Apixaban

Deep Vein Thrombosis, Arthroplasty, Pulmonary Embolism + 8 more
Treatment
16 FDA approvals
20 Active Studies for Apixaban

What is Apixaban

ApixabanThe Generic name of this drug
Treatment SummaryApixaban (brand name Eliquis) is a medication taken by mouth to prevent and treat blood clots. Apixaban works by blocking a substance in the body called factor Xa, which helps reduce the risk of thromboembolic diseases. It was approved by the FDA in 2012.
Eliquisis the brand name
image of different drug pills on a surface
Apixaban Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Eliquis
Apixaban
2012
15

Approved as Treatment by the FDA

Apixaban, otherwise known as Eliquis, is approved by the FDA for 16 uses which include Non Valvular Atrial Fibrillation (nv AF) and Recurrent Pulmonary Embolism (Disorder) .
Non Valvular Atrial Fibrillation (nv AF)
Recurrent Pulmonary Embolism (Disorder)
Deep Vein Thrombosis
Prophylaxis of Deep Vein Thrombosis
Deep vein thrombosis recurrent
Arthroplasty
recurrent Prophylaxis of Deep Vein Thrombosis
Deep Vein Thrombosis
Total Knee Arthroplasty
Stroke
Atrial Fibrillation
Systemic Embolism
Pulmonary Embolism
Disease
Pulmonary Embolism
Deep Vein Thrombosis

Effectiveness

How Apixaban Affects PatientsApixaban stops the activation of certain proteins that help form a blood clot. It does this by blocking the free and bound forms of factor Xa and prothrominase, preventing clots from forming.
How Apixaban works in the bodyApixaban works to prevent blood clots by blocking the action of an enzyme called factor Xa. It also limits the production of another enzyme, prothrominase, which helps form clots. By inhibiting these enzymes, apixaban helps keep the blood from clotting.

When to interrupt dosage

The recommended measure of Apixaban is contingent upon the diagnosed condition, including Deep Vein Thrombosis (DVT), Deep Vein Thrombosis and Arthroplasty. The amount of dosage is contingent upon the technique of administration (e.g. Oral or Tablet, film coated - Oral) outlined in the following table.
Condition
Dosage
Administration
Deep Vein Thrombosis
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Pulmonary Embolism
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Atrial Fibrillation
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Disease
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Deep Vein Thrombosis
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Stroke
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
recurrent Prophylaxis of Deep Vein Thrombosis
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Total Knee Arthroplasty
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Systemic Embolism
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Arthroplasty
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Pulmonary Embolism
, 2.5 mg, 5.0 mg, 10.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Warnings

Apixaban Contraindications
Condition
Risk Level
Notes
Hemorrhage
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Apixaban may interact with Pulse Frequency
There are 20 known major drug interactions with Apixaban.
Common Apixaban Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
Apixaban may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Major
Apixaban may increase the anticoagulant activities of (S)-Warfarin.
4-hydroxycoumarin
Major
Apixaban may increase the anticoagulant activities of 4-hydroxycoumarin.
Abciximab
Major
Apixaban may increase the anticoagulant activities of Abciximab.
Acenocoumarol
Major
Apixaban may increase the anticoagulant activities of Acenocoumarol.
Apixaban Toxicity & Overdose RiskAnimal studies suggest a higher risk of maternal bleeding, but no increase in fetal malformations or deaths. It is unknown if this applies to humans, so it should only be used if the benefits outweigh the risks. There is not enough information to determine if it is safe and effective for labor and birth. Animal studies suggest that it can be excreted in milk, so nursing mothers should consider stopping breastfeeding or taking apixaban. Safety and effectiveness in pediatric and geriatric patients has not been studied yet. Patients with end stage renal disease may have different reactions to apixaban, but no dosage adjustments are necessary for mild hepatic impairment
image of a doctor in a lab doing drug, clinical research

Apixaban Novel Uses: Which Conditions Have a Clinical Trial Featuring Apixaban?

83 active trials are analyzing the potential of Apixaban to ameliorate Deep Vein Thrombosis (DVT), Stroke and Pulmonary Embolism.
Condition
Clinical Trials
Trial Phases
Pulmonary Embolism
25 Actively Recruiting
Phase 4, Phase 3, Early Phase 1, Not Applicable
Total Knee Arthroplasty
6 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 4
recurrent Prophylaxis of Deep Vein Thrombosis
0 Actively Recruiting
Atrial Fibrillation
4 Actively Recruiting
Not Applicable
Deep Vein Thrombosis
0 Actively Recruiting
Deep Vein Thrombosis
10 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 4
Disease
0 Actively Recruiting
Arthroplasty
3 Actively Recruiting
Not Applicable
Stroke
9 Actively Recruiting
Phase 4, Phase 1, Not Applicable
Pulmonary Embolism
0 Actively Recruiting
Systemic Embolism
3 Actively Recruiting
Not Applicable

Apixaban Reviews: What are patients saying about Apixaban?

5Patient Review
4/27/2017
Apixaban for Blood Clot in a Deep Vein
This was easy to take and I didn't experience any side effects after my body adjusted. I did have a few headaches at first, but they quickly dissipated.
5Patient Review
1/5/2014
Apixaban for Treatment to Prevent Blood Clots in Chronic Atrial Fibrillation
I was unable to take Pradaxa due to the bleeding it caused, but this other drug has been working great for me.
5Patient Review
5/21/2017
Apixaban for Blood Clot in Lung
I took one 5mg tablet twice a day as directed, and I noticed zero negative side effects. This is much better than Warfarin for me, which left me feeling disoriented, clumsy, and with constant headaches.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about apixaban

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is apixaban and Eliquis the same thing?

"Eliquis is an anticoagulant that works by stopping the enzyme complex factor Xa from working. This reduces the likelihood of blood clots forming in the body, and therefore reduces the risk of a stroke or heart attack."

Answered by AI

What should I avoid when taking apixaban?

"There is some evidence that taking ginger, ginkgo biloba, turmeric, or certain Chinese herbs along with a blood-thinning medication like apixaban may increase the risk of bleeding. Also, St. John's wort may make apixaban less effective."

Answered by AI

What are side effects of apixaban?

"The following are symptoms of something serious: bleeding gums, nosebleeds, heavy vaginal bleeding, red, pink, or brown urine, red or black, tarry stools, coughing up or vomiting blood or material that looks like coffee grounds, swelling or joint pain, headache."

Answered by AI

What is apixaban drug used for?

"UK

Apixaban is a medicine that helps to prevent blood clots. It is used to treat people with atrial fibrillation (a heart condition that can cause an irregular heart beat) and to prevent stroke."

Answered by AI

Is Eliquis and apixaban the same?

"Eliquis is an anticoagulant that works by stopping an enzyme complex called factor Xa. This prevents blood clots from forming in your body, so you're less likely to have a stroke or heart attack."

Answered by AI

Clinical Trials for Apixaban

Have you considered Apixaban clinical trials? We made a collection of clinical trials featuring Apixaban, we think they might fit your search criteria.
Have you considered Apixaban clinical trials? We made a collection of clinical trials featuring Apixaban, we think they might fit your search criteria.
Have you considered Apixaban clinical trials? We made a collection of clinical trials featuring Apixaban, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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