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What is Zomig
ZolmitriptanThe Generic name of this drug
Treatment SummaryZolmitriptan is a drug used to treat acute migraine headaches. It is part of a class of medications called triptans that work by stimulating serotonin receptors in the brain. Zolmitriptan was first approved by the FDA in 1997 and is available in a tablet or nasal spray form. It is commonly used together with a non-steroidal anti-inflammatory drug (NSAID) such as naproxen. Zolmitriptan is considered the gold standard for acute migraine treatment.
Zomigis the brand name
Zomig Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zomig
Zolmitriptan
1998
91
Effectiveness
How Zomig Affects PatientsZolmitriptan is a drug used to treat migraines. It works by activating certain serotonin receptors in the brain, which reduces symptoms of migraine. It can also cause narrowing of the blood vessels, which can lead to heart problems, stroke, and other dangerous side effects. Other potential side effects include chest, throat, neck, and jaw pain; medication overuse headaches; and serotonin syndrome. People with phenylketonuria should be aware that ZOMIG-ZMT contains phenylalanine.
How Zomig works in the bodyMigraines are intense headaches that can come with other symptoms like sensitivity to light and sound. The cause of migraines is not fully understood, but it involves both the nervous system and blood vessels in the head. Triptans, including zolmitriptan, work to reduce migraine symptoms in three ways. They help block pain signals in the brain and reduce blood vessel dilation and release of a peptide that widens blood vessels. Triptans also act on serotonin receptors to help reduce pain and possibly limit the spread of a wave of depolarization in the brain that may contribute to migraine.
When to interrupt dosage
The proposed dosage of Zomig is contingent upon the determined condition, for example Cluster Headache, Migraine and moderate to severe hepatic impairment. The amount of dosage is subject to the delivery system (e.g. Spray, metered - Nasal or Tablet, multilayer, extended release - Oral) featured in the table beneath.Condition
Dosage
Administration
Migraine
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Liver
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Migraine Disorders
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Cluster Headache
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Warnings
Zomig has fourteen contraindications and should not be concomitantly taken with the conditions presented in the following table.Zomig ContraindicationsCondition
Risk Level
Notes
Coronary Artery Vasospasm
Do Not Combine
cardiac accessory conduction pathway disorders
Do Not Combine
Basilar-Type Migraine
Do Not Combine
history of stroke
Do Not Combine
Peripheral Vascular Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Coronary Artery Disease
Do Not Combine
Transient Ischemic Attack
Do Not Combine
Wolff-Parkinson-White Syndrome
Do Not Combine
Hypertensive disease
Do Not Combine
Pulse Frequency
Do Not Combine
intestinal ischemia
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Zolmitriptan may interact with Pulse Frequency
Common Zomig Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Zolmitriptan may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Zolmitriptan may increase the serotonergic activities of Mirtazapine.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Zolmitriptan is combined with Oliceridine.
Zomig Toxicity & Overdose RiskNot much is known about the toxicity of zolmitriptan, but an overdose can lead to serious side effects such as changes in the cardiovascular system and excessive narrowing of the blood vessels. Patients who take a single 50mg dose of zolmitriptan may also feel drowsy. If someone overdoses on zolmitriptan, they should receive medical attention and supportive care.
Zomig Novel Uses: Which Conditions Have a Clinical Trial Featuring Zomig?
At present, 65 active clinical trials are being conducted to evaluate the potential of Zomig to ameliorate moderate or severe hepatic impairment, Cluster Headache and Migraine Disorders.Condition
Clinical Trials
Trial Phases
Cluster Headache
4 Actively Recruiting
Phase 1, Phase 3, Phase 2
Migraine Disorders
0 Actively Recruiting
Liver
0 Actively Recruiting
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Zomig Reviews: What are patients saying about Zomig?
5Patient Review
2/20/2009 This drug has been an incredible help for my migraines. I get relief from headaches within 30-60 minutes of taking the pill, which is a vast improvement from how long it used to take me. The only downside is that I usually run out of pills before the end of the month.
5Patient Review
6/12/2009 This drug is amazing! I've been suffering from migraines since I was 8 years old, and this is the first treatment that has really helped. I only have to take it once every 24 hours, and it completely eliminates my migraine pain as well as any neck or shoulder pain I might be experiencing. It's a miracle drug, and I absolutely love it!
5Patient Review
10/8/2009 I've been using Zomig for migraines for about seven years now. The only side effects I ever experienced were a weight on my chest and some lightheadedness. Unfortunately, the price of this medication caused my insurance rates to go up; however, I found Cafergot to be just as effective and much cheaper, so I switched.
5Patient Review
10/8/2009 This medication is perfect for me as a busy mom and daycare provider. I can take it at the start of a migraine, continue to work, then get relief later on without having to re-medicate.
5Patient Review
3/30/2009 This drug has been incredibly effective in treating my migraines with no negative side effects that I know of.
5Patient Review
4/17/2012 Zomig is the only migraine medication that has ever worked for me, so I'm willing to put up with a few side effects. These include increased sensitivity to temperature changes (especially when washing my hands), feeling cold, and jaw pain after eating or drinking.
5Patient Review
1/24/2013 This drug definitely works for me, it's a life saver! The only side effects it gives me is drowsiness, I feel kind if "loopy" afterwards so I can't really drive. It also can make me hyper and I feel the muscles in my neck and shoulders tense up.
5Patient Review
9/10/2015 Zomig ZMT has been a life-saver for me. It works incredibly fast, and I haven't experienced any negative side effects.
5Patient Review
4/1/2010 Though it comes with some drowsy and sensitive side effects, this is the only medication that has worked for me in terms of migraine relief.
