Mango Intake for Metabolic Syndrome

Overseen By Genesis G Guerra Gaitan, MS

Age: < 65

Sex: Any

Trial Phase: Academic

Sponsor: University of California, Davis

Must not be taking: Prescription drugs, Supplements

Disqualifiers: Food allergies, Exercise routine, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

Duration: 4 weeks

25 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial examines how eating mangos daily for four weeks affects the gut and metabolism in teens. Participants will replace snacks like cookies and chips with Ataulfo mangos to assess any health changes. The trial includes two groups: one will eat mangos daily, and the other will not. Teens aged 12-19 who identify as Hispanic/Latino and have a BMI in the 85th percentile or higher may be suitable candidates. As an unphased trial, this study provides a unique opportunity to explore the potential health benefits of mangos in a supportive research environment.

Will I have to stop taking my current medications?

Yes, you will need to stop taking your current prescription medications, except for asthma inhalers, to participate in this trial.

What prior data suggests that Ataulfo mango intake is safe for adolescents?

Research has shown that mangos are generally safe to eat. One study found that eating mangos daily for 24 weeks helped lower blood sugar levels without major side effects. Another study discovered that consuming mangos daily for two weeks reduced blood pressure in healthy women. These findings suggest that mangos are well-tolerated and could be safe for regular consumption. However, individual reactions can vary, so consulting a doctor before making significant dietary changes is advisable. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Unlike traditional treatments for metabolic syndrome, which often include medications like metformin or statins to manage blood sugar and cholesterol levels, Ataulfo mango offers a natural alternative. Researchers are excited about this treatment because it introduces a new active ingredient: the bioactive compounds found in mangoes, which may help improve metabolic health. This approach is particularly appealing as it taps into the potential health benefits of whole foods, offering a more holistic and potentially less side-effect-prone option for managing the condition.

What evidence suggests that eating Ataulfo mangoes might be an effective treatment for metabolic syndrome?

Research has shown that eating mangos regularly can improve various aspects of metabolic health. In this trial, participants in the mango arm will consume Ataulfo mangos to evaluate their effects on metabolic syndrome. One study found that eating mangos daily helped adults with prediabetes manage their blood sugar levels better, improved their insulin response, and positively affected their body weight and fat. Another study found that mangos helped lower systolic blood pressure (the top number in readings) and reduced inflammation. Evidence also suggests that eating mangos can decrease insulin resistance, a common issue in many metabolic conditions. Overall, these studies suggest that adding mangos to the diet might benefit those with metabolic syndrome and related issues. ^{1 5 6 7 8}

Who Is on the Research Team?

Roberta R Holt, PhD

Principal Investigator

University of California, Davis

Are You a Good Fit for This Trial?

This trial is for Hispanic/Latino adolescents aged 12-19 with a BMI in the 85th percentile or higher. Participants must be willing to follow study protocols, eat mangos daily, and use a smartphone or tablet to document their intake. Girls who menstruate should have regular monthly cycles.

Inclusion Criteria

I identify as Hispanic/Latino.

I am willing and able to follow the study's requirements.

I can use a smartphone or tablet daily and am willing to take product photos for the study.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants consume either ¾ cups of mango or continue their habitual diet for 4 weeks

4 weeks

1 visit (in-person) at the start and end of each 4-week period

Washout

Participants undergo a 4-week washout period before crossing over to the alternate group

4 weeks

Crossover Treatment

Participants switch to the alternate group and consume either ¾ cups of mango or continue their habitual diet for another 4 weeks

4 weeks

1 visit (in-person) at the start and end of each 4-week period

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Ataulfo mango

Trial Overview

The study tests if eating Ataulfo mangos every day for four weeks can improve gut health and reduce risks related to heart disease and metabolism compared to typical high-calorie, low-nutrient snacks like cookies or chips.

How Is the Trial Designed?

Group I: Mango arm Experimental Treatment 1 Intervention

Ataulfo Mango intake

Group II: No mango intake Active Control 1 Intervention

4 weeks of no mango intake

Who Is Running the Clinical Trial?

University of California, Davis

Lead Sponsor

Trials

958

Recruited

4,816,000+

Citations

1.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC9027361/

Mango “Ataulfo” Peel Extract Improves Metabolic ... - PMC - NIH

In this study, a mango peel ethanolic extract (MPE) rich in a wide range of phytochemicals with a presumably anti-diabetic effect was prepared ...

2.

mdpi.com

mdpi.com/2304-8158/14/17/2971

Daily Mango Intake Improves Glycemic and Body ...

Conclusions: The daily consumption of mango for 24 weeks improved the glycemic control, insulin sensitivity, and body composition in adults with prediabetes, ...

3.

researchgate.net

researchgate.net/publication/390018500_Short-Term_Cardiometabolic_Response_to_Mango_Intake_in_Postmenopausal_Women

Short-Term Cardiometabolic Response to Mango Intake in ...

Background: Consumption of mangos has been associated with improved diet quality, with reported reductions in systolic blood pressure and inflammatory ...

4.

news-medical.net

news-medical.net/news/20250305/Daily-mango-consumption-may-improve-insulin-sensitivity-in-overweight-or-obese-adults.aspx

Daily mango consumption may improve insulin sensitivity ...

The results showed that participants who ate mangos experienced significant reductions in insulin resistance, as measured by the Homeostasis ...

5.

scholarworks.calstate.edu

scholarworks.calstate.edu/downloads/wh2472921

MANGOS TO REDUCE CARDIOMETABOLIC RISK ...

The results showed that the mango consumption modestly reduced glucose levels and increased HDL-C one-hour post-meal, with no significant effect on ...

6.

sciencedirect.com

sciencedirect.com/science/article/pii/S2475299123111292

Fully Ripe “Ataulfo” Mango (Mangifera indica L) Peel, Pulp ...

Fully Ripe “Ataulfo” Mango (Mangifera indica L) Peel, Pulp and Isolated Fiber: Sources of Bioactive Components Against Metabolic Syndrome. Author links open ...

7.

cdn.nutrition.org

cdn.nutrition.org/article/S2475-2991(23)11129-2/fulltext

Fully Ripe “Ataulfo” Mango (Mangifera indica L) Peel, Pulp ...

According to the reported literature, our products could have bioactive components against the metabolic syndrome related factors, and even better, mango peel ...

8.

tandfonline.com

tandfonline.com/doi/full/10.1080/27697061.2025.2478937

Short-Term Cardiometabolic Response to Mango Intake in ...

In conclusion, two weeks of daily mango intake was associated with a significant decrease in multiple BP outcomes in a group of healthy postmenopausal women.