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What is Zebeta
BisoprololThe Generic name of this drug
Treatment SummaryBisoprolol is a drug used to treat high blood pressure and works by blocking the effects of certain hormones in the body. It has a long-lasting effect and only needs to be taken once a day, and is generally well-tolerated. Bisoprolol is a more selectivity option than other non-selective beta-blocker drugs and can be used alone or in combination with other medications to treat hypertension. It can also be useful in patients with COPD.
Zebetais the brand name
Zebeta Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zebeta
Bisoprolol
1993
134
Approved as Treatment by the FDA
Bisoprolol, also known as Zebeta, is approved by the FDA for 3 uses including Hypertensive disease and Hypertensive disease .Hypertensive disease
Used in combination with Hydrochlorothiazide / Losartan to help manage High Blood Pressure (Hypertension)
Hypertensive disease
Mild Hypertension
Effectiveness
How Zebeta Affects PatientsBisoprolol is a drug used to reduce heart rate, contractility, and blood pressure. Studies have shown that when taken by patients with decreased heart function, it can reduce the risk of death from cardiovascular and other causes.
How Zebeta works in the bodyBisoprolol works to reduce high blood pressure by blocking certain receptors that respond to the hormone epinephrine. This lowers the amount of work the heart needs to do and decreases the demand for oxygen. It also decreases the amount of renin released from the kidneys, which normally causes an increase in blood pressure. Lastly, it may reduce the signals sent from the brain to the rest of the body, further lowering blood pressure and heart rate.
When to interrupt dosage
The amount of Zebeta relies on the ascertained condition, including Mild Hypertension, Operative Surgery and Cardiovascular Events. The quantity of dosage is contingent upon the technique of delivery (e.g. Tablet, coated - Oral or Oral) detailed in the table hereunder.Condition
Dosage
Administration
Cardiovascular Events
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Premature ventricular contractions
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Cardiac Arrhythmia
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Chronic Stable Angina Pectoris
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Operative Surgery
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Cardiac Arrhythmia
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Mild Hypertension
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Congestive Heart Failure
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of cardiovascular event
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Supraventricular Arrhythmias
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Atrial Fibrillation
, 5.0 mg, 10.0 mg, 2.5 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Zebeta ContraindicationsCondition
Risk Level
Notes
overt cardiac failure
Do Not Combine
third degree AV block
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Sinus bradycardia/bradycardia
Do Not Combine
Ventricular Failure, Right
Do Not Combine
Common Zebeta Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Bisoprolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Bisoprolol.
Abediterol
Major
The therapeutic efficacy of Abediterol can be decreased when used in combination with Bisoprolol.
Acebutolol
Major
The risk or severity of adverse effects can be increased when Bisoprolol is combined with Acebutolol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Bisoprolol.
Zebeta Toxicity & Overdose RiskThe lowest toxic dose of bisoprolol in mice is 730mg/kg. Signs of an overdose include low blood pressure, heart failure, slow heartbeat, breathing problems, and low blood sugar. Treatment involves supportive care, glucagon to help with slow heartbeat and low blood pressure, IV glucose to treat hypoglycemia, atropine for bradycardia, medicines and fluids for hypotension, and bronchodilators for bronchospasm. Hemodialysis may not be effective in removing the drug from the bloodstream.
Zebeta Novel Uses: Which Conditions Have a Clinical Trial Featuring Zebeta?
573 studies are actively assessing the potential of Zebeta to provide therapeutic relief for Operative Surgery, Supraventricular Arrhythmias and Chronic Stable Angina Pectoris.Condition
Clinical Trials
Trial Phases
Cardiovascular Events
3 Actively Recruiting
Not Applicable
Hypertensive disease
0 Actively Recruiting
Cardiac Arrhythmia
0 Actively Recruiting
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Operative Surgery
84 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1
Mild Hypertension
0 Actively Recruiting
Chronic Stable Angina Pectoris
1 Actively Recruiting
Not Applicable
Supraventricular Arrhythmias
0 Actively Recruiting
Congestive Heart Failure
312 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Atrial Fibrillation
146 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Cardiac Arrhythmia
0 Actively Recruiting
prophylaxis of cardiovascular event
0 Actively Recruiting
Premature ventricular contractions
4 Actively Recruiting
Phase 4, Not Applicable, Phase 3
Zebeta Reviews: What are patients saying about Zebeta?
