Zurampic

Hyperuricemia, Arthritis, Gouty

Treatment

3 FDA approvals

5 Active Studies for Zurampic

Treatment for

Hyperuricemia

What is Zurampic

LesinuradThe Generic name of this drug

Treatment SummaryLesinurad (marketed as Zurampic and Duzallo) is a medication used to lower uric acid levels in people with gout who have not been able to lower their uric acid levels with a xanthine oxidase inhibitor alone. It works by blocking the enzymes responsible for absorbing uric acid from the kidneys. Lesinurad is FDA-approved for use in combination with a xanthine oxidase inhibitor and can be prescribed under the brand name Duzallo.

Zurampicis the brand name

Zurampic Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Zurampic

Lesinurad

2016

Approved as Treatment by the FDA

Lesinurad, otherwise known as Zurampic, is approved by the FDA for 3 uses which include Hyperuricemia and Hyperuricemia .

Hyperuricemia

Used to treat Hyperuricemia in combination with null

Hyperuricemia

Used to treat Hyperuricemia in combination with null

Arthritis, Gouty

Used to treat Gouty Arthritis in combination with null

Effectiveness

How Zurampic Affects PatientsTaking lesinurad regularly will gradually lower the amount of uric acid in the blood, and cause more uric acid to be passed in urine.

How Zurampic works in the bodyLesinurad works by blocking two transporter enzymes, URAT1 and OAT4. URAT1 is responsible for bringing uric acid into the body, so blocking it increases the amount of uric acid that is removed from the body.

When to interrupt dosage

The advised dose of Zurampic is contingent upon the diagnosed condition. The amount of dosage fluctuates according to the administration technique (e.g. Tablet, film coated - Oral or Tablet, film coated) as stated in the table below.

Condition

Dosage

Administration

Arthritis, Gouty

200.0 mg,

, Tablet, film coated, Oral, Tablet, film coated - Oral

Hyperuricemia

200.0 mg,

, Tablet, film coated, Oral, Tablet, film coated - Oral

Warnings

Zurampic has six contraindications and should not be employed in combination with the afflictions listed in the subsequent table.Zurampic Contraindications

Condition

Risk Level

Notes

Lesch-Nyhan Syndrome

Do Not Combine

Tumor Lysis Syndrome

Do Not Combine

Renal Transplant Recipient Patients

Do Not Combine

Kidney Failure

Do Not Combine

on dialysis

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Zurampic.

Common Zurampic Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Lesinurad.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Lesinurad.

Acenocoumarol

Major

The metabolism of Acenocoumarol can be increased when combined with Lesinurad.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Lesinurad.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Lesinurad.

Zurampic Novel Uses: Which Conditions Have a Clinical Trial Featuring Zurampic?

Three clinical trials are currently underway to evaluate the potential of Zurampic in alleviating Gouty Arthritis.

Condition

Clinical Trials

Trial Phases

Arthritis, Gouty

4 Actively Recruiting

Phase 2, Phase 3, Not Applicable

Hyperuricemia

3 Actively Recruiting

Phase 3, Phase 1

Patient Q&A Section about zurampic

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is ZURAMPIC used for?

"ZURAMPIC should be taken with a xanthine oxidase inhibitor in order to lower uric acid levels in the blood for adult patients with gout."

Answered by AI

What is the drug probenecid used for?

"Probenecid is used to treat chronic gout or gouty arthritis by removing excess uric acid from the body, though it does not cure gout. After taking probenecid for a few months, it will help prevent gout attacks."

Answered by AI

Why was lesinurad discontinued?

"- The FDA has announced that Ironwood Pharmaceuticals will no longer be producing Duzallo (lesinurad/allopurinol) and Zurampic (lesinurad). The discontinuation is due to business reasons and not because of any safety, efficacy, or quality issues."

Answered by AI

What is probenecid used for?

"Probenecid is a medication used to treat chronic gout or gouty arthritis by removing excess uric acid from the body. Although probenecid does not cure gout, it can help prevent gout attacks after a few months of use."

Answered by AI

What class of drug is lesinurad?

"Lesinurad is a medication that helps the kidneys remove uric acid from the body."

Answered by AI

Clinical Trials for Zurampic

Have you considered Zurampic clinical trials? We made a collection of clinical trials featuring Zurampic, we think they might fit your search criteria.