Apixaban

Deep Vein Thrombosis, Arthroplasty, Pulmonary Embolism + 8 more

Treatment

11 FDA approvals

20 Active Studies for Apixaban

Treatment for

Deep Vein Thrombosis

What is Apixaban

ApixabanThe Generic name of this drug

Treatment SummaryApixaban (brand name Eliquis) is a medication taken by mouth to prevent and treat blood clots. Apixaban works by blocking a substance in the body called factor Xa, which helps reduce the risk of thromboembolic diseases. It was approved by the FDA in 2012.

Eliquisis the brand name

image of different drug pills on a surface

Apixaban Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Eliquis

Apixaban

2012

15

Approved as Treatment by the FDA

Apixaban, otherwise known as Eliquis, is approved by the FDA for 11 uses which include Disease and recurrent Prophylaxis of Deep Vein Thrombosis .

Disease

recurrent Prophylaxis of Deep Vein Thrombosis

Atrial Fibrillation

Pulmonary Embolism

Total Knee Arthroplasty

Arthroplasty

Systemic Embolism

Deep Vein Thrombosis

Pulmonary Embolism

Stroke

Deep Vein Thrombosis

Effectiveness

How Apixaban Affects PatientsApixaban stops the activation of certain proteins that help form a blood clot. It does this by blocking the free and bound forms of factor Xa and prothrominase, preventing clots from forming.

How Apixaban works in the bodyApixaban works to prevent blood clots by blocking the action of an enzyme called factor Xa. It also limits the production of another enzyme, prothrominase, which helps form clots. By inhibiting these enzymes, apixaban helps keep the blood from clotting.

When to interrupt dosage

The recommended measure of Apixaban is contingent upon the diagnosed condition, including Deep Vein Thrombosis (DVT), Deep Vein Thrombosis and Arthroplasty. The amount of dosage is contingent upon the technique of administration (e.g. Oral or Tablet, film coated - Oral) outlined in the following table.

Condition

Dosage

Administration

Total Knee Arthroplasty

, 2.5 mg, 5.0 mg, 10.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

recurrent Prophylaxis of Deep Vein Thrombosis

, 2.5 mg, 5.0 mg, 10.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Disease

, 2.5 mg, 5.0 mg, 10.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Deep Vein Thrombosis

, 2.5 mg, 5.0 mg, 10.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Atrial Fibrillation

, 2.5 mg, 5.0 mg, 10.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Stroke

, 2.5 mg, 5.0 mg, 10.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Arthroplasty

, 2.5 mg, 5.0 mg, 10.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Deep Vein Thrombosis

, 2.5 mg, 5.0 mg, 10.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Pulmonary Embolism

, 2.5 mg, 5.0 mg, 10.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Pulmonary Embolism

, 2.5 mg, 5.0 mg, 10.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Systemic Embolism

, 2.5 mg, 5.0 mg, 10.0 mg

, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Warnings

Apixaban Contraindications

Condition

Risk Level

Notes

Hemorrhage

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Apixaban may interact with Pulse Frequency

There are 20 known major drug interactions with Apixaban.

Common Apixaban Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Major

Apixaban may increase the anticoagulant activities of (R)-warfarin.

(S)-Warfarin

Major

Apixaban may increase the anticoagulant activities of (S)-Warfarin.

4-hydroxycoumarin

Major

Apixaban may increase the anticoagulant activities of 4-hydroxycoumarin.

Abciximab

Major

Apixaban may increase the anticoagulant activities of Abciximab.

Acenocoumarol

Major

Apixaban may increase the anticoagulant activities of Acenocoumarol.