5Patient Review
12/7/2009 I've been on this treatment for two years now and it's done wonders for me. I haven't had to increase my dosage, which is great. I find that taking it at night before bed helps me avoid any dizziness or other side effects.
5Patient Review
5/19/2015 I take this medication every night, and I have yet to experience any negative side effects. If anything, it's lowered my intraocular pressure so much that my ophthalmologist took me off Lumigan!
4.3Patient Review
10/12/2009 Zebeta has been very effective for me in terms of reducing palpitations. It's also lowered my blood pressure, though it wasn't high to begin with. I'm concerned that it might be exacerbating my GERD symptoms, though. Additionally, I have psoriasis and just learned that Zebeta use is contraindicated for this condition.
4.3Patient Review
9/23/2010 I've been taking Zebeta for three weeks now and it's definitely an improvement over Bystolic. I started taking it in the morning, but after reading other users' reviews, I switched to taking it at night. I do feel a little bit dizzy in the morning now, but that's nothing compared to how I felt on Bystolic.
4.3Patient Review
12/31/2009 This medication has been great for regulating my blood pressure and heart rate. I tried the generic version but it didn't work as well, so now I pay the higher price. Occasionally, I get tingling in my hands and toes.
4.3Patient Review
1/25/2014 This drug has helped to lower my heart rate. However, even though the bottom number is good, the top number remains high. I have no side effects from this medication; however, my other BP med isn't working as well.
4.3Patient Review
12/19/2012 I had a double bypass surgery 3 years ago. I've been taking this medication at 5mg since then, and it really helps. I only realize how much it help when I forget to refill my prescription and run out.
4Patient Review
7/6/2009 Generally, this drug has had more positive than negative effects for me. It effectively controlled my heart palpitations and allowed me to cardio exercise again. However, I have experienced some numbness/tingling in my extremities as a side effect.
3.7Patient Review
2/21/2011 I've been taking 2.5mg for almost a year now to combat slightly high blood pressure and palpitations. I'm very pleased with how well it works for both issues; however, I have to cut the tablets in order to get this dosage, as they're not available at that lower strength. Fortunately, taking them at bedtime has also helped with tiredness and dizziness.
3.7Patient Review
2/1/2016 I've gained seven pounds in the six months since I started taking this medication. I'm hoping a lower dose will help with that because it's already tough to maintain my weight as a woman in her mid-40s. I've also noticed that my hands and fingers swell up and go numb at night.
3.3Patient Review
9/28/2012 I've been using Zebeta to manage my high blood pressure. It's helped lower my bottom number, but my top number is still too high. I'm also on a "water pill" as directed by my doctor, but it doesn't seem to be helping. Not sure what the next course of action should be.
3.3Patient Review
3/9/2012 I've been taking Zebeta for high blood pressure for a few years. At first, it seemed to work well; however, my top number has been running high lately. My doctor prescribed Triamterene w/hctz 37.5/25 a few months ago, but my pressure is still running about 135 over 71, with a pulse of about 65. Should I be concerned?
3Patient Review
3/20/2016 I've been gaining weight, even though I'm eating less. It's also become more difficult to breathe, especially when I'm active. This might be a serious problem, so I'm going to discuss it with my doctor soon. My heart rate is really low (in the 60s) and that might be affecting my metabolism.
2.7Patient Review
10/12/2012 This medication led to me having to go to the washroom more frequently than usual.
2.3Patient Review
7/17/2022 While this medication was helpful in controlling my blood pressure, the side effects were too much for me to handle. I gained a lot of weight, and developed severe pain in my legs and joints as well as an itchy rash on both arms. In short, this didn't work out for me.
Patient Q&A Section about zebeta
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of medication is Zebeta?
"Zebeta is an antihypertensive drug that belongs to a class of beta blockers. These drugs are used to lower blood pressure by blocking the beta receptors."
Answered by AI
What is Zebeta prescribed for?
"This medication is used to treat high blood pressure by lowering it. This helps prevent strokes, heart attacks, and kidney problems."
Answered by AI
Does Zebeta cause weight gain?
"Weight gain can occur as a side effect of some beta blockers, with the average weight gain being around 2.6 pounds (1.2 kilograms)."
Answered by AI
Is Zebeta discontinued?
"If generic versions of the drug Zebeta have been approved by the FDA, there may be generic equivalents available. The Zebeta brand name has been discontinued in the U.S."
Answered by AI