Bosentan

Pulmonary Arterial Hypertension, ocular bacterial infections, Conjunctivitis

Treatment

2 FDA approvals

0 Active Studies for Bosentan

Treatment for

Pulmonary Arterial Hypertension

What is Bosentan

Bosentan

The Generic name of this drug

Treatment Summary

Bosentan, sold under the brand name Tracleer, is a medication used to treat pulmonary hypertension. It works by blocking endothelin molecules which, if left unchecked, can cause blood vessels to narrow and lead to high blood pressure.

Tracleer

is the brand name

Bosentan Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Tracleer

Bosentan

2001

Approved as Treatment by the FDA

Bosentan, also called Tracleer, is approved by the FDA for 2 uses which include NYHA Functional Class II-IV Pulmonary arterial hypertension and Pulmonary Arterial Hypertension .

NYHA Functional Class II-IV Pulmonary arterial hypertension

Helps manage NYHA Functional Class II-IV Pulmonary arterial hypertension

Pulmonary Arterial Hypertension

Helps manage NYHA Functional Class II-IV Pulmonary arterial hypertension

Effectiveness

How Bosentan Affects Patients

Bosentan is a drug that helps treat pulmonary arterial hypertension (PAH) by blocking endothelin, a chemical that causes blood vessels to narrow. Blocking endothelin helps prevent the harmful effects of PAH.

How Bosentan works in the body

Endothelin-1 (ET-1) is a hormone that affects the body by binding to receptors in the blood vessels and muscles. It seems to have a stronger effect on ET-A receptors than on ET-B receptors. People with pulmonary arterial hypertension have more ET-1 in their lungs and bloodstream. Bosentan works by blocking the effects of ET-1 at the ET-A and ET-B receptors.

When to interrupt dosage

The proposed measure of Bosentan is contingent upon the diagnosed state, including Pulmonary Arterial Hypertension, ocular bacterial contaminations and Ocular Inflammation. The degree of dosage relies upon the method of delivery (e.g. Tablet, film covered - Oral or Tablet, dissolvable - Oral) outlined in the accompanying table.

Condition

Dosage

Administration

Pulmonary Arterial Hypertension

, 62.5 mg, 125.0 mg, 32.0 mg

, Tablet, Oral, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Tablet, soluble, Tablet, soluble - Oral, Tablet, coated, Tablet, coated - Oral

ocular bacterial infections

, 62.5 mg, 125.0 mg, 32.0 mg

Conjunctivitis

, 62.5 mg, 125.0 mg, 32.0 mg

Warnings

Bosentan has two contraindications and should not be employed in combination with the conditions outlined in the following table.

Bosentan Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Bosentan.

Common Bosentan Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Bosentan.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Bosentan.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Bosentan.

Amifostine

Major

Bosentan may increase the hypotensive activities of Amifostine.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Bosentan.

Bosentan Toxicity & Overdose Risk

Bosentan has been tested on healthy volunteers, with a single dose of up to 2400 mg, and on patients for a maximum of two months at 2000 mg per day. The most common side effect is mild to moderate headache. When taken in combination with cyclosporine A, the dose of bosentan was increased to 500-1000 mg twice per day, resulting in intense headache and nausea. Patients may also experience a decrease in blood pressure or an increase in heart rate. In the event of an overdose, patients may experience low blood pressure requiring medical attention.

image of a doctor in a lab doing drug, clinical research

Bosentan Novel Uses: Which Conditions Have a Clinical Trial Featuring Bosentan?

At present, four clinical trials are being conducted to investigate the potential of Bosentan for treating ocular bacterial infections, Ocular Inflammation and Pulmonary Arterial Hypertension.

Condition

Clinical Trials

Trial Phases

ocular bacterial infections

0 Actively Recruiting

Conjunctivitis

0 Actively Recruiting

Pulmonary Arterial Hypertension

0 Actively Recruiting

Bosentan Reviews: What are patients saying about Bosentan?

Patient Review

7/13/2013

Bosentan for Pulmonary Arterial Hypertension

I feel so much better after using this treatment! I can breathe easily and my overall activity has improved.

Patient Review

1/15/2014

Bosentan for Pulmonary Arterial Hypertension

This medication is easy to remember to take, and I've noticed a significant difference since starting it.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about bosentan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is bosentan mechanism?

"The drug bosentan works by inhibiting endothelin-1 receptors. Endothelin-1 is a substance that causes blood vessels to narrow and also promotes cell growth, inflammation, and the formation of scar tissue."

Answered by AI

What is bosentan used for?

"Bosentan is used to treat the symptoms of pulmonary arterial hypertension in both adults and children aged three or older. The drug improves patients' ability to exercise and slows down the worsening of their physical condition."

Answered by AI

Is bosentan over the counter?

"Bosentan is a drug used to treat pulmonary arterial hypertension (PAH). It is available only from a certified pharmacy and must be taken under a special program. Bosentan improves the patient's ability to exercise and prevents the condition from worsening."

Answered by AI

What kind of drug is bosentan?

"Bosentan is a type of medication that is used to block the effects of endothelin. Endothelin is a natural substance that causes blood vessels to narrow, which can prevent normal blood flow in people who have pulmonary arterial hypertension (PAH). blocking the effects of endothelin can help improve blood flow and reduce symptoms in people with PAH."

Answered by AI