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What is Ambrisentan
AmbrisentanThe Generic name of this drug
Treatment SummaryAmbrisentan is a medication used to treat pulmonary arterial hypertension (PAH). It helps to relax the muscles in the blood vessels, reducing blood pressure. It is taken orally and is approved for use in Europe, Canada, and the United States. It is used alone to improve exercise ability and delay worsening of PAH or in combination with tadalafil to reduce the risks of disease progression, hospitalization, and improve exercise ability. Studies have found it to be effective in treating PAH caused by idiopathic or heritable conditions and connective tissue diseases, predominantly in patients in WHO Functional Class II-III.
Letairisis the brand name
Ambrisentan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Letairis
Ambrisentan
2007
26
Approved as Treatment by the FDA
Ambrisentan, otherwise called Letairis, is approved by the FDA for 1 uses such as Pulmonary Arterial Hypertension .Pulmonary Arterial Hypertension
Helps manage Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)
Effectiveness
How Ambrisentan Affects PatientsAmbrisentan is a drug that is generally taken once a day. Taking 10 mg of ambrisentan does not change the heartbeat, but taking 40 mg can cause a slight increase. It does not cause major changes to the heartbeat without other medicines. Taking ambrisentan for 12 weeks has been seen to decrease a certain hormone in the blood (BNP) by 29-45%, while taking a placebo caused an 11% increase.
How Ambrisentan works in the bodyEndothelin-1 (ET-1) is a natural body molecule which can cause increased pressure in the lungs in some people. Ambrisentan works by blocking ET-1 from attaching to its receptors, stopping it from causing the blood vessels to constrict. This allows the vessels to stay wide open, reducing pressure and improving lung function. Ambrisentan only blocks the action of ET-1, not other molecules like nitric oxide and prostacyclin, so it doesn't interfere with the body's natural processes.
When to interrupt dosage
The advisable dosage of Ambrisentan is contingent upon the diagnosed condition. The quantity of dosage fluctuates as per the method of delivery (e.g. Tablet - Oral or Oral) reported in the table below.Condition
Dosage
Administration
Pulmonary Arterial Hypertension
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet - Oral, Tablet
Warnings
Ambrisentan has one contraindication. Therefore, it should not be employed alongside any of the conditions present in the following table.Ambrisentan ContraindicationsCondition
Risk Level
Notes
Pulmonary Fibrosis
Do Not Combine
Common Ambrisentan Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Ambrisentan may increase the hypotensive activities of Amifostine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Ambrisentan.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Ambrisentan.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Ambrisentan.
Carbamazepine
Major
The metabolism of Carbamazepine can be decreased when combined with Ambrisentan.
Ambrisentan Toxicity & Overdose RiskAmbrisentan has a high risk of harming unborn babies and has been found to be toxic in doses of 3160mg/kg or higher in rats. No evidence has been found that it has any potential to cause cancer in rats or mice, even when taken orally on a daily basis for two years.
Ambrisentan Novel Uses: Which Conditions Have a Clinical Trial Featuring Ambrisentan?
At present, 53 active clinical trials are assessing the potential of Ambrisentan to alleviate Pulmonary Arterial Hypertension.Condition
Clinical Trials
Trial Phases
Pulmonary Arterial Hypertension
0 Actively Recruiting
Patient Q&A Section about ambrisentan
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How effective is ambrisentan?
"Patients not taking ambrisentan saw no change in their 6MWD.
The improvement in exercise capacity was overall +21 m, with patients on ambrisentan monotherapy having a +32 m improvement in their 6MWD. Patients not taking ambrisentan saw no change in their 6MWD."
Answered by AI
What are side effects of ambrisentan?
"Symptoms may include a stuffy or runny nose, sinus pain, headache, abdominal or stomach pain, vomiting, constipation, sore throat, or."
Answered by AI
What is the medication ambrisentan used for?
"Ambrisentan is used to treat pulmonary arterial hypertension, either by itself or in combination with tadalafil. Ambrisentan may improve the ability to exercise and slow the worsening of symptoms in people with this condition."
Answered by AI
How long does it take for ambrisentan to work?
"It will usually take a month of taking ambrisentan (Letairis) to see an improvement in exercise ability, though it can sometimes take up to three months to see the full effects of the medication."
Answered by AI