Ketorolac Injection for Kidney Stones
What You Need to Know Before You Apply
What is the purpose of this trial?
This is a pilot study to (1) evaluate the effect of Ketorolac on inflammatory response and its impact on stent related symptoms in patients undergoing stent placement procedure and (2) assess feasibility of recruitment, randomization, assessment procedures and implementation of the study intervention.
Will I have to stop taking my current medications?
If you are taking chronic NSAIDs (non-steroidal anti-inflammatory drugs) or steroids, you will need to stop them to participate in this trial. However, taking a daily low-dose Aspirin (81 mg) is allowed.
Is ketorolac safe for humans?
How does the drug ketorolac injection differ from other treatments for kidney stones?
Ketorolac injection is unique for kidney stones because it is a nonsteroidal anti-inflammatory drug (NSAID) that can be administered intravenously to provide rapid pain relief, unlike other treatments that may not work as quickly or effectively for acute pain. It is recommended as a first-line treatment for acute renal colic, which is the severe pain caused by kidney stones, when not contraindicated.12456
Who Is on the Research Team?
Alana Desai, MD
Principal Investigator
Washington University School of Medicine
Are You a Good Fit for This Trial?
Adults over 18 planning to have a stent placed for kidney stones can join. They must be able to consent and not be on steroids, have GI ulcers, or liver/kidney issues. Pregnant women, those with existing stents or certain other health problems are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Preoperative Treatment
Participants receive a one-time intravenous injection of Ketorolac or saline prior to the ureteroscopic procedure
Postoperative Monitoring
Participants are monitored for stent-related symptoms and complete symptom questionnaires
Follow-up
Participants are monitored for safety and effectiveness after stent removal
What Are the Treatments Tested in This Trial?
Interventions
- Ketorolac Trometamol
Find a Clinic Near You
Who Is Running the Clinical Trial?
Washington University School of Medicine
Lead Sponsor