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What is Avandamet
RosiglitazoneThe Generic name of this drug
Treatment SummaryMetformin is an antihyperglycemic medication used to treat type II diabetes. It works by reducing blood sugar levels without causing low blood sugar (hypoglycemia). Metformin also helps people with type II diabetes by making their bodies more responsive to insulin, which can lead to a decrease in insulin resistance and lower plasma fasting insulin levels. This medication also helps people with type II diabetes lose weight. Metformin has been approved by the FDA since 1995 and is available in regular and extended release forms. It is currently the first choice of medication for treating type II diabetes, and is prescribed to over 120 million people worldwide.
Avandiais the brand name
Avandamet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avandia
Rosiglitazone
1999
51
Effectiveness
How Avandamet Affects PatientsInsulin is a hormone that controls sugar levels in the blood. People with type 2 diabetes have trouble responding to insulin, which can cause their blood sugar levels to be too high. Metformin helps by decreasing the amount of sugar produced by the liver, reducing the amount of sugar absorbed in the intestines, and making it easier for cells to absorb sugar from the blood. Unlike other diabetes medicines, metformin does not increase the amount of insulin in the blood. In a 29-week study, people taking metformin had their fasting blood sugar levels drop by an average of 59 mg/dL, while those taking a placebo had
How Avandamet works in the bodyMetformin works to lower blood sugar levels by reducing the amount of glucose produced in the liver, decreasing the absorption of glucose in the intestines, and increasing the body's sensitivity to insulin. It does this by entering cells and mitochondria, where it blocks an enzyme called complex I, resulting in increased AMP: ATP ratios. This activates an enzyme called AMP-activated protein kinase (AMPK). AMPK then stops the production of a molecule called fructose 1,6-bisphosphatase, which helps create glucose in the liver. It also inhibits adenylate cyclase and reduces the production of a molecule
When to interrupt dosage
The measure of Avandamet relies on the diagnosed affliction, including Diet, inadequate response to metformin and Diabetic Ketoacidosis. The dosage fluctuates as per the technique of delivery (e.g. Oral or Tablet - Oral) detailed in the accompanying table.Condition
Dosage
Administration
Diet
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Type 2 Diabetes
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Physical Activity
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Warnings
Avandamet ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Rosiglitazone may interact with Pulse Frequency
Hypesthesia
Do Not Combine
Hypesthesia
Do Not Combine
Common Avandamet Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Rosiglitazone.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Rosiglitazone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Rosiglitazone.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Rosiglitazone.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Rosiglitazone.
Avandamet Toxicity & Overdose RiskThe toxic dose of Metformin in rats is 1g/kg taken orally, and 500mg/kg taken intraperitoneally or 300 mg/kg taken subcutaneously. In mice, the toxic dose is 1450mg/kg taken orally, 420 mg/kg intraperitoneally, or 225mg/kg subcutaneously. Metformin overdose may cause lactic acidosis, which is a dangerous buildup of lactic acid in the bloodstream. Symptoms of lactic acidosis include malaise, muscle pain, abdominal pain, breathing difficulty, and increased sleepiness. Those with decreased renal function or who are elderly
Avandamet Novel Uses: Which Conditions Have a Clinical Trial Featuring Avandamet?
At present, 346 active studies are being conducted to determine the potential efficacy of Avandamet in the treatment of Type 2 Diabetes, Type 1 Diabetes and inadequate response to metformin.Condition
Clinical Trials
Trial Phases
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
Diet
5 Actively Recruiting
Not Applicable
Avandamet Reviews: What are patients saying about Avandamet?
5Patient Review
9/21/2007 I took this medication for approximately three years with no side effects whatsoever.
4.3Patient Review
10/19/2008 This treatment is effective, but it's quite pricey.
3Patient Review
11/5/2007 I found that this treatment caused extreme erectile dysfunction in men. I'm not sure if the same occurs for women, but sexual drive quickly diminishes while taking this medication. Additionally, no ED medications seem to work alongside it.
2.7Patient Review
10/12/2007 I'm wondering if this medication causes gas. I take 500mg of metformin and 2miligrams of avandamet at night, which has unfortunately resulted in some terrible gas issues.
2.7Patient Review
9/24/2007 I took this drug for over a year, and it caused some serious side effects like swelling in my legs and feet, poor circulation, and pain. My doctor decided that the risks weren't worth the benefits of taking the medication, so he changed my prescription.
2.7Patient Review
12/7/2007 I was experiencing a lot of negative side effects from this medication, including leg swelling, feet swelling, fatigue, back pain, and bleeding in my urine.
2.3Patient Review
11/17/2008 Unfortunately, this medication gave me cold hands and feet as well as weight gain. Additionally, I experienced some issues with erectile dysfunction.
1.3Patient Review
6/11/2008 Unfortunately, this caused me a lot of pain and I couldn't have sex while taking it.
Patient Q&A Section about avandamet
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Avandamet used for?
"Avandamet is a combination of two oral diabetes medicines that help control blood sugar levels for people with type 2 diabetes who do not use daily insulin injections."
Answered by AI
Is AVANDAMET still available?
"Avandamet, a combination of rosiglitazone and metformin, was used to control blood sugar in people with type 2 diabetes, but it is no longer available in the U.S."
Answered by AI
What is the drug metformin used for?
"UK
Metformin is a type of medicine used to treat type 2 diabetes. It is usually taken with a meal or snack."
Answered by AI
What drug class is Avandamet?
"Avandamet pairs two different kinds of diabetes medication in order to better control blood sugar levels in patients with type 2 diabetes. Rosiglitazone maleate, a member of the thiazolidinedione class, and metformin hydrochloride, a member of the biguanide class, work together to improve glycemic control."
Answered by AI