupt dosage
The recommended measure of Cardene is contingent upon the diagnosed affliction, including Hypertensive disease, Ischemic Stroke and Hypertensive disease. The amount likewise fluctuates as per the technique of delivery (e.g. Injection or Capsule, gelatin coated) featured in the table beneath.Condition
Dosage
Administration
Hypertensive disease
, 2.5 mg/mL, 0.1 mg/mL, 0.2 mg/mL, 20.0 mg, 30.0 mg, 45.0 mg, 60.0 mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Injection, solution - Intraventricular, Intraventricular
Chronic Stable Angina Pectoris
, 2.5 mg/mL, 0.1 mg/mL, 0.2 mg/mL, 20.0 mg, 30.0 mg, 45.0 mg, 60.0 mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Injection, solution - Intraventricular, Intraventricular
prophylaxis of migraine headaches
, 2.5 mg/mL, 0.1 mg/mL, 0.2 mg/mL, 20.0 mg, 30.0 mg, 45.0 mg, 60.0 mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Injection, solution - Intraventricular, Intraventricular
Migraine
, 2.5 mg/mL, 0.1 mg/mL, 0.2 mg/mL, 20.0 mg, 30.0 mg, 45.0 mg, 60.0 mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Injection, solution - Intraventricular, Intraventricular
Hypertensive disease
, 2.5 mg/mL, 0.1 mg/mL, 0.2 mg/mL, 20.0 mg, 30.0 mg, 45.0 mg, 60.0 mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Injection, solution - Intraventricular, Intraventricular
Ischemic Stroke
, 2.5 mg/mL, 0.1 mg/mL, 0.2 mg/mL, 20.0 mg, 30.0 mg, 45.0 mg, 60.0 mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Injection, solution - Intraventricular, Intraventricular
Brain Hemorrhage
, 2.5 mg/mL, 0.1 mg/mL, 0.2 mg/mL, 20.0 mg, 30.0 mg, 45.0 mg, 60.0 mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Injection, solution - Intraventricular, Intraventricular
Warnings
Cardene ContraindicationsCondition
Risk Level
Notes
advanced aortic stenosis
Do Not Combine
Common Cardene Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Nicardipine.
Abrocitinib
Major
The metabolism of Abrocitinib can be decreased when combined with Nicardipine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Nicardipine.
Acepromazine
Major
Nicardipine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Acetohexamide
Major
The metabolism of Acetohexamide can be decreased when combined with Nicardipine.
Cardene Toxicity & Overdose RiskThe amount of a certain drug required to kill half of a group of rats is 184mg/kg, while the amount required to kill half of a group of mice is 322mg/kg.
Cardene Novel Uses: Which Conditions Have a Clinical Trial Featuring Cardene?
Currently, 101 active clinical trials are being conducted to assess the potential of Cardene in treating Ischemic Stroke, prophylaxis of migraine headaches and Hypertensive Disease.Condition
Clinical Trials
Trial Phases
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Ischemic Stroke
1 Actively Recruiting
Not Applicable
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable
Brain Hemorrhage
10 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2
prophylaxis of migraine headaches
0 Actively Recruiting
Hypertensive disease
0 Actively Recruiting
Cardene Reviews: What are patients saying about Cardene?
5Patient Review
2/21/2011 This calcium channel blocker has been the only one effective for me; however, it hasn't been available since December. The manufacturer, EKR Therapeutic Inc., keeps promising delivery each month but fails to do so. I have had to go to the ER twice because of high blood pressure (280/05) as a result of not having this medication and other medications not working. This is a criminal act on the part of the manufacturer.
5Patient Review
2/13/2011 CardeneSR was the only channel blocker that worked for me, and now it's been discontinued. Lots of empty promises from pharmaceutical companies.
5Patient Review
2/21/2011 This calcium channel blocker has been the only one effective for me; however, it hasn't been available since December. The manufacturer, EKR Therapeuti Inc., keeps promising delivery every month but never follows through. I've had to go to the ER twice because of my blood pressure spiking without this medication, and other meds haven't worked. This is a criminal on the manufactures part.
5Patient Review
2/13/2011 CardeneSR has been the only medication that's worked for me. I'm disappointed that it's no longer available.
3.7Patient Review
8/22/2012 I was told I would not be able to get cardene sr - New Company took it over. The only medication that has worked for me, was on it for about 10yrs. I have tried quite a few medications since then nothing has worked. I just found out that it is in production and My Dr was able to order it for me.
3.7Patient Review
8/22/2012 I was told I wouldn't be able to get cardene sr - a new company took it over. The only medication that has worked for me in the past, and I was on it for about 10 years. I've tried quite a few medications since then with no success. Luckily, I just found out that it is back in production and my doctor was able to order it for me.
Patient Q&A Section about cardene
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the difference between Cardizem and Cardene?
"Cardene and Cardizem are two different types of calcium channel blockers. Cardene is a dihydropyridine, while Cardizem is a benzothiazepine."
Answered by AI
What is Cardene drip used for?
"IV nicardipine (Cardene IV) has a relatively rapid onset/offset of action, and is therefore useful for situations requiring the rapid control of blood pressure (BP). IV nicardipine was shown to be just as effective as IV nitroprusside in reducing BP in short-term studies of patients with severe or postoperative hypertension."
Answered by AI
Is Cardene a vasodilator?
"Its effect is greater on the arterioles than on the veins and capillaries.
It improves blood flow to the brain by dilating arteries, which results in increased oxygen delivery. It has a greater effect on arterioles than veins and capillaries."
Answered by AI
What type of drug is Cardene?
"Cardene IV works by relaxing the blood vessels so the heart does not have to work as hard.
Cardene IV is a medication used to manage the symptoms of high blood pressure and chronic stable angina. It may be used by itself or in combination with other drugs. Cardene IV belongs to a class of drugs known as calcium channel blockers, specifically dihydropyridines. These drugs work by relaxing the blood vessels, which lessens the workload of the heart."
Answered by AI