Wellbutrin

Smoke, Reducing diet, Seasonal Affective Disorder + 5 more

Treatment

3 FDA approvals

20 Active Studies for Wellbutrin

Treatment for

Smoke

What is Wellbutrin

BupropionThe Generic name of this drug

Treatment SummaryBupropion (also known as Wellbutrin®) is a medication used to treat Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and to help people quit smoking. It works by blocking certain enzymes that cause the brain to absorb certain neurotransmitters, such as norepinephrine and dopamine, for a longer period of time. Unlike other antidepressants, Bupropion does not affect serotonin levels and is less likely to cause sexual side effects, sedation, or weight gain. Bupropion can also be used as an add-on medication when the first-line treatments of depression

Wellbutrinis the brand name

Wellbutrin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Wellbutrin

Bupropion

1986

741

Approved as Treatment by the FDA

Bupropion, also known as Wellbutrin, is approved by the FDA for 3 uses which include Smoke and Smoking Cessation .

Smoke

Smoking Cessation

Depression

Effectiveness

How Wellbutrin Affects PatientsBupropion is a type of drug used to treat depression that is not related to other antidepressant medications. It helps balance the levels of dopamine and norepinephrine in the brain, but does not affect serotonin. Bupropion can cause stimulant effects in some people, making it potentially addictive. It can also lower the seizure threshold, making it dangerous for people with pre-existing seizure conditions. Finally, it can raise blood pressure, so it is not advised for those with high blood pressure or cardiovascular disease.

How Wellbutrin works in the bodyBupropion is a drug that works on two of our brain's neurotransmitters: norepinephrine and dopamine. It stops them from leaving the brain quickly, so that their effects can be felt for longer. This makes it useful for treating depression and helping with smoking cessation. When combined with naltrexone in the drug Contrave, bupropion is thought to work on the brain's appetite regulation pathways, reducing food intake and increasing energy expenditure.

When to interrupt dosage

The suggested measure of Wellbutrin is contingent upon the determined condition, for example, Depressive Bipolar Disorder, Depression and Disease. The amount as well changes according to the technique of delivery (e.g. Tablet, extended release or Tablet, film coated, extended release) presented in the table below.

Condition

Dosage

Administration

Depression

, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg

, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit

Obesity

, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg

, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit

Mood Disorders

, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg

, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit

Smoking Cessation

, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg

, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit

Smoke

, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg

, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit

Attention Deficit Hyperactivity Disorder

, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg

, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit

Reducing diet

, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg

, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit

Seasonal Affective Disorder

, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg

, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit

Warnings

Wellbutrin Contraindications

Condition

Risk Level

Notes

Bulimia Nervosa

Do Not Combine

ethanol

Do Not Combine

Hypertensive disease

Do Not Combine

Anorexia Nervosa

Do Not Combine

abrupt cessation of barbiturates

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Pulse Frequency

Do Not Combine

Epilepsy

Do Not Combine

abrupt cessation of antiepileptic drugs

Do Not Combine

Benzodiazepines

Do Not Combine

Pulse Frequency

Do Not Combine

Anorexia Nervosa

Do Not Combine

Anorexia Nervosa

Do Not Combine

There are 20 known major drug interactions with Wellbutrin.

Common Wellbutrin Drug Interactions

Drug Name

Risk Level

Description

4-Methoxyamphetamine

Major

The metabolism of 4-Methoxyamphetamine can be decreased when combined with Bupropion.

5-methoxy-N,N-dimethyltryptamine

Major

The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Bupropion.

Acebutolol

Major

The metabolism of Acebutolol can be decreased when combined with Bupropion.

Acetaminophen

Major

The metabolism of Acetaminophen can be decreased when combined with Bupropion.

Almotriptan

Major

The metabolism of Almotriptan can be decreased when combined with Bupropion.

Wellbutrin Toxicity & Overdose RiskSymptoms of an overdose on this drug may include seizures, seeing and hearing things that are not real, passing out, rapid heartbeat, and heart failure.

Wellbutrin Novel Uses: Which Conditions Have a Clinical Trial Featuring Wellbutrin?

Currently, there are 490 active trials examining the effectiveness of Wellbutrin in treating Attention Deficit Hyperactivity Disorder, Depression and aiding Smoking Cessation.

Condition

Clinical Trials

Trial Phases

Smoke

0 Actively Recruiting

Mood Disorders

21 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 4, Phase 1

Obesity

132 Actively Recruiting

Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1

Seasonal Affective Disorder

0 Actively Recruiting

Attention Deficit Hyperactivity Disorder

71 Actively Recruiting

Phase 4, Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1

Smoking Cessation

95 Actively Recruiting

Early Phase 1, Phase 2, Phase 4, Not Applicable, Phase 1, Phase 3

Depression

197 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1

Reducing diet

0 Actively Recruiting

Patient Q&A Section about wellbutrin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the mental side effects of Wellbutrin?

"Bupropion may cause people to feel agitated, irritable, or display other abnormal behaviors. It may also cause people to have suicidal thoughts or tendencies, or to become more depressed."

Answered by AI

What does Wellbutrin do to you?

"Bupropion is used to treat depression by restoring the balance of certain natural chemicals in your brain."

Answered by AI

What are the most common side effects of Wellbutrin?

"First week or two: headaches, dry mouth, nausea, dizziness, insomnia, constipation, sore throat, fast heartbeat. Other common side effects: abdominal pain, anxiety."

Answered by AI

What does Wellbutrin treat best?

