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What is Aubagio
TeriflunomideThe Generic name of this drug
Treatment SummaryTeriflunomide is a medication used to treat multiple sclerosis, specifically the relapsing forms. It works by reducing the activity of the immune system and is sold under the brand name Aubagio®. There is an important warning about the risk of liver damage and birth defects for people taking this drug, so patients should discuss this with their doctor before beginning treatment.
Aubagiois the brand name
Aubagio Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aubagio
Teriflunomide
2013
44
Approved as Treatment by the FDA
Teriflunomide, also known as Aubagio, is approved by the FDA for 1 uses which include Multiple Sclerosis .Multiple Sclerosis
Helps manage Multiple Sclerosis
Effectiveness
How Aubagio Affects PatientsTeriflunomide is a drug that helps reduce inflammation and slow cell growth. It does this by decreasing the number of active white blood cells in the central nervous system.
How Aubagio works in the bodyWe don't know exactly how teriflunomide works in Multiple Sclerosis, but it likely has something to do with preventing the production of a type of molecule called pyrimidine. This is done by blocking a specific enzyme in the mitochondria, which is thought to have an immunomodulatory effect.
When to interrupt dosage
The suggested dosage of Aubagio is contingent upon the diagnosed condition . The amount of dosage is contingent upon the method of administration (e.g. Tablet, film coated or Tablet - Oral) featured in the table beneath.Condition
Dosage
Administration
Multiple Sclerosis
, 14.0 mg, 7.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Aubagio ContraindicationsCondition
Risk Level
Notes
Severe Hepatic Impairment
Do Not Combine
females of reproductive potential
Do Not Combine
Pulse Frequency
Do Not Combine
Common Aubagio Drug Interactions
Drug Name
Risk Level
Description
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Teriflunomide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Acteoside
Major
The risk or severity of adverse effects can be increased when Teriflunomide is combined with Acteoside.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Teriflunomide.
Antilymphocyte immunoglobulin (horse)
Major
The risk or severity of adverse effects can be increased when Teriflunomide is combined with Antilymphocyte immunoglobulin (horse).
Bacillus calmette-guerin substrain russian BCG-I live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Teriflunomide.
Aubagio Toxicity & Overdose RiskPregnant women and women of childbearing age should not take teriflunomide as it can cause birth defects. Additionally, those with severe liver damage should also avoid taking teriflunomide as it can lead to liver failure and death.
Aubagio Novel Uses: Which Conditions Have a Clinical Trial Featuring Aubagio?
193 ongoing clinical trials are currently examining the potential of Aubagio to provide therapeutic benefits for Multiple Sclerosis.Condition
Clinical Trials
Trial Phases
Multiple Sclerosis
195 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4, Early Phase 1
Aubagio Reviews: What are patients saying about Aubagio?
5Patient Review
5/27/2017 So far, no complaints. I had a slight case of diarrhea, but that could have been from something else entirely. My doctor took me off the medication for a few days while I was traveling, but I'm back on now and haven't had any problems. Tysabri was tough to keep up with, so this pill form is much easier. Plus, I was JCV positive which made it even more difficult.
5Patient Review
8/13/2020 I've been on this medication for over three years and it's been great. My MRIs have stayed the same and I haven't had any relapses. This was the third drug I tried and, in my opinion, it's much simpler than the others.
5Patient Review
7/6/2018 I was diagnosed with MS a few years ago and started taking Aubagio immediately as my doctor thought it would be the best course of action. I experienced some hair loss after the first three months, but it came back no problem. After one year of taking the medication, MRIs show no progression or new lesions. I've had some stomach upsets but they're manageable with immodium. The only downside is that it's very expensive and assistance organizations run out of donations quickly.
4.3Patient Review
1/11/2015 The listed side effect of alopecia is more like excessive shedding. My case has been steadily improving for the past six months. The peripheral neuropathy I experienced during months three and four was quite severe, but it has since all but disappeared. I am scheduled for an MRI soon to check on the effectiveness of this treatment, but so far I have not had any relapses while taking Aubagio.
