Adzenys Xr-Odt

Narcolepsy, Depression, Attention Deficit Hyperactivity Disorder + 1 more
Treatment
2 FDA approvals
20 Active Studies for Adzenys Xr-Odt

What is Adzenys Xr-Odt

AmphetamineThe Generic name of this drug
Treatment SummaryAmphetamine is a controlled drug used for specific medical conditions. It was discovered in 1910 and first synthesized by 1927. In 1935, it was approved by Smith, Kline and French for treatment of drug-induced anesthesia, arousal, and insomnia. During World War II, amphetamine was used to keep soldiers alert, which led to an overproduction of the drug and an increase in black market sale. In 1976, it was approved by the FDA.
Adderallis the brand name
image of different drug pills on a surface
Adzenys Xr-Odt Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Adderall
Amphetamine
1996
507

Approved as Treatment by the FDA

Amphetamine, also known as Adderall, is approved by the FDA for 2 uses which include Attention Deficit Hyperactivity Disorder and Narcolepsy .
Attention Deficit Hyperactivity Disorder
Used to treat Attention Deficit Hyperactivity Disorder (ADHD) in combination with Dextroamphetamine
Narcolepsy

Effectiveness

How Adzenys Xr-Odt Affects PatientsAmphetamine increases the levels of two key brain chemicals - noradrenaline in the prefrontal cortex and dopamine in the striatum - in a dose and time-dependent manner. This has been linked to improved school performance, behavior, and demeanor in ADHD patients. While amphetamine has been linked to cognitive enhancement, it can also lead to psychiatric dangers such as paranoia when misused. It can also worsen depression and anxiety.
How Adzenys Xr-Odt works in the bodyAmphetamine has a similar structure to the catecholamine neurotransmitters, which makes it easy for it to be taken up by the presynaptic nerve terminals. Once inside the terminal, it is stored by a protein called VMAT2 and is then released into the synapse. Amphetamine also increases monoamine concentration by preventing its reuptake and inhibiting an enzyme called MAO that breaks down neurotransmitters. The l-isomer of amphetamine is less potent than the d-isomer when it comes to releasing dopamine.

When to interrupt dosage

The measure of Adzenys Xr-Odt is contingent upon the diagnosed illness, including Disease, Chronic Pain and Attention Deficit Hyperactivity Disorder. The amount additionally diverges as per the method of delivery (e.g. Oral or Tablet - Oral) noted in the table hereunder.
Condition
Dosage
Administration
Attention Deficit Hyperactivity Disorder
, 5.0 mg, 10.0 mg, 3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, 18.8 mg, 2.5 mg/mL, 3.125 mg, 9.375 mg, 6.25 mg, 1.875 mg, 2.5 mg, 7.5 mg, 1.25 mg, 3.75 mg, 15.0 mg, 1.25 mg/mL, 18.75 mg, 25.0 mg, 7.26 mg, 12.11 mg, 2.42 mg, 9.69 mg, 14.53 mg, 4.84 mg, 20.0 mg, 60.0 mg, 40.0 mg, 30.0 mg
Tablet - Oral, , Oral, Tablet, Capsule, extended release, Capsule, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Suspension, extended release - Oral, Suspension, extended release, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral
Narcolepsy
, 5.0 mg, 10.0 mg, 3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, 18.8 mg, 2.5 mg/mL, 3.125 mg, 9.375 mg, 6.25 mg, 1.875 mg, 2.5 mg, 7.5 mg, 1.25 mg, 3.75 mg, 15.0 mg, 1.25 mg/mL, 18.75 mg, 25.0 mg, 7.26 mg, 12.11 mg, 2.42 mg, 9.69 mg, 14.53 mg, 4.84 mg, 20.0 mg, 60.0 mg, 40.0 mg, 30.0 mg
Tablet - Oral, , Oral, Tablet, Capsule, extended release, Capsule, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Suspension, extended release - Oral, Suspension, extended release, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral
Depression
, 5.0 mg, 10.0 mg, 3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, 18.8 mg, 2.5 mg/mL, 3.125 mg, 9.375 mg, 6.25 mg, 1.875 mg, 2.5 mg, 7.5 mg, 1.25 mg, 3.75 mg, 15.0 mg, 1.25 mg/mL, 18.75 mg, 25.0 mg, 7.26 mg, 12.11 mg, 2.42 mg, 9.69 mg, 14.53 mg, 4.84 mg, 20.0 mg, 60.0 mg, 40.0 mg, 30.0 mg
Tablet - Oral, , Oral, Tablet, Capsule, extended release, Capsule, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Suspension, extended release - Oral, Suspension, extended release, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral
Chronic Pain
, 5.0 mg, 10.0 mg, 3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, 18.8 mg, 2.5 mg/mL, 3.125 mg, 9.375 mg, 6.25 mg, 1.875 mg, 2.5 mg, 7.5 mg, 1.25 mg, 3.75 mg, 15.0 mg, 1.25 mg/mL, 18.75 mg, 25.0 mg, 7.26 mg, 12.11 mg, 2.42 mg, 9.69 mg, 14.53 mg, 4.84 mg, 20.0 mg, 60.0 mg, 40.0 mg, 30.0 mg
Tablet - Oral, , Oral, Tablet, Capsule, extended release, Capsule, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Suspension, extended release - Oral, Suspension, extended release, Capsule - Oral, Capsule, Tablet, extended release, Tablet, extended release - Oral