"Bupropion is a medication used to treat depression. It is available under the brand names Aplenzin, Wellbutrin, Wellbutrin SR, and Wellbutrin XL."

Answered by AI

What does Wellbutrin do for you?

"Loss of interest or pleasure in activities.

Bupropion is an antidepressant medication that affects the brain. It is approved to treat major depressive disorder, seasonal affective disorder, and to help people quit smoking. Symptoms of depression include feeling sad, empty, or tearful, and loss of interest or pleasure in activities."

Answered by AI

What is the downside of Wellbutrin?

"Side effects that are commonly experienced by people who take WELLBUTRIN include feeling agitated, having a dry mouth, trouble sleeping, headaches/migraines, nausea/vomiting, constipation, trembling, feeling dizzy, sweating a lot, blurry vision, having a fast heart rate, feeling confused, being hostile, and having problems with hearing."

Answered by AI

Clinical Trials for Wellbutrin

Image of The University of Texas health Science Center at Houston in Houston, United States.

Bupropion +1 More for Smoking Cessation

This trial aims to test if giving a combination of injectable naltrexone and oral bupropion to individuals with schizophrenia who smoke cigarettes is safe and possible. They will also look at how

Waitlist Available

The University of Texas health Science Center at HoustonJin H Yoon, PhD

Image of Centre for Addiction and Mental Health in Toronto, Canada.

Behavioral Parent Training for Conduct Disorder

Toronto, Canada

"This trial will create individual profiles for children with Disruptive Behaviour Disorder and their parents, using psychological, emotional, and neuropsychological factors. These profiles will help predict how they will respond to a

Centre for Addiction and Mental HealthBrendan F. Andrade, PhD

Image of University Health Network in Toronto, Canada.

Theta-Burst Stimulation for Depression, Bipolar Disorder

Toronto, Canada

This trial aims to see if a certain type of brain stimulation can help reduce depression symptoms in people with bipolar disorder. Participants will either receive the active stimulation or a fake stimulation for 30 days, and

Waitlist Available

University Health Network (+1 Sites)

Image of Clinical Research Site in Encino, United States.

Solriamfetol for Depression

This trial, called PARADIGM, is testing a drug called solriamfetol to see if it is safe and effective in treating major depressive disorder in adults.

Clinical Research Site (+22 Sites)Axsome Therapeutics, Inc.

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Image of Novus Neurology in Tuscaloosa, United States.

Accelerated Intermittent Theta Burst Stimulation (iTBS) Deep Transcranial Magnetic Stimulation (Deep TMS) for Depression

This trial aims to test a new treatment device called BrainsWay Deep Transcranial Magnetic Stimulation for Major Depressive Disorder. The study will compare the safety and effectiveness of this device to the current

Waitlist Available

Novus Neurology (+5 Sites)Brainsway

Image of Somenek + Pittman MD: Advanced Plastic Surgery in Washington, United States.

Sculptra +1 More for Photoaging

Washington, United States

This trial will involve adult subjects who have taken or are currently taking a certain type of medication and have noticeable cheek wrinkles and issues with the shape of their midface. They will be treated with injections to

Somenek + Pittman MD: Advanced Plastic Surgery (+1 Sites)Michael Somenek, MDGalderma R&D

Image of University of Southern California in Los Angeles, United States.

Heart rate variability biofeedback for Depression

Los Angeles, CA

This trial aims to study different subtypes of depression by looking at how people regulate their emotions and their physiological responses. The study involves assessing affect, regulation strategies, and physiological activity in young adults with depression

University of Southern California

Image of Toronto Western Hospital in Toronto, Canada.

Psilocybin for Depression

Toronto, Canada

This trial will test if one or two doses of psilocybin can help patients with treatment-resistant depression. It will investigate which dosing is more effective in relieving depressive symptoms and if a second

Toronto Western HospitalJoshua Rosenblat, MD, MSc

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Exercise Training for Stroke

"This trial aims to see if a 15-week lifestyle management program can help improve physical and psychosocial issues in Veterans who have had a stroke, similar to the benefits seen in weight loss interventions for

Waitlist Available

Ralph H. Johnson VA Medical Center, Charleston, SCChris M Gregory, PhD

Image of Cincinnati Children's Hospital Medical Center in Cincinnati, United States.

Personalized ADHD Medication Experiment for Attention Deficit Hyperactivity Disorder (ADHD)

This trial aims to test personalized medication experiments to help make decisions about future medication use for adolescents. The researchers believe that their intervention will increase the adolescents' involvement in decision making and reduce uncertainty about future medication

Cincinnati Children's Hospital Medical CenterWilliam Brinkman, MD, MEd, MSc

Image of Centre for Addiction and Mental Health in Toronto, Canada.

Intermittent Theta Burst Stimulation for Alcoholism

Toronto, Canada

This trial aims to investigate a new treatment approach for alcohol use disorder (AUD) that also targets depressive symptoms. The study will use theta burst stimulation (TBS) as a form of transcranial

Centre for Addiction and Mental Health

Image of Brigham and Women's Hospital in Boston, United States.

Endoscopic Sleeve Gastroplasty - Belt +1 More for Metabolic Diseases

"This trial will compare two different methods of placing sutures in the stomach to see which one leads to more weight loss. The study will use the Endomina system to measure the amount of weight lost

Waitlist Available

Brigham and Women's HospitalChristopher C Thompson, MD, MScEndo Tools Therapeutics S.A.

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