Acular

Eye Pain, Inflammation, corneal refractive surgery + 20 more

Treatment

2 FDA approvals

20 Active Studies for Acular

What is Acular

Ketorolac

The Generic name of this drug

Treatment Summary

Titanium dioxide is a natural oxide of titanium found in minerals like ilmenite, rutile and anatase. It is used as a white pigment in paint, cosmetics and other products, and is known by its other names such as titanium white or Pigment White 6 (PW6).

Toradol

is the brand name

Acular Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Toradol

Ketorolac

1991

316

Approved as Treatment by the FDA

Ketorolac, also called Toradol, is approved by the FDA for 2 uses like caudal epidural block therapy and induction of Nerve Block .

caudal epidural block therapy

Used to treat caudal epidural block therapy in combination with Bupivacaine

induction of Nerve Block

Used to treat induction of Nerve Block in combination with Bupivacaine

Effectiveness

How Acular works in the body

Sunscreen agents help to protect your skin from harmful UV rays by absorbing the radiation within a certain range of wavelengths. The type and amount of UV radiation absorbed depend on the molecular structure of the sunscreen.

When to interrupt dosage

The recommended dosage of Acular is contingent upon the established condition, such as Wound, Atopic Dermatitis and abrasions. The amount of dosage is contingent on the technique of delivery specified in the accompanying table.

Condition

Dosage

Administration

Macular Edema, Cystoid

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

induction of Local Anaesthesia

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Miosis disorder

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Seasonal Allergic Conjunctivitis

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Cataract Surgery

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Ocular Itching

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Eye Pain

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Intraocular Lens Replacement

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Macular Edema, Cystoid

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

postoperative ocular pain

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Pain

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

caudal epidural block therapy

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Macular Edema

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Acute Coryza

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Pupil

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

induction of Nerve Block

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Pericarditis Acute

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Inflammation

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

corneal refractive surgery

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Induced Hyperthermia

, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL

Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated, Tablet, film coated - Oral, Oral, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid, Liquid - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Kit, Tablet, Tablet - Oral, Kit - Infiltration; Intramuscular; Intravenous; Topical, Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Injection, solution - Intraocular, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Topical, Spray, metered - Topical, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Solution - Intramuscular, Intraocular, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Kit - Ophthalmic

Warnings

Acular Contraindications

Condition

Risk Level

Notes

Heart failure

Do Not Combine

Hyperkalemia

Do Not Combine

Renal Insufficiency

Do Not Combine

Hemorrhagic Disorders

Do Not Combine

Kidney Failure

Do Not Combine

A History of Gastric or Duodenal Ulcers

Do Not Combine

Liver Diseases

Do Not Combine

Major Surgery

Do Not Combine

Pulse Frequency

Do Not Combine

Gastrointestinal Hemorrhage

Do Not Combine

Crohn's Disease

Do Not Combine

suspected cerebrovascular bleeding

Do Not Combine

active Gastrointestinal Bleeding

Do Not Combine

NSAID-Induced Asthma

Do Not Combine

Severe Hepatic Impairment

Do Not Combine

incomplete hemostasis

Do Not Combine

Coronary Artery Bypass Grafting

Do Not Combine

Gastrointestinal Perforation

Do Not Combine

Pulse Frequency

Do Not Combine

Hemorrhage

Do Not Combine

Peptic Ulcer

Do Not Combine

Pulse Frequency

Do Not Combine

Labour

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Third trimester of pregnancy

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Ketorolac may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Ketorolac may interact with Pulse Frequency

There are 20 known major drug interactions with Acular.

Common Acular Drug Interactions

Drug Name

Risk Level

Description

Aceclofenac

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Aceclofenac.

Acemetacin

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Acemetacin.

Acetylsalicylic acid

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Acetylsalicylic acid.

Alclofenac

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Alclofenac.

Alminoprofen

Major

The risk or severity of adverse effects can be increased when Ketorolac is combined with Alminoprofen.

Acular Toxicity & Overdose Risk

The toxic dose of titanium dioxide when inhaled in rats is greater than 100ug/kg. Studies have shown that titanium dioxide can cause changes to bronchi and trachea in animals, and may potentially cause cancer in humans.

image of a doctor in a lab doing drug, clinical research

Acular Novel Uses: Which Conditions Have a Clinical Trial Featuring Acular?

74 active clinical trials are currently examining the efficacy of Acular in providing Ultraviolet Therapy, relieving abrasions and treating Sunburn.