Apixaban Toxicity & Overdose RiskAnimal studies suggest a higher risk of maternal bleeding, but no increase in fetal malformations or deaths. It is unknown if this applies to humans, so it should only be used if the benefits outweigh the risks. There is not enough information to determine if it is safe and effective for labor and birth. Animal studies suggest that it can be excreted in milk, so nursing mothers should consider stopping breastfeeding or taking apixaban. Safety and effectiveness in pediatric and geriatric patients has not been studied yet. Patients with end stage renal disease may have different reactions to apixaban, but no dosage adjustments are necessary for mild hepatic impairment

image of a doctor in a lab doing drug, clinical research

Apixaban Novel Uses: Which Conditions Have a Clinical Trial Featuring Apixaban?

83 active trials are analyzing the potential of Apixaban to ameliorate Deep Vein Thrombosis (DVT), Stroke and Pulmonary Embolism.

Condition

Clinical Trials

Trial Phases

Deep Vein Thrombosis

0 Actively Recruiting

Atrial Fibrillation

4 Actively Recruiting

Not Applicable

Total Knee Arthroplasty

15 Actively Recruiting

Phase 3, Not Applicable, Phase 2, Phase 4

Pulmonary Embolism

0 Actively Recruiting

Arthroplasty

10 Actively Recruiting

Not Applicable, Phase 4, Phase 2

recurrent Prophylaxis of Deep Vein Thrombosis

0 Actively Recruiting

Systemic Embolism

2 Actively Recruiting

Not Applicable

Disease

0 Actively Recruiting

Deep Vein Thrombosis

16 Actively Recruiting

Phase 4, Phase 3, Not Applicable, Phase 1, Phase 2

Pulmonary Embolism

34 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Early Phase 1, Phase 1, Phase 2

Stroke

11 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Apixaban Reviews: What are patients saying about Apixaban?

5Patient Review

4/27/2017

Apixaban for Blood Clot in a Deep Vein

This was easy to take and I didn't experience any side effects after my body adjusted. I did have a few headaches at first, but they quickly dissipated.

5Patient Review

1/5/2014

Apixaban for Treatment to Prevent Blood Clots in Chronic Atrial Fibrillation

I was unable to take Pradaxa due to the bleeding it caused, but this other drug has been working great for me.

5Patient Review

5/21/2017

Apixaban for Blood Clot in Lung

I took one 5mg tablet twice a day as directed, and I noticed zero negative side effects. This is much better than Warfarin for me, which left me feeling disoriented, clumsy, and with constant headaches.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about apixaban

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is apixaban and Eliquis the same thing?

"Eliquis is an anticoagulant that works by stopping the enzyme complex factor Xa from working. This reduces the likelihood of blood clots forming in the body, and therefore reduces the risk of a stroke or heart attack."

Answered by AI

What should I avoid when taking apixaban?

"There is some evidence that taking ginger, ginkgo biloba, turmeric, or certain Chinese herbs along with a blood-thinning medication like apixaban may increase the risk of bleeding. Also, St. John's wort may make apixaban less effective."

Answered by AI

What are side effects of apixaban?

"The following are symptoms of something serious: bleeding gums, nosebleeds, heavy vaginal bleeding, red, pink, or brown urine, red or black, tarry stools, coughing up or vomiting blood or material that looks like coffee grounds, swelling or joint pain, headache."

Answered by AI

What is apixaban drug used for?

"UK

Apixaban is a medicine that helps to prevent blood clots. It is used to treat people with atrial fibrillation (a heart condition that can cause an irregular heart beat) and to prevent stroke."

Answered by AI

Is Eliquis and apixaban the same?

"Eliquis is an anticoagulant that works by stopping an enzyme complex called factor Xa. This prevents blood clots from forming in your body, so you're less likely to have a stroke or heart attack."

Answered by AI

Clinical Trials for Apixaban

Image of Michigan Emergency Department Improvement Collaborative partners in Ann Arbor, United States.

MEDIC site for Pulmonary Embolism

This trial is testing a new way to improve the treatment of patients with pulmonary embolism to see if it can help avoid unnecessary hospital stays.

Waitlist Available

Michigan Emergency Department Improvement Collaborative partnersGeoff Barnes

Image of University Hospitals Cleveland Medical Center in Cleveland, United States.

