Mindfulness Training for Depression
What You Need to Know Before You Apply
What is the purpose of this trial?
This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Healthy Minds smartphone app) into the inter-session intervals of clinically administered accelerated intermittent theta-burst stimulation (aiTBS) for major depressive disorder (MDD). Participants receive aiTBS as standard clinical care at MUSC; the research intervention is daily guided mindfulness practice during the aiTBS course. Outcomes include feasibility/acceptability, changes in state mindfulness and hedonic tone (Day 0 to Day 5), perceived ease of meditation, trait mindfulness at 4 and 12 weeks, and durability of antidepressant response (PHQ-9) at 4 and 12 weeks.
Who Is on the Research Team?
Clayton Olash, MD
Principal Investigator
Medical University of South Carolina
Are You a Good Fit for This Trial?
This trial is for English-speaking individuals with major depressive disorder (MDD) who are already enrolled in an accelerated intermittent theta-burst stimulation (aiTBS) course at MUSC. Participants must have a smartphone or be willing to use one provided by the study.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive accelerated intermittent theta-burst stimulation (aiTBS) with daily guided mindfulness practice via the Healthy Minds app
Follow-up
Participants are monitored for changes in trait mindfulness and antidepressant response
What Are the Treatments Tested in This Trial?
Interventions
- Guided Mindfulness Practice (Healthy Minds app)
Trial Overview
The trial tests the addition of guided mindfulness practice, using the Healthy Minds app, during aiTBS treatment sessions for depression. It aims to see if this combination is feasible and acceptable, and how it affects mood and mindfulness up to 12 weeks after treatment.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medical University of South Carolina
Lead Sponsor
University of Wisconsin, Madison
Collaborator
National Institute on Drug Abuse (NIDA)
Collaborator
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