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What is Avapro
IrbesartanThe Generic name of this drug
Treatment SummaryIrbesartan is a medication used to treat high blood pressure and diabetic kidney disease. It is usually taken in combination with hydrochlorothiazide, and it does not usually cause a dry cough like some other similar medications. Irbesartan was approved by the FDA in 1997.
Avaprois the brand name
Avapro Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avapro
Irbesartan
1997
246
Approved as Treatment by the FDA
Irbesartan, also called Avapro, is approved by the FDA for 5 uses such as not adequately controlled with monotherapy and multiple antihypertensive drugs likely required .not adequately controlled with monotherapy
Used to treat not adequately controlled with monotherapy in combination with Hydrochlorothiazide
multiple antihypertensive drugs likely required
Used to treat multiple antihypertensive drugs likely required in combination with Hydrochlorothiazide
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Treatment Naive
Used to treat Treatment Naive in combination with Hydrochlorothiazide
Diabetic Nephropathy
Helps manage Diabetic Nephropathy
Effectiveness
How Avapro Affects PatientsIrbesartan is a medication that helps regulate blood pressure and is used to treat high blood pressure and kidney damage related to diabetes. It is usually taken once daily and has a wide safety range, with a low dose of 150mg per day and a high dose of 900mg per day being well tolerated in healthy human subjects.
How Avapro works in the bodyIrbesartan blocks the angiotensin II hormone from binding to certain cells. These cells, like those in the adrenal gland and in the walls of blood vessels, would normally respond to angiotensin II by constricting and increasing the amount of aldosterone released. By blocking the ability of angiotensin II to bind to these cells, irbesartan causes them to relax, reducing blood pressure.
When to interrupt dosage
The proposed measure of Avapro is contingent upon the recognized condition, for example Hypertensive disease, not adequately managed with monotherapy and Diabetic Nephropathy. The quantity of dosage is contingent upon the delivery technique expressed in the table beneath.Condition
Dosage
Administration
Diabetic Nephropathy
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
multiple antihypertensive drugs likely required
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
not adequately controlled with monotherapy
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Treatment Naive
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Avapro ContraindicationsCondition
Risk Level
Notes
Hypesthesia
Do Not Combine
Volume depletion
Do Not Combine
Chronic Kidney Disease
Do Not Combine
Renal Artery Stenosis
Do Not Combine
Type 2 Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Irbesartan may interact with Pulse Frequency
Common Avapro Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Irbesartan.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Irbesartan.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Irbesartan.
Amifostine
Major
Irbesartan may increase the hypotensive activities of Amifostine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Irbesartan.
Avapro Toxicity & Overdose RiskThe lowest toxic dose of this drug in humans is 30mg/kg over a period of six weeks. If someone overdoses on this drug, they may experience low blood pressure and a rapid or slow heartbeat. Treatment for these symptoms includes giving terlipressin, which acts as a substitute for traditional vasopressors if they are not successful in restoring blood pressure.
Avapro Novel Uses: Which Conditions Have a Clinical Trial Featuring Avapro?
19 active clinical investigations are currently being conducted to assess the potential of Avapro to ameliorate Diabetic Nephropathy, Hypertensive disease, and the likely requirement of multiple antihypertensive drugs.Condition
Clinical Trials
Trial Phases
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Treatment Naive
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting
not adequately controlled with monotherapy
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Avapro Reviews: What are patients saying about Avapro?
5Patient Review
3/14/20135Patient Review
4/8/20135Patient Review
10/27/2013 At first, I didn't think this drug had any side effects. However, now I'm not so sure. I seem to feel blue when I'm on it, and when the script ran out I definitely felt happier. But I'm back on it now..
5Patient Review
1/20/2014 I've been on a few different blood pressure medications, and this one has by far been the most effective. Within two days of starting it, my numbers were down to 120/70. I have experienced some lightheadedness if I stand up too quickly, but that's the only side effect I've noticed. It's worth it to find a medication that works for you—your health is worth it.
5Patient Review
9/18/2013 Avapro is the best blood pressure medication I've tried. Not only does it work well, but I haven't experienced any negative side effects like other drugs in this class have given me (e.g., anxiety, interrupted sleep, decreased energy and libido, a very NASTY dry cough, etc.)
