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What is Benazepril Hydrochloride
AmlodipineThe Generic name of this drug
Treatment SummaryBenazepril, brand name Lotensin, is a medication used to treat high blood pressure, congestive heart failure, and chronic renal failure. Benazepril is converted into its active form benazeprilat in the liver, which is an angiotensin-converting enzyme (ACE) inhibitor that helps reduce blood pressure.
Norvascis the brand name
Benazepril Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norvasc
Amlodipine
1992
1199
Approved as Treatment by the FDA
Amlodipine, also known as Norvasc, is approved by the FDA for 4 uses like angiographically documented disease and Chronic Stable Angina Pectoris .angiographically documented disease
Used to treat angiographically documented disease in combination with Atorvastatin
Chronic Stable Angina Pectoris
Used to treat Chronic Stable Angina Pectoris in combination with Atorvastatin
Coronary Artery Disease (CAD)
Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin
Vasospastic Angina
Used to treat Vasospastic Angina in combination with Atorvastatin
Effectiveness
How Benazepril Hydrochloride Affects PatientsBenazepril is a drug used to treat high blood pressure, heart failure, and other conditions. It works by blocking an enzyme in the body called angiotensin-converting enzyme (ACE). This enzyme helps produce a hormone called angiotensin II, which can cause blood vessels to tighten and raise blood pressure. By blocking ACE, Benazepril reduces blood pressure, prevents stroke, and helps protect the kidneys from damage.
How Benazepril Hydrochloride works in the bodyBenazeprilat works by blocking the enzyme that helps create angiotensin, a hormone that narrows blood vessels. This prevents angiotensin from forming, which in turn lowers blood pressure and stops the body from producing as much of it. This leads to relaxed blood vessels and a decrease in stress hormones, allowing the body to regulate its blood pressure more easily.
When to interrupt dosage
The suggested dose of Benazepril Hydrochloride is contingent upon the diagnosed ailment, including Kidney Diseases, Diabetic Nephropathy and previous treatment. The quantity of dosage varies, as per the method of delivery (e.g. Capsule or Tablet - Oral) outlined in the table hereunder.Condition
Dosage
Administration
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
angiographically documented disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Congestive Heart Failure
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Primary Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Coronary Artery Disease (CAD)
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Cardiovascular Events
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Lifestyle Modification
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Vasospastic Angina
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Hypertensive disease
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
High Cardiovascular Risk
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Dyslipidemias
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Chronic Stable Angina Pectoris
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
inadequate response to diet
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Mixed Dyslipidaemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Pharmacotherapy
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Homozygous Familial Hypercholesterolemia
10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Solution, Solution - Oral, Suspension - Oral, Suspension
Warnings
Benazepril Hydrochloride has two contraindications and ought not to be utilized for the conditions in the following table.Benazepril Hydrochloride ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Amlodipine may interact with Pulse Frequency
Common Benazepril Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Amlodipine may increase the hypotensive activities of Amifostine.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Ziprasidone.
Abafungin
Minor
The therapeutic efficacy of Abafungin can be increased when used in combination with Amlodipine.
Benazepril Hydrochloride Toxicity & Overdose RiskPossible side effects from taking Metoprolol include headache, dizziness, tiredness, sleepiness, dizziness when standing up, nausea, and cough. Overdosing on Metoprolol is likely to cause dangerously low blood pressure.
Benazepril Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Benazepril Hydrochloride?
325 active clinical trials are analyzing the potential of Benazepril Hydrochloride in treating previously managed Kidney Diseases and Diabetic Nephropathy.Condition
Clinical Trials
Trial Phases
inadequate response to diet
0 Actively Recruiting
Hypertensive disease
2 Actively Recruiting
Not Applicable
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Primary Hypercholesterolemia
16 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Mixed Dyslipidaemia
0 Actively Recruiting
Congestive Heart Failure
315 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Homozygous Familial Hypercholesterolemia
4 Actively Recruiting
Phase 3, Phase 2
Vasospastic Angina
0 Actively Recruiting
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
High Cardiovascular Risk
1 Actively Recruiting
Phase 2
Pharmacotherapy
0 Actively Recruiting
Dyslipidemias
1 Actively Recruiting
Phase 2
Cardiovascular Events
3 Actively Recruiting
Not Applicable
angiographically documented disease
0 Actively Recruiting
Lifestyle Modification
1 Actively Recruiting
Not Applicable
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable
Benazepril Hydrochloride Reviews: What are patients saying about Benazepril Hydrochloride?
