What is Acetaminophen And Caffeine
ButalbitalThe Generic name of this drug
Treatment SummaryButalbital is a type of barbiturate that is used to relieve muscle tension and reduce anxiety. It has a low level of effectiveness and can be dangerous when abused or taken in high doses. It can be prescribed in combination with other medications such as aspirin, acetaminophen, and caffeine for tension headaches, but should not be used for migraines. Butalbital can lead to tolerance, dependence, and overdose, so its use should be carefully monitored.
Fiorinalis the brand name
Acetaminophen And Caffeine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Fiorinal
Butalbital
1976
283
Approved as Treatment by the FDA
Butalbital, also known as Fiorinal, is approved by the FDA for 2 uses such as Inadequate analgesia and Tension Headache .Inadequate analgesia
Used to treat Inadequate analgesia in combination with Acetaminophen
Tension Headache
Used to treat Tension Headache in combination with Acetaminophen
Effectiveness
How Acetaminophen And Caffeine Affects PatientsButalbital is a medicine that calms down the activity of the body and brain. It can cause sedation, hypnosis, and even coma when taken in higher doses. It can help with pain and anxiety, but in some cases it can also cause paradoxical excitement instead of sedation. Butalbital can be habit-forming and can lead to tolerance, dependence, and addiction. It is sometimes used in combination with other drugs to reduce the unwanted stimulating effects of those drugs. Butalbital may also lower blood pressure and heart rate when taken in high enough doses.
How Acetaminophen And Caffeine works in the bodyButalbital is a central nervous system depressant that stops neurons from firing and releasing neurotransmitters. It works by attaching to GABA receptors on neurons, allowing chloride ions to enter the neuron and stopping it from firing. Butalbital can also bind to benzodiazepine receptors and prolong the effect of GABA, further preventing neural firing. It may also work to reduce excitatory impulses by blocking glutamate receptors. Butalbital may also enhance the effects of opioids when taken together.
When to interrupt dosage
The sum of Acetaminophen And Caffeine is contingent on the recognized condition. The quantity of dosage is determined by the mode of delivery as noted in the table below.Condition
Dosage
Administration
Tension Headache
50.0 mg, , 25.0 mg/mg, 25.0 mg, 5.0 mg/mL
Oral, , Capsule - Oral, Syrup - Oral, Capsule, Tablet, Syrup, Tablet, coated, Tablet - Oral, Tablet, coated - Oral
Inadequate analgesia
50.0 mg, , 25.0 mg/mg, 25.0 mg, 5.0 mg/mL
Oral, , Capsule - Oral, Syrup - Oral, Capsule, Tablet, Syrup, Tablet, coated, Tablet - Oral, Tablet, coated - Oral
Warnings
Acetaminophen And Caffeine ContraindicationsCondition
Risk Level
Notes
Porphyria
Do Not Combine
Porphyria
Do Not Combine
Post-Tonsillectomy
Do Not Combine
post-adenoidectomy
Do Not Combine
Common Acetaminophen And Caffeine Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Butalbital.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Butalbital.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Butalbital.
Alpelisib
Major
The metabolism of Alpelisib can be increased when combined with Butalbital.
Amiodarone
Major
The metabolism of Amiodarone can be increased when combined with Butalbital.
Acetaminophen And Caffeine Toxicity & Overdose RiskThe highest dose of butalbital that can be safely taken orally by an adult woman is 400 mg/kg. The lowest poisonous dose for rats is 160 mg/kg. Symptoms of an overdose include extreme drowsiness, confusion, loss of consciousness, shallow breathing, low blood pressure, and shock. Overdosing on barbiturates can be fatal, as can the withdrawal symptoms that may follow.
Acetaminophen And Caffeine Novel Uses: Which Conditions Have a Clinical Trial Featuring Acetaminophen And Caffeine?
An ongoing investigation is assessing the potential of Acetaminophen and Caffeine to provide relief from Tension Headache.Condition
Clinical Trials
Trial Phases
Tension Headache
1 Actively Recruiting
Phase 2
Inadequate analgesia
0 Actively Recruiting
Patient Q&A Section about acetaminophen and caffeine
What drug has acetaminophen and caffeine?
"The drug Butalbital, which is a combination of acetaminophen and caffeine, is used to relieve symptoms of tension headaches." - Anonymous Online Contributor
Unverified Answer
How does acetaminophen react with caffeine?
"According to lead researcher Sid Nelson, a professor of medicinal chemistry, caffeine can interact with an enzyme to form a toxic metabolite of acetaminophen. This can result in liver damage." - Anonymous Online Contributor
Unverified Answer