Actiq

Anesthesia procedures, Induction of anesthesia therapy, Anesthetic premedication therapy + 7 more

Treatment

8 FDA approvals

2 Active Studies for Actiq

What is Actiq

Fentanyl

The Generic name of this drug

Treatment Summary

Fentanyl is a powerful opioid painkiller developed in the 1950s for the treatment of severe pain and anesthesia. It is similar to morphine and oxycodone, and is commonly used in cancer patients and those who have undergone surgery. Unfortunately, it has also been used as an adulterant in illegal drugs, making it a dangerous drug that can cause fatal overdoses. Fentanyl was approved by the FDA in 1968 and is estimated to cause 11 deaths in Canada each day.

Fentanyl Citrate

is the brand name

image of different drug pills on a surface

Actiq Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Fentanyl Citrate

Fentanyl

1984

322

Approved as Treatment by the FDA

Fentanyl, commonly known as Fentanyl Citrate, is approved by the FDA for 8 uses which include Anesthetic premedication therapy and Pain .

Anesthetic premedication therapy

Used to treat Anesthetic premedication therapy in combination with Droperidol

Pain

Helps manage Cancer Related Pain (Breakthrough Pain)

Cancer Related Pain (Breakthrough Pain)

Helps manage Cancer Related Pain (Breakthrough Pain)

opioid tolerant

Helps manage opioid tolerant

Anesthesia procedures

Used to treat Maintenance of anesthesia therapy in combination with Droperidol

High Risk Surgery

Used to treat High Risk Surgery in combination with Oxygen

Induction of anesthesia therapy

Used to treat Induction of anesthesia therapy in combination with Droperidol

Anesthetics

Used to treat Anesthetics Agent in combination with Oxygen

Effectiveness

How Actiq Affects Patients

Fentanyl is a strong painkiller that activates opioid receptors in the body and is effective for several hours at a time. It can be habit-forming and should not be taken with alcohol or sedative medications.

How Actiq works in the body

Fentanyl binds to opioid receptors, blocking nerve signals and reducing pain. It does this by attaching to G-proteins, which turn off enzymes that control how much calcium enters a cell. This causes the cell to become more negatively charged, stopping nerve activity and reducing pain.

When to interrupt dosage

The measure of Actiq is contingent upon the diagnosed ailment, including Anesthesia, Conduction, Preanesthetic Medication and General Anesthesia. The quantity can be seen in the table below, subject to the approach of administration.

Condition

Dosage

Administration

Induction of anesthesia therapy

0.025 mg/hour, 0.05 mg/hour, 0.075 mg/hour, , 0.1 mg/hour, 0.0125 mg/hour, 0.1 mg, 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 0.3 mg, 0.012 mg/hour, 0.25 mg/hour, 0.5 mg/hour, 0.75 mg/hour, 0.01 mg/mL, 0.02 mg/mL, 0.025 mg/mL, 0.05 mg/mL, 0.002 mg/mL, 0.003 mg/mL, 0.001 mg/mL, 0.005 mg/mL, 2.55 mg/[USP'U], 5.1 mg/[USP'U], 7.65 mg/[USP'U], 10.2 mg/[USP'U], 1.28 mg/[USP'U], 1.2 mg, 1.6 mg, 0.012 mg, 0.05 mg, 0.075 mg, 0.025 mg, 2.5 mg, 5.0 mg, 7.5 mg, 10.0 mg, 0.0875 mg/hour, 0.04 mg/dose, 0.01 mg/hour, 0.0025 mg/hour, 0.005 mg/hour, 0.0125 mg, 0.04 mg, 0.0375 mg/hour, 0.0625 mg/hour, 0.01 mg, 0.03 mg, 0.1 mg/mL, 0.1 mg/spray, 0.4 mg/spray, 0.2 mg/dose, 0.1 mg/dose, 0.05 mg/dose, 0.037 mg/hour, 0.25 mg/mL

, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Buccal; Oral; Transmucosal, Tablet - Buccal; Oral; Transmucosal, Tablet, Nasal, Spray, Spray - Nasal, Patch, Patch - Transdermal, Oral; Transmucosal, Lozenge, Lozenge - Oral; Transmucosal, Sublingual, Tablet - Sublingual, Injection, solution - Intravenous, Injection, solution, Intravenous, Epidural, Injection, solution - Epidural, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Solution, Solution - Epidural; Intramuscular; Intravenous, Liquid - Epidural; Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Epidural; Intramuscular; Intravenous, Buccal, Film, soluble, Film, soluble - Buccal, Buccal; Sublingual, Tablet - Buccal; Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Spray - Sublingual, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Tablet, effervescent, Tablet, effervescent - Buccal; Sublingual, Transmucosal, Lozenge - Transmucosal, Tablet - Buccal, Solution - Nasal, Film - Buccal, Epidural; Intravenous, Injection, solution - Epidural; Intravenous, Patch, extended release, electrically controlled, Patch, extended release, electrically controlled - Transdermal, Aerosol, spray - Nasal

General Anesthesia

0.025 mg/hour, 0.05 mg/hour, 0.075 mg/hour, , 0.1 mg/hour, 0.0125 mg/hour, 0.1 mg, 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 0.3 mg, 0.012 mg/hour, 0.25 mg/hour, 0.5 mg/hour, 0.75 mg/hour, 0.01 mg/mL, 0.02 mg/mL, 0.025 mg/mL, 0.05 mg/mL, 0.002 mg/mL, 0.003 mg/mL, 0.001 mg/mL, 0.005 mg/mL, 2.55 mg/[USP'U], 5.1 mg/[USP'U], 7.65 mg/[USP'U], 10.2 mg/[USP'U], 1.28 mg/[USP'U], 1.2 mg, 1.6 mg, 0.012 mg, 0.05 mg, 0.075 mg, 0.025 mg, 2.5 mg, 5.0 mg, 7.5 mg, 10.0 mg, 0.0875 mg/hour, 0.04 mg/dose, 0.01 mg/hour, 0.0025 mg/hour, 0.005 mg/hour, 0.0125 mg, 0.04 mg, 0.0375 mg/hour, 0.0625 mg/hour, 0.01 mg, 0.03 mg, 0.1 mg/mL, 0.1 mg/spray, 0.4 mg/spray, 0.2 mg/dose, 0.1 mg/dose, 0.05 mg/dose, 0.037 mg/hour, 0.25 mg/mL

, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Buccal; Oral; Transmucosal, Tablet - Buccal; Oral; Transmucosal, Tablet, Nasal, Spray, Spray - Nasal, Patch, Patch - Transdermal, Oral; Transmucosal, Lozenge, Lozenge - Oral; Transmucosal, Sublingual, Tablet - Sublingual, Injection, solution - Intravenous, Injection, solution, Intravenous, Epidural, Injection, solution - Epidural, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Solution, Solution - Epidural; Intramuscular; Intravenous, Liquid - Epidural; Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Epidural; Intramuscular; Intravenous, Buccal, Film, soluble, Film, soluble - Buccal, Buccal; Sublingual, Tablet - Buccal; Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Spray - Sublingual, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Tablet, effervescent, Tablet, effervescent - Buccal; Sublingual, Transmucosal, Lozenge - Transmucosal, Tablet - Buccal, Solution - Nasal, Film - Buccal, Epidural; Intravenous, Injection, solution - Epidural; Intravenous, Patch, extended release, electrically controlled, Patch, extended release, electrically controlled - Transdermal, Aerosol, spray - Nasal

Anesthesia procedures

0.025 mg/hour, 0.05 mg/hour, 0.075 mg/hour, , 0.1 mg/hour, 0.0125 mg/hour, 0.1 mg, 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 0.3 mg, 0.012 mg/hour, 0.25 mg/hour, 0.5 mg/hour, 0.75 mg/hour, 0.01 mg/mL, 0.02 mg/mL, 0.025 mg/mL, 0.05 mg/mL, 0.002 mg/mL, 0.003 mg/mL, 0.001 mg/mL, 0.005 mg/mL, 2.55 mg/[USP'U], 5.1 mg/[USP'U], 7.65 mg/[USP'U], 10.2 mg/[USP'U], 1.28 mg/[USP'U], 1.2 mg, 1.6 mg, 0.012 mg, 0.05 mg, 0.075 mg, 0.025 mg, 2.5 mg, 5.0 mg, 7.5 mg, 10.0 mg, 0.0875 mg/hour, 0.04 mg/dose, 0.01 mg/hour, 0.0025 mg/hour, 0.005 mg/hour, 0.0125 mg, 0.04 mg, 0.0375 mg/hour, 0.0625 mg/hour, 0.01 mg, 0.03 mg, 0.1 mg/mL, 0.1 mg/spray, 0.4 mg/spray, 0.2 mg/dose, 0.1 mg/dose, 0.05 mg/dose, 0.037 mg/hour, 0.25 mg/mL

, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Buccal; Oral; Transmucosal, Tablet - Buccal; Oral; Transmucosal, Tablet, Nasal, Spray, Spray - Nasal, Patch, Patch - Transdermal, Oral; Transmucosal, Lozenge, Lozenge - Oral; Transmucosal, Sublingual, Tablet - Sublingual, Injection, solution - Intravenous, Injection, solution, Intravenous, Epidural, Injection, solution - Epidural, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Solution, Solution - Epidural; Intramuscular; Intravenous, Liquid - Epidural; Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Epidural; Intramuscular; Intravenous, Buccal, Film, soluble, Film, soluble - Buccal, Buccal; Sublingual, Tablet - Buccal; Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Spray - Sublingual, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Tablet, effervescent, Tablet, effervescent - Buccal; Sublingual, Transmucosal, Lozenge - Transmucosal, Tablet - Buccal, Solution - Nasal, Film - Buccal, Epidural; Intravenous, Injection, solution - Epidural; Intravenous, Patch, extended release, electrically controlled, Patch, extended release, electrically controlled - Transdermal, Aerosol, spray - Nasal

High Risk Surgery

0.025 mg/hour, 0.05 mg/hour, 0.075 mg/hour, , 0.1 mg/hour, 0.0125 mg/hour, 0.1 mg, 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 0.3 mg, 0.012 mg/hour, 0.25 mg/hour, 0.5 mg/hour, 0.75 mg/hour, 0.01 mg/mL, 0.02 mg/mL, 0.025 mg/mL, 0.05 mg/mL, 0.002 mg/mL, 0.003 mg/mL, 0.001 mg/mL, 0.005 mg/mL, 2.55 mg/[USP'U], 5.1 mg/[USP'U], 7.65 mg/[USP'U], 10.2 mg/[USP'U], 1.28 mg/[USP'U], 1.2 mg, 1.6 mg, 0.012 mg, 0.05 mg, 0.075 mg, 0.025 mg, 2.5 mg, 5.0 mg, 7.5 mg, 10.0 mg, 0.0875 mg/hour, 0.04 mg/dose, 0.01 mg/hour, 0.0025 mg/hour, 0.005 mg/hour, 0.0125 mg, 0.04 mg, 0.0375 mg/hour, 0.0625 mg/hour, 0.01 mg, 0.03 mg, 0.1 mg/mL, 0.1 mg/spray, 0.4 mg/spray, 0.2 mg/dose, 0.1 mg/dose, 0.05 mg/dose, 0.037 mg/hour, 0.25 mg/mL

, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Buccal; Oral; Transmucosal, Tablet - Buccal; Oral; Transmucosal, Tablet, Nasal, Spray, Spray - Nasal, Patch, Patch - Transdermal, Oral; Transmucosal, Lozenge, Lozenge - Oral; Transmucosal, Sublingual, Tablet - Sublingual, Injection, solution - Intravenous, Injection, solution, Intravenous, Epidural, Injection, solution - Epidural, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Solution, Solution - Epidural; Intramuscular; Intravenous, Liquid - Epidural; Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Epidural; Intramuscular; Intravenous, Buccal, Film, soluble, Film, soluble - Buccal, Buccal; Sublingual, Tablet - Buccal; Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Spray - Sublingual, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Tablet, effervescent, Tablet, effervescent - Buccal; Sublingual, Transmucosal, Lozenge - Transmucosal, Tablet - Buccal, Solution - Nasal, Film - Buccal, Epidural; Intravenous, Injection, solution - Epidural; Intravenous, Patch, extended release, electrically controlled, Patch, extended release, electrically controlled - Transdermal, Aerosol, spray - Nasal