Warnings

Adzenys Xr-Odt Contraindications
Condition
Risk Level
Notes
Agitation
Do Not Combine
advanced arteriosclerosis
Do Not Combine
Drug abuse
Do Not Combine
Hyperthyroidism
Do Not Combine
Hypertensive disease
Do Not Combine
symptomatic cardiovascular disease
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Amphetamine may interact with Pulse Frequency
There are 20 known major drug interactions with Adzenys Xr-Odt.
Common Adzenys Xr-Odt Drug Interactions
Drug Name
Risk Level
Description
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Amphetamine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Amphetamine.
Dacomitinib
Major
The metabolism of Dacomitinib can be decreased when combined with Amphetamine.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Amphetamine.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Amphetamine.
Adzenys Xr-Odt Toxicity & Overdose RiskThe typical fatal dose of amphetamine is 6.4 mg/l. An overdose on amphetamine can lead to high body temperature, difficulty breathing, seizures, acidosis, kidney failure, liver damage, and coma. Neurological effects include confusion, aggression, irritability, headaches, and hallucinations. Cardiovascular effects include irregular heartbeats, heart muscle damage, heart attack, and stroke. Gastrointestinal effects include abdominal pain, vomiting, diarrhea, cramps, loss of appetite, and bleeding. Animal studies have not found amphetamine to cause cancer, chromosomal damage, or fertility issues.
image of a doctor in a lab doing drug, clinical research

Adzenys Xr-Odt Novel Uses: Which Conditions Have a Clinical Trial Featuring Adzenys Xr-Odt?

Presently, there are 710 active studies investigating the possibility of Adzenys Xr-Odt to serve as a therapeutic intervention for Depression, Disease and Narcolepsy.
Condition
Clinical Trials
Trial Phases
Chronic Pain
32 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Attention Deficit Hyperactivity Disorder
74 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1
Narcolepsy
9 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4, Phase 1
Depression
693 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4

Adzenys Xr-Odt Reviews: What are patients saying about Adzenys Xr-Odt?

5Patient Review
5/3/2018
Adzenys Xr-Odt for Attention Deficit Disorder with Hyperactivity
I was amazed at how well this worked for my daughter! It was a real life-changer, but unfortunately we can't keep up with the costs.
5Patient Review
3/19/2019
Adzenys Xr-Odt for Attention Deficit Disorder with Hyperactivity
I've never felt better taking a medication! Adzenys is so natural feeling-- no initial bump and no let down in the evenings. The only side effect I experienced was dry mouth. No problems with blood pressure or sleep, even though my blood pressure is controlled by medication. This drug helped me to be more focused, alert, and productive.
5Patient Review
9/22/2016
Adzenys Xr-Odt for Attention Deficit Disorder with Hyperactivity
5Patient Review
11/10/2016
Adzenys Xr-Odt for Attention Deficit Disorder with Hyperactivity
We switched my son to this treatment from Concerta and so far it's going well! We've found that it only lasts for about 8 hours, but there isn't the crash at the end of the day and he's been sleeping soundly through the night.
4.7Patient Review
5/4/2021
Adzenys Xr-Odt for Attention Deficit Disorder with Hyperactivity
We made the switch to this treatment from Eveekeo when we were seeking an extended release medication for my son that he wouldn't have to take during school hours. We couldn't be happier. It lasts around seven to eight hours with no hard crash and no issues falling asleep at night. Very satisfied.
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Patient Q&A Section about adzenys xr-odt

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does Adzenys XR-ODT last?

"Adzenys XR-ODT is a tablet that is designed to dissolve in your mouth instead of being swallowed. It has an effect that lasts for 10 to 12 hours."

Answered by AI

Is Adzenys XR-ODT the same as Adderall?

"Adzenys XR-ODT is the first FDA-approved extended-release orally disintegrating amphetamine tablet. It is bioequivalent to Adderall XR, but is not a generic of it."

Answered by AI

What is Adzenys XR-ODT used for?

"This medication is used to treat attention deficit hyperactivity disorder - ADHD. It works by altering the levels of certain natural substances in the brain. Amphetamine is a type of drug classified as a stimulant."

Answered by AI

How long does Adzenys XR-ODT take to kick in?

"The main difference between Adzenys XR-ODT and other medications is that Adzenys XR-ODT starts working within an hour, while other medications work instantly. Adzenys XR-ODT also lasts up to 12 hours, while other medications only last for a few hours."

Answered by AI

Clinical Trials for Adzenys Xr-Odt

Have you considered Adzenys Xr-Odt clinical trials? We made a collection of clinical trials featuring Adzenys Xr-Odt, we think they might fit your search criteria.
Have you considered Adzenys Xr-Odt clinical trials? We made a collection of clinical trials featuring Adzenys Xr-Odt, we think they might fit your search criteria.
Have you considered Adzenys Xr-Odt clinical trials? We made a collection of clinical trials featuring Adzenys Xr-Odt, we think they might fit your search criteria.