Zurampic
Hyperuricemia, Arthritis, Gouty
Treatment
3 FDA approvals
4 Active Studies for Zurampic
Treatment for
Hyperuricemia
What is Zurampic
Lesinurad
The Generic name of this drug
Treatment Summary
Lesinurad (marketed as Zurampic and Duzallo) is a medication used to lower uric acid levels in people with gout who have not been able to lower their uric acid levels with a xanthine oxidase inhibitor alone. It works by blocking the enzymes responsible for absorbing uric acid from the kidneys. Lesinurad is FDA-approved for use in combination with a xanthine oxidase inhibitor and can be prescribed under the brand name Duzallo.
Zurampic
is the brand name
Zurampic Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zurampic
Lesinurad
2016
4
Approved as Treatment by the FDA
Lesinurad, otherwise known as Zurampic, is approved by the FDA for 3 uses which include Hyperuricemia and Hyperuricemia .
Hyperuricemia
Used to treat Hyperuricemia in combination with null
Hyperuricemia
Used to treat Hyperuricemia in combination with null
Arthritis, Gouty
Used to treat Gouty Arthritis in combination with null
Effectiveness
How Zurampic Affects Patients
Taking lesinurad regularly will gradually lower the amount of uric acid in the blood, and cause more uric acid to be passed in urine.
How Zurampic works in the body
Lesinurad works by blocking two transporter enzymes, URAT1 and OAT4. URAT1 is responsible for bringing uric acid into the body, so blocking it increases the amount of uric acid that is removed from the body.
When to interrupt dosage
The advised dose of Zurampic is contingent upon the diagnosed condition. The amount of dosage fluctuates according to the administration technique (e.g. Tablet, film coated - Oral or Tablet, film coated) as stated in the table below.
Condition
Dosage
Administration
Arthritis, Gouty
200.0 mg,
Tablet, film coated, Tablet, film coated - Oral, Oral,
Hyperuricemia
200.0 mg,
Tablet, film coated, Tablet, film coated - Oral, Oral,
Warnings
Zurampic has six contraindications and should not be employed in combination with the afflictions listed in the subsequent table.
Zurampic Contraindications
Condition
Risk Level
Notes
Lesch-Nyhan Syndrome
Do Not Combine
Tumor Lysis Syndrome
Do Not Combine
Renal Transplant Recipient Patients
Do Not Combine
Kidney Failure
Do Not Combine
on dialysis
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Zurampic.
Common Zurampic Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Lesinurad.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Lesinurad.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be increased when combined with Lesinurad.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Lesinurad.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Lesinurad.
Zurampic Novel Uses: Which Conditions Have a Clinical Trial Featuring Zurampic?
Three clinical trials are currently underway to evaluate the potential of Zurampic in alleviating Gouty Arthritis.
Condition
Clinical Trials
Trial Phases
Arthritis, Gouty
0 Actively Recruiting
Hyperuricemia
3 Actively Recruiting
Phase 3, Phase 1
Patient Q&A Section about zurampic
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Why was lesinurad discontinued?
"- The FDA has announced that Ironwood Pharmaceuticals will no longer be producing Duzallo (lesinurad/allopurinol) and Zurampic (lesinurad). The discontinuation is due to business reasons and not because of any safety, efficacy, or quality issues."
Answered by AI
What class of drug is lesinurad?
"Lesinurad is a medication that helps the kidneys remove uric acid from the body."
Answered by AI