Benazepril Hydrochloride

Congestive Heart Failure, Primary Hypercholesterolemia, Coronary Disease + 13 more
Treatment
5 FDA approvals
20 Active Studies for Benazepril Hydrochloride

What is Benazepril Hydrochloride

AmlodipineThe Generic name of this drug
Treatment SummaryBenazepril, brand name Lotensin, is a medication used to treat high blood pressure, congestive heart failure, and chronic renal failure. Benazepril is converted into its active form benazeprilat in the liver, which is an angiotensin-converting enzyme (ACE) inhibitor that helps reduce blood pressure.
Norvascis the brand name
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Benazepril Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norvasc
Amlodipine
1992
1199

Approved as Treatment by the FDA

Amlodipine, also known as Norvasc, is approved by the FDA for 5 uses like Coronary Artery Disease (CAD) and Vasospastic Angina .
Coronary Artery Disease (CAD)
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Vasospastic Angina
Used to treat Vasospastic Angina in combination with Atorvastatin
Coronary Disease
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Coronary Artery Disease
Used to treat angiographically documented disease in combination with Atorvastatin
Angina, Stable
Used to treat Chronic Stable Angina Pectoris in combination with Atorvastatin

Effectiveness

How Benazepril Hydrochloride Affects PatientsBenazepril is a drug used to treat high blood pressure, heart failure, and other conditions. It works by blocking an enzyme in the body called angiotensin-converting enzyme (ACE). This enzyme helps produce a hormone called angiotensin II, which can cause blood vessels to tighten and raise blood pressure. By blocking ACE, Benazepril reduces blood pressure, prevents stroke, and helps protect the kidneys from damage.
How Benazepril Hydrochloride works in the bodyBenazeprilat works by blocking the enzyme that helps create angiotensin, a hormone that narrows blood vessels. This prevents angiotensin from forming, which in turn lowers blood pressure and stops the body from producing as much of it. This leads to relaxed blood vessels and a decrease in stress hormones, allowing the body to regulate its blood pressure more easily.

When to interrupt dosage

The suggested dose of Benazepril Hydrochloride is contingent upon the diagnosed ailment, including Kidney Diseases, Diabetic Nephropathy and previous treatment. The quantity of dosage varies, as per the method of delivery (e.g. Capsule or Tablet - Oral) outlined in the table hereunder.
Condition
Dosage
Administration
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
High Cardiovascular Risk
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Pharmacotherapy
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Homozygous Familial Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Vasospastic Angina
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
inadequate response to diet
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Congestive Heart Failure
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Primary Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Cardiovascular Events
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Lifestyle Modification
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Angina, Stable
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Artery Disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension

Warnings

Benazepril Hydrochloride has two contraindications and ought not to be utilized for the conditions in the following table.Benazepril Hydrochloride Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amlodipine may interact with Pulse Frequency
There are 20 known major drug interactions with Benazepril Hydrochloride.
Common Benazepril Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Amlodipine may increase the hypotensive activities of Amifostine.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Ziprasidone.
Abafungin
Minor
The therapeutic efficacy of Abafungin can be increased when used in combination with Amlodipine.
Benazepril Hydrochloride Toxicity & Overdose RiskPossible side effects from taking Metoprolol include headache, dizziness, tiredness, sleepiness, dizziness when standing up, nausea, and cough. Overdosing on Metoprolol is likely to cause dangerously low blood pressure.
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Benazepril Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Benazepril Hydrochloride?

325 active clinical trials are analyzing the potential of Benazepril Hydrochloride in treating previously managed Kidney Diseases and Diabetic Nephropathy.
Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
176 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Dyslipidemias
1 Actively Recruiting
Phase 2
inadequate response to diet
0 Actively Recruiting
Homozygous Familial Hypercholesterolemia
1 Actively Recruiting
Phase 3
Hypertensive disease
3 Actively Recruiting
Not Applicable
Vasospastic Angina
1 Actively Recruiting
Phase 2, Phase 3
Dyslipidemias
0 Actively Recruiting
Primary Hypercholesterolemia
10 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Coronary Disease
1 Actively Recruiting
Not Applicable
Lifestyle Modification
2 Actively Recruiting
Not Applicable
Angina, Stable
1 Actively Recruiting
Not Applicable
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Coronary Artery Disease
0 Actively Recruiting
High Cardiovascular Risk
1 Actively Recruiting
Phase 2
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Pharmacotherapy
0 Actively Recruiting

Benazepril Hydrochloride Reviews: What are patients saying about Benazepril Hydrochloride?

5Patient Review
3/31/2016
Benazepril Hydrochloride for High Blood Pressure
My blood pressure has gone down significantly since I started taking this medication, and my pulse is much lower too.
5Patient Review
10/23/2012
Benazepril Hydrochloride for High Blood Pressure
5Patient Review
11/18/2012
Benazepril Hydrochloride for High Blood Pressure
4.7Patient Review
6/27/2013
Benazepril Hydrochloride for High Blood Pressure
I find that this treatment makes me have to urinate more frequently, especially at night.
4Patient Review
11/23/2016
Benazepril Hydrochloride for High Blood Pressure
This medication was successful in lowering my blood pressure for the most part; however, I recently had to go to the ICU because it caused kidney failure. This is after 5 years of use with no other adverse effects, save for occasional lightheadedness. Now, I'm having issues with blood pressure bottoming out suddenly, urinary difficulties, dehydration, severe nausea and vomiting. My doctor has me still taking 10mg per day, but if I don't take it for a couple days I seem to do better.
View All Reviews
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Patient Q&A Section about benazepril hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is benazepril hydrochloride used for?

"Benazepril is a medication used to treat high blood pressure. Hypertension puts extra strain on the heart and arteries, and if left unchecked, can lead to serious health problems."

Answered by AI

What are the side effects of benazepril HCL?

"The person has the following symptoms: a cough, a headache, dizziness, fatigue, dizziness upon standing, an increased serum creatinine level, drowsiness, and nausea."

Answered by AI

What is the difference between benazepril and benazepril hydrochloride?

"Benazeprilat inhibits ACE, preventing the conversion of angiotensin I (AT-I) to angiotensin II (AT-II); AT-II is a potent vasoconstrictor.

Benazepril Hydrochloride is a substance that inhibits the conversion of angiotensin I to angiotensin II. As a prodrug, it is metabolized to its active form, benazeprilat, which inhibits ACE. AT-II is a vasoconstrictor, and by preventing its formation, benazeprilat reduces hypertension."

Answered by AI

Is benazepril hydrochloride a diuretic?

"Generic Name: benazepril-hydrochlorothiazide

Benazepril works by relaxing blood vessels, causing them to widen. This action lowers blood pressure and also reduces the workload on the heart. The hydrochlorothiazide diuretic increases the amount of urine you make, which decreases excess water and salt in your body. This diuretic effect also helps to lower blood pressure by reducing the amount of fluid in the blood vessels."

Answered by AI

Clinical Trials for Benazepril Hydrochloride

Have you considered Benazepril Hydrochloride clinical trials? We made a collection of clinical trials featuring Benazepril Hydrochloride, we think they might fit your search criteria.
Have you considered Benazepril Hydrochloride clinical trials? We made a collection of clinical trials featuring Benazepril Hydrochloride, we think they might fit your search criteria.
Have you considered Benazepril Hydrochloride clinical trials? We made a collection of clinical trials featuring Benazepril Hydrochloride, we think they might fit your search criteria.
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