Anesthetics

0.025 mg/hour, 0.05 mg/hour, 0.075 mg/hour, , 0.1 mg/hour, 0.0125 mg/hour, 0.1 mg, 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 0.3 mg, 0.012 mg/hour, 0.25 mg/hour, 0.5 mg/hour, 0.75 mg/hour, 0.01 mg/mL, 0.02 mg/mL, 0.025 mg/mL, 0.05 mg/mL, 0.002 mg/mL, 0.003 mg/mL, 0.001 mg/mL, 0.005 mg/mL, 2.55 mg/[USP'U], 5.1 mg/[USP'U], 7.65 mg/[USP'U], 10.2 mg/[USP'U], 1.28 mg/[USP'U], 1.2 mg, 1.6 mg, 0.012 mg, 0.05 mg, 0.075 mg, 0.025 mg, 2.5 mg, 5.0 mg, 7.5 mg, 10.0 mg, 0.0875 mg/hour, 0.04 mg/dose, 0.01 mg/hour, 0.0025 mg/hour, 0.005 mg/hour, 0.0125 mg, 0.04 mg, 0.0375 mg/hour, 0.0625 mg/hour, 0.01 mg, 0.03 mg, 0.1 mg/mL, 0.1 mg/spray, 0.4 mg/spray, 0.2 mg/dose, 0.1 mg/dose, 0.05 mg/dose, 0.037 mg/hour, 0.25 mg/mL

, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Buccal; Oral; Transmucosal, Tablet - Buccal; Oral; Transmucosal, Tablet, Nasal, Spray, Spray - Nasal, Patch, Patch - Transdermal, Oral; Transmucosal, Lozenge, Lozenge - Oral; Transmucosal, Sublingual, Tablet - Sublingual, Injection, solution - Intravenous, Injection, solution, Intravenous, Epidural, Injection, solution - Epidural, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Solution, Solution - Epidural; Intramuscular; Intravenous, Liquid - Epidural; Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Epidural; Intramuscular; Intravenous, Buccal, Film, soluble, Film, soluble - Buccal, Buccal; Sublingual, Tablet - Buccal; Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Spray - Sublingual, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Tablet, effervescent, Tablet, effervescent - Buccal; Sublingual, Transmucosal, Lozenge - Transmucosal, Tablet - Buccal, Solution - Nasal, Film - Buccal, Epidural; Intravenous, Injection, solution - Epidural; Intravenous, Patch, extended release, electrically controlled, Patch, extended release, electrically controlled - Transdermal, Aerosol, spray - Nasal

Anesthetic premedication therapy

0.025 mg/hour, 0.05 mg/hour, 0.075 mg/hour, , 0.1 mg/hour, 0.0125 mg/hour, 0.1 mg, 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 0.3 mg, 0.012 mg/hour, 0.25 mg/hour, 0.5 mg/hour, 0.75 mg/hour, 0.01 mg/mL, 0.02 mg/mL, 0.025 mg/mL, 0.05 mg/mL, 0.002 mg/mL, 0.003 mg/mL, 0.001 mg/mL, 0.005 mg/mL, 2.55 mg/[USP'U], 5.1 mg/[USP'U], 7.65 mg/[USP'U], 10.2 mg/[USP'U], 1.28 mg/[USP'U], 1.2 mg, 1.6 mg, 0.012 mg, 0.05 mg, 0.075 mg, 0.025 mg, 2.5 mg, 5.0 mg, 7.5 mg, 10.0 mg, 0.0875 mg/hour, 0.04 mg/dose, 0.01 mg/hour, 0.0025 mg/hour, 0.005 mg/hour, 0.0125 mg, 0.04 mg, 0.0375 mg/hour, 0.0625 mg/hour, 0.01 mg, 0.03 mg, 0.1 mg/mL, 0.1 mg/spray, 0.4 mg/spray, 0.2 mg/dose, 0.1 mg/dose, 0.05 mg/dose, 0.037 mg/hour, 0.25 mg/mL

, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Buccal; Oral; Transmucosal, Tablet - Buccal; Oral; Transmucosal, Tablet, Nasal, Spray, Spray - Nasal, Patch, Patch - Transdermal, Oral; Transmucosal, Lozenge, Lozenge - Oral; Transmucosal, Sublingual, Tablet - Sublingual, Injection, solution - Intravenous, Injection, solution, Intravenous, Epidural, Injection, solution - Epidural, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Solution, Solution - Epidural; Intramuscular; Intravenous, Liquid - Epidural; Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Epidural; Intramuscular; Intravenous, Buccal, Film, soluble, Film, soluble - Buccal, Buccal; Sublingual, Tablet - Buccal; Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Spray - Sublingual, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Tablet, effervescent, Tablet, effervescent - Buccal; Sublingual, Transmucosal, Lozenge - Transmucosal, Tablet - Buccal, Solution - Nasal, Film - Buccal, Epidural; Intravenous, Injection, solution - Epidural; Intravenous, Patch, extended release, electrically controlled, Patch, extended release, electrically controlled - Transdermal, Aerosol, spray - Nasal

Pain

0.025 mg/hour, 0.05 mg/hour, 0.075 mg/hour, , 0.1 mg/hour, 0.0125 mg/hour, 0.1 mg, 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 0.3 mg, 0.012 mg/hour, 0.25 mg/hour, 0.5 mg/hour, 0.75 mg/hour, 0.01 mg/mL, 0.02 mg/mL, 0.025 mg/mL, 0.05 mg/mL, 0.002 mg/mL, 0.003 mg/mL, 0.001 mg/mL, 0.005 mg/mL, 2.55 mg/[USP'U], 5.1 mg/[USP'U], 7.65 mg/[USP'U], 10.2 mg/[USP'U], 1.28 mg/[USP'U], 1.2 mg, 1.6 mg, 0.012 mg, 0.05 mg, 0.075 mg, 0.025 mg, 2.5 mg, 5.0 mg, 7.5 mg, 10.0 mg, 0.0875 mg/hour, 0.04 mg/dose, 0.01 mg/hour, 0.0025 mg/hour, 0.005 mg/hour, 0.0125 mg, 0.04 mg, 0.0375 mg/hour, 0.0625 mg/hour, 0.01 mg, 0.03 mg, 0.1 mg/mL, 0.1 mg/spray, 0.4 mg/spray, 0.2 mg/dose, 0.1 mg/dose, 0.05 mg/dose, 0.037 mg/hour, 0.25 mg/mL

, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Buccal; Oral; Transmucosal, Tablet - Buccal; Oral; Transmucosal, Tablet, Nasal, Spray, Spray - Nasal, Patch, Patch - Transdermal, Oral; Transmucosal, Lozenge, Lozenge - Oral; Transmucosal, Sublingual, Tablet - Sublingual, Injection, solution - Intravenous, Injection, solution, Intravenous, Epidural, Injection, solution - Epidural, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Solution, Solution - Epidural; Intramuscular; Intravenous, Liquid - Epidural; Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Epidural; Intramuscular; Intravenous, Buccal, Film, soluble, Film, soluble - Buccal, Buccal; Sublingual, Tablet - Buccal; Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Spray - Sublingual, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Tablet, effervescent, Tablet, effervescent - Buccal; Sublingual, Transmucosal, Lozenge - Transmucosal, Tablet - Buccal, Solution - Nasal, Film - Buccal, Epidural; Intravenous, Injection, solution - Epidural; Intravenous, Patch, extended release, electrically controlled, Patch, extended release, electrically controlled - Transdermal, Aerosol, spray - Nasal

Pain

0.025 mg/hour, 0.05 mg/hour, 0.075 mg/hour, , 0.1 mg/hour, 0.0125 mg/hour, 0.1 mg, 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 0.3 mg, 0.012 mg/hour, 0.25 mg/hour, 0.5 mg/hour, 0.75 mg/hour, 0.01 mg/mL, 0.02 mg/mL, 0.025 mg/mL, 0.05 mg/mL, 0.002 mg/mL, 0.003 mg/mL, 0.001 mg/mL, 0.005 mg/mL, 2.55 mg/[USP'U], 5.1 mg/[USP'U], 7.65 mg/[USP'U], 10.2 mg/[USP'U], 1.28 mg/[USP'U], 1.2 mg, 1.6 mg, 0.012 mg, 0.05 mg, 0.075 mg, 0.025 mg, 2.5 mg, 5.0 mg, 7.5 mg, 10.0 mg, 0.0875 mg/hour, 0.04 mg/dose, 0.01 mg/hour, 0.0025 mg/hour, 0.005 mg/hour, 0.0125 mg, 0.04 mg, 0.0375 mg/hour, 0.0625 mg/hour, 0.01 mg, 0.03 mg, 0.1 mg/mL, 0.1 mg/spray, 0.4 mg/spray, 0.2 mg/dose, 0.1 mg/dose, 0.05 mg/dose, 0.037 mg/hour, 0.25 mg/mL

, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Buccal; Oral; Transmucosal, Tablet - Buccal; Oral; Transmucosal, Tablet, Nasal, Spray, Spray - Nasal, Patch, Patch - Transdermal, Oral; Transmucosal, Lozenge, Lozenge - Oral; Transmucosal, Sublingual, Tablet - Sublingual, Injection, solution - Intravenous, Injection, solution, Intravenous, Epidural, Injection, solution - Epidural, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Solution, Solution - Epidural; Intramuscular; Intravenous, Liquid - Epidural; Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Epidural; Intramuscular; Intravenous, Buccal, Film, soluble, Film, soluble - Buccal, Buccal; Sublingual, Tablet - Buccal; Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Spray - Sublingual, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Tablet, effervescent, Tablet, effervescent - Buccal; Sublingual, Transmucosal, Lozenge - Transmucosal, Tablet - Buccal, Solution - Nasal, Film - Buccal, Epidural; Intravenous, Injection, solution - Epidural; Intravenous, Patch, extended release, electrically controlled, Patch, extended release, electrically controlled - Transdermal, Aerosol, spray - Nasal

Anesthesia, Conduction

0.025 mg/hour, 0.05 mg/hour, 0.075 mg/hour, , 0.1 mg/hour, 0.0125 mg/hour, 0.1 mg, 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 0.3 mg, 0.012 mg/hour, 0.25 mg/hour, 0.5 mg/hour, 0.75 mg/hour, 0.01 mg/mL, 0.02 mg/mL, 0.025 mg/mL, 0.05 mg/mL, 0.002 mg/mL, 0.003 mg/mL, 0.001 mg/mL, 0.005 mg/mL, 2.55 mg/[USP'U], 5.1 mg/[USP'U], 7.65 mg/[USP'U], 10.2 mg/[USP'U], 1.28 mg/[USP'U], 1.2 mg, 1.6 mg, 0.012 mg, 0.05 mg, 0.075 mg, 0.025 mg, 2.5 mg, 5.0 mg, 7.5 mg, 10.0 mg, 0.0875 mg/hour, 0.04 mg/dose, 0.01 mg/hour, 0.0025 mg/hour, 0.005 mg/hour, 0.0125 mg, 0.04 mg, 0.0375 mg/hour, 0.0625 mg/hour, 0.01 mg, 0.03 mg, 0.1 mg/mL, 0.1 mg/spray, 0.4 mg/spray, 0.2 mg/dose, 0.1 mg/dose, 0.05 mg/dose, 0.037 mg/hour, 0.25 mg/mL

, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Buccal; Oral; Transmucosal, Tablet - Buccal; Oral; Transmucosal, Tablet, Nasal, Spray, Spray - Nasal, Patch, Patch - Transdermal, Oral; Transmucosal, Lozenge, Lozenge - Oral; Transmucosal, Sublingual, Tablet - Sublingual, Injection, solution - Intravenous, Injection, solution, Intravenous, Epidural, Injection, solution - Epidural, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Solution, Solution - Epidural; Intramuscular; Intravenous, Liquid - Epidural; Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Epidural; Intramuscular; Intravenous, Buccal, Film, soluble, Film, soluble - Buccal, Buccal; Sublingual, Tablet - Buccal; Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Spray - Sublingual, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Tablet, effervescent, Tablet, effervescent - Buccal; Sublingual, Transmucosal, Lozenge - Transmucosal, Tablet - Buccal, Solution - Nasal, Film - Buccal, Epidural; Intravenous, Injection, solution - Epidural; Intravenous, Patch, extended release, electrically controlled, Patch, extended release, electrically controlled - Transdermal, Aerosol, spray - Nasal

