Zenatane

Sezary Syndrome, Acne Vulgaris, Acne Conglobata + 4 more

Treatment

11 Active Studies for Zenatane

What is Zenatane

Isotretinoin

The Generic name of this drug

Treatment Summary

Isotretinoin is a type of vitamin A used to treat severe acne. It was previously sold under the brand name Accutane, but is now only available in the United States through a special program called iPLEDGE. The drug was approved by the FDA in 1982 and can have serious side effects during pregnancy.

Accutane

is the brand name

image of different drug pills on a surface

Zenatane Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Accutane

Isotretinoin

1982

78

Effectiveness

How Zenatane Affects Patients

It is not clearly understood how isotretinoin works in the body.

How Zenatane works in the body

Isotretinoin works by manipulating cells to stop the production of sebum and block pores. It also helps to reduce the size of sebum ducts and make the area less hospitable for acne-causing bacteria. It may also increase immune responses and reduce inflammation. The exact way that it works is not fully understood, but there is some evidence that it interacts with FoxO1, which could explain a lot of its effects.

When to interrupt dosage

The recommended measure of Zenatane is contingent upon the diagnosed affliction, such as Acne conglobata, Acne Vulgaris and Pregnancy. The dosage varies as per the technique of delivery (e.g. Capsule - Oral or Capsule) displayed in the table beneath.

Condition

Dosage

Administration

Sezary Syndrome

, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg

Oral, Capsule, , Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Gel, Gel - Topical, Topical

Acne Conglobata

, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg

Oral, Capsule, , Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Gel, Gel - Topical, Topical

Rosacea

, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg

Oral, Capsule, , Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Gel, Gel - Topical, Topical

Acne Vulgaris

, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg

Oral, Capsule, , Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Gel, Gel - Topical, Topical

Neuroblastoma

, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg

Oral, Capsule, , Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Gel, Gel - Topical, Topical

Mycosis Fungoides

, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg

Oral, Capsule, , Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Gel, Gel - Topical, Topical

Acne Vulgaris

, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg

Oral, Capsule, , Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Gel, Gel - Topical, Topical

Warnings

Zenatane has five contraindications and should not be blended with the circumstances specified in the following table.

Zenatane Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Isotretinoin may interact with Pulse Frequency

Carcinoma, Basal Cell

Do Not Combine

Squamous cell carcinoma

Do Not Combine

history of squamous cell

Do Not Combine

family history of basal cell carcinoma

Do Not Combine

There are 20 known major drug interactions with Zenatane.

Common Zenatane Drug Interactions

Drug Name

Risk Level

Description

Clomocycline

Major

The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Clomocycline.

Demeclocycline

Major

The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Demeclocycline.

Doxycycline

Major

The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Doxycycline.

Eravacycline

Major

The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Eravacycline.

Metacycline

Major

The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Metacycline.

Zenatane Toxicity & Overdose Risk

Overdosing on Isotretinoin can cause vomiting, facial flushing, cracked lips, abdominal pain, headache, dizziness, and lack of coordination. Children may experience toxicity with doses as low as 30mg/kg, while men and women may experience it with 24mg/kg and 56mg/kg respectively. In animal studies, Isotretinoin has been linked to an increased risk of cancer and abnormal growth in the adrenal glands when taken in high doses. It has also been associated with testicular atrophy in dogs. No effects were seen in humans on sperm count or other reproductive measures.

Zenatane Novel Uses: Which Conditions Have a Clinical Trial Featuring Zenatane?

At present, 65 clinical trials are being conducted to assess the potential of Zenatane in alleviating Rosacea, Neuroblastoma (NB) and Acne conglobata.

Condition

Clinical Trials

Trial Phases

Mycosis Fungoides

0 Actively Recruiting

Sezary Syndrome

9 Actively Recruiting

Phase 2, Phase 1

Rosacea

2 Actively Recruiting

Early Phase 1, Phase 2

Acne Vulgaris

0 Actively Recruiting

Acne Conglobata

0 Actively Recruiting

Acne Vulgaris

0 Actively Recruiting

Neuroblastoma

0 Actively Recruiting

Zenatane Reviews: What are patients saying about Zenatane?

5

Patient Review

4/8/2016

Zenatane for Severe Difficult to Treat Nodular Acne

I started seeing results within a few days, though it did come with some dry skin. Carrying chapstick and moisturizer helped a lot.

