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What is Wellbutrin Xl
BupropionThe Generic name of this drug
Treatment SummaryBupropion is a medication used to treat depression, seasonal affective disorder, and help people quit smoking. It works by preventing the breakdown of two important neurotransmitters (norepinephrine and dopamine), which helps to maintain their levels in the brain. Bupropion is different from other antidepressants because it does not cause sexual side effects, sedation, or weight gain as much as other medications. When used to help quit smoking, bupropion works by targeting dopamine pathways in the brain associated with nicotine cravings. Bupropion can also be used together with naltrexone as a weight management aid, as
Wellbutrinis the brand name
Wellbutrin Xl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Wellbutrin
Bupropion
1986
741
Approved as Treatment by the FDA
Bupropion, also known as Wellbutrin, is approved by the FDA for 3 uses which include Smoke and Smoking Cessation .Smoke
Smoking Cessation
Depression
Effectiveness
How Wellbutrin Xl Affects PatientsBupropion is an antidepressant drug that works differently than some other types of antidepressant drugs. It has a weak effect on certain receptors in the brain and does not affect serotonin levels. Taking Bupropion may cause some stimulant effects, such as increased activity and mild behavior changes, and it has the potential to be abused. Bupropion can also lower the seizure threshold, so people with seizure conditions should not take it. Additionally, Bupropion can increase blood pressure, but clinical trials have not found an increased risk of stroke or heart attack in people taking it.
How Wellbutrin Xl works in the bodyBupropion is a medication that helps to extend the action of two neurotransmitters, norepinephrine and dopamine. It is mostly used to treat depression, but can also be used to help with smoking cessation and weight management. It works differently than other antidepressants, so it has fewer side effects like sedation, sexual side effects, and weight gain. For smoking cessation, bupropion prevents dopamine reuptake, which is involved in the reward pathways of nicotine. It also blocks receptors that react to nicotine, blunting its effects. For weight management, bupropion works on areas of the brain responsible for appetite and
When to interrupt dosage
Condition
Dosage
Administration
Obesity
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoke
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Seasonal Affective Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Attention Deficit Hyperactivity Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Reducing diet
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Depression
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Mood Disorders
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoking Cessation
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Warnings
Wellbutrin Xl has fifteen contraindications, so it shouldn't be used in combination with the conditions enumerated in the following table.Wellbutrin Xl ContraindicationsCondition
Risk Level
Notes
Bulimia Nervosa
Do Not Combine
ethanol
Do Not Combine
Hypertensive disease
Do Not Combine
Anorexia Nervosa
Do Not Combine
abrupt cessation of barbiturates
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Epilepsy
Do Not Combine
abrupt cessation of antiepileptic drugs
Do Not Combine
Benzodiazepines
Do Not Combine
Pulse Frequency
Do Not Combine
Anorexia Nervosa
Do Not Combine
Anorexia Nervosa
Do Not Combine
Common Wellbutrin Xl Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Bupropion.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Bupropion.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Bupropion.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Bupropion.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Bupropion.
Wellbutrin Xl Toxicity & Overdose RiskAn overdose of Cymbalta may cause seizures, hallucinations, loss of consciousness, a rapid heartbeat, and even potentially fatal cardiac arrest.
Wellbutrin Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Wellbutrin Xl?
490 active clinical trials are presently assessing the potential of Wellbutrin Xl to address Attention Deficit Hyperactivity Disorder, Depression and Smoking Cessation.Condition
Clinical Trials
Trial Phases
Obesity
134 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1
Attention Deficit Hyperactivity Disorder
71 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1
Smoking Cessation
97 Actively Recruiting
Early Phase 1, Phase 2, Phase 4, Not Applicable, Phase 1, Phase 3
Depression
198 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Smoke
0 Actively Recruiting
Mood Disorders
21 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 4, Phase 1
Seasonal Affective Disorder
0 Actively Recruiting
Reducing diet
0 Actively Recruiting
Wellbutrin Xl Reviews: What are patients saying about Wellbutrin Xl?
5Patient Review
9/4/2022 This medication is a godsend. The first time I took it, I could feel the depression leaving my body. It was amazing. I was able to take it for years with no side effects and it really helped me. When I lost my insurance and couldn't afford it anymore, I went back into depression again.
5Patient Review
7/11/2022 I tried a lower dosage at first, but it didn't really help me too much. Once I upped the dosage to 300mg in the morning, though, I saw a significant improvement in my mood and outlook on life.
5Patient Review
7/10/2021 I took 150 mg of this medication and it completely changed my mood. I was no longer depressed and thinking about suicide, which was a huge relief. It also helped me with my CBT as I was able to accept the therapist's questions and talk openly. I didn't experience any side effects, except for weight loss (which wasn't necessarily a bad thing).
4.3Patient Review
11/26/2021 I've been taking Wellbutrin XL 300 for about four months. I tried increasing the dosage to 450 XL, but I had a horrible reaction and felt confused and disoriented. I decreased back to 300 XL, but my anger issues are still present. What should I do? Lower the dose and gradually stop taking the medication?
4.3Patient Review
2/8/2022 I've found that this treatment increases my appetite, which has in turn lead to me putting on some weight. I also feel more calm and collected when thinking about things.
3.7Patient Review
4/20/2022 While this medication did not do much to alleviate my bipolar depression, it had a significant positive impact on my sex life.
2.7Patient Review
9/26/2021 I've been on this medication for two months now. I have seen a slight decrease in my anxiety and depression, but the side effects are really starting to pile up. Exhausting migraines, high blood pressure, blurry vision, dizziness, swollen face, irritability, hostile or suicidal mood... it's just too much. And apparently withdrawal is going to be even worse.
2.3Patient Review
9/1/2022 I've been on bupropion xl for 11 weeks and I'm still experiencing side effects. Is this common? When will they go away?
1.7Patient Review
5/31/2022 This medication is completely ineffective and made me feel worse in every way. I stopped taking it as soon as I could.
1.3Patient Review
9/5/2021 I'm on day five of taking Wellbutrin XL 150 mg per day, and I can't stand it. The insomnia is awful, and my anxiety has actually gotten worse since starting this medication. If anyone has any advice or experience quitting after only a few days, please let me know!
Patient Q&A Section about wellbutrin xl
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does WELLBUTRIN XL give you energy?
"Some patients may feel more energetic and motivated when taking Wellbutrin because it increases levels of dopamine."
Answered by AI
How does WELLBUTRIN XL make you feel?
"Most side effects of WELLBUTRIN XL are mild and include: insomnia, congestion, dry mouth, dizziness, anxiety, nausea, constipation, and muscle aches."
Answered by AI
What does WELLBUTRIN XL do?
"Wellbutrin XL is a prescription medication used to treat depression in adults, as well as seasonal affective disorder."
Answered by AI
Is WELLBUTRIN XL for anxiety or depression?
"Bupropion, which is sold under the brand name Wellbutrin, is a medication that is used to treat mood disorders such as depression and seasonal affective disorder. In addition to these conditions, Wellbutrin is also used to treat other conditions such as smoking cessation, ADHD, and anxiety."
Answered by AI