What is Amidate
EtomidateThe Generic name of this drug
Treatment SummaryImidazole is a type of drug used as an anesthetic and hypnotic. It is known to have little impact on the cardiovascular system, blood gases, or breathing. It is sometimes used to put a patient to sleep during medical procedures.
Etomidateis the brand name
Amidate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Etomidate
Etomidate
1996
53
Approved as Treatment by the FDA
Etomidate, also known as Etomidate, is approved by the FDA for 1 uses like General Anesthesia .General Anesthesia
Effectiveness
How Amidate Affects PatientsEtomidate is a drug used to cause unconsciousness so that anesthesia can be administered. It works by affecting the level of the reticular-activating system in the brain. Its effects last longer than thiopental and methohexital, but not as long as barbituates or propofol. The drug causes unconsciousness quickly, with recovery taking place soon after as a result of its metabolism and redistribution in the body. It does not induce analgesia.
How Amidate works in the bodyEtomidate binds to a special region of the GABA receptor, which controls the flow of chloride ions in and out of cells. By binding to this region, etomidate keeps the chloride ion channel open longer. This increases the inhibitory effects of GABA, which reduces activity in the thalamus.
When to interrupt dosage
The proposed measure of Amidate is contingent upon the diagnosed condition. The amount of dosage fluctuates, in accordance with the method of delivery (e.g. Injection, solution or Solution - Intravenous) detailed in the table below.Condition
Dosage
Administration
General Anesthesia
2.0 mg/mL, , 4.0 mg/mL
Injection, solution, Solution - Intravenous, Injection, solution - Intravenous, Injection, Intravenous, , Injection - Intravenous, Solution
Warnings
There are 20 known major drug interactions with Amidate.Common Amidate Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Etomidate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of sedation and somnolence can be increased when Etomidate is combined with Deutetrabenazine.
Ethanol
Major
Etomidate may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Iobenguane
Major
The therapeutic efficacy of Iobenguane can be decreased when used in combination with Etomidate.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Etomidate is combined with Oliceridine.
Amidate Toxicity & Overdose RiskTaking etomidate may cause pain during injection, muscle spasms, and decreased activity of the adrenal gland up to 6 hours afterwards.
Amidate Novel Uses: Which Conditions Have a Clinical Trial Featuring Amidate?
Currently, 4 clinical trials are underway to investigate the potential of Amidate as an effective treatment for General Anesthesia.Condition
Clinical Trials
Trial Phases
General Anesthesia
4 Actively Recruiting
Phase 3, Phase 1
Amidate Reviews: What are patients saying about Amidate?
5Patient Review
7/18/2012 I've used this product for over 25 years to manage my anxiety. It's been integral in allowing me to have a successful career without putting undue stress on my family.
5Patient Review
4/28/2011 meprobamate has been an effective anti-depressant for me and my mother when other drugs have not worked.
5Patient Review
4/19/2017 I currently can't afford this medication, as a 30-day supply costs over $400. My doctor has substituted generic Valium instead, which was originally prescribed to me over 25 years ago for skeletal pain and muscle tension. I don't prefer the generic Valium, as it doesn't work as well for me with far more side effects. I just don't understand the drug companies at all.
5Patient Review
10/8/2021 Meprobamate is an excellent medication for stress and anxiety. It allows me to move on from negativity and disappointment, especially regarding people. I only use it occasionally when I really need it, as opposed to taking advantage of the drug.
5Patient Review
4/28/2011 Meprobamate has been an effective anti-depressant for me, and it's something that I've turned to after other drugs haven't worked.
5Patient Review
7/18/2012 I've used this medication for over 25 years to manage my anxiety. It's been a lifesaver, both in terms of my career and family life. I would highly recommend it to others struggling with similar issues.
5Patient Review
4/19/2017 The price for 30 pills is outrageous, so I am currently not taking the medication. My doctor substituted generic Valium instead, which was prescribed to me over 25 years ago for skeletal pain and muscle tension. I don't like the generic Valium, but it does its job with no side effects.