Aidoc for Pulmonary Embolism

This trial aims to study the use of an artificial intelligence program to identify patients at high risk of pulmonary embolism. The goal is to determine if this AI program can help in deciding which patients need

Waitlist Available

University Hospitals Cleveland Medical CenterJun Li, MD

Image of University of Michigan in Ann Arbor, United States.

Cannabidiol for Osteoarthritis

This trial aims to investigate how taking cannabidiol (CBD) every day affects the need for opioid pain medication and other symptoms after knee replacement surgery. The researchers want to determine if CBD can be

University of Michigan (+1 Sites)Kevin F Boehnke

Image of Intermountain Medical Center in Murray, United States.

At-risk patients for which an alert is sent during the intervention phase

This trial is testing a new algorithm that uses patient age and blood test results to identify patients who may benefit from a blood thinner to decrease their risk of blood clots. The trial will evaluate the use

Waitlist Available

Intermountain Medical CenterScott C. Woller, MDJanssen Pharmaceuticals

Have you considered Apixaban clinical trials? We made a collection of clinical trials featuring Apixaban, we think they might fit your search criteria.

Explore trials for Apixaban

Image of Hospital for Special Surgery in New York, United States.

Mindfulness Meditation Intervention for Total Knee Arthroplasty

This trial aims to see if mindfulness meditation before knee surgery can improve mental and physical health compared to those who did not meditate. Participants will either meditate before surgery or wait 90 days post-s

Hospital for Special SurgeryChristopher Li, MD

Image of St. Bernards Medical Center in Jonesboro, United States.

Laminar Left Atrial Appendage Closure System for Atrial Fibrillation

"This trial aims to compare a new device, the Laminar Left Atrial Appendage Closure System, to existing devices used to prevent strokes in patients with atrial fibrillation. Participants will be randomly

Waitlist Available

St. Bernards Medical Center (+3 Sites)Devi Nair, MDLaminar, Inc.

Image of Temple University in Philadelphia, United States.

BEC Catheter for Pulmonary Embolism

Philadelphia, PA

This trial tests a new catheter to safely treat blood clots in the lungs with a drug and special spray.

Waitlist Available

Temple UniversityParth Rali, MD

Image of Rothman Orthopaedic Institute in Philadelphia, United States.

Mindfulness App for Post-Knee Surgery Pain

Philadelphia, PA

This trial will evaluate whether using the app Headspace before/after knee replacement can improve outcomes, reduce pain & opioid use in those with anxiety/depression.

Waitlist Available

Rothman Orthopaedic Institute

Have you considered Apixaban clinical trials? We made a collection of clinical trials featuring Apixaban, we think they might fit your search criteria.

Explore trials for Apixaban

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Energize! Program for Knee Replacement

This trial tests if an online program can help adults with knee replacements get active, reduce pain, and improve physical function.

Waitlist Available

University of South Carolina

Image of Huntsville Hospital in Huntsville, United States.

Symphony Thrombectomy System for Embolism

This trial studied using a device to treat PE and found it to be safe and effective.

Huntsville Hospital (+1 Sites)Imperative Care, Inc.

Image of UAB Division of Cardiovascular Disease in Birmingham, United States.

FlowTriever System + Anticoagulation for Pulmonary Embolism

This trial compares treatments for a type of blood clot in the lungs: one with a new device plus anticoagulation vs. anticoagulation alone.

UAB Division of Cardiovascular Disease (+51 Sites)Frances Mae West, MDInari Medical

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Aromatherapy for Postoperative Care in Knee Replacement

This trial tests if aromatherapy may reduce post-op anxiety, pain, opioid use & nausea in total knee replacement patients.

Senior-friendly

Hospital for Special SurgeryUchenna Umeh, MD

Have you considered Apixaban clinical trials? We made a collection of clinical trials featuring Apixaban, we think they might fit your search criteria.

Explore trials for Apixaban

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