Zomig

Migraine, Cluster Headache, Liver + 1 more
Treatment
20 Active Studies for Zomig

What is Zomig

ZolmitriptanThe Generic name of this drug
Treatment SummaryZolmitriptan is a drug used to treat acute migraine headaches. It is part of a class of medications called triptans that work by stimulating serotonin receptors in the brain. Zolmitriptan was first approved by the FDA in 1997 and is available in a tablet or nasal spray form. It is commonly used together with a non-steroidal anti-inflammatory drug (NSAID) such as naproxen. Zolmitriptan is considered the gold standard for acute migraine treatment.
Zomigis the brand name
image of different drug pills on a surface
Zomig Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zomig
Zolmitriptan
1998
91

Effectiveness

How Zomig Affects PatientsZolmitriptan is a drug used to treat migraines. It works by activating certain serotonin receptors in the brain, which reduces symptoms of migraine. It can also cause narrowing of the blood vessels, which can lead to heart problems, stroke, and other dangerous side effects. Other potential side effects include chest, throat, neck, and jaw pain; medication overuse headaches; and serotonin syndrome. People with phenylketonuria should be aware that ZOMIG-ZMT contains phenylalanine.
How Zomig works in the bodyMigraines are intense headaches that can come with other symptoms like sensitivity to light and sound. The cause of migraines is not fully understood, but it involves both the nervous system and blood vessels in the head. Triptans, including zolmitriptan, work to reduce migraine symptoms in three ways. They help block pain signals in the brain and reduce blood vessel dilation and release of a peptide that widens blood vessels. Triptans also act on serotonin receptors to help reduce pain and possibly limit the spread of a wave of depolarization in the brain that may contribute to migraine.

When to interrupt dosage

The proposed dosage of Zomig is contingent upon the determined condition, for example Cluster Headache, Migraine and moderate to severe hepatic impairment. The amount of dosage is subject to the delivery system (e.g. Spray, metered - Nasal or Tablet, multilayer, extended release - Oral) featured in the table beneath.
Condition
Dosage
Administration
Migraine Disorders
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Migraine
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Cluster Headache
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Liver
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal

Warnings

Zomig has fourteen contraindications and should not be concomitantly taken with the conditions presented in the following table.Zomig Contraindications
Condition
Risk Level
Notes
Coronary Vasospasm
Do Not Combine
cardiac accessory conduction pathway disorders
Do Not Combine
Basilar-Type Migraine
Do Not Combine
Stroke
Do Not Combine
Peripheral Vascular Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Coronary Artery Disease
Do Not Combine
Transient Ischemic Attack
Do Not Combine
Wolff-Parkinson-White Syndrome
Do Not Combine
Hypertensive disease
Do Not Combine
Pulse Frequency
Do Not Combine
intestinal ischemia
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Zolmitriptan may interact with Pulse Frequency
There are 20 known major drug interactions with Zomig.
Common Zomig Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Zolmitriptan may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Zolmitriptan may increase the serotonergic activities of Mirtazapine.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Zolmitriptan is combined with Oliceridine.
Zomig Toxicity & Overdose RiskNot much is known about the toxicity of zolmitriptan, but an overdose can lead to serious side effects such as changes in the cardiovascular system and excessive narrowing of the blood vessels. Patients who take a single 50mg dose of zolmitriptan may also feel drowsy. If someone overdoses on zolmitriptan, they should receive medical attention and supportive care.
image of a doctor in a lab doing drug, clinical research

Zomig Novel Uses: Which Conditions Have a Clinical Trial Featuring Zomig?

At present, 65 active clinical trials are being conducted to evaluate the potential of Zomig to ameliorate moderate or severe hepatic impairment, Cluster Headache and Migraine Disorders.
Condition
Clinical Trials
Trial Phases
Liver
0 Actively Recruiting
Migraine Disorders
0 Actively Recruiting
Migraine
52 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Cluster Headache
3 Actively Recruiting
Phase 1, Phase 2

Zomig Reviews: What are patients saying about Zomig?

5Patient Review
2/20/2009
Zomig for Migraine Headache
This drug has been an incredible help for my migraines. I get relief from headaches within 30-60 minutes of taking the pill, which is a vast improvement from how long it used to take me. The only downside is that I usually run out of pills before the end of the month.
5Patient Review
6/12/2009
Zomig for Migraine Headache
This drug is amazing! I've been suffering from migraines since I was 8 years old, and this is the first treatment that has really helped. I only have to take it once every 24 hours, and it completely eliminates my migraine pain as well as any neck or shoulder pain I might be experiencing. It's a miracle drug, and I absolutely love it!
5Patient Review
10/8/2009
Zomig for Migraine Headache
I've been using Zomig for migraines for about seven years now. The only side effects I ever experienced were a weight on my chest and some lightheadedness. Unfortunately, the price of this medication caused my insurance rates to go up; however, I found Cafergot to be just as effective and much cheaper, so I switched.
5Patient Review
10/8/2009
Zomig for Migraine Headache
This medication is perfect for me as a busy mom and daycare provider. I can take it at the start of a migraine, continue to work, then get relief later on without having to re-medicate.
5Patient Review
3/30/2009
Zomig for Migraine Headache
This drug has been incredibly effective in treating my migraines with no negative side effects that I know of.
View All Reviews

Patient Q&A Section about zomig

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Zomig an opioid?

"Zomig is a drug used to treat pain from migraines, but it is not a narcotic."

Answered by AI

How does Zomig make you feel?

"Zolmitriptan is a type of medication that is designed to work by narrowing the blood vessels around the brain, stop pain signals from being sent to the brain, and block the release of certain natural substances that are known to cause pain, nausea, and other symptoms related to migraines."

Answered by AI

What is Zomig used for?

"This medication is used to treat migraines. It helps to relieve headache, pain, and other migraine symptoms including nausea, vomiting, and sensitivity to light and sound. Prompt treatment with this medication can help you return to your normal routine and may decrease your need for other pain medications."

Answered by AI

Is Zomig good for migraines?

"Zolmitriptan is a drug that is used to relieve the symptoms of a migraine headache. These symptoms can include nausea, vomiting, sensitivity to light, and sensitivity to sound. Zolmitriptan is not a regular pain reliever and should only be used to relieve the pain of a migraine headache."

Answered by AI

Clinical Trials for Zomig

Have you considered Zomig clinical trials? We made a collection of clinical trials featuring Zomig, we think they might fit your search criteria.
Have you considered Zomig clinical trials? We made a collection of clinical trials featuring Zomig, we think they might fit your search criteria.
Have you considered Zomig clinical trials? We made a collection of clinical trials featuring Zomig, we think they might fit your search criteria.
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