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What is Atripla
EmtricitabineThe Generic name of this drug
Treatment SummaryEfavirenz (brand names Sustiva® and Stocrin®) is a medication used to treat HIV-1. When used in combination with other antiretroviral medications, it can reduce the risk of HIV transmission from high-risk exposures. It is usually combined with lamivudine and either zidovudine or tenofovir for HIV infection that has not previously been treated. Efavirenz is part of a highly active antiretroviral therapy (HAART) regimen for HIV treatment.
Emtrivais the brand name
Atripla Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Emtriva
Emtricitabine
2003
131
Approved as Treatment by the FDA
Emtricitabine, also called Emtriva, is approved by the FDA for 2 uses including HIV and adults and pediatric patients weighing at least 17 kg .HIV
Helps manage Human Immunodeficiency Virus Type 1 (HIV-1) Infection
adults and pediatric patients weighing at least 17 kg
Effectiveness
How Atripla Affects PatientsEfavirenz is a type of medicine used to treat HIV infections. It is usually taken as part of a three-drug regimen that includes another type of HIV medication, such as lamivudine, stavudine or zidovudine, and a protease inhibitor. It was originally approved for use in patients who had not responded to treatment with zidovudine.
How Atripla works in the bodyEfavirenz works to stop HIV from reproducing by stopping an enzyme called reverse transcriptase from copying viral RNA. This stops the virus from making new copies of itself. Though human DNA polymerase is less likely to be affected by efavirenz, this may still be a cause of some of the drug's side effects.
When to interrupt dosage
The measure of Atripla is contingent upon the indicated condition. The amount of dosage will be contingent upon the technique of delivery (e.g. Tablet or Capsule - Oral), as shown in the table beneath.Condition
Dosage
Administration
HIV Transmission
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV test negative
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Anti-Retroviral Agents
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
weight more than 35 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
weight at least 14 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV Infections
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
weight at least 35 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Antiretroviral Therapy
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
treatment failure
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
adults and pediatric patients weighing at least 17 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Sexual Behaviour
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
not requiring CYP3A inhibitors
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Warnings
Atripla ContraindicationsCondition
Risk Level
Notes
HIV
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Emtricitabine may interact with Pulse Frequency
Common Atripla Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Emtricitabine.
Procainamide
Major
The excretion of Procainamide can be decreased when combined with Emtricitabine.
Topotecan
Major
The excretion of Topotecan can be decreased when combined with Emtricitabine.
Cefradine
Minor
The excretion of Cefradine can be decreased when combined with Emtricitabine.
Estrone sulfate
Minor
The excretion of Estrone sulfate can be decreased when combined with Emtricitabine.
Atripla Novel Uses: Which Conditions Have a Clinical Trial Featuring Atripla?
44 active studies are currently assessing the potential of Atripla to provide Antiretroviral Therapy.Condition
Clinical Trials
Trial Phases
treatment failure
0 Actively Recruiting
HIV Transmission
0 Actively Recruiting
HIV
0 Actively Recruiting
Anti-Retroviral Agents
0 Actively Recruiting
HIV Infections
0 Actively Recruiting
HIV test negative
0 Actively Recruiting
adults and pediatric patients weighing at least 17 kg
0 Actively Recruiting
Antiretroviral Therapy
2 Actively Recruiting
Phase 3, Phase 1
HIV
42 Actively Recruiting
Phase 2, Phase 3, Phase 1, Phase 4, Not Applicable, Early Phase 1
HIV
146 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
not requiring CYP3A inhibitors
0 Actively Recruiting
weight more than 35 kg
0 Actively Recruiting
weight at least 35 kg
0 Actively Recruiting
weight at least 14 kg
0 Actively Recruiting
Sexual Behaviour
17 Actively Recruiting
Phase 2, Not Applicable, Phase 4
Atripla Reviews: What are patients saying about Atripla?
5Patient Review
8/31/2015 This treatment saved my life. When I started it, my CD4 was less than 600 and my copy count was in excess of 350K. Within 6 months, my CD4 was up to 970, and my viral load was undetectable, and I've remained this way for over 2 years.
5Patient Review
1/19/2018 Atripla is most effective when taken before bed. The side effects are strongest in the first few weeks, but they should dissipate after that.
5Patient Review
6/4/2014 I've only been on Atripla for 4 weeks, but it's going well so far. I had slight dizziness on the first day and sickness on day 3, but I'm attributing that to taking 2 ibuprofen for sinus pain. My girlfriend caught HIV from me and she's been on Atripla for 10 months now. Her viral load is undetectable now, which is great news.
5Patient Review
2/9/20145Patient Review
3/22/20145Patient Review
2/28/2017 I've been on Atripla for over five years with no problems. My labs are great, but I'm suddenly feeling more symptoms. Has anyone else experienced this?
4.7Patient Review
8/20/2015 Atripla has been working well for me for almost three years now. The only side effects I've noticed are a light dizziness, some irritability, and diarrhea if I eat or drink within 12 hours of taking the medication. Additionally, I sometimes have strange dreams.
4.7Patient Review
9/2/2014 I felt a little dizzy for the first few days, but that passed. I also had very vivid dreams--that was interesting. After one month, my viral load went from 35k to <20--so it's working well! The only downside is that coffee makes me have to use the restroom immediately.
4.7Patient Review
5/5/2014 This medication can cause obesity, so doctors should warn their patients that they may need to change their eating habits.
4.3Patient Review
11/21/2014 I constantly battle dry skin, and lately I've been struggling with an increased appetite which has lead to weight gain. On top of that, I'm pretty much always dealing with some sort of yeast infection. So, needless to say, I'm really hoping to find a less toxic solution soon.
4.3Patient Review
6/30/2014 I saw a significant increase in my CD4 and decrease in my viral load after just three months of treatment. The only downside was the severe drowsiness I felt for about 24 hours every day, as well as some vivid dreams during the first few weeks. Overall, though, it was worth it and I'm hoping to be undetectable at my six month mark.
3.7Patient Review
2/8/2018 I've been on Atripla for six years, but some of the side effects are really tough to deal with. My sleep quality has decreased dramatically, and I often feel bad a few hours after taking the pill. Additionally, I've been feeling depressed more frequently, and my memory isn't what it used to be. Does anyone know of a better medicine than Atripla?
3.7Patient Review
7/29/2020 After taking this drug for ten years, I started to experience intense psychological problems. Additionally, the osteopenia in my bones got worse and my lipodystrophy (a side effect of many HIV medications) worsened. There are much better alternatives to Atripla out there that don't come with these nasty side effects.
3.7Patient Review
6/22/2014 I'm not sure if there's a difference between the 300 mg and 245 mg versions of this drug; however, both seem to work well for me.
3Patient Review
3/12/2022 I had some physical problems after using this treatment.
Patient Q&A Section about atripla
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why is Atripla discontinued?
"The branded version of Atripla will be discontinued at the end of 2021 because there is not a high demand for it."
Answered by AI
What is Atripla tablets used for?
"This lowers your chance of getting HIV complications (such as new infections, cancer) and increases your life span.
This product contains 3 different medications: efavirenz, emtricitabine, and tenofovir. These medications are used to help control HIV infection. They work by decreasing the amount of HIV in the body, which helps the immune system to work better. This in turn lowers the person's chance of developing HIV complications, and increases their life span."
Answered by AI
What are the long term side effects of Atripla?
"If you have kidney problems, you may experience increased thirst and urination, muscle pain or weakness. If you have liver problems, you may experience swelling around your midsection, right-sided upper stomach pain, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes)."
Answered by AI