Your session is about to expire
What is Aloxi
RaloxifeneThe Generic name of this drug
Treatment SummaryRaloxifene is a prescription drug used to treat the symptoms of postmenopausal osteoporosis and reduce the risk of breast cancer in postmenopausal women. It works by blocking estrogen receptors in certain parts of the body, like the breast and uterus, while stimulating estrogen receptors in others, like the bones. It is available in many countries and was approved by the FDA in 1997. Common side effects include an increased risk of stroke and venous thromboembolism. Women who have a history of stroke, atrial fibrillation, or high blood pressure should speak to their doctor before taking raloxif
Evistais the brand name
Aloxi Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Evista
Raloxifene
1998
50
Approved as Treatment by the FDA
Raloxifene, otherwise known as Evista, is approved by the FDA for 3 uses which include Osteoporosis and Postmenopausal Osteoporosis .Osteoporosis
Postmenopausal Osteoporosis
Malignant Neoplasms
Effectiveness
How Aloxi Affects PatientsRaloxifene is a drug that helps to increase bone mineral density, reduce the risk of fractures, and decrease the risk of breast cancer in post-menopausal women. It works by blocking some of the effects of estrogen, which helps to reduce inflammation and improve bone strength. It also helps to lower levels of cholesterol and LDL cholesterol in the blood. However, it is not known if it will have the same cardioprotective effects as hormone replacement therapy.
How Aloxi works in the bodyRaloxifene is a drug that affects the estrogen hormone in different ways in different parts of the body. It works by binding to estrogen receptors and causing a change in gene expression that can have an anti-inflammatory or anti-cancer effect. In bones, raloxifene acts like estrogen to promote bone growth and strength. In the breasts, raloxifene acts as an antagonist to estrogen to prevent cancerous cell growth and reduce inflammation.
When to interrupt dosage
The proposed measure of Aloxi is contingent upon the diagnosed condition, including Osteoporosis, Osteoporosis induced by glucocorticoid and Postmenopausal Osteoporosis. The dosage level is reliant upon the administration approach featured in the table beneath.Condition
Dosage
Administration
Osteoporosis
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Osteoporosis caused by glucocorticoid
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Postmenopausal Osteoporosis
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Malignant Neoplasms
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Breast
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Aloxi has two contraindications and should not be employed when dealing with any of the circumstances in the following table.Aloxi ContraindicationsCondition
Risk Level
Notes
Pulmonary Embolism
Do Not Combine
potential for pregnancy
Do Not Combine
Common Aloxi Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Raloxifene.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Raloxifene.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Raloxifene.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Raloxifene.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Raloxifene.
Aloxi Toxicity & Overdose RiskThe toxic dose of raloxifene in rats is more than 810 times the amount of a human dose. No deaths have been reported from overdosing on raloxifene, but one non-fatal case exists when someone took 1.5 grams. Common side effects of taking too much raloxifene include leg cramps, hot flashes, and dizziness. In two 18-month-old children who accidentally took 180 mg of raloxifene, they experienced ataxia, dizziness, vomiting, rash, diarrhea, tremor, flushing, and elevated alkaline phosphatase levels
Aloxi Novel Uses: Which Conditions Have a Clinical Trial Featuring Aloxi?
71 active trials are being conducted to investigate the utility of Aloxi in treating Postmenopausal Osteoporosis, Osteoporosis induced by glucocorticoid therapy and Breast Disorders.Condition
Clinical Trials
Trial Phases
Postmenopausal Osteoporosis
3 Actively Recruiting
Not Applicable, Phase 4
Breast
1 Actively Recruiting
Not Applicable
Malignant Neoplasms
22 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 1
Osteoporosis
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3
Osteoporosis caused by glucocorticoid
0 Actively Recruiting
Aloxi Reviews: What are patients saying about Aloxi?
5Patient Review
1/18/2009 Decadron and Aloxi have been highly effective for me in preventing nausea and vomiting. I just finished my third treatment with this chemotherapy regimen, and so far the Aloxi has been great! I would definitely recommend it to others.
5Patient Review
12/18/20074.7Patient Review
7/21/2018 Aloxi was the only IV medication I received prior to my infusion of etoposide over three days. That was 10 days ago, and since then I haven't experienced any nausea or vomiting. The only reason I didn't give this five stars is because of the level of sedation it caused me. For round two, I'm going to get Aloxi infused on day one, then take etoposide pills at home on days 2 and 3.
4.7Patient Review
1/8/20094.3Patient Review
4/9/2010 I've had no significant nausea from my chemotherapy, and I attribute this largely to the thorough combination of drugs given as premedication.
4Patient Review
5/9/2012 I had a slight headache the entire time I was on this medication, but it did help with my nausea and vomiting.
3.7Patient Review
5/26/2012 Six hours after receiving Aloxi injection, I experienced a horrible headache that was nearly migraine level. I have had a couple of migraines in my life but not a chronic problem. Had to use ice pack alternatively with heat to get relief and my pain pills did nothing (percoset) for relief. 48 hours after dosing, was given Fioriset to help control pain. Didn't have nausea from the chemo but did from the migraine. Dr. will try something different next infusion.
2.3Patient Review
8/14/2014 I was given Aloxi and Emend IV, and have been incredibly nauseous since. I was given Zofran for relief but was told not to take it because of the risk of QT prolongation. Honestly, I feel terrible right now.
Patient Q&A Section about aloxi
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of medication is Aloxi?
"Aloxi is a medication used to prevent nausea and vomiting. It is effective against nausea and vomiting caused by surgery or cancer treatments such as chemotherapy or radiation."
Answered by AI
What is Aloxi given for?
"This medication is used to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy). It is also used to prevent nausea and vomiting after surgery. Palonosetron works by inhibiting the action of serotonin, which is a natural substance that causes vomiting."
Answered by AI
Is Aloxi the same as Zofran?
"Ondansetron and palonosetron are anti-nausea medications. They are used to prevent nausea and vomiting caused by cancer chemotherapy. They are also used to prevent vomiting and nausea after surgery."
Answered by AI
How long is Aloxi effective?
"Palonosetron is a long-acting medication that prevents nausea and vomiting from chemotherapy. It is usually only necessary to take one dose, which lasts for 3 to 5 days."
Answered by AI