Condition

Clinical Trials

Trial Phases

Inflammation

50 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 3

Induced Hyperthermia

0 Actively Recruiting

caudal epidural block therapy

4 Actively Recruiting

Not Applicable, Phase 4, Phase 3, Phase 2

Intraocular Lens Replacement

0 Actively Recruiting

Acute Coryza

0 Actively Recruiting

Macular Edema, Cystoid

0 Actively Recruiting

induction of Nerve Block

0 Actively Recruiting

Pupil

0 Actively Recruiting

Local Anaesthesia therapy

0 Actively Recruiting

corneal refractive surgery

0 Actively Recruiting

Seasonal Allergic Conjunctivitis

0 Actively Recruiting

Eye Pain

1 Actively Recruiting

Phase 1

postoperative ocular pain

0 Actively Recruiting

Eye

0 Actively Recruiting

Ocular Itching

0 Actively Recruiting

Pericarditis Acute

1 Actively Recruiting

Phase 2, Phase 3

Miosis disorder

0 Actively Recruiting

Macular Edema, Cystoid

0 Actively Recruiting

Macular Edema

1 Actively Recruiting

Phase 1, Phase 2

Cataract Surgery

3 Actively Recruiting

Not Applicable

Acular Reviews: What are patients saying about Acular?

5

Patient Review

12/4/2008

Acular for Allergic Conjunctivitis

I've used Acular for two decades now to great effect. It's the only thing that helps with my seasonal allergies and itchy eyes, but the increased cost is really becoming a problem.

4.7

Patient Review

10/30/2007

Acular for Allergic Conjunctivitis

The only downside is the burning sensation you feel for a few seconds after applying the drops to your eyes.

4.3

Patient Review

5/8/2014

Acular for Inflammation of the Eye Following Surgery

Acular has been working great for me post-operatively. I've been using it for three weeks to manage pain and inflammation following a trabeculectomy, and so far I haven't had any issues with pain or inflammation since my surgery.

3

Patient Review

11/9/2014

Acular for Inflammation of the Eye Following Surgery

My 82 year old mother had a severe reaction to Acular eye drops the day after starting to take it, was very dizzy, even when laying down room was spinning, and she had trouble describing how bad she felt. Her doctor said to stop taking it immediately. One day later she still experienced some dizziness, and two days later she is feeling better.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about acular

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is ACULAR eye drops a steroid?

"Acular is a non-steroidal anti-inflammatory drug, not a steroid. Steroids and NSAIDs are often used for similar conditions, including eye pain or inflammation, though they are different medications."

Answered by AI

What is ACULAR eye drops used for?

"ACULAR is a non-steroidal anti-inflammatory drug (NSAID) used to relieve eye inflammation following surgery in adults. The active ingredient in ACULAR is ketorolac trometamol."

Answered by AI

How long can I use ACULAR eye drops?

"Use the ACULAR® eye drops for as long as your doctor prescribes, which is usually 2-4 weeks."

Answered by AI

Is ACULAR an anti-inflammatory?

"Acular is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve eyeitching caused by seasonal allergies. It is also used to reduce swelling, pain,and burning or stinging after cataract surgery or corneal refractive surgery."

Answered by AI

Clinical Trials for Acular

Image of University of Oklahoma Health Campus in Oklahoma City, United States.

Disulfiram for Rheumatoid Arthritis

18 - 75
All Sexes
Oklahoma City, OK

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and systemic immune activation. Obesity is common among individuals with RA and is associated with increased disease activity, reduced treatment response, and worse functional outcomes. Inflammation in adipose tissue, driven in part by activation of the NLRP3 inflammasome and downstream gasdermin D (GSDMD)-mediated pathways, may contribute to systemic inflammation and RA disease severity. Disulfiram (DSF), an FDA-approved medication for alcohol use disorder, has recently been identified as an inhibitor of GSDMD-mediated inflammatory signaling and pyroptosis. Preclinical studies suggest that DSF reduces inflammasome activation, inflammatory cytokine release, and metabolic dysfunction. This study is a 12-week, randomized, double-blind, placebo-controlled pilot trial designed to evaluate the safety, tolerability, and preliminary efficacy of DSF in overweight and obese adults with active RA despite stable disease-modifying antirheumatic drug (DMARD) therapy. Participants will be randomized to receive either DSF (250 mg daily) or placebo. The primary objective is to assess safety and tolerability. Secondary and exploratory objectives include evaluating the effects of DSF on systemic inflammation, RA disease activity, metabolic parameters, and adipose tissue inflammasome activation. Findings from this study will inform the feasibility and design of larger clinical trials targeting GSDMD-mediated inflammation in RA.

