Atripla

Antiretroviral Therapy, HIV test negative, HIV Infections + 12 more
Treatment
2 FDA approvals
20 Active Studies for Atripla

What is Atripla

EmtricitabineThe Generic name of this drug
Treatment SummaryEfavirenz (brand names Sustiva® and Stocrin®) is a medication used to treat HIV-1. When used in combination with other antiretroviral medications, it can reduce the risk of HIV transmission from high-risk exposures. It is usually combined with lamivudine and either zidovudine or tenofovir for HIV infection that has not previously been treated. Efavirenz is part of a highly active antiretroviral therapy (HAART) regimen for HIV treatment.
Emtrivais the brand name
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Atripla Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Emtriva
Emtricitabine
2003
131

Approved as Treatment by the FDA

Emtricitabine, also called Emtriva, is approved by the FDA for 2 uses including adults and pediatric patients weighing at least 17 kg and HIV .
adults and pediatric patients weighing at least 17 kg
HIV
Helps manage Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Effectiveness

How Atripla Affects PatientsEfavirenz is a type of medicine used to treat HIV infections. It is usually taken as part of a three-drug regimen that includes another type of HIV medication, such as lamivudine, stavudine or zidovudine, and a protease inhibitor. It was originally approved for use in patients who had not responded to treatment with zidovudine.
How Atripla works in the bodyEfavirenz works to stop HIV from reproducing by stopping an enzyme called reverse transcriptase from copying viral RNA. This stops the virus from making new copies of itself. Though human DNA polymerase is less likely to be affected by efavirenz, this may still be a cause of some of the drug's side effects.

When to interrupt dosage

The measure of Atripla is contingent upon the indicated condition. The amount of dosage will be contingent upon the technique of delivery (e.g. Tablet or Capsule - Oral), as shown in the table beneath.
Condition
Dosage
Administration
Antiretroviral Therapy
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV test negative
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV Infections
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV Transmission
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Anti-Retroviral Agents
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
HIV
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
adults and pediatric patients weighing at least 17 kg
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
not requiring CYP3A inhibitors
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
treatment failure
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Obesity
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Obesity
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Obesity
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Sexual Behaviour
200.0 mg, , 100.0 mg, 133.0 mg, 167.0 mg, 10.0 mg/mL, 120.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral

Warnings

Atripla Contraindications
Condition
Risk Level
Notes
HIV
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Emtricitabine may interact with Pulse Frequency
There are 20 known major drug interactions with Atripla.
Common Atripla Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Emtricitabine.
Procainamide
Major
The excretion of Procainamide can be decreased when combined with Emtricitabine.
Topotecan
Major
The excretion of Topotecan can be decreased when combined with Emtricitabine.
Cefradine
Minor
The excretion of Cefradine can be decreased when combined with Emtricitabine.
Estrone sulfate
Minor
The excretion of Estrone sulfate can be decreased when combined with Emtricitabine.
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Atripla Novel Uses: Which Conditions Have a Clinical Trial Featuring Atripla?

44 active studies are currently assessing the potential of Atripla to provide Antiretroviral Therapy.
Condition
Clinical Trials
Trial Phases
Anti-Retroviral Agents
0 Actively Recruiting
HIV
132 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
HIV Infections
0 Actively Recruiting
treatment failure
0 Actively Recruiting
Sexual Behaviour
16 Actively Recruiting
Not Applicable, Phase 4
adults and pediatric patients weighing at least 17 kg
0 Actively Recruiting
HIV Transmission
0 Actively Recruiting
Obesity
0 Actively Recruiting
Antiretroviral Therapy
1 Actively Recruiting
Phase 2
HIV
0 Actively Recruiting
Obesity
0 Actively Recruiting
not requiring CYP3A inhibitors
0 Actively Recruiting
HIV test negative
0 Actively Recruiting
HIV
38 Actively Recruiting
Phase 2, Phase 3, Early Phase 1, Not Applicable, Phase 1, Phase 4
Obesity
0 Actively Recruiting

Atripla Reviews: What are patients saying about Atripla?

5Patient Review
8/31/2015
Atripla for HIV
This treatment saved my life. When I started it, my CD4 was less than 600 and my copy count was in excess of 350K. Within 6 months, my CD4 was up to 970, and my viral load was undetectable, and I've remained this way for over 2 years.
5Patient Review
1/19/2018
Atripla for HIV
Atripla is most effective when taken before bed. The side effects are strongest in the first few weeks, but they should dissipate after that.
5Patient Review
6/4/2014
Atripla for HIV
I've only been on Atripla for 4 weeks, but it's going well so far. I had slight dizziness on the first day and sickness on day 3, but I'm attributing that to taking 2 ibuprofen for sinus pain. My girlfriend caught HIV from me and she's been on Atripla for 10 months now. Her viral load is undetectable now, which is great news.
5Patient Review
2/9/2014
Atripla for HIV
5Patient Review
3/22/2014
Atripla for HIV
View All Reviews
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Patient Q&A Section about atripla

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is Atripla discontinued?

"The branded version of Atripla will be discontinued at the end of 2021 because there is not a high demand for it."

Answered by AI

What is Atripla tablets used for?

"This lowers your chance of getting HIV complications (such as new infections, cancer) and increases your life span.

This product contains 3 different medications: efavirenz, emtricitabine, and tenofovir. These medications are used to help control HIV infection. They work by decreasing the amount of HIV in the body, which helps the immune system to work better. This in turn lowers the person's chance of developing HIV complications, and increases their life span."

Answered by AI

Is Atripla still prescribed?

"Atripla and Truvada are both approved for use in people of any age, as long as they weigh at least 88 pounds (40 kilograms) and 37 pounds (17 kilograms) respectively. Truvada is also approved for the prevention of HIV."

Answered by AI

What are the long term side effects of Atripla?

"If you have kidney problems, you may experience increased thirst and urination, muscle pain or weakness. If you have liver problems, you may experience swelling around your midsection, right-sided upper stomach pain, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes)."

Answered by AI

Clinical Trials for Atripla

Have you considered Atripla clinical trials? We made a collection of clinical trials featuring Atripla, we think they might fit your search criteria.
Have you considered Atripla clinical trials? We made a collection of clinical trials featuring Atripla, we think they might fit your search criteria.
Have you considered Atripla clinical trials? We made a collection of clinical trials featuring Atripla, we think they might fit your search criteria.
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