Zortress

Advance Directives, Steroid therapy, Carcinoid Tumor + 11 more

Treatment

22 FDA approvals

0 Active Studies for Zortress

What is Zortress

Everolimus

The Generic name of this drug

Treatment Summary

Everolimus is a drug related to sirolimus (Rapamycin) that works by blocking a protein called mTORC1. It is used to prevent organ rejection in transplant patients. Unlike other mTOR inhibitors, Everolimus only targets the mTORC1 protein and not the mTORC2 protein.

Afinitor

is the brand name

Zortress Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Afinitor

Everolimus

2009

59

Approved as Treatment by the FDA

Everolimus, also known as Afinitor, is approved by the FDA for 22 uses including Kidney Transplant Rejection and unresectable gastrointestinal origin Progressive Neuroendocrine Tumors .

Kidney Transplant Rejection

Used to treat Kidney Transplant Rejection in combination with Basiliximab

unresectable gastrointestinal origin Progressive Neuroendocrine Tumors

Subependymal giant cell astrocytoma, tuberous sclerosis complex

locally advanced lung origin Progressive Neuroendocrine Tumors

Tuberous Sclerosis

Neuroendocrine Tumors

Tuberous Sclerosis

Lung

metastatic lung origin Progressive Neuroendocrine Tumors

pancreatic origin Progressive Neuroendocrine Tumors

Liver Transplant Rejection

Used to treat Liver Transplant Rejection in combination with Tacrolimus

metastatic gastrointestinal origin Progressive Neuroendocrine Tumors

unresectable lung origin Progressive Neuroendocrine Tumors

locally advanced gastrointestinal origin Progressive Neuroendocrine Tumors

Advance Directives

Used to treat refractory, advanced Breast cancer in combination with Exemestane

Renal angiomyolipoma, tuberous sclerosis complex

refractory Advanced Renal Cell Carcinoma

Neuroendocrine Tumors

Neoplasm Metastasis

Neuroendocrine Tumors

Steroid therapy

Used to treat Steroid therapy in combination with Tacrolimus

Neuroendocrine Tumors

Effectiveness

How Zortress works in the body

Everolimus stops cells from multiplying by blocking the mTOR protein. This protein is responsible for helping cells grow and divide, but when blocked by everolimus, the cells cannot move forward with their growth. Everolimus also prevents cells from creating new blood vessels and using glucose for energy. As a result, cell multiplication and growth are significantly reduced.

When to interrupt dosage

The prescribed amount of Zortress is contingent upon the diagnosed condition, such as metastatic lung origin Progressive Neuroendocrine Tumors, Heart and Advance Directives. The amount of dosage may vary, depending on the method of delivery (e.g. Tablet or Oral) detailed in the table beneath.

Condition

Dosage

Administration

Advance Directives

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

Steroid therapy

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

Carcinoid Tumor

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

Tuberous Sclerosis

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

Tuberous Sclerosis

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

Waldenstrom Macroglobulinemia

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

refractory Advanced Renal Cell Carcinoma

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

Neoplasm Metastasis

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

Neuroendocrine Tumors

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

Neuroendocrine Tumors

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

pancreatic origin Progressive Neuroendocrine Tumors

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

Neuroendocrine Tumors

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

Lung

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

Neuroendocrine Tumors

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Zortress.

Common Zortress Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Everolimus is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Everolimus is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abemaciclib

Major

The serum concentration of Abemaciclib can be increased when it is combined with Everolimus.

Abetimus

Major

The risk or severity of adverse effects can be increased when Everolimus is combined with Abetimus.

Acteoside

Major

The risk or severity of adverse effects can be increased when Everolimus is combined with Acteoside.

Zortress Toxicity & Overdose Risk

The median dose of this drug required to inhibit cell growth is 0.63 nanomoles.

image of a doctor in a lab doing drug, clinical research

Zortress Novel Uses: Which Conditions Have a Clinical Trial Featuring Zortress?

16 active clinical trials are assessing the capacity of Zortress to mitigate locally advanced lung origin Progressive Neuroendocrine Tumors, advanced Carcinoid tumor and Cardiac disorders.

Condition

Clinical Trials

Trial Phases

pancreatic origin Progressive Neuroendocrine Tumors

0 Actively Recruiting

Steroid therapy

0 Actively Recruiting

Carcinoid Tumor

0 Actively Recruiting

Tuberous Sclerosis

0 Actively Recruiting

Advance Directives

0 Actively Recruiting

refractory Advanced Renal Cell Carcinoma

0 Actively Recruiting

Tuberous Sclerosis

0 Actively Recruiting

Neuroendocrine Tumors

0 Actively Recruiting

Neuroendocrine Tumors

0 Actively Recruiting

Neuroendocrine Tumors

0 Actively Recruiting

Neuroendocrine Tumors

0 Actively Recruiting

Waldenstrom Macroglobulinemia

0 Actively Recruiting

Neoplasm Metastasis

0 Actively Recruiting

Lung

0 Actively Recruiting

Zortress Reviews: What are patients saying about Zortress?

5

Patient Review

2/21/2011

Zortress for Prevent Kidney Transplant Rejection

I had some easy bruising, headaches, and fever; but nothing that was bad enough to make me stop taking the medication.

5

Patient Review

7/24/2020

Zortress for Prevention of Liver Transplant Rejection

So far, this drug regimen is working perfectly with no side effects. Blood tests look great!

3.7

Patient Review

4/26/2016

Zortress for Prevention of Liver Transplant Rejection

The packaging is my only issue with this product. It's very difficult to get the pills out, and it usually takes me close to an hour.

3.3

Patient Review

11/5/2018

Zortress for Prevention of Liver Transplant Rejection

I've found that the packaging is a bit of a pain, but I've learned to work around it. I cut along each pill from one end of the blister pack to the other and then use my thumb nail to remove each pill. It still takes some time, but it's much better than it was before.

3

Patient Review

10/10/2021

Zortress for Prevention of Liver Transplant Rejection

I had a liver transplant two years ago, and I've been having issues with urination and a runny nose. My doctor says that my labs are great, but I think the medication needs to be changed.

3

Patient Review

6/1/2016

Zortress for Prevention of Liver Transplant Rejection

I've been on this medication for six months, and I really don't like it. The packaging is very difficult to open if you have arthritis, and the side effects (ankle/leg swelling, headaches, increased blood pressure and glucose levels) are just too much for me.

2.3

Patient Review

7/25/2013

Zortress for Prevention of Liver Transplant Rejection

I bruise really easily and also had severe swelling in my lower extremities. Additionally, my sex drive suffered while taking this medication.

Patient Q&A Section about zortress

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is zortress an immunosuppressant?

"It works by slowing down the body's immune response.

Zortress prevents the body from rejecting a transplanted organ by slowing down the body's immune response."

Answered by AI

Is zortress the same as everolimus?

"Everolimus (Zortress) is an immunosuppressant drug used to prevent rejection in organ transplant patients. It is typically used in conjunction with other immunosuppressive drugs."

Answered by AI

What are the side effects of zortress?

"Common symptoms of COVID-19 include constipation, diarrhea, headache, nausea, vomiting, sores in the mouth/throat, swelling in your legs/ankles/feet, and tiredness."

Answered by AI

What is zortress used for?

"ZORTRESS is used to prevent the body from attacking a transplanted kidney or liver. This medicine is taken to prevent transplant rejection, which occurs when the body's immune system sees the new organ as a foreign object and attempts to destroy it."

Answered by AI