opioid tolerant

0.025 mg/hour, 0.05 mg/hour, 0.075 mg/hour, , 0.1 mg/hour, 0.0125 mg/hour, 0.1 mg, 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 0.3 mg, 0.012 mg/hour, 0.25 mg/hour, 0.5 mg/hour, 0.75 mg/hour, 0.01 mg/mL, 0.02 mg/mL, 0.025 mg/mL, 0.05 mg/mL, 0.002 mg/mL, 0.003 mg/mL, 0.001 mg/mL, 0.005 mg/mL, 2.55 mg/[USP'U], 5.1 mg/[USP'U], 7.65 mg/[USP'U], 10.2 mg/[USP'U], 1.28 mg/[USP'U], 1.2 mg, 1.6 mg, 0.012 mg, 0.05 mg, 0.075 mg, 0.025 mg, 2.5 mg, 5.0 mg, 7.5 mg, 10.0 mg, 0.0875 mg/hour, 0.04 mg/dose, 0.01 mg/hour, 0.0025 mg/hour, 0.005 mg/hour, 0.0125 mg, 0.04 mg, 0.0375 mg/hour, 0.0625 mg/hour, 0.01 mg, 0.03 mg, 0.1 mg/mL, 0.1 mg/spray, 0.4 mg/spray, 0.2 mg/dose, 0.1 mg/dose, 0.05 mg/dose, 0.037 mg/hour, 0.25 mg/mL

, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Buccal; Oral; Transmucosal, Tablet - Buccal; Oral; Transmucosal, Tablet, Nasal, Spray, Spray - Nasal, Patch, Patch - Transdermal, Oral; Transmucosal, Lozenge, Lozenge - Oral; Transmucosal, Sublingual, Tablet - Sublingual, Injection, solution - Intravenous, Injection, solution, Intravenous, Epidural, Injection, solution - Epidural, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Solution, Solution - Epidural; Intramuscular; Intravenous, Liquid - Epidural; Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Epidural; Intramuscular; Intravenous, Buccal, Film, soluble, Film, soluble - Buccal, Buccal; Sublingual, Tablet - Buccal; Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Spray - Sublingual, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous, Tablet, effervescent, Tablet, effervescent - Buccal; Sublingual, Transmucosal, Lozenge - Transmucosal, Tablet - Buccal, Solution - Nasal, Film - Buccal, Epidural; Intravenous, Injection, solution - Epidural; Intravenous, Patch, extended release, electrically controlled, Patch, extended release, electrically controlled - Transdermal, Aerosol, spray - Nasal

Warnings

Actiq has thirteen counterindications and should not be used in the presence of the conditions specified in the following table.

Actiq Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Fentanyl may interact with Pulse Frequency

short opioid analgesia requirement

Do Not Combine

Asthma

Do Not Combine

Pain

Do Not Combine

Asthma

Do Not Combine

Mental Depression

Do Not Combine

opioid non-tolerant patients

Do Not Combine

known or suspected gastrointestinal obstruction

Do Not Combine

Intestinal Pseudo-Obstruction

Do Not Combine

Paralytic Ileus

Do Not Combine

management of acute or intermittent pain

Do Not Combine

Pain

Do Not Combine

respiratory compromise

Do Not Combine

There are 20 known major drug interactions with Actiq.

Common Actiq Drug Interactions

Drug Name

Risk Level

Description

Copanlisib

Major

The metabolism of Copanlisib can be decreased when combined with Fentanyl.

Eluxadoline

Major

The risk or severity of constipation can be increased when Fentanyl is combined with Eluxadoline.

Oliceridine

Major

The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Fentanyl is combined with Oliceridine.

Paclitaxel

Major

The metabolism of Paclitaxel can be decreased when combined with Fentanyl.

Sirolimus

Major

The metabolism of Sirolimus can be decreased when combined with Fentanyl.

Actiq Toxicity & Overdose Risk

The toxic dose for fentanyl in rats is 2.91mg/kg when injected and 18mg/kg when taken orally. Since the toxic dose in humans is unknown, it is important to be aware of the signs of an overdose. Symptoms of an overdose may include difficulty breathing, sleepiness, confusion, limp muscles, cold skin, pupil constriction, fluid in the lungs, slow or irregular heartbeat, low blood pressure, obstructed airways, and death. If someone overdoses on fentanyl, they should be given naloxone or nalmefene to counteract the effects of the drug and receive medical support to help them breathe or

image of a doctor in a lab doing drug, clinical research

Actiq Novel Uses: Which Conditions Have a Clinical Trial Featuring Actiq?