5Patient Review
2/17/2016 Avapro has been really helpful for me in managing my blood pressure, but recently it's become difficult to find in stores. I've tried other medications that just don't work as well, so please make Avapro available again soon!
4.7Patient Review
2/24/2014 I was on the medication for over a month when I started feeling awful. I thought maybe I had the flu, but then I realized that it might be the Avapro. Sure enough, after doing some research online, I found that I had nearly all of the listed side effects. As soon as I stopped taking the drug, I felt better almost immediately. However, it took my doctor several days to get me another prescription (during which time I felt terrible). Now I'm on my third medication and experiencing more side effects.
4.7Patient Review
8/26/2014 Was put on 150mg, 6 months later, blood pressure tested for routine pre op surgery test and blood pressure was out of control! No one had a clue that it was totally ineffective. Doctor raised (doubled) dosage to 300mg. That solved the problem, and my blood pressure has been good for 1 1/2 years now.
4.3Patient Review
1/28/20134.3Patient Review
6/8/2015 I was on this medication for a few years and it effectively controlled my blood pressure; however, I developed a cough and shortness of breath. My doctor has put me on Avapro 300mg starting 6/9, so we'll see how that goes.
3.7Patient Review
5/24/2015 I had high hopes for Avapro to help lower my blood pressure, but unfortunately it didn't work as well as I'd hoped. It did lower my blood pressure some, but not enough. I also experienced some digestive issues while taking this medication.
3Patient Review
4/1/20133Patient Review
7/2/2020 This drug was effective at reducing my blood pressure. However, it also caused a number of side effects like headaches, fatigue, and numbness in my feet. I'm going to try something else after two weeks on this medication.
3Patient Review
7/20/2013 About five years ago, I started taking this medication and four weeks in, I developed a chronic lower back problem. An MRI showed nothing, but I suspect it's from the drug. Even so, it does help control my blood pressure.
2.7Patient Review
7/27/2014 Avapro worked well for me with no side effects. However, when I was given the generic version (Ibesartan) over a period of 2 years, I developed short bursts of adrenaline which gave me a fast heart rate. It totally cured my high blood pressure. My problem is convincing my cardiologist that this is the cause of my quick heartbeats.
2.3Patient Review
2/7/2014 So far this treatment is effective for me, but I want to do more research before continuing.
1.7Patient Review
5/2/2020 I was taking the maximum dosage for 9 months and experienced awful side effects the whole time. I constantly felt tired, had to urinate frequently, and got daily cramps in my feet. I wouldn't wish this on anyone.
1.7Patient Review
9/1/2022 Out of the ten possible side effects of Avopro, I experienced diarrhea, upset stomach muscle weakness, tiredness and low energy. These were by far the worst of them all. Consequently, I've asked my doctor for a different prescription.
1Patient Review
9/7/2019 I was taking 75 mg every day for 7 years ( high blood pressure) and after researching realised that a lot of my health problems were caused by this drug.I could not understand why I was feeling like I did because I did everything right re: lifestyle changes. Have ceased taking it . 2 weeks off it and feel fantastic and back to my old self.
Patient Q&A Section about avapro
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Avapro a good blood pressure medicine?
"Irbesartan is an effective blood pressure medication that is especially beneficial for those with diabetes. It has minimal side effects and only needs to be taken once a day."
Answered by AI
What are the side effects for Avapro?
"These are some of the side effects you may experience as your body adjusts to the medication: dizziness, lightheadedness, upset stomach, diarrhea, heartburn, or tiredness."
Answered by AI
What is Avapro 150 mg used for?
"This medication works by blocking a hormone that controls blood vessels.
Irbesartan is used to treat high blood pressure and help protect the kidneys from damage due to diabetes. By blocking a hormone that controls blood vessels, it lowers high blood pressure and prevents strokes, heart attacks, and kidney problems."
Answered by AI
What is the difference between Avapro and irbesartan?
"Ibesartan is a drug used to treat high blood pressure. It is available as a pill that is taken orally. It comes in three different strengths: 75 mg, 150 mg, and 300 mg."
Answered by AI