Aloxi

Osteoporosis, Osteoporosis, Osteoporosis, Postmenopausal + 2 more
Treatment
6 FDA approvals
20 Active Studies for Aloxi

What is Aloxi

RaloxifeneThe Generic name of this drug
Treatment SummaryRaloxifene is a prescription drug used to treat the symptoms of postmenopausal osteoporosis and reduce the risk of breast cancer in postmenopausal women. It works by blocking estrogen receptors in certain parts of the body, like the breast and uterus, while stimulating estrogen receptors in others, like the bones. It is available in many countries and was approved by the FDA in 1997. Common side effects include an increased risk of stroke and venous thromboembolism. Women who have a history of stroke, atrial fibrillation, or high blood pressure should speak to their doctor before taking raloxif
Evistais the brand name
image of different drug pills on a surface
Aloxi Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Evista
Raloxifene
1998
50

Approved as Treatment by the FDA

Raloxifene, otherwise known as Evista, is approved by the FDA for 6 uses which include Osteoporosis and Postmenopausal Osteoporosis .
Osteoporosis
Postmenopausal Osteoporosis
Invasive Breast Cancer
Osteoporosis
Osteoporosis, Postmenopausal
Malignant Neoplasms

Effectiveness

How Aloxi Affects PatientsRaloxifene is a drug that helps to increase bone mineral density, reduce the risk of fractures, and decrease the risk of breast cancer in post-menopausal women. It works by blocking some of the effects of estrogen, which helps to reduce inflammation and improve bone strength. It also helps to lower levels of cholesterol and LDL cholesterol in the blood. However, it is not known if it will have the same cardioprotective effects as hormone replacement therapy.
How Aloxi works in the bodyRaloxifene is a drug that affects the estrogen hormone in different ways in different parts of the body. It works by binding to estrogen receptors and causing a change in gene expression that can have an anti-inflammatory or anti-cancer effect. In bones, raloxifene acts like estrogen to promote bone growth and strength. In the breasts, raloxifene acts as an antagonist to estrogen to prevent cancerous cell growth and reduce inflammation.

When to interrupt dosage

The proposed measure of Aloxi is contingent upon the diagnosed condition, including Osteoporosis, Osteoporosis induced by glucocorticoid and Postmenopausal Osteoporosis. The dosage level is reliant upon the administration approach featured in the table beneath.
Condition
Dosage
Administration
Osteoporosis
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Osteoporosis
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Osteoporosis, Postmenopausal
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Breast
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Malignant Neoplasms
60.0 mg,
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Aloxi has two contraindications and should not be employed when dealing with any of the circumstances in the following table.Aloxi Contraindications
Condition
Risk Level
Notes
Pulmonary Embolism
Do Not Combine
potential for pregnancy
Do Not Combine
There are 20 known major drug interactions with Aloxi.
Common Aloxi Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Raloxifene.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Raloxifene.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Raloxifene.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Raloxifene.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Raloxifene.
Aloxi Toxicity & Overdose RiskThe toxic dose of raloxifene in rats is more than 810 times the amount of a human dose. No deaths have been reported from overdosing on raloxifene, but one non-fatal case exists when someone took 1.5 grams. Common side effects of taking too much raloxifene include leg cramps, hot flashes, and dizziness. In two 18-month-old children who accidentally took 180 mg of raloxifene, they experienced ataxia, dizziness, vomiting, rash, diarrhea, tremor, flushing, and elevated alkaline phosphatase levels

Aloxi Novel Uses: Which Conditions Have a Clinical Trial Featuring Aloxi?

71 active trials are being conducted to investigate the utility of Aloxi in treating Postmenopausal Osteoporosis, Osteoporosis induced by glucocorticoid therapy and Breast Disorders.
Condition
Clinical Trials
Trial Phases
Osteoporosis
34 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3
Osteoporosis, Postmenopausal
0 Actively Recruiting
Osteoporosis
0 Actively Recruiting
Breast
2 Actively Recruiting
Not Applicable
Malignant Neoplasms
4 Actively Recruiting
Phase 2, Not Applicable

Aloxi Reviews: What are patients saying about Aloxi?

5Patient Review
1/18/2009
Aloxi for Prevent Nausea and Vomiting from Cancer Chemotherapy
Decadron and Aloxi have been highly effective for me in preventing nausea and vomiting. I just finished my third treatment with this chemotherapy regimen, and so far the Aloxi has been great! I would definitely recommend it to others.
5Patient Review
12/18/2007
Aloxi for Prevent Nausea and Vomiting from Cancer Chemotherapy
4.7Patient Review
7/21/2018
Aloxi for Prevent Nausea and Vomiting from Cancer Chemotherapy
Aloxi was the only IV medication I received prior to my infusion of etoposide over three days. That was 10 days ago, and since then I haven't experienced any nausea or vomiting. The only reason I didn't give this five stars is because of the level of sedation it caused me. For round two, I'm going to get Aloxi infused on day one, then take etoposide pills at home on days 2 and 3.
4.7Patient Review
1/8/2009
Aloxi for Prevent Nausea and Vomiting from Cancer Chemotherapy
4.3Patient Review
4/9/2010
Aloxi for Nausea and Vomiting caused by Cancer Drugs
I've had no significant nausea from my chemotherapy, and I attribute this largely to the thorough combination of drugs given as premedication.
View All Reviews
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aloxi

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of medication is Aloxi?

"Aloxi is a medication used to prevent nausea and vomiting. It is effective against nausea and vomiting caused by surgery or cancer treatments such as chemotherapy or radiation."

Answered by AI

What is Aloxi given for?

"This medication is used to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy). It is also used to prevent nausea and vomiting after surgery. Palonosetron works by inhibiting the action of serotonin, which is a natural substance that causes vomiting."

Answered by AI

Is Aloxi the same as Zofran?

"Ondansetron and palonosetron are anti-nausea medications. They are used to prevent nausea and vomiting caused by cancer chemotherapy. They are also used to prevent vomiting and nausea after surgery."

Answered by AI

How long is Aloxi effective?

"Palonosetron is a long-acting medication that prevents nausea and vomiting from chemotherapy. It is usually only necessary to take one dose, which lasts for 3 to 5 days."

Answered by AI

Clinical Trials for Aloxi

Have you considered Aloxi clinical trials? We made a collection of clinical trials featuring Aloxi, we think they might fit your search criteria.
Have you considered Aloxi clinical trials? We made a collection of clinical trials featuring Aloxi, we think they might fit your search criteria.
Have you considered Aloxi clinical trials? We made a collection of clinical trials featuring Aloxi, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top