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What is Zoledronic
Zoledronic acidThe Generic name of this drug
Treatment SummaryZoledronic acid, also known as CGP 42'446, is a medication used to prevent and treat osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone. It was first described in 1994 and approved by the FDA in 2001. Zoledronic acid is similar to other drugs such as ibandronic acid, minodronic acid, and risedronic acid.
Zometais the brand name
Zoledronic Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zometa
Zoledronic acid
2001
53
Effectiveness
How Zoledronic Affects PatientsZoledronic acid is a drug that helps prevent bone loss. It is safe to use, with few side effects, and produces long-lasting effects. However, there are some risks associated with taking this drug that patients should be aware of, such as electrolyte deficiencies, kidney damage, jawbone loss, unusual thigh fractures, breathing difficulties, liver problems, low calcium levels, and risks for pregnant women.
How Zoledronic works in the bodyBisphosphonates are taken into the bone, where they bind to substances that help the body break down the bone. Osteoclasts, which are responsible for breaking down the bone, then absorb bisphosphonates. These molecules cause the osteoclasts to detach from bones, preventing further bone resorption. Additionally, nitrogen-containing bisphosphonates like zoledronate are thought to cause tumor cells to die off by blocking certain proteins from forming. This leads to cell death and apoptosis.
When to interrupt dosage
The amount of Zoledronic is based on the identified affliction, including Bone Mineral Density, Paget’s Disease and Osteoporosis caused by glucocorticoid. The quantity fluctuates as per the method of delivery, as indicated in the table beneath.Condition
Dosage
Administration
Bone Metastases
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Malignant Neoplasms
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Glucocorticoids
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Multiple Myeloma
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Chemotherapy
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Paget's Disease of Bone
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Osteoporosis caused by glucocorticoid
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Disease
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Males with low bone mineral density
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Postmenopause
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Paget’s Disease
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Bone Mineral Density
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Osteoporosis
, 0.05 mg/mL, 4.0 mg/mL, 4.0 mg, 5.0 mg, 0.04 mg/mL, 0.8 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Kit, Injection, Injection - Intravenous, Solution, Solution - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous
Warnings
Zoledronic has four contraindications and must not be employed when encountering any of the disorders listed in the following table.Zoledronic ContraindicationsCondition
Risk Level
Notes
creatinine clearance less than 35 mL/min
Do Not Combine
Hypocalcemia
Do Not Combine
evidence of acute renal impairment
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Zoledronic Acid may interact with Pulse Frequency
Common Zoledronic Drug Interactions
Drug Name
Risk Level
Description
Alendronic acid
Minor
The risk or severity of adverse effects can be increased when Zoledronic acid is combined with Alendronic acid.
Clodronic acid
Minor
The risk or severity of adverse effects can be increased when Zoledronic acid is combined with Clodronic acid.
Etidronic acid
Minor
The risk or severity of adverse effects can be increased when Zoledronic acid is combined with Etidronic acid.
Ibandronate
Minor
The risk or severity of adverse effects can be increased when Zoledronic acid is combined with Ibandronate.
Incadronic acid
Minor
The risk or severity of adverse effects can be increased when Zoledronic acid is combined with Incadronic acid.
Zoledronic Toxicity & Overdose RiskOverdosing on this drug may lead to problems with the kidneys, calcium, phosphorus, and magnesium levels in the body. Treatment for overdose involves giving the patient the missing ions through an intravenous injection.
Zoledronic Novel Uses: Which Conditions Have a Clinical Trial Featuring Zoledronic?
320 active studies are currently being conducted to explore the potential of Zoledronic acid in mitigating Osteoporosis, Malignant Neoplasms and Solid Tumors.Condition
Clinical Trials
Trial Phases
Multiple Myeloma
12 Actively Recruiting
Phase 2, Phase 1
Bone Mineral Density
2 Actively Recruiting
Not Applicable
Postmenopause
5 Actively Recruiting
Phase 2, Not Applicable
Chemotherapy
2 Actively Recruiting
Not Applicable
Males with low bone mineral density
0 Actively Recruiting
Paget's Disease of Bone
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Paget’s Disease
0 Actively Recruiting
Bone Metastases
8 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 3
Osteoporosis
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3
Disease
5 Actively Recruiting
Not Applicable, Early Phase 1
Glucocorticoids
0 Actively Recruiting
Osteoporosis caused by glucocorticoid
0 Actively Recruiting
Zoledronic Reviews: What are patients saying about Zoledronic?
5Patient Review
11/30/2021 I'm going in for my third infusion soon and have been really happy with the results. My bone density has improved, which is great considering my mom's osteoporosis. I haven't had any negative side effects so far, so I would definitely recommend this treatment to others.
5Patient Review
11/30/2021 I'm going in for my third infusion of this treatment soon, and it has been working great for me. I've had no side effects and it has improved my bone density significantly. My mother's hip broke due to her osteoporosis, so I'm grateful that this is helping me avoid the same fate.
