Dexmedetomidine for Pain Relief
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests dexmedetomidine, a sedative and pain relief medication, to determine the optimal dose for pain relief after upper arm surgery. Researchers are examining how long each dose can block pain signals when combined with standard local anesthetics. They expect the highest dose to provide the longest-lasting effect. Individuals undergoing surgery on their arm below the elbow, without certain medical conditions, might be suitable candidates for this trial. As a Phase 2 trial, the research focuses on assessing the treatment's effectiveness in an initial, smaller group of participants.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that dexmedetomidine is generally safe when combined with local anesthetics for nerve blocks in the shoulder area. In past studies, most patients tolerated it well. However, about 7% experienced temporary bradycardia, or a slower heart rate. Importantly, no patients encountered breathing problems.
Some studies also found that dexmedetomidine might increase the risk of other side effects, though these were not detailed. Awareness of potential side effects is important. Overall, the treatment appears well-tolerated, but like any medication, it carries potential risks.12345Why are researchers excited about this trial's treatments?
Dexmedetomidine is unique because it enhances pain relief when added to local anesthetics during infraclavicular brachial plexus blocks. While standard pain management options like opioids can have significant side effects and addiction potential, dexmedetomidine offers a non-opioid alternative. This treatment works by targeting specific receptors in the nervous system to provide sedation and analgesia without respiratory depression. Researchers are excited because it could potentially improve pain management with fewer side effects and lower risk of addiction.
What evidence suggests that this trial's treatments could be effective for pain relief?
Research shows that adding dexmedetomidine to local anesthetics enhances the effectiveness and duration of nerve blocks. Studies have found that combining dexmedetomidine with local anesthetics accelerates the onset and prolongs the duration of nerve blocks. Specifically, dexmedetomidine increases the duration of pain relief and reduces postoperative pain, making it a promising option for enhancing nerve blocks, such as those used in the shoulder area. In this trial, researchers are testing different doses of dexmedetomidine—1 mcg/kg, 0.67 mcg/kg, and 1.33 mcg/kg—to determine the optimal dose for pain relief.46789
Who Is on the Research Team?
Julián Aliste, MD
Principal Investigator
McGill University Health Centre/Research Institute of the McGill University Health Centre
Are You a Good Fit for This Trial?
This trial is for individuals experiencing acute or postoperative pain, specifically those undergoing hand surgery that requires an infraclavicular block. Participants should be suitable for caudal epidural block therapy and not have anosognosia or other conditions that would exclude them from the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Preoperative Preparation
Preparation and randomization of patients for the infraclavicular brachial plexus block
Treatment
Administration of the infraclavicular brachial plexus block with different doses of dexmedetomidine
Immediate Postoperative Monitoring
Monitoring of motor and sensory block duration and other immediate postoperative outcomes
Follow-up
Participants are monitored for safety and effectiveness after treatment, including motor function return and any side effects
What Are the Treatments Tested in This Trial?
Interventions
- Dexmedetomidine
Find a Clinic Near You
Who Is Running the Clinical Trial?
McGill University Health Centre/Research Institute of the McGill University Health Centre
Lead Sponsor