Altace

Cardiovascular Diseases, Stroke, Congestive Heart Failure + 10 more
Treatment
8 FDA approvals
20 Active Studies for Altace

What is Altace

RamiprilThe Generic name of this drug
Treatment SummaryRamipril is a medication used to treat high blood pressure, congestive heart failure, and kidney disease. It works by blocking an enzyme that helps to regulate blood pressure, which helps to lower it. It can also reduce the risk of heart attack, stroke, and death in people who are at high risk of cardiovascular events.
Altaceis the brand name
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Altace Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Altace
Ramipril
1991
208

Approved as Treatment by the FDA

Ramipril, commonly known as Altace, is approved by the FDA for 8 uses which include Heart failure and Heart Attack .
Heart failure
Helps manage Heart Failure
Heart Attack
Helps manage Myocardial Infarction
Stroke
Congestive Heart Failure
Helps manage Heart Failure
high risk cardiovascular event
High Cardiovascular Risk
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Felodipine
Cardiovascular Diseases

Effectiveness

How Altace Affects PatientsRamipril is a drug that helps lower blood pressure. It works by blocking the enzyme that turns a hormone called angiotensin I into angiotensin II, which makes your blood vessels tighten and your blood pressure increase. Angiotensin II also tells your kidneys to retain more salt and water, which adds to the pressure in your blood vessels. By blocking the enzyme, ramipril helps lower your blood pressure by letting your blood vessels relax and by preventing your kidneys from holding on to extra salt and water. Additionally, ramipril increases the amount of a chemical called bradykinin, which helps relax your blood
How Altace works in the bodyRamipril works by blocking the action of an enzyme called ACE. ACE is responsible for creating a certain type of hormone, called angiotensin II, which narrows blood vessels and can cause inflammation. By blocking ACE, ramipril stops the hormone from forming and helps to widen blood vessels and reduce inflammation. Ramipril also stops the breakdown of bradykinin, which is thought to be responsible for the dry-cough side effect. In addition, ramipril has counteracting effects that help to relax blood vessels and promote blood flow.

When to interrupt dosage

The measure of Altace is contingent upon the diagnosed condition, including Adrenal gland hypofunction, Albumin Creatinine Ratio >3mg/mmol and Heart Attack. The degree of dosage is contingent upon the method of delivery (e.g. Capsule - Oral or Tablet - Oral) featured in the table beneath.
Condition
Dosage
Administration
Adrenal gland hypofunction
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Cardiovascular Diseases
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Stroke
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Congestive Heart Failure
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Cardiovascular Events
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Diabetic Nephropathies
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Heart Attack
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Hypertensive disease
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
High Cardiovascular Risk
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Albumin Creatinine Ratio >3mg/mmol
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Renal Insufficiency, Chronic
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
Albumin Creatinine Ratio >30mg/mmol
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral
adequately controlled by simultaneous administration of component drugs
, 5.0 mg, 2.5 mg, 10.0 mg, 1.25 mg, 0.1 mg, 15.0 mg
, Capsule, Oral, Capsule - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral

Warnings

Altace has one counter-indication, so it should not be incorporated when encountering any of the circumstances in the subsequent table.Altace Contraindications
Condition
Risk Level
Notes
Type 2 Diabetes
Do Not Combine
There are 20 known major drug interactions with Altace.
Common Altace Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Ramipril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Ramipril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Ramipril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Ramipril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Ramipril.
Altace Toxicity & Overdose RiskOverdosing on ramipril may cause excessive blood vessel dilation, slow heart rate, imbalanced electrolytes, and kidney failure. Liver damage has been reported in humans and animals, and no carcinogenic or mutagenic effects have been detected in studies. Fertility is not affected by doses up to 500mg/kg/day and no birth defects have been observed in rats, monkeys, and rabbits. The toxic dose of ramipril is 10 g/kg in rats, 10.5 g/kg in mice, and 1 g/kg in dogs.
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Altace Novel Uses: Which Conditions Have a Clinical Trial Featuring Altace?

421 active studies are currently underway to assess the potential of Altace to ameliorate Adrenal Gland Hypofunction when administered in conjunction with other medications and reduce the risk of Cardiovascular Events.
Condition
Clinical Trials
Trial Phases
Heart Attack
26 Actively Recruiting
Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1, Phase 3
Stroke
9 Actively Recruiting
Phase 4, Phase 1, Not Applicable
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Diabetic Nephropathies
0 Actively Recruiting
Adrenal gland hypofunction
26 Actively Recruiting
Early Phase 1, Not Applicable, Phase 4, Phase 2, Phase 3, Phase 1
adequately controlled by simultaneous administration of component drugs
0 Actively Recruiting
High Cardiovascular Risk
1 Actively Recruiting
Phase 2
Renal Insufficiency, Chronic
0 Actively Recruiting
Albumin Creatinine Ratio >3mg/mmol
0 Actively Recruiting
Congestive Heart Failure
173 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Albumin Creatinine Ratio >30mg/mmol
0 Actively Recruiting
Cardiovascular Diseases
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3

Altace Reviews: What are patients saying about Altace?

5Patient Review
6/4/2013
Altace for High Blood Pressure
So far, no negative effects that I'm aware of. Blood pressure has lowered since taking this in conjunction with Bisoprolol. However, I have been urinating more frequently; not sure if that's related or not.
5Patient Review
1/1/2011
Altace for Chronic Heart Failure
5Patient Review
7/23/2011
Altace for High Blood Pressure
5Patient Review
11/1/2011
Altace for High Blood Pressure
4.7Patient Review
2/14/2011
Altace for Treatment to Prevent a Heart Attack
View All Reviews
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Patient Q&A Section about altace

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Altace used to treat?

"Ramipril treats hypertension by reducing the amount of blood that flows through your blood vessels. This lowers your blood pressure and helps prevent strokes, heart attacks, and kidney problems. Ramipril also helps improve survival rates after a heart attack."

Answered by AI

What are the side effects of Altace?

"The symptoms of the flu include a headache, a cough, feelings of fatigue, dizziness, a spinning sensation, feelings of general discomfort, nausea, and vomiting."

Answered by AI

What is the difference between ramipril and Altace?

"Ramipril, marketed under the brand name Altace among others, is a medication used to treat high blood pressure, congestive heart failure, and heart attacks. It is also used to prevent renal and retinal complications of diabetes. It is a reasonable initial treatment for hypertension."

Answered by AI

Who should not take Altace?

"If you believe you may have become pregnant while taking this medication, tell your doctor immediately. You should not take this medication while taking sacubitril. Do not take this medication and sacubitril/valsartan (Entresto®) within 36 hours of each other, as this may cause serious allergic reactions, including anaphylaxis."

Answered by AI

Clinical Trials for Altace

Have you considered Altace clinical trials? We made a collection of clinical trials featuring Altace, we think they might fit your search criteria.
Have you considered Altace clinical trials? We made a collection of clinical trials featuring Altace, we think they might fit your search criteria.
Have you considered Altace clinical trials? We made a collection of clinical trials featuring Altace, we think they might fit your search criteria.
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