Xofigo

Castration

Treatment

1 FDA approval

20 Active Studies for Xofigo

Treatment for

Castration

What is Xofigo

Radium Ra 223 dichlorideThe Generic name of this drug

Treatment SummaryRadium Ra 223 Dichloride is a radioactive medication used to treat certain types of cancer that have spread to the bones. It works by attaching to the hydroxyapatite in areas of high bone turnover, and it was approved by the FDA in 2013 under the brand name Xofigo (formerly called Alpharadin). Xofigo is typically used in patients with metastatic bone cancer or prostate cancer that is resistant to castration therapy. It is important to note that this medication can cause fetal harm, so it should not be used in pregnant women.

Xofigois the brand name

Xofigo Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Xofigo

Radium Ra 223 dichloride

2013

Approved as Treatment by the FDA

Radium Ra 223 dichloride, also known as Xofigo, is approved by the FDA for 1 uses including Castration .

Castration

Effectiveness

How Xofigo Affects PatientsRadium Ra 223 Dichloride works by destroying cancer cells that have spread to the bones.

How Xofigo works in the bodyRadium Ra 223 Dichloride is a radioactive material that acts like calcium in the body. It binds to areas of high bone turnover, like those of bone metastases, and emits a high energy that damages the cells. This stops the cancerous cells from spreading, while not affecting the healthy cells in the area.

When to interrupt dosage

The suggested measure of Xofigo is contingent upon the diagnosed affliction. The amount of dosage varies, depending on the technique of delivery (e.g. Injection - Intravenous or Intravenous) outlined in the table underneath.

Condition

Dosage

Administration

Castration

, 0.03 mCi/mL, 0.0297 mCi/mL, 0.09 mCi/mL

, Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous

Warnings

Common Xofigo Drug Interactions

Drug Name

Risk Level

Description

Xofigo Toxicity & Overdose RiskRadium Ra 223 Dichloride should not be taken by pregnant or childbearing age women, as it can be harmful to a fetus. Other side effects may include changes in blood tests, swelling of the limbs, nausea, vomiting, and diarrhea.

image of a doctor in a lab doing drug, clinical research

Xofigo Novel Uses: Which Conditions Have a Clinical Trial Featuring Xofigo?

Thirty active clinical trials are evaluating the potential of Xofigo to ameliorate Castration-related conditions.

Condition

Clinical Trials

Trial Phases

Castration

21 Actively Recruiting

Phase 1, Phase 2, Phase 3

Patient Q&A Section about xofigo

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How is Xofigo administered?

"Xofigo should be injected slowly over the course of a minute through an IV. The IV line should be flushed with a saline solution before and after the injection of Xofigo, which is a pharmaceutical that emits alpha particles. Only authorized personnel in designated clinical settings should use and administer Xofigo."

Answered by AI

What are the side effects of Xofigo?

"The potential side effects of the medication are nausea, diarrhea, vomiting, swelling of the arms or legs, and low blood cell counts."

Answered by AI

What is Xofigo used for?

"Xofigo is a medication used to treat prostate cancer that has spread to your bone. It helps prevent symptoms caused by the cancer in your bones."

Answered by AI

Can Xofigo cure cancer?

"While Xofigo is not yet FDA-approved to treat breast cancer specifically, it may be used to treat bone metastases from breast cancer off-label. Xofigo is still being investigated for this potential use."

Answered by AI