4.3Patient Review
8/31/2016 So far, this medication has been good to me. I just hope it becomes more widely available soon so I can take advantage of rewards programs like air miles.
4Patient Review
4/23/2018 I was diagnosed in 2013 with the JCV virus. I've been on 14mg of AUBAGIO for a little over a year and things are going well. I experienced some hair shedding initially for about three months, but it has since tapered off. The numbness, tingling, and burning associated with MS is still present but happens much less frequently. Fatigue has also decreased significantly, which is a relief. All things considered, I'm happy with AUBAGIO treatments.
4Patient Review
7/23/2016 The pill form is great and easy to take, but the packaging is not friendly for those with arthritis or other conditions that make it difficult to open. I had my granddaughter help me get them out and put them in an old pill case. So far so good on this medication!
3Patient Review
8/2/2015 I've only been on Aubagio for two weeks now, and I was given IV steroids the week before starting this medication. So far, I haven't seen any changes in my MS symptoms like headaches, muscle spasms, numbness, and nerve pain.
2.7Patient Review
3/31/2016 I've been taking Abaugio for eight months now. While it's caused hair loss, that side effect has begun to subside somewhat. I'm still experiencing relapses of my MS symptoms, like hot burning feet at night, numbness and tingling in my fingers, and migraines. I've also gotten bronchitis, viruses, and pneumonia twice since starting the medication. I'm not sure if I'll continue taking it or not, but I'm willing to give it a little more time.
2.3Patient Review
7/20/2014 I gained 35lbs while taking this medication, and have also experienced hair loss. I haven't found it to be very helpful overall.
2.3Patient Review
1/9/2016 I was on Aubagio for a total of seven months. Around the three-month mark, I started losing hair; my primary care physician said it was due to stress from surgery. By the seventh month, I had lost two-thirds of my hair. I eventually figured out that this medication was the culprit and stopped taking it immediately at the advice of my neurologist.
2Patient Review
2/5/2017 I'm still experiencing the same symptoms and no improvement. My hair loss has been significant, though this treatment is much easier to use than other treatments I've tried in the past.
1.7Patient Review
11/5/2019 I had to stop taking Aubagio after 2 1/2 years. My most recent MRI showed significant progression, and the side effects were high blood pressure, upset stomach, cognitive issues, coarser hair and fatigue.
1Patient Review
8/6/2016 I'm not sure if this medication is helping me or not. I've been taking it daily, but I just had a relapse.
Patient Q&A Section about aubagio
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What kind of drug is Aubagio?
"Aubagio is a drug that inhibits the function of specific immune cells that have been implicated in MS. It is related to leflunomide, a drug used to treat rheumatoid arthritis."
Answered by AI
What does Aubagio do to your body?
"Aubagio may cause a serious skin condition called Stevens-Johnson syndrome. This can cause painful sores on your mouth, throat, eyes, or genitals. In one case, a person who took Aubagio developed a fatal condition called toxic epidermal necrolysis."
Answered by AI
Is Aubagio an immunosuppressant?
"A low WBC count may increase your risk of infection. You should call your doctor right away if you have any signs of infection, such as a fever. Yes, Aubagio (teriflunomide) may affect how your body fights infection by lowering your white blood cell (WBC) count. WBCs are found in your blood and are responsible for fighting infection. A low WBC count may put you at a higher risk for infection. Be sure to call your doctor right away if you have any signs of infection, such as a fever."
Answered by AI
Is Aubagio a chemotherapy drug?
"Chemotherapy (chemo) is a type of cancer treatment that uses drugs to destroy cancer cells.
No, Aubagio is not a chemotherapy medication. Chemotherapy is a type of cancer treatment that uses drugs to destroy cancer cells, but Aubagio is not used for this purpose."
Answered by AI