Calcitriol

Hypoparathyroidism, Osteodystrophy, Hemodialysis + 4 more
Treatment
13 Active Studies for Calcitriol

What is Calcitriol

CalcitriolThe Generic name of this drug
Treatment SummaryCalcitriol is a form of vitamin D that is produced in the body when 7-dehydrocholesterol is exposed to UV light. It is then converted to vitamin D3 in the skin, and then to calcitriol in the liver and kidneys. Calcitriol helps to regulate calcium levels in the blood and is used to treat secondary hyperparathyroidism, hypocalcemia, osteoporosis, and psoriasis. It can be taken orally or intravenously and is sold under the brand names Rocaltrol, Calcijex, and Decostriol.
Calcitriolis the brand name
image of different drug pills on a surface
Calcitriol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Calcitriol
Calcitriol
2001
85

Effectiveness

How Calcitriol Affects PatientsCalcitriol is an active form of vitamin D used to help maintain healthy bones and regulate calcium levels in the body. It can also be used to treat certain cancers and autoimmune diseases. When taken, the effects of one dose of calcitriol will last for 3-5 days. It works by increasing the amount of calcium absorbed from food and the amount of calcium released from bones, as well as by suppressing cell growth in some types of cancer cells. Calcitriol can also be used in combination with other drugs to enhance their anti-cancer effects. Vitamin D deficiency is thought to increase the risk of tuberculosis, and calcitri
How Calcitriol works in the bodyCalcitriol is used to treat psoriasis and has anticarcinogenic and immunomodulatory effects. It works by binding to vitamin D receptors in cells, which then activate certain genes to suppress inflammation and tumor growth. It also affects certain immune cells and cytokines, which helps reduce inflammation. Calcitriol also suppresses the expression of a protein called the aryl hydrocarbon receptor in pro-inflammatory cells, which helps to reduce inflammation.

When to interrupt dosage

The measure of Calcitriol is contingent upon the diagnosed condition, for example Plaque Psoriasis, Vitamin D Resistant Rickets and Chronic Kidney Disease. The dosage likewise fluctuates as indicated by the method of delivery featured in the table beneath.
Condition
Dosage
Administration
Osteodystrophy
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit
Hemodialysis
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit
Hyperparathyroidism, Secondary
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit
Hypoparathyroidism
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit
Hypocalcemia
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit
Chronic Kidney Disease
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit
Rickets
0.001 mg/mL, , 0.0005 mg, 0.00025 mg, 0.000003 mg/mg, 0.002 mg/mL, 1.0 mg/mL, 2.0 mg/mg
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Topical, Ointment, Ointment - Topical, Solution, Solution - Oral, Capsule, Capsule - Oral, Solution - Intravenous, Kit

Warnings

Calcitriol Contraindications
Condition
Risk Level
Notes
evidence of vitamin D toxicity
Do Not Combine
Hypercalcemia
Do Not Combine
There are 20 known major drug interactions with Calcitriol.
Common Calcitriol Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Calcitriol.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Calcitriol.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Calcitriol.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Calcitriol.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Calcitriol.
Calcitriol Toxicity & Overdose RiskThe most toxic dose of calcitriol in rats has been found to be 620 micrograms/kg. Symptoms of calcitriol toxicity are similar to those of vitamin D poisoning, including weakness, headache, fatigue, stomach upset, dry mouth, muscle pain, bone pain, increased urination and thirst, loss of appetite, weight loss, conjunctivitis, and abnormal heart rhythms. In rare cases, the toxicity can cause psychosis.
image of a doctor in a lab doing drug, clinical research

Calcitriol Novel Uses: Which Conditions Have a Clinical Trial Featuring Calcitriol?

30 active studies are investigating the potential of Calcitriol for Hemodialysis, Hypocalcemia and Plaque Psoriasis treatment.
Condition
Clinical Trials
Trial Phases
Hyperparathyroidism, Secondary
4 Actively Recruiting
Phase 3, Not Applicable
Chronic Kidney Disease
2 Actively Recruiting
Phase 3, Phase 1
Osteodystrophy
0 Actively Recruiting
Rickets
3 Actively Recruiting
Phase 1, Phase 3, Phase 2
Hypoparathyroidism
3 Actively Recruiting
Not Applicable, Phase 2
Hemodialysis
0 Actively Recruiting
Hypocalcemia
0 Actively Recruiting

Calcitriol Reviews: What are patients saying about Calcitriol?

5Patient Review
3/20/2010
Calcitriol for Condition caused by Low Levels of Parathyroid Hormone
This medication has been essential for me. Without it, I experience a lot of pain in my muscles and joints. I know this is something I'll have to take for the rest of my life, but I wish it was more affordable.
5Patient Review
8/27/2019
Calcitriol for Condition caused by Low Levels of Parathyroid Hormone
I had primary hyperparathyroidism and had to have 3 1/2 glands removed. This left me with hypoparathyroidism and hungry bone syndrome, which made it extremely difficult to keep my calcium levels stable. Calcitrol has been a lifesaver for me. I've been on it for about a year now, and it's helped me immensely.
5Patient Review
2/11/2013
Calcitriol for Hyperparathyroidism caused by Chronic Kidney Failure
I have hypoparathyroidism as a result of my surgeon removing them during a lcitrol. Methyroidectomy does nothing for me, and I am constantly in an out of the hospital for IV calcium.
5Patient Review
6/4/2010
Calcitriol for Condition caused by Low Levels of Parathyroid Hormone
My rheumatologist prescribed Calcitriol for me after my blood tests showed that I had scleroderma, which affects my Vitamin D absorption.
5Patient Review
6/19/2009
Calcitriol for Condition caused by Low Levels of Parathyroid Hormone
View All Reviews
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Patient Q&A Section about calcitriol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Which is better vitamin D or calcitriol?

"It was determined in the early 1970's that calcitriol was the active form of vitamin d. Calcitriol is over 1,000 times as potent as Vitamin D2 and D3 in binding to the vitamin D receptor."

Answered by AI

Is calcitriol and vitamin D the same?

"The most active form of vitamin d, calcitriol, only lasts for a few hours. It was originally thought that it was only produced in the kidney, but it is now known to be produced in many other tissues as well."

Answered by AI

What is the use of calcitriol?

"Calcitriol is used to treat low levels of calcium and bone disease in patients who have kidney or parathyroid gland disorders."

Answered by AI

What is the main effect of calcitriol?

"The only way that the body can increase its calcium stores is by increasing the production of calcium transport proteins in the gastrointestinal tract, which leads to increased uptake of calcium from the gut."

Answered by AI

Clinical Trials for Calcitriol

Have you considered Calcitriol clinical trials? We made a collection of clinical trials featuring Calcitriol, we think they might fit your search criteria.
Have you considered Calcitriol clinical trials? We made a collection of clinical trials featuring Calcitriol, we think they might fit your search criteria.
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