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What is Carac
FluorouracilThe Generic name of this drug
Treatment SummaryAllantoin is a naturally occurring substance found in the human body and in some foods. It is produced in the body during exercise, when uric acid is converted to allantoin in the muscles. Allantoin is also used in a variety of commercial products such as toothpastes, shampoos, and skin care products. Studies have shown that allantoin can help speed up the wound healing process.
Efudexis the brand name
Carac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Efudex
Fluorouracil
1970
62
Approved as Treatment by the FDA
Fluorouracil, also known as Efudex, is approved by the FDA for 1 uses like Actinic keratosis .Actinic keratosis
Used to treat hyperkeratotic actinic keratosis in combination with Salicylic acid
Effectiveness
How Carac Affects PatientsResearch is still ongoing to understand the exact effects of allantoin, but studies suggest that it can help moisturize and soften skin, as well as increase the water content of the skin and help remove dead skin cells from the surface of the skin. These activities may help promote cell growth and speed up wound healing.
How Carac works in the bodyIt's unclear how allantoin works in the body, but studies suggest it helps wounds heal faster. This is seen in rats that were given allantoin and experienced increased blood flow, inflammation, and collagen production in their wounds compared to those that didn't receive treatment.
When to interrupt dosage
The recommended dosage of Carac is contingent upon the established condition, such as Dental cleaning treatment, Skin and Scarring. The amount of dosage is contingent upon the application approach featured in the table underneath.Condition
Dosage
Administration
Colon Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Actinic keratosis
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Superficial Basal Cell Carcinoma
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Breast Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Rectal Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Verruca (Warts)
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Pancreatic Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Actinic Keratosis
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Stomach Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Warnings
Carac ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Carac Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with Abetimus.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Fluorouracil.
Acteoside
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with Acteoside.
Carac Toxicity & Overdose RiskNo tests have been conducted to determine the effects of long-term exposure to allantoin. Moreover, studies indicate that animals who were given allantoin did not develop significantly more tumors than those who were not treated. Because allantoin is found naturally in humans and considered safe, no additional tests are needed to evaluate toxicity, mutagenicity, or carcinogenicity.
Carac Novel Uses: Which Conditions Have a Clinical Trial Featuring Carac?
Seventeen active clinical trials are presently evaluating the potential of Carac to address Skin, Dental cleaning and Scarring conditions.Condition
Clinical Trials
Trial Phases
Colon Cancer
64 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Pancreatic Cancer
229 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Breast Cancer
715 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Actinic keratosis
0 Actively Recruiting
Verruca (Warts)
0 Actively Recruiting
Actinic Keratosis
11 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Stomach Cancer
125 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable
Rectal Cancer
52 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Superficial Basal Cell Carcinoma
4 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Carac Reviews: What are patients saying about Carac?
5Patient Review
3/23/2015 I had great results using carac on my forehead and nose. The only downside was that it felt like a bad sunburn, but that went away after two weeks. My skin feels softer now and I'm reassured knowing that many precancerous spots are gone.
5Patient Review
4/13/2016 The Carac cream really helped me. It was a bit aggressive at first, but it worked wonders.
5Patient Review
11/12/2017 I've done this treatment three times over the years, and each time it's been incredibly effective. The side effects are tough to deal with but manageable, and the itching is awful. I don't use any moisturizer during the treatment as it seems to lessen the effectiveness of the drug. It's definitely worth it in the end though.
5Patient Review
8/6/2014 Carac has been great at removing my skin cancers. The rashes it causes are unfortunately a bit of an annoyance, but they eventually clear up.
5Patient Review
6/8/2013 This treatment is vastly superior to other options, like surgery.
4.7Patient Review
9/16/2016 I've been using this to treat pre-cancer on my scalp, and it's done a great job so far. The crusting and flaking has decreased by at least 50%, and there's very little redness or burning. I would caution people to make sure they cover the entire area when applying it, though.
4Patient Review
1/30/2017 I've had to have surgery a few times, but I've found that an annual treatment of Carac is much more tolerable. It usually takes two to three weeks for the cream to work on problem areas, but it's better than waiting for something worse to happen. The side effects are unpleasant but manageable.
3.3Patient Review
2/17/2015 Carac was working well for the pre-cancerous lesions on my chest, but the side effects were unbearable. I couldn't make it more than five days before giving up.
3Patient Review
1/1/2018 This treatment effectively removed many precancerous spots from my face; however, I immediately began to lose large amounts of hair. Two months later, I have several bald spots and very thin hair. This is a rare side effect of the medication, and unfortunately it has had a drastic impact on my appearance.
2.3Patient Review
12/21/2015 I haven't used this long enough to have a strong opinion either way.
Patient Q&A Section about carac
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Carac cream chemotherapy?
"Efudex and Carac creams for chemotherapy contain the active ingredient fluorouracil (5-FU). This ingredient stops abnormal cell growth, making the creams effective for treating skin cancers and precancerous lesions."
Answered by AI
How long does it take Carac cream to work?
"There is no need to increase the frequency of application of Carac Cream when extending the duration of treatment from 2 to 4 weeks, as local irritation is not markedly increased. Any irritation that does occur is generally resolved within 2 weeks of stopping treatment."
Answered by AI
What is Carac cream used for?
"This medication is used on the skin to treat pre-cancerous and cancerous skin growths. Fluorouracil is an anti-metabolite medication. It works by blocking the growth of abnormal cells that cause the skin condition."
Answered by AI
Is Carac cream the same as fluorouracil?
"Carac is a dermatologic cream that contains fluorouracil, a pyrimidine compound. The molecular formula for fluorouracil is C4H3FN2O2 and the molecule has a mass of 130.08 daltons."
Answered by AI