Phase 2
Waitlist Available

University of Oklahoma Health Campus

Beatriz Y Hanaoka, MD, MSc

Image of University of California, Riverside in Riverside, United States.

Acetazolamide for Altitude Sickness

18 - 65
All Sexes
Riverside, CA

High altitude travel can lead to inflammation in the body and activation of innate immune cells. The investigators' prior research demonstrates that 1 to 3 days at 3800 m elevation leads to increased expression of genes in blood cells that code for proteins that signal cell damage (damage associated molecular patterns (DAMPs)), cell receptors involved in innate immune responses, as well as increases in monocyte and neutrophil cells which promote inflammation. This study will investigate the potential mechanisms underlying these effects using the drug Acetazolamide, a carbonic anhydrase inhibitor which is known to reduce symptoms of Acute Mountain Sickness.

Phase < 1
Waitlist Available

University of California, Riverside

Image of Brigham and women's hospital in Boston, United States.

Corticosteroids for Heart Failure

18 - 80
All Sexes
Boston, MA

This pilot study investigates whether giving a short course of intravenous corticosteroids (methylprednisolone) alongside standard medical care can help patients recovering from heart failure-related cardiogenic shock. Heart failure-related cardiogenic shock happens when chronic heart dysfunction causes poor blood circulation and congestion throughout the body. Often, this condition triggers severe inflammation, making it harder for the heart and other organs to recover, even when temporary mechanical heart pumps are used to support blood flow. The study aims to see if reducing this inflammation with corticosteroids is safe and can help patients get better faster. Researchers will enroll 30 adult patients hospitalized with early-stage (SCAI Stage B or C) cardiogenic shock related to heart failure. To participate, patients must also show high levels of inflammation in their blood, specifically a high-sensitivity C-reactive protein (hsCRP) level of 20 mg/L or higher Participants will be randomly assigned by chance to one of two groups. One group will receive the standard of care alone. The other group will receive the standard of care plus a 7-day course of intravenous methylprednisolone. The main goal of the study is to measure the change in inflammation levels (hsCRP) over 7 days. Researchers will also monitor how well the patients' organs recover, track their need for blood pressure medications or mechanical heart pumps, and monitor for any side effects to ensure the treatment is safe

Phase 2
Waitlist Available

Brigham and women's hospital

Image of Exercise and Performance Nutrition Laboratory in Saint Charles, United States.

Multi-Strain Postbiotic for Inflammation and Gastrointestinal Symptoms

18 - 55
All Sexes
Saint Charles, MO

This study will evaluate the effects of a multi-strain postbiotic supplement on markers of inflammation, immune function, gastrointestinal symptoms, psychological well-being, and intestinal permeability in healthy adults. The primary objective is to determine whether four weeks of postbiotic supplementation alters physiological and perceptual responses to a standardized bout of moderate-to-high intensity exercise compared with placebo. Approximately 50 healthy men and women aged 18 to 55 years will be enrolled in a randomized, double-blind, placebo-controlled, parallel-group clinical trial. Participants will be randomly assigned to receive either a multi-strain postbiotic supplement or a matched placebo for 28 days. At the end of the supplementation period, participants will complete a 45-minute treadmill exercise bout at 75% of their individually determined maximum heart rate. Blood samples will be collected to assess biomarkers of inflammation, immune activity, and recovery. Gastrointestinal symptoms, intestinal permeability, anxiety, and perceived recovery will be evaluated using validated questionnaires. This study is designed to determine whether postbiotic supplementation modulates physiological stress responses and subjective well-being following prolonged exercise in healthy adults.

Waitlist Available
Paid Trial

Exercise and Performance Nutrition Laboratory

Chad M Kerksick, PhD

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Image of Byers Eye Institute in Palo Alto, United States.