5Patient Review
10/8/2021 Meprobamate is an excellent medication for managing stress and anxiety. It has helped me to move on from negative thoughts and experiences, especially regarding people. I only use it occasionally when I really need it, as it is a mild tranquilizer.
5Patient Review
7/18/2012 This medication has been a godsend for me. It's allowed me to stay calm and collected in an extremely high-stress job, and I know that it's improved my performance reviews as a result. My family is also much better off financially because of this treatment helping me keep my career.
5Patient Review
4/19/2017 The cost of this medication is outrageous, so I've had to switch to a generic Valium which isn't nearly as effective. This was prescribed to me over 25 years ago for skeletal pain and muscle tension with no side effects. I don't understand the drug companies' thinking behind creating new drugs with more side effects but making them cheaper and easier to get covered by insurance programs.
5Patient Review
10/8/2021 Meprobamate is an excellent anti-stress and anti-anxiety medication. It helps me to move on from negativity and disappointment, particularly when it comes to people. I only use it occasionally when I really need it, as opposed to taking advantage of the drug.
5Patient Review
8/19/20105Patient Review
1/27/20115Patient Review
8/19/20105Patient Review
1/27/20115Patient Review
8/19/20105Patient Review
1/27/20115Patient Review
4/28/2011 I use meprobamate as an antidepressant, and it works when other drugs have not.
4.7Patient Review
6/10/2014 While this drug certainly helped with my anxiety, I found that xanax and valium were more effective for me.
4.7Patient Review
6/10/2014 While this drug does help with anxiety, stress and tension, I found that Xanax and Valium were more effective for me.
4.7Patient Review
6/10/2014 This drug helped me with my anxiety, stress, and tension. However, I found that Xanax and Valium were more effective for me when it came to dealing with anxiety specifically.
4.3Patient Review
7/29/2014 This works well and I'm pleased with the results.
4.3Patient Review
7/29/2014 This treatment works well for me. It's effective and I appreciate that.
4.3Patient Review
7/29/2014 This works well.
4Patient Review
10/21/20104Patient Review
10/21/20104Patient Review
10/21/20103Patient Review
5/16/2014 I find this drug very helpful in terms of relaxation and sleep. I've been taking it for over a year now with no adverse effects.
3Patient Review
6/30/2015 This drug is very addictive and habit-forming. Be careful!
3Patient Review
5/16/2014 I've been taking this drug for over a year now to help me sleep, and it's been working great! No negative side effects that I can tell.
3Patient Review
6/30/2015 This drug is very habit-forming and addictive. Please be careful.
3Patient Review
5/16/2014 This drug has been helping me sleep soundly for over a year now with no adverse effects.
3Patient Review
6/30/2015 This treatment can be extremely habit-forming and addictive. Please use caution when taking it.
1.7Patient Review
3/26/2016 This medication is very weak and not useful for people who suffer from serious anxiety. If anything, it made my anxiety worse. I do not recommend this to anyone.
1.7Patient Review
3/26/2016 This didn't do much for me. If anything, it made my anxiety worse. Not worth the money or time, in my opinion.
1.7Patient Review
3/26/2016 This medication was very weak and did not help my serious anxiety at all. In fact, things got worse when I took two of them. I would not recommend this to anyone.
Patient Q&A Section about amidate
What is Etomidate and propofol?
"Propofol causes smooth and rapid induction, rapid recovery, and cerebro-protective effect, but it can also lead to hypotension, bradycardia, respiratory depression, and pain on injection. Etomidate is a hypnotic agent that leads to minimal histamine release and a very stable hemodynamic profile." - Anonymous Online Contributor
Unverified Answer
What class of medication is Etomidate?
"Etomidate is an intravenous anesthetic agent that has a very short duration of action and is not a barbiturate." - Anonymous Online Contributor
Unverified Answer
What is Amidate used for?
"This medicine is used to induce general anesthesia and may be used alone or with other medications. It belongs to a class of drugs called systemic general anesthetics." - Anonymous Online Contributor
Unverified Answer