43 active studies are being conducted to assess the potential of Actiq to reduce Pain, provide Anesthetics and act as Preanesthetic Medication.

Condition

Clinical Trials

Trial Phases

Pain

0 Actively Recruiting

Anesthetic premedication therapy

0 Actively Recruiting

Anesthesia, Conduction

0 Actively Recruiting

General Anesthesia

1 Actively Recruiting

Phase 4

Induction of anesthesia therapy

0 Actively Recruiting

opioid tolerant

0 Actively Recruiting

Anesthetics

1 Actively Recruiting

Phase 3

High Risk Surgery

0 Actively Recruiting

Anesthesia procedures

0 Actively Recruiting

Pain

0 Actively Recruiting

Actiq Reviews: What are patients saying about Actiq?

5

Patient Review

1/25/2011

Actiq for Breakthrough Pain in Opioid Tolerant Patients

This medication is a true godsend for me. I have chronic back pain, and there are days when the level of pain is so high that my oral pain medication doesn't even make a dent. This breakthrough medication has helped me on those days, and I don't know what I would do without it.

5

Patient Review

4/8/2011

Actiq for Breakthrough Pain in Opioid Tolerant Patients

The lollipop worked great for me, but I was unaware of the damage it was doing to my teeth. I've lost at least eight teeth and have had to spend a lot of money on dental bills (even with insurance). My insurance company stopped covering it because I don't have cancer, but nothing else has worked as well for me.

5

Patient Review

5/10/2013

Actiq for Breakthrough Pain in Opioid Tolerant Patients

I had been using this medication for five years before stopped. I did it the right way and weaned myself off gradually, so I didn't experience any withdrawal symptoms. However, now that I've been off of the medication for almost three months, my pain has gotten worse again. Now I need to find a new doctor in the area who will prescribe this medication for me. My quality of life has decreased significantly since stopping this medication, and I am desperate for help.

5

Patient Review

1/10/2011

Actiq for Breakthrough Pain in Opioid Tolerant Patients

5

Patient Review

4/3/2012

Actiq for Breakthrough Pain in Opioid Tolerant Patients

I've heard that people can die from mixing Actiq and Xanax. Is this true?

4.7

Patient Review

12/25/2011

Actiq for Breakthrough Pain in Opioid Tolerant Patients

This is an incredibly effective treatment, especially when used with duragesic patches. I was taking three 600mcg suckers a day as needed, and it's the only thing that touches the breakthrough pain that is just intolerable. However, you've got to have really good insurance because this stuff is $1280 for a box of 30 (that's what they bill our med plan-I copay $10). Stay away from oxycontin and suggest this instead; my pain management doctor says very few plans cover it however.

4.3

Patient Review

2/1/2011

Actiq for Breakthrough Pain in Opioid Tolerant Patients

I've been using Actiq for a while now, and it's great for when I need quick relief from pain. It's expensive, but if you can swing it, I recommend giving it a try.

4.3

Patient Review

11/3/2010

Actiq for Breakthrough Pain in Opioid Tolerant Patients

4

Patient Review

1/8/2011

Actiq for Breakthrough Pain in Opioid Tolerant Patients

3

Patient Review

10/22/2011

Actiq for Breakthrough Pain in Opioid Tolerant Patients

This treatment provides quick relief for chronic pain.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about actiq

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What class drug is Actiq?

"The drug Actiq belongs to a class of drugs known as opioid analgesics, which are drugs that act on the nervous system to relieve pain."

Answered by AI

Is Actiq available?

"The FDA has required a restricted program, called a Risk Evaluation and Mitigation Strategy (REMS), for ACTIQ due to the risk for misuse, abuse, addiction, and overdose."

Answered by AI

What is Actiq prescribed for?

"ACTIQ (fentanyl citrate taken through the mucus membranes) is indicated for the management of breakthrough pain in cancer patients 16 years of age and older who are already receiving and who are tolerant to around-the-clock opioids for their underlying persistent cancer pain."

Answered by AI

Is Actiq an opioid?

"Fentanyl Citrate is a type of opioid that is used to treat pain. It works by attaching to opioid receptors in the brain, spinal cord, and gastrointestinal tract."

Answered by AI

Clinical Trials for Actiq