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What is Captopril And Hydrochlorothiazide
CaptoprilThe Generic name of this drug
Treatment SummaryCaptopril is a medication used to treat high blood pressure. It works by blocking the enzyme that converts angiotensin I, a hormone that helps regulate blood pressure, into angiotensin II. By stopping this conversion, Captopril helps to lower blood pressure levels.
Capotenis the brand name
Captopril And Hydrochlorothiazide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Capoten
Captopril
1981
183
Approved as Treatment by the FDA
Captopril, otherwise known as Capoten, is approved by the FDA for 6 uses like Ventricular Dysfunction, Left and Heart Attack .Ventricular Dysfunction, Left
Helps manage ejection fraction of 40% or less Left ventricular dysfunction
Heart Attack
Helps manage Myocardial Infarction
Type 1 Diabetes
Helps manage Type 1 Diabetes Mellitus
Diabetic Nephropathy
Helps manage Diabetic Nephropathy
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Hydrochlorothiazide
Congestive Heart Failure
Helps manage Congestive Heart Failure (CHF)
Effectiveness
How Captopril And Hydrochlorothiazide Affects PatientsCaptopril, an ACE inhibitor, works by blocking the action of a hormone system (RAAS) that controls blood pressure and water balance. When there is stress or reduced blood pressure in the kidneys, this system (renin-angiotensin-aldosterone system) releases a hormone (renin) that changes into another hormone (angiotensin I) which then changes into yet another hormone (angiotensin II). This hormone (angiotensin II) raises blood pressure in three ways: it encourages the body to absorb more salt and water, it releases another hormone (vasopressin) that also
How Captopril And Hydrochlorothiazide works in the bodyThere are two forms of ACE: one found in the body and one found in the testicles. The body form is made of two parts that work together to control blood pressure. ACE inhibitors target both parts, but have a stronger effect on the part that affects blood pressure. Captopril is an ACE inhibitor that stops the body from breaking down a molecule called ATI. This lowers the amount of a second molecule (ATII) in the body, which also helps reduce blood pressure. Captopril also increases the activity of a molecule called renin, which helps regulate blood pressure. Captopril is very good at binding to ACE,
When to interrupt dosage
The advisable dosage of Captopril And Hydrochlorothiazide is contingent upon the recognized condition, such as Heart Attack, Non-STEMI Acute Coronary Syndrome and Aldosteronism. The measure of dosage modifies as per the technique of delivery (e.g. Oral or Tablet - Oral) highlighted in the table beneath.Condition
Dosage
Administration
Heart Attack
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Hypertensive crisis
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Ventricular Dysfunction, Left
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Non-STEMI Acute Coronary Syndrome
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Hypertensive disease
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Congestive Heart Failure
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Renal Artery Stenosis
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Aldosteronism
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Congestive Heart Failure
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Diabetic Nephropathy
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Type 1 Diabetes
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Raynaud's Phenomenon
25.0 mg, , 50.0 mg, 12.5 mg, 100.0 mg, 30.0 mg, 15.0 mg, 6.25 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated
Warnings
There are 20 known major drug interactions with Captopril And Hydrochlorothiazide.Common Captopril And Hydrochlorothiazide Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Captopril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Captopril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Captopril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Captopril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Captopril.
Captopril And Hydrochlorothiazide Toxicity & Overdose RiskSigns of an overdose on ramipril include vomiting and low blood pressure. Possible side effects include a rash, changes in the sense of taste, low blood pressure, stomach irritation, coughing, and swelling.
Captopril And Hydrochlorothiazide Novel Uses: Which Conditions Have a Clinical Trial Featuring Captopril And Hydrochlorothiazide?
554 active investigations are assessing the potential of Captopril And Hydrochlorothiazide as a therapeutic intervention for Type 1 Diabetes, Heart Attack and Hypertensive crisis.Condition
Clinical Trials
Trial Phases
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Renal Artery Stenosis
0 Actively Recruiting
Non-STEMI Acute Coronary Syndrome
1 Actively Recruiting
Phase 3
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Type 1 Diabetes
144 Actively Recruiting
Phase 3, Phase 1, Early Phase 1, Not Applicable, Phase 2, Phase 4
Hypertensive crisis
0 Actively Recruiting
Raynaud's Phenomenon
1 Actively Recruiting
Phase 4
Heart Attack
53 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Congestive Heart Failure
22 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Ventricular Dysfunction, Left
0 Actively Recruiting
Aldosteronism
0 Actively Recruiting
Congestive Heart Failure
313 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Captopril And Hydrochlorothiazide Reviews: What are patients saying about Captopril And Hydrochlorothiazide?
5Patient Review
7/12/2014 I took this medication for three months as prescribed, and then was able to reduce my dosage to half a tablet for the fourth month. My doctor then told me I could stop taking it altogether.
4.3Patient Review
1/10/20092Patient Review
4/3/2010Patient Q&A Section about captopril and hydrochlorothiazide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Which diuretic is used with captopril?
"The drug Captopril belongs to a class of drugs known as ACE inhibitors. Its function is to relax blood vessels so that blood can flow more easily. The drug Hydrochlorothiazide is a diuretic, often called a "water pill". This drug works by increasing the amount of urine you make, which in turn causes your body to get rid of extra salt and water."
Answered by AI
What medications should not be taken with captopril?
"Some drugs that may interact with this one are: aliskiren, certain drugs that make the immune system weaker/ raise the risk of infection (such as everolimus, sirlimus), lithium, drugs that might make potassium levels in the blood go up (such as ARBs like losartan/valsartan, birth control pills that have ..."
Answered by AI
Can you take captopril with hydrochlorothiazide?
"The combination of captopril and hydrochlorothiazide is used to treat high blood pressure. Captopril is an angiotensin-converting enzyme (ACE) inhibitor, which works by decreasing the amount of certain chemicals that tighten the blood vessels, making for smoother bloodflow."
Answered by AI
What medications should not be taken with hydrochlorothiazide?
"The following drugs may have a negative interaction with hydrochlorothiazide, resulting in lowered blood pressure: barbiturates, lithium, blood pressure drugs, cholesterol-lowering drugs, corticosteroids, diabetes drugs, narcotics, and nonsteroidal anti-inflammatory drugs (NSAIDs)."
Answered by AI