What is Xeloda
CapecitabineThe Generic name of this drug
Treatment SummaryCapecitabine is a chemotherapy drug taken orally that is used to treat metastatic breast and colorectal cancers. This drug is converted into a different medication, called fluorouracil, in the tumor, which prevents the growth of cancer cells by stopping them from producing DNA.
Xelodais the brand name
Xeloda Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Xeloda
Capecitabine
1998
61
Approved as Treatment by the FDA
Capecitabine, otherwise known as Xeloda, is approved by the FDA for 10 uses including Stage III Colon Cancer and Colorectal Carcinoma .Stage III Colon Cancer
Used in combination with Peginterferon alfa-2a for Stage III Colon Cancer
Colorectal Carcinoma
Used to treat Unresectable or Metastatic Colorectal Cancer in combination with null
Malignant Neoplasms
Used to treat Advanced or Metastatic Breast Cancer in combination with Docetaxel
Therapeutic procedure
Used to treat previous anthracycline treatment in combination with Docetaxel
disease progression after chemotherapy
Used to treat disease progression after chemotherapy in combination with Docetaxel
Pharmacotherapy
Used to treat Refractory to irinotecan-based chemotherapy in combination with Oxaliplatin
Duke's C Colon cancer
Colorectal Carcinoma
Used to treat refractory, metastatic Colorectal carcinoma in combination with Oxaliplatin
Metastatic Colorectal Carcinoma
Metastatic Breast Cancer
Used to treat Metastatic Breast Cancer in combination with Docetaxel
Effectiveness
How Xeloda Affects PatientsCapecitabine is a drug used to treat metastatic breast cancer and colon cancer. It is taken orally and does not become active until it is broken down in the body, usually in higher concentrations in tumors. The drug is converted to fluorouracil and then further broken down into two other compounds (FdUMP and FUTP) which attack both cancer and healthy cells.
How Xeloda works in the bodyCapecitabine is a drug that is activated in tumors. It works by preventing the formation of thymidine, which is needed to make DNA. Capecitabine also creates a metabolic error in which RNA is incorrectly formed. This interferes with the production of proteins, which can damage the tumor cells.
When to interrupt dosage
The proposed dosage of Xeloda depends upon the diagnosed affliction, such as Pancreatic Metastatic Cancer, Malignant Neoplasms and Esophageal Cancer. The prescribed amount of dosage is contingent upon the technique of delivery (e.g. Tablet or Tablet, film coated - Oral) listed in the table underneath.Condition
Dosage
Administration
Stomach Cancer
, 500.0 mg, 150.0 mg, 300.0 mg
Tablet, Tablet, film coated - Oral, Oral, Tablet, film coated, , Tablet - Oral
Malignant Neoplasms
, 500.0 mg, 150.0 mg, 300.0 mg
Tablet, Tablet, film coated - Oral, Oral, Tablet, film coated, , Tablet - Oral
Colorectal Carcinoma
, 500.0 mg, 150.0 mg, 300.0 mg
Tablet, Tablet, film coated - Oral, Oral, Tablet, film coated, , Tablet - Oral
Duke's C Colon cancer
, 500.0 mg, 150.0 mg, 300.0 mg
Tablet, Tablet, film coated - Oral, Oral, Tablet, film coated, , Tablet - Oral
Esophageal Cancer
, 500.0 mg, 150.0 mg, 300.0 mg
Tablet, Tablet, film coated - Oral, Oral, Tablet, film coated, , Tablet - Oral
Pancreatic Metastatic Cancer
, 500.0 mg, 150.0 mg, 300.0 mg
Tablet, Tablet, film coated - Oral, Oral, Tablet, film coated, , Tablet - Oral
Pancreatic Endocrine Carcinoma
, 500.0 mg, 150.0 mg, 300.0 mg
Tablet, Tablet, film coated - Oral, Oral, Tablet, film coated, , Tablet - Oral
refractory peritoneal cancer
, 500.0 mg, 150.0 mg, 300.0 mg
Tablet, Tablet, film coated - Oral, Oral, Tablet, film coated, , Tablet - Oral
Metastatic Colorectal Carcinoma
, 500.0 mg, 150.0 mg, 300.0 mg
Tablet, Tablet, film coated - Oral, Oral, Tablet, film coated, , Tablet - Oral
Refractory Fallopian Tube Carcinoma
, 500.0 mg, 150.0 mg, 300.0 mg
Tablet, Tablet, film coated - Oral, Oral, Tablet, film coated, , Tablet - Oral
Metastatic Breast Cancer
, 500.0 mg, 150.0 mg, 300.0 mg
Tablet, Tablet, film coated - Oral, Oral, Tablet, film coated, , Tablet - Oral
refractory Ovarian cancer
, 500.0 mg, 150.0 mg, 300.0 mg
Tablet, Tablet, film coated - Oral, Oral, Tablet, film coated, , Tablet - Oral
Warnings
Xeloda ContraindicationsCondition
Risk Level
Notes
Anus Diseases
Do Not Combine
Dihydropyrimidine Dehydrogenase Deficiency
Do Not Combine
Anus Diseases
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Capecitabine may interact with Anus Diseases
Severe Hypersensitivity Reactions
Do Not Combine
Capecitabine may interact with Anus Diseases
Common Xeloda Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Capecitabine is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Capecitabine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Capecitabine is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Capecitabine is combined with Acteoside.
Aldosterone
Major
The risk or severity of adverse effects can be increased when Capecitabine is combined with Aldosterone.