LLM-Based Education for Cataract Surgery

18+
All Sexes
Palo Alto, CA

Patients with cataracts disease need to choose what type of artificial lens will go into their eye prior to surgery date. Some lenses are standard and are usually covered by insurance. Other "premium" lenses have various benefits such as reducing the need for glasses but usually require out-of-pocket costs. The combined busy outpatient clinic and complexity of artificial lens choices in the ever-changing world of cataract surgery tends to lead patients confused about their available lens options. There is an abundance of educational material present in premium lenses, however these are limited by accessibility and are standardized at single educational levels. Therefore in the present study, we want to test whether giving patients a short LLM powered AI-guided explanation from Custom GPT from OpenAI of lens options prior to their consultation with their doctor can improve visit efficiency, physician explanation and patient understanding of lens options. We will compare two groups: standard of care versus standard of care plus AI education. The LLM in this study is intended to provide supplemental information about premium intraocular lens(IOLs) options to study participants, and is no means supposed to replace a health care professional in the diagnosis, cure, treatment, and/or mitigation of disease. Study is analogous to giving a verified health pamphlet to a patient for them to view and learn different IOL options, in other words, facilitating patient understanding of their options. The LLM will be trained by several health care professionals and MD specialists to provide sufficient instructions. Sources will include verified online resources and MD information. The investigators hope to learn if a large language model-based educational tool can improve visit efficiency, physician explanation and patient understanding of intraocular lens options. New knowledge of this study could guide how cataract counseling is delivered in the future and may help clinics spend more time on individualized questions instead of repeating generic information.

Waitlist Available
Has No Placebo

Byers Eye Institute

Robert T Chang, MD

Image of University of New Brunswick in Fredericton, Canada.

Mediterranean Diet for Toddler Health

24 - 36
All Sexes
Fredericton, Canada

Toddlerhood (ages 2-3) is a critical window when the gut microbiome is still developing and eating habits are being established. Yet, many Canadian toddlers eat diets high in sugar and salt, which may affect long-term health. This study will test whether a MED diet can improve dietary inflammation, gut health, and body composition in toddlers and whether a tailored nutrition education program for parents can help families maintain healthy eating patterns. In this study, toddlers will be randomly assigned to a 3-week MED diet or their usual diet. Families in the MED diet group will receive free meal boxes for the 3 weeks, plus guidance from a nutrition researcher through a structured education program. The standard diet group will continue their regular diet with general nutrition advice. Researchers will collect dietary information, body composition assessments, and stool samples to measure gut microbiome composition and metabolites. This first study of a controlled diet intervention in toddlers, combining behavioral support, high-quality food provision, and advanced gut microbiome analysis, will help understand how early diet shapes lifelong eating habits and health, guiding public health strategies and precision nutrition approaches to prevent chronic disease from early life.

Waitlist Available
Has No Placebo

University of New Brunswick

Dr. Maryam Kebbe, PhD, CLC

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Image of University of California, San Francisco in San Francisco, United States.

Vision Centers for Eye Care

Any Age
All Sexes
San Francisco, CA

The goal of this clinical trial is to evaluate the effect of vision centers on access to eye care and eye health outcomes in South Asia. The main questions it aims to answer are: 1. Do vision centers increase visits to eyecare centers? 2. Do vision centers increase spectacle ownership and wearing? 3. Do vision centers improve visual acuity of the population? Researchers will compare outcomes in communities randomized to have a vision center is established with communities randomized to delay establishment of a vision center. Outcomes will be assessed through population-based surveys at baseline and after two years as well as through hospital records collected throughout the study period.

Waitlist Available
Has No Placebo

University of California, San Francisco

Kieran O'Brien, PhD, MPH

Image of UConn Health in Farmington, United States.

Cognitive Remediation for Memory and Thinking Difficulties

18+
All Sexes
Farmington, CT

The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in some older adults following a viral infection. The main questions it aims to answer are: * Does computerized cognitive remediation improve cognitive performance and day-to-day functioning in older adults with postviral neurocognitive dysfunction? * Will treatment effects be maintained over time, leading to better long term cognitive outcomes? * Does the treatment lead to reductions in blood-based markers of inflammation as a potential mechanism of cognitive symptom improvement? * Can the treatment be optimized and refined based on feedback from participants to improve user (patient) experience? Researchers will compare the computerized cognitive remediation program to an active computer-based control condition (alternative computer activities) to see if the computerized cognitive remediation program works to treat postviral neurocognitive dysfunction. Participation takes approximately 43-48 hours over 7 months, with most activities (40-46 hours) completed within the first 7-8 weeks, including: * Initial intake visit: Eligibility confirmation (\~2-3 hours) * Computer activities: About 5 hours per week for \~6 weeks (total \~30 hours) completed on a computer tablet provided by the study and loaned to participants for use during the treatment phase * Weekly remote check-in meetings: \~30 minutes each during treatment * Blood draws: Two sessions (before and after treatment), \~20-30 minutes each * Three research visits: Pre-treatment, post-treatment, and 6-month follow-up (\~2-3 hours each, including assessments of cognitive, emotional, and daily functioning)

Recruiting
Has No Placebo

UConn Health

Cutter Lindbergh, Ph.D.

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