Xeloda

Ovarian Neoplasms, Pancreatic Endocrine Carcinoma, refractory peritoneal cancer + 8 more
Treatment
8 FDA approvals
20 Active Studies for Xeloda

What is Xeloda

CapecitabineThe Generic name of this drug
Treatment SummaryCapecitabine is a chemotherapy drug taken orally that is used to treat metastatic breast and colorectal cancers. This drug is converted into a different medication, called fluorouracil, in the tumor, which prevents the growth of cancer cells by stopping them from producing DNA.
Xelodais the brand name
image of different drug pills on a surface
Xeloda Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Xeloda
Capecitabine
1998
61

Approved as Treatment by the FDA

Capecitabine, otherwise known as Xeloda, is approved by the FDA for 8 uses including refractory, metastatic Colorectal carcinoma and Duke's C Colon cancer .
refractory, metastatic Colorectal carcinoma
Used to treat refractory, metastatic Colorectal carcinoma in combination with Oxaliplatin
Duke's C Colon cancer
Metastatic Colorectal Carcinoma
Metastatic Breast Cancer
Used to treat Metastatic Breast Cancer in combination with Docetaxel
Colorectal Carcinoma
Used to treat refractory, metastatic Colorectal carcinoma in combination with Oxaliplatin
Colorectal Neoplasms
Colorectal Neoplasms
Metastatic Breast Cancer
Used to treat Metastatic Breast Cancer in combination with Docetaxel

Effectiveness

How Xeloda Affects PatientsCapecitabine is a drug used to treat metastatic breast cancer and colon cancer. It is taken orally and does not become active until it is broken down in the body, usually in higher concentrations in tumors. The drug is converted to fluorouracil and then further broken down into two other compounds (FdUMP and FUTP) which attack both cancer and healthy cells.
How Xeloda works in the bodyCapecitabine is a drug that is activated in tumors. It works by preventing the formation of thymidine, which is needed to make DNA. Capecitabine also creates a metabolic error in which RNA is incorrectly formed. This interferes with the production of proteins, which can damage the tumor cells.

When to interrupt dosage

The proposed dosage of Xeloda depends upon the diagnosed affliction, such as Pancreatic Metastatic Cancer, Malignant Neoplasms and Esophageal Cancer. The prescribed amount of dosage is contingent upon the technique of delivery (e.g. Tablet or Tablet, film coated - Oral) listed in the table underneath.
Condition
Dosage
Administration
Colorectal Neoplasms
500.0 mg, , 150.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Pancreatic Neoplasms
500.0 mg, , 150.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Stomach Cancer
500.0 mg, , 150.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Ovarian Neoplasms
500.0 mg, , 150.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Pancreatic Endocrine Carcinoma
500.0 mg, , 150.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
refractory peritoneal cancer
500.0 mg, , 150.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Colorectal Carcinoma
500.0 mg, , 150.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Metastatic Breast Cancer
500.0 mg, , 150.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Refractory Fallopian Tube Carcinoma
500.0 mg, , 150.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Malignant Neoplasms
500.0 mg, , 150.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Colorectal Neoplasms
500.0 mg, , 150.0 mg, 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Xeloda.
Common Xeloda Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Capecitabine is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Capecitabine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Capecitabine is combined with Abetimus.
Abrocitinib
Major
The metabolism of Abrocitinib can be decreased when combined with Capecitabine.
Acetohexamide
Major
The metabolism of Acetohexamide can be decreased when combined with Capecitabine.
image of a doctor in a lab doing drug, clinical research

Xeloda Novel Uses: Which Conditions Have a Clinical Trial Featuring Xeloda?

Currently, 337 active clinical trials are assessing the potential of Xeloda to manage Duke's C Colon cancer, Pancreatic Endocrine Carcinoma and refractory peritoneal cancer.
Condition
Clinical Trials
Trial Phases
Stomach Cancer
112 Actively Recruiting
Phase 2, Phase 3, Phase 1, Not Applicable
Colorectal Neoplasms
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Colorectal Carcinoma
0 Actively Recruiting
Metastatic Breast Cancer
1 Actively Recruiting
Phase 1, Phase 2
Colorectal Neoplasms
0 Actively Recruiting
Refractory Fallopian Tube Carcinoma
4 Actively Recruiting
Phase 2, Phase 1
Pancreatic Endocrine Carcinoma
10 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Ovarian Neoplasms
0 Actively Recruiting
refractory peritoneal cancer
0 Actively Recruiting
Pancreatic Neoplasms
25 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3

Xeloda Reviews: What are patients saying about Xeloda?

5Patient Review
6/21/2018
Xeloda for Breast Cancer that has Spread to Another Part of the Body
I've been taking Xeloda for 5 years now, and it's been a real help. I have to take it 1 week on, 1 week off, which can be tough, but it's worth it. The fatigue can be hard to deal with, but overall I'm doing much better than I was 7 years ago.
5Patient Review
1/5/2018
Xeloda for Breast Cancer that has Spread to Another Part of the Body
Even at half the standard dosage, this medication was still effective. I experienced some fever, low blood pressure, weakness, and nausea on the second day, so I decreased my dose. Now I'm just feeling a slight fatigue and minimal hand and foot peeling. In the 15 months that I've been taking this medication, my CA 15-3 score has dropped from almost 800 to 20.
5Patient Review
10/3/2020
Xeloda for Breast Cancer that has Spread to Another Part of the Body
I've been using this medication for a while now, and only recently started experiencing some negative side effects. I'm trying to combat them by being extra vigilant about my skincare routine, but I'm still worried about what the future holds.
5Patient Review
12/18/2018
Xeloda for Lymph Node Positive Colon Cancer
2012, I was diagnosed with stage 3-c colon cancer. The lymph nodes were involved, so I had to take xeloda for 18 months. This caused some nasty side effects in my hands.
5Patient Review
11/21/2016
Xeloda for Breast Cancer that has Spread to Another Part of the Body
After just three months, I'm feeling almost back to my old self again. The fatigue I was experiencing from my Stage 4 breast cancer is nearly gone.
View All Reviews
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Patient Q&A Section about xeloda

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Xeloda a chemo pill?

"Capecitabine is a chemotherapy drug, also known by its chemical name, Xeloda. It belongs to a class of drugs known as antimetabolites, which also includes other chemotherapy drugs such as Fluorouracil, Gemzar, and Methotrexate."

Answered by AI

What type of cancer does Xeloda treat?

"Xeloda is a chemotherapy medication used in combination with other cancer treatments. It is most often used to treat breast cancer that has stopped responding to other chemotherapy drugs."

Answered by AI

What does Xeloda do to your body?

"XELODA can lead to heart problems, such as: a heart attack, reduced blood flow to the heart, chest pain, irregular heartbeats, changes in the electrical activity of your heart as seen on an electrocardiogram (ECG), problems with your heart muscle, heart failure, and sudden death."

Answered by AI

What are the long term side effects of Xeloda?

"The long-term effects of taking Xeloda can include developing heart problems or kidney failure, which could last for a long time or be permanent. Xeloda may also cause a permanent loss of fertility."

Answered by AI

Clinical Trials for Xeloda

Have you considered Xeloda clinical trials? We made a collection of clinical trials featuring Xeloda, we think they might fit your search criteria.
Have you considered Xeloda clinical trials? We made a collection of clinical trials featuring Xeloda, we think they might fit your search criteria.
Have you considered Xeloda clinical trials? We made a collection of clinical trials featuring Xeloda, we think they might fit your search criteria.
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