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What is Zortress
EverolimusThe Generic name of this drug
Treatment SummaryEverolimus is a drug related to sirolimus (Rapamycin) that works by blocking a protein called mTORC1. It is used to prevent organ rejection in transplant patients. Unlike other mTOR inhibitors, Everolimus only targets the mTORC1 protein and not the mTORC2 protein.
Afinitoris the brand name
Zortress Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Afinitor
Everolimus
2009
59
Approved as Treatment by the FDA
Everolimus, also known as Afinitor, is approved by the FDA for 12 uses including Lung and Tuberous Sclerosis .Lung
Tuberous Sclerosis
unresectable gastrointestinal origin Progressive Neuroendocrine Tumors
refractory Advanced Renal Cell Carcinoma
Advance Directives
Used to treat refractory, advanced Breast cancer in combination with Exemestane
Neoplasm Metastasis
Steroid therapy
Used to treat Steroid therapy in combination with Tacrolimus
Neuroendocrine Tumors
Tuberous Sclerosis
locally advanced lung origin Progressive Neuroendocrine Tumors
pancreatic origin Progressive Neuroendocrine Tumors
metastatic lung origin Progressive Neuroendocrine Tumors
Effectiveness
How Zortress works in the bodyEverolimus stops cells from multiplying by blocking the mTOR protein. This protein is responsible for helping cells grow and divide, but when blocked by everolimus, the cells cannot move forward with their growth. Everolimus also prevents cells from creating new blood vessels and using glucose for energy. As a result, cell multiplication and growth are significantly reduced.
When to interrupt dosage
The prescribed amount of Zortress is contingent upon the diagnosed condition, such as metastatic lung origin Progressive Neuroendocrine Tumors, Heart and Advance Directives. The amount of dosage may vary, depending on the method of delivery (e.g. Tablet or Oral) detailed in the table beneath.Condition
Dosage
Administration
Advance Directives
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Waldenstrom Macroglobulinemia
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
metastatic lung origin Progressive Neuroendocrine Tumors
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
pancreatic origin Progressive Neuroendocrine Tumors
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Tuberous Sclerosis
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Tuberous Sclerosis
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Neuroendocrine Tumors
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
unresectable gastrointestinal origin Progressive Neuroendocrine Tumors
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
refractory Advanced Renal Cell Carcinoma
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Steroid therapy
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
advanced Carcinoid tumor
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Lung
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Neoplasm Metastasis
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
locally advanced lung origin Progressive Neuroendocrine Tumors
2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg
, Tablet, for suspension, Oral, Tablet, for suspension - Oral, Tablet, Tablet - Oral
Warnings
There are 20 known major drug interactions with Zortress.Common Zortress Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Everolimus is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Everolimus is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Everolimus.
Abetimus
Major
The risk or severity of adverse effects can be increased when Everolimus is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Everolimus is combined with Acteoside.
Zortress Toxicity & Overdose RiskThe median dose of this drug required to inhibit cell growth is 0.63 nanomoles.
Zortress Novel Uses: Which Conditions Have a Clinical Trial Featuring Zortress?
16 active clinical trials are assessing the capacity of Zortress to mitigate locally advanced lung origin Progressive Neuroendocrine Tumors, advanced Carcinoid tumor and Cardiac disorders.Condition
Clinical Trials
Trial Phases
Steroid therapy
0 Actively Recruiting
Waldenstrom Macroglobulinemia
0 Actively Recruiting
advanced Carcinoid tumor
0 Actively Recruiting
metastatic lung origin Progressive Neuroendocrine Tumors
0 Actively Recruiting
Tuberous Sclerosis
0 Actively Recruiting
pancreatic origin Progressive Neuroendocrine Tumors
0 Actively Recruiting
Tuberous Sclerosis
0 Actively Recruiting
Advance Directives
0 Actively Recruiting
unresectable gastrointestinal origin Progressive Neuroendocrine Tumors
0 Actively Recruiting
Neoplasm Metastasis
0 Actively Recruiting
Neuroendocrine Tumors
0 Actively Recruiting
Lung
0 Actively Recruiting
refractory Advanced Renal Cell Carcinoma
0 Actively Recruiting
locally advanced lung origin Progressive Neuroendocrine Tumors
0 Actively Recruiting
Zortress Reviews: What are patients saying about Zortress?
5Patient Review
2/21/2011 I had some easy bruising, headaches, and fever; but nothing that was bad enough to make me stop taking the medication.
5Patient Review
7/24/2020 So far, this drug regimen is working perfectly with no side effects. Blood tests look great!
3.7Patient Review
4/26/2016 The packaging is my only issue with this product. It's very difficult to get the pills out, and it usually takes me close to an hour.
3.3Patient Review
11/5/2018 I've found that the packaging is a bit of a pain, but I've learned to work around it. I cut along each pill from one end of the blister pack to the other and then use my thumb nail to remove each pill. It still takes some time, but it's much better than it was before.
3Patient Review
10/10/2021 I had a liver transplant two years ago, and I've been having issues with urination and a runny nose. My doctor says that my labs are great, but I think the medication needs to be changed.
3Patient Review
6/1/2016 I've been on this medication for six months, and I really don't like it. The packaging is very difficult to open if you have arthritis, and the side effects (ankle/leg swelling, headaches, increased blood pressure and glucose levels) are just too much for me.
2.3Patient Review
7/25/2013 I bruise really easily and also had severe swelling in my lower extremities. Additionally, my sex drive suffered while taking this medication.
Patient Q&A Section about zortress
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is zortress an immunosuppressant?
"It works by slowing down the body's immune response.
Zortress prevents the body from rejecting a transplanted organ by slowing down the body's immune response."
Answered by AI
Is zortress the same as everolimus?
"Everolimus (Zortress) is an immunosuppressant drug used to prevent rejection in organ transplant patients. It is typically used in conjunction with other immunosuppressive drugs."
Answered by AI
What are the side effects of zortress?
"Common symptoms of COVID-19 include constipation, diarrhea, headache, nausea, vomiting, sores in the mouth/throat, swelling in your legs/ankles/feet, and tiredness."
Answered by AI
What is zortress used for?
"ZORTRESS is used to prevent the body from attacking a transplanted kidney or liver. This medicine is taken to prevent transplant rejection, which occurs when the body's immune system sees the new organ as a foreign object and attempts to destroy it."
Answered by AI