3.3Patient Review
9/12/2016 Ever since I started this monthly treatment, I've been having eye pain. It's only above my left eye, and it lasts for about a week each time. I have to take aspirins and Benadryl to make it go away. From what I can tell, this is a rare side effect of the medication, but it's still really frustrating.
3.3Patient Review
9/12/2016 I've been on this monthly treatment since August 2016. Each time, I end up with a throbbing pain above my left eye that lasts for six days, no matter how many aspirins or Benadryls I take. From what I can tell, this is a rare side effect of the medication; however, the treatment is supposed to last for three years. Here's hoping it clears up soon.
2.7Patient Review
3/10/2022 I'm early on in the treatment process, but I had a severe reaction that caused flu-like symptoms and intense body aches that have lasted for over a week. I hope this isn't indicative of how the rest of the treatment will go, as the pain has been unbearable at times.
2.7Patient Review
9/16/2022 After being diagnosed with primary osteoporosis following a series of rib fractures, I received my first dose of zoledronic acid 18 hours ago. Unfortunately, it feels like all of my fractures have re-broken and I am in a great deal of pain.
2.7Patient Review
3/10/2022 I'm early on in the treatment, but I had a bad reaction that gave me flu-like symptoms: sickness and severe aches primarily in my upper body. It's been over a week and I'm still not feeling better. This was injected for bone marrow edema--I really hope the side effects don't continue because they're quite debilitating.
2.7Patient Review
9/16/2022 I was diagnosed with primary osteoporosis a few months ago after suffering from multiple rib fractures. I received my first dose of zoledronic acid 18 hours ago, and now feel like every fracture is broken again. This is terrible.
1.7Patient Review
10/6/2022 I've only had this treatment three days ago, so I can't yet speak to its efficacy. However, the pain it has caused me is unlike anything I've ever experienced. It feels as if someone is inside my skeleton, scraping at it with a knife. I can hardly stand, let alone walk. The doctors say to take paracetamol—I must be experiencing some sort of rare reaction if that's their suggestion. Thankfully, I found this website and saw that others have had similar experiences.
1.7Patient Review
10/6/2022 I can't speak to the efficacy of this treatment yet, but I can say that the pain is unbearable. It feels like someone is stabbing me in my bones. I haven't been able to walk since beginning this treatment and doctors just tell me to take acetaminophen-- as if that's going to help! Thankful to find others with similar experiences online.
1Patient Review
3/23/2019 This is the worst drug I've ever taken. Four months later and I'm still in pain. This caused ringing in my ears and problems with my bones. My arthritis flared up immediately after taking this, and I'm still suffering from it. I wish I'd never taken it.
1Patient Review
12/7/2018 Do not take this drug. I was hospitalized just five days after receiving the infusion, due to a high fever and body aches. It's now December and I'm still feeling the effects of this terrible medication.
1Patient Review
11/12/2022 I received this treatment and, that night, I was in a great deal of pain. I also developed a kidney infection which required antibiotics to clear up. Even after two weeks, I'm still not feeling well. I urge you to avoid this treatment if possible.
1Patient Review
3/23/2019 This is by far the worst drug I've ever taken. I'm four months in and still experiencing a range of awful side effects, including but not limited to tinnitus and problems with my bones in my ears. The company tried telling me it was caused by smoking, which is absolute rubbish – it happened immediately after the infusion. They don't seem to care about the long-term risks of this treatment; all they care about is making money. This has destroyed me.
1Patient Review
11/12/2022 I ended up with a kidney infection after this treatment that left me feeling exhausted and in pain for weeks. I wouldn't recommend it to anyone.
1Patient Review
12/7/2018 Do not take this drug! I was hospitalized just five days after receiving the infusion. I had a fever of 104, couldn't walk or breathe, and my entire body ached. It's now December 7th and I'm STILL experiencing side effects.
Patient Q&A Section about zoledronic
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the side effect of zoledronic acid?
"The most common adverse effect associated with zoledronic acid infusion is fever. Sometimes people also report feeling like they have the flu, including fever, chills, bone pain, and/or joint pain and muscle pain. These symptoms usually go away within 24 to 48 hours and don't usually require treatment."
Answered by AI
Is zoledronic acid a form of chemotherapy?
"Zoledronic acid is not a cancer chemotherapy, and will not slow or stop the spread of cancer, but can be used to treat bone disease in cancer patients. It is a medication in the class of bisphosphonates."
Answered by AI
What is the drug zoledronic used for?
"Zoledronic acid injection is used to treat hypercalcemia by helping to reduce the levels of calcium in the blood in patients with some types of cancer."
Answered by AI
What is a zoledronic infusion?
"Aclasta is an osteoporosis medication prescribed to help strengthen your bones and reduce your risk of breaking a bone. Zoledronic acid, the active ingredient in Aclasta, is a 'bisphosphonate' - a group of medications that work by slowing down the cells that break down bone. Aclasta is available as an annual intravenous infusion (drip)."
Answered by AI