5

Patient Review

3/16/2017

Zenatane for Severe Difficult to Treat Nodular Acne

I'm really disappointed that this manufacturer is discontinuing this product. I tried Absorica and Claravis, but they were too strong and gave me nose bleeds. Zenatane didn't have that problem.

5

Patient Review

9/12/2016

Zenatane for Severe Difficult to Treat Nodular Acne

I saw a significant improvement in my acne after just one month of using Zenatane, and by the fourth month it was completely gone.

5

Patient Review

1/18/2016

Zenatane for Severe Difficult to Treat Nodular Acne

It can be tough to go through the treatment process, but it's worth it in the end.

5

Patient Review

10/29/2014

Zenatane for Severe Difficult to Treat Nodular Acne

I'm really glad my doctor recommended this to me. It's the best thing I've ever tried for my acne!

5

Patient Review

8/16/2015

Zenatane for Severe Difficult to Treat Nodular Acne

I had been struggling with acne for years, trying oral and topical antibiotics to no avail. When I started this treatment, it was very harsh on my skin for the first month or so; however, my dermatologist prescribed a steroid to help me through that tough transition period. Now, four months in, my skin is finally starting to clear up and I couldn't be happier!

4.7

Patient Review

7/10/2014

Zenatane for Severe Difficult to Treat Nodular Acne

4.3

Patient Review

5/3/2015

Zenatane for Severe Difficult to Treat Nodular Acne

I'm really hoping that this treatment will help with my dry skin. So far, it's been alright but I haven't seen the full effects yet.

4

Patient Review

7/13/2013

Zenatane for Severe Difficult to Treat Nodular Acne

3

Patient Review

9/8/2014

Zenatane for Severe Difficult to Treat Nodular Acne

I had struggled with acne for my entire life before trying this treatment. It was a long six months, but it completely cleared up my skin. I would definitely recommend it to others who are struggling with similar issues.

3

Patient Review

6/12/2013

Zenatane for Severe Difficult to Treat Nodular Acne

1.7

Patient Review

10/12/2016

Zenatane for Severe Difficult to Treat Nodular Acne

I've been taking this medication for five months now with no positive changes.

1

Patient Review

1/1/2016

Zenatane for Severe Difficult to Treat Nodular Acne

Three weeks in and I've got to say, my lips have never been drier. They feel raw and almost sandpapery. Not sure how much longer I can take this.

1

Patient Review

2/9/2016

Zenatane for Severe Difficult to Treat Nodular Acne

I only took this medication for three days. Almost immediately after taking the first dose, I felt incredibly thirsty and developed muscle and joint pain.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about zenatane

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Accutane the same as Zenatane?

"Zenatane, a medication similar to Accutane, is only able to be marketed under a specific restricted distribution program (iPLEDGE) that has been approved by the Food and Drug Administration (FDA). This is because Zenatane can cause severe birth defects."

Answered by AI

What is the generic drug for Zenatane?

"Isotretinoin is a drug used to treat severe acne that has not responded to other therapy such as antibiotics. It is more expensive than other acne treatments."

Answered by AI

Is Zenatane an antibiotic?

"Zenatane is a form of vitamin A that is used to treat severe acne that has not responded to other treatments, including antibiotics."

Answered by AI

What is Zenatane used for?

"This medication is used to treat severe cystic acne that has not responded to other treatment. It belongs to a class of drugs known as retinoids."

Answered by AI

Clinical Trials for Zenatane

Have you considered Zenatane clinical trials?

We made a collection of clinical trials featuring Zenatane, we think they might fit your search criteria.
Go to Trials

Have you considered Zenatane clinical trials?

We made a collection of clinical trials featuring Zenatane, we think they might fit your search criteria.
Go to Trials
Image of Los Angeles County-USC Medical Center in Los Angeles, United States.

Talimogene Laherparepvec + Nivolumab for Skin Cancer and Lymphoma

18+
All Sexes
Los Angeles, CA

This phase II trial studies how well talimogene laherparepvec and nivolumab work in treating patients with lymphomas that do not responded to treatment (refractory) or non-melanoma skin cancers that have spread to other places in the body (advanced) or do not responded to treatment. Biological therapies, such as talimogene laherparepvec, use substances made from living organisms that may stimulate or suppress the immune system in different ways and stop tumor cells from growing. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving talimogene laherparepvec and nivolumab may work better compared to usual treatments in treating patients with lymphomas or non-melanoma skin cancers.

Phase 2
Waitlist Available

Los Angeles County-USC Medical Center (+40 Sites)

Ann (Annie) W Silk