5Patient Review
3/31/2016 My blood pressure has gone down significantly since I started taking this medication, and my pulse is much lower too.
5Patient Review
10/23/20125Patient Review
11/18/20124.7Patient Review
6/27/2013 I find that this treatment makes me have to urinate more frequently, especially at night.
4Patient Review
11/23/2016 This medication was successful in lowering my blood pressure for the most part; however, I recently had to go to the ICU because it caused kidney failure. This is after 5 years of use with no other adverse effects, save for occasional lightheadedness. Now, I'm having issues with blood pressure bottoming out suddenly, urinary difficulties, dehydration, severe nausea and vomiting. My doctor has me still taking 10mg per day, but if I don't take it for a couple days I seem to do better.
4Patient Review
2/14/20134Patient Review
4/7/2014 This treatment effectively lowered my blood pressure.
3.7Patient Review
8/14/2013 I'm a little concerned about this dry cough I've had since starting the medication. Some say it's called a "cardiac cough", but my doctor disagrees with that diagnosis. Help!
3.7Patient Review
9/10/2013 I'm a new user and I haven't been able to maintain a lower blood pressure with this medication.
3.7Patient Review
2/25/2013 Nausea developed after years of successful treatment.
3.7Patient Review
3/31/2013 This treatment really helped me relax.
3.7Patient Review
6/15/2022 I've been on this medication for about six months. The 5mg-a-day tablet doesn't seem to be helping as much as I'd hoped. My blood pressure has been in the normal range most of the time, but there are occasional high readings—especially before a doctor's appointment. I was told that it could help your kidneys if taken daily, but I'm not sure about that.
3.3Patient Review
1/4/2017 I'm a 62 year old woman who started taking this medication four months ago. I was on 5mg, but my blood pressure gradually started to increase until it was out of control. I'll be starting a new regimen of 5mg twice a day to see if that helps.
3Patient Review
2/21/2014 I recently started taking this medication and I am Black. I'm wondering if the fact that the pharmacy printout says not to use in Black people is something to be concerned about?
2.3Patient Review
1/30/2017 The medicine lowered my blood pressure but I had a really annoying dry cough. Also, if I caught sunlight or blue LED lights just right it would give me a migraine. These effects went away when I stopped taking the medicine for two months, and then came back when I started again. So far the new medication (Lozartan) is working well!
1.7Patient Review
12/16/2013 I'm not satisfied because my doctor increased my dosage without monitoring my blood work, and as a result my creatinine level was raised to 3.7. I'm still not back to normal numbers five weeks later.
1.3Patient Review
11/19/2013 My blood pressure is consistently high when I'm not on this medication, often reading over 200/100. Even with the meds, my BP usually hovers around 140/90, which is still too high in my opinion.
1Patient Review
3/11/2014 I used this medication for six months and saw no benefits. In fact, I developed a number of undesirable side effects, like a dry cough and digestive problems. I'll be trying a different medication now.
1Patient Review
5/18/2015 I would recommend monitoring your blood pressure closely while taking this medication, as it caused my numbers to skyrocket.
Patient Q&A Section about benazepril hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is benazepril hydrochloride used for?
"Benazepril is a medication used to treat high blood pressure. Hypertension puts extra strain on the heart and arteries, and if left unchecked, can lead to serious health problems."
Answered by AI
What are the side effects of benazepril HCL?
"The person has the following symptoms: a cough, a headache, dizziness, fatigue, dizziness upon standing, an increased serum creatinine level, drowsiness, and nausea."
Answered by AI
What is the difference between benazepril and benazepril hydrochloride?
"Benazeprilat inhibits ACE, preventing the conversion of angiotensin I (AT-I) to angiotensin II (AT-II); AT-II is a potent vasoconstrictor.
Benazepril Hydrochloride is a substance that inhibits the conversion of angiotensin I to angiotensin II. As a prodrug, it is metabolized to its active form, benazeprilat, which inhibits ACE. AT-II is a vasoconstrictor, and by preventing its formation, benazeprilat reduces hypertension."
Answered by AI
Is benazepril hydrochloride a diuretic?
"Generic Name: benazepril-hydrochlorothiazide
Benazepril works by relaxing blood vessels, causing them to widen. This action lowers blood pressure and also reduces the workload on the heart. The hydrochlorothiazide diuretic increases the amount of urine you make, which decreases excess water and salt in your body. This diuretic effect also helps to lower blood pressure by reducing the amount of fluid in the blood vessels."
Answered by AI