Xeloda Novel Uses: Which Conditions Have a Clinical Trial Featuring Xeloda?
Currently, 337 active clinical trials are assessing the potential of Xeloda to manage Duke's C Colon cancer, Pancreatic Endocrine Carcinoma and refractory peritoneal cancer.Condition
Clinical Trials
Trial Phases
Refractory Fallopian Tube Carcinoma
6 Actively Recruiting
Phase 2, Phase 1, Early Phase 1
refractory Ovarian cancer
0 Actively Recruiting
Pancreatic Endocrine Carcinoma
12 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Pancreatic Metastatic Cancer
25 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3, Early Phase 1
Duke's C Colon cancer
0 Actively Recruiting
refractory peritoneal cancer
0 Actively Recruiting
Colorectal Carcinoma
0 Actively Recruiting
Stomach Cancer
131 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Early Phase 1
Metastatic Breast Cancer
84 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4
Esophageal Cancer
72 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3
Malignant Neoplasms
0 Actively Recruiting
Metastatic Colorectal Carcinoma
27 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Xeloda Reviews: What are patients saying about Xeloda?
5Patient Review
6/21/2018 I've been taking Xeloda for 5 years now, and it's been a real help. I have to take it 1 week on, 1 week off, which can be tough, but it's worth it. The fatigue can be hard to deal with, but overall I'm doing much better than I was 7 years ago.
5Patient Review
1/5/2018 Even at half the standard dosage, this medication was still effective. I experienced some fever, low blood pressure, weakness, and nausea on the second day, so I decreased my dose. Now I'm just feeling a slight fatigue and minimal hand and foot peeling. In the 15 months that I've been taking this medication, my CA 15-3 score has dropped from almost 800 to 20.
5Patient Review
10/3/2020 I've been using this medication for a while now, and only recently started experiencing some negative side effects. I'm trying to combat them by being extra vigilant about my skincare routine, but I'm still worried about what the future holds.
5Patient Review
12/18/2018 2012, I was diagnosed with stage 3-c colon cancer. The lymph nodes were involved, so I had to take xeloda for 18 months. This caused some nasty side effects in my hands.
5Patient Review
11/21/2016 After just three months, I'm feeling almost back to my old self again. The fatigue I was experiencing from my Stage 4 breast cancer is nearly gone.
4.7Patient Review
12/14/2018 Tumors decreased in size relatively quickly. I experienced tiredness and diarrhea at the beginning, but after six months the side effects were more manageable. I take 1500mg twice a day for one week, then have one week off. The drug is working well for me so far!
4.3Patient Review
2/11/2017 My liver metastasis reappeared after two years of anti-oestrogen therapy. Xeloda is supposed to be a "gentle" chemo, and I'm now on my sixth cycle. So far the met has decreased with few side effects, though I have experienced some thickening of palms and occasionally nasty GORD (gastroesophageal reflux disease) and dizziness at the start of treatment. Dizziness still persists occasionally but GORD seems to be under control.
4.3Patient Review
6/16/2022 So far, I've only been using Xeloda for four months, but I'm really seeing some great results. My tumors have shrunk and my last MRI showed no new mets in my brain. The hand and foot syndrome, diarrhea, and fatigue are definitely manageable side effects.
4Patient Review
11/9/2017 I took Xleoda for five years and always felt great - no problems whatsoever. I'm grateful to God for His healing power. My prayers go out to all who are suffering; God doesn't play favorites, He is merciful to all.
3Patient Review
9/24/2022 I'm a little anxious starting this treatment on Monday, but all of the positive reviews have been really helpful. I'm hoping to see some improvements in my neuropathy, fatigue, and sore joints in the next few weeks. If anyone could give me some encouragement, that would be much appreciated!
2Patient Review
10/29/2019 I unfortunately did not see any benefits from this treatment. I have stage 4 metastatic breast cancer.
1.7Patient Review
7/11/20161Patient Review
4/11/2018 My mother is suffering from ovarian cancer and she's currently receiving chemotherapy medication in both IV and oral form. She takes Xeloda 1500 mg tablets in the morning and evening, respectively. We've noticed some side effects after the third and fourth cycles, including vomiting and stomach pain. However, her doctor has been careful in treating her condition.
1Patient Review
8/3/2016 I strongly advise against this drug. After starting to take it, my mother passed away shortly afterwards. I believe this medication was a contributing factor in her death.
Patient Q&A Section about xeloda
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Xeloda a chemo pill?
"Capecitabine is a chemotherapy drug, also known by its chemical name, Xeloda. It belongs to a class of drugs known as antimetabolites, which also includes other chemotherapy drugs such as Fluorouracil, Gemzar, and Methotrexate."
Answered by AI
What type of cancer does Xeloda treat?
"Xeloda is a chemotherapy medication used in combination with other cancer treatments. It is most often used to treat breast cancer that has stopped responding to other chemotherapy drugs."
Answered by AI
What does Xeloda do to your body?
"XELODA can lead to heart problems, such as: a heart attack, reduced blood flow to the heart, chest pain, irregular heartbeats, changes in the electrical activity of your heart as seen on an electrocardiogram (ECG), problems with your heart muscle, heart failure, and sudden death."
Answered by AI
What are the long term side effects of Xeloda?
"The long-term effects of taking Xeloda can include developing heart problems or kidney failure, which could last for a long time or be permanent. Xeloda may also cause a permanent loss of fertility."
Answered by AI