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What is Zenatane
IsotretinoinThe Generic name of this drug
Treatment SummaryIsotretinoin is a type of vitamin A used to treat severe acne. It was previously sold under the brand name Accutane, but is now only available in the United States through a special program called iPLEDGE. The drug was approved by the FDA in 1982 and can have serious side effects during pregnancy.
Accutaneis the brand name
Zenatane Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Accutane
Isotretinoin
1982
78
Effectiveness
How Zenatane Affects PatientsIt is not clearly understood how isotretinoin works in the body.
How Zenatane works in the bodyIsotretinoin works by manipulating cells to stop the production of sebum and block pores. It also helps to reduce the size of sebum ducts and make the area less hospitable for acne-causing bacteria. It may also increase immune responses and reduce inflammation. The exact way that it works is not fully understood, but there is some evidence that it interacts with FoxO1, which could explain a lot of its effects.
When to interrupt dosage
The recommended measure of Zenatane is contingent upon the diagnosed affliction, such as Acne conglobata, Acne Vulgaris and Pregnancy. The dosage varies as per the technique of delivery (e.g. Capsule - Oral or Capsule) displayed in the table beneath.Condition
Dosage
Administration
Sezary Syndrome
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
refractory Acne vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Rosacea
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Vulgaris
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
early Mycosis Fungoides (MF)
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Neuroblastoma (NB)
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Acne Conglobata
, 10.0 mg, 20.0 mg, 40.0 mg, 30.0 mg, 0.05 %, 25.0 mg, 35.0 mg, 8.0 mg, 24.0 mg, 28.0 mg, 16.0 mg, 32.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Topical, Gel, Gel - Topical
Warnings
Zenatane has five contraindications and should not be blended with the circumstances specified in the following table.Zenatane ContraindicationsCondition
Risk Level
Notes
history of basal cell carcinoma
Do Not Combine
Squamous cell carcinoma
Do Not Combine
history of squamous cell
Do Not Combine
family history of basal cell carcinoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Isotretinoin may interact with Pulse Frequency
Common Zenatane Drug Interactions
Drug Name
Risk Level
Description
Clomocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Clomocycline.
Demeclocycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Demeclocycline.
Doxycycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Doxycycline.
Eravacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Eravacycline.
Metacycline
Major
The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Metacycline.
Zenatane Toxicity & Overdose RiskOverdosing on Isotretinoin can cause vomiting, facial flushing, cracked lips, abdominal pain, headache, dizziness, and lack of coordination. Children may experience toxicity with doses as low as 30mg/kg, while men and women may experience it with 24mg/kg and 56mg/kg respectively. In animal studies, Isotretinoin has been linked to an increased risk of cancer and abnormal growth in the adrenal glands when taken in high doses. It has also been associated with testicular atrophy in dogs. No effects were seen in humans on sperm count or other reproductive measures.
Zenatane Novel Uses: Which Conditions Have a Clinical Trial Featuring Zenatane?
At present, 65 clinical trials are being conducted to assess the potential of Zenatane in alleviating Rosacea, Neuroblastoma (NB) and Acne conglobata.Condition
Clinical Trials
Trial Phases
Acne Vulgaris
0 Actively Recruiting
Acne Conglobata
0 Actively Recruiting
refractory Acne vulgaris
0 Actively Recruiting
early Mycosis Fungoides (MF)
0 Actively Recruiting
Rosacea
8 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2, Phase 4
Sezary Syndrome
18 Actively Recruiting
Phase 2, Phase 1
Neuroblastoma (NB)
1 Actively Recruiting
Early Phase 1
Zenatane Reviews: What are patients saying about Zenatane?
5Patient Review
4/8/2016 I started seeing results within a few days, though it did come with some dry skin. Carrying chapstick and moisturizer helped a lot.
5Patient Review
3/16/2017 I'm really disappointed that this manufacturer is discontinuing this product. I tried Absorica and Claravis, but they were too strong and gave me nose bleeds. Zenatane didn't have that problem.
5Patient Review
9/12/2016 I saw a significant improvement in my acne after just one month of using Zenatane, and by the fourth month it was completely gone.
5Patient Review
1/18/2016 It can be tough to go through the treatment process, but it's worth it in the end.
5Patient Review
10/29/2014 I'm really glad my doctor recommended this to me. It's the best thing I've ever tried for my acne!
5Patient Review
8/16/2015 I had been struggling with acne for years, trying oral and topical antibiotics to no avail. When I started this treatment, it was very harsh on my skin for the first month or so; however, my dermatologist prescribed a steroid to help me through that tough transition period. Now, four months in, my skin is finally starting to clear up and I couldn't be happier!
4.7Patient Review
7/10/20144.3Patient Review
5/3/2015 I'm really hoping that this treatment will help with my dry skin. So far, it's been alright but I haven't seen the full effects yet.
4Patient Review
7/13/20133Patient Review
9/8/2014 I had struggled with acne for my entire life before trying this treatment. It was a long six months, but it completely cleared up my skin. I would definitely recommend it to others who are struggling with similar issues.
3Patient Review
6/12/20131.7Patient Review
10/12/2016 I've been taking this medication for five months now with no positive changes.
1Patient Review
1/1/2016 Three weeks in and I've got to say, my lips have never been drier. They feel raw and almost sandpapery. Not sure how much longer I can take this.
1Patient Review
2/9/2016 I only took this medication for three days. Almost immediately after taking the first dose, I felt incredibly thirsty and developed muscle and joint pain.
Patient Q&A Section about zenatane
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Accutane the same as Zenatane?
"Zenatane, a medication similar to Accutane, is only able to be marketed under a specific restricted distribution program (iPLEDGE) that has been approved by the Food and Drug Administration (FDA). This is because Zenatane can cause severe birth defects."
Answered by AI
What is the generic drug for Zenatane?
"Isotretinoin is a drug used to treat severe acne that has not responded to other therapy such as antibiotics. It is more expensive than other acne treatments."
Answered by AI
Is Zenatane an antibiotic?
"Zenatane is a form of vitamin A that is used to treat severe acne that has not responded to other treatments, including antibiotics."
Answered by AI
What is Zenatane used for?
"This medication is used to treat severe cystic acne that has not responded to other treatment. It belongs to a class of drugs known as retinoids."
Answered by AI