5Patient Review
10/4/2009 This drug is essential for me to be able to function. It prevents migraines from occurring every 18 hours.
5Patient Review
11/10/2008 Zomig is the only drug I've taken that has been able to completely get rid of a migraine immediately.
5Patient Review
12/9/2014 Zomig has been effective for me about 75% of the time, which is a huge relief. I know that if I don't take it in time though, I'm in for a few very miserable days.
5Patient Review
12/7/2010 After trying many other migraine medications I finally found "THE ONE"! Side effects for me are so minor not worth mentioning. Bye-bye migraines!
5Patient Review
1/6/2012 I've been taking this medication for years and it really works well for me. I do have a few side effects, like joint pain, but it's worth it to me because it prevents migraines.
5Patient Review
4/17/2012 Zomig is the only migraine medication that has ever worked for me. While there are some listed side effects that I experience, such as sensitivity to heat/cold and jaw aches, they are well worth it because this drug always stops my migraines.
5Patient Review
12/9/2014 Zomig is effective for me about 75% of the time, as long as I take it early enough. If not, I have to suffer through migraines for three or four days straight, which includes nonstop vomiting and incredible pain that makes it hard to eat, drink, or even move. The pills that dissolve work best for me since I end up throwing everything else up.
5Patient Review
1/24/2013 This drug is really effective for me, and the side effects are manageable. The drowsiness it causes can be a bit much, but it's worth it to not have anxiety attacks.
5Patient Review
9/10/2015 Zomig ZMT has been my go-to for many years. It works faster than the tabs, with no side effects. I've tried all sorts of medication for migraines, and this is by far the best one.
5Patient Review
2/20/2009 This drug is an incredible help for migraines. I've suffered from them for over a decade, and this medication eliminates the pain within half an hour to an hour. The only issue I have is that my prescription only allows me to have 9 pills per month, and I usually need more than that.
5Patient Review
10/4/2009 This drug is essential for me to be able to function. It keeps migraines at bay if I take it every 18 hours.
5Patient Review
11/10/2008 Zomig is the only drug I've found that can completely get rid of a migraine immediately.
5Patient Review
10/8/2009 I've been taking this medication for seven years to manage chronic migraines. The weight on my chest and dizziness were the only side-effects I experienced. However, the rates for my insurance went up because of how expensive the medication is. I then tried Cafergot as an alternative and had good success with it; plus, it's cheaper which is great.
5Patient Review
4/1/2010 Though it comes with some mild side effects for me, this medication is the only one that has worked to relieve my migraines.
5Patient Review
12/7/2010 After trying many other migraine medications, I found one that finally worked for me! The side effects are so minor that they're not worth mentioning. Goodbye migraines!
5Patient Review
8/27/20085Patient Review
9/8/20085Patient Review
8/27/20085Patient Review
9/8/20085Patient Review
3/30/2009 This drug is incredibly effective at treating migraines with no know side effects.
5Patient Review
6/12/2009 This drug has been a complete game changer for me. I've had migraines since I was a child, and this is the first medication that has really helped to eliminate them. Not only does it get rid of the migraine itself, but it also helps with the neck and shoulder pain I have from an old work injury. I highly recommend it!
5Patient Review
10/8/2009 This medication is perfect for me as a busy mom and daycare provider. I can take it at the start of a migraine and be able to continue working without having to medicate, then lay down in a quiet room to get relief.
5Patient Review
1/6/2012 I've been taking this medication for a while now and I really appreciate it. It has some side effects, like making my joints hurt, but that's better than the migraines!
4.7Patient Review
12/22/2009 This medication is excellent and always effective for me. However, an interesting side effect is that my finger tips and toes become very sensitive to hot water for several hours afterwards.
4.7Patient Review
12/22/2009 This medication is excellent and it always works for me. The only interesting side-effect I've noticed is that my fingers and toes become very sensitive to hot water for a few hours after taking it.
4.3Patient Review
10/23/2008 I would definitely recommend this to anyone who suffers from migraines. I'm the kind of person whose body quickly adapts to medications, so I've tried Imitrex and Maxalt among other meds-- but they all stopped working after a few treatments. Zomig ZMT has been wonderful for me for a few years now; it really helps with the pain and the side effects are much better than dealing with a migraine itself. I make sure to keep one in my purse, desk, and travel bag just in case I need it while I'm out and about.
4.3Patient Review
10/23/2008 I would recommend this to anyone who knows the pain of migraines. I find that it works better than other medications I've tried, and the side effects are more manageable than the migraine itself.
Patient Q&A Section about zomig
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Zomig an opioid?
"Zomig is a drug used to treat pain from migraines, but it is not a narcotic."
Answered by AI
How does Zomig make you feel?
"Zolmitriptan is a type of medication that is designed to work by narrowing the blood vessels around the brain, stop pain signals from being sent to the brain, and block the release of certain natural substances that are known to cause pain, nausea, and other symptoms related to migraines."
Answered by AI
What is Zomig used for?
"This medication is used to treat migraines. It helps to relieve headache, pain, and other migraine symptoms including nausea, vomiting, and sensitivity to light and sound. Prompt treatment with this medication can help you return to your normal routine and may decrease your need for other pain medications."
Answered by AI
Is Zomig good for migraines?
"Zolmitriptan is a drug that is used to relieve the symptoms of a migraine headache. These symptoms can include nausea, vomiting, sensitivity to light, and sensitivity to sound. Zolmitriptan is not a regular pain reliever and should only be used to relieve the pain of a migraine headache."
Answered by AI