Wellbutrin

Smoke, Reducing diet, Seasonal Affective Disorder + 5 more
Treatment
4 FDA approvals
20 Active Studies for Wellbutrin

What is Wellbutrin

BupropionThe Generic name of this drug
Treatment SummaryBupropion (also known as Wellbutrin®) is a medication used to treat Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and to help people quit smoking. It works by blocking certain enzymes that cause the brain to absorb certain neurotransmitters, such as norepinephrine and dopamine, for a longer period of time. Unlike other antidepressants, Bupropion does not affect serotonin levels and is less likely to cause sexual side effects, sedation, or weight gain. Bupropion can also be used as an add-on medication when the first-line treatments of depression
Wellbutrinis the brand name
Wellbutrin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Wellbutrin
Bupropion
1986
741

Approved as Treatment by the FDA

Bupropion, also known as Wellbutrin, is approved by the FDA for 4 uses which include Smoke and Smoking Cessation .
Smoke
Smoking Cessation
Depression
Obesity
Used to treat Obesity in combination with Naltrexone

Effectiveness

How Wellbutrin Affects PatientsBupropion is a type of drug used to treat depression that is not related to other antidepressant medications. It helps balance the levels of dopamine and norepinephrine in the brain, but does not affect serotonin. Bupropion can cause stimulant effects in some people, making it potentially addictive. It can also lower the seizure threshold, making it dangerous for people with pre-existing seizure conditions. Finally, it can raise blood pressure, so it is not advised for those with high blood pressure or cardiovascular disease.
How Wellbutrin works in the bodyBupropion is a drug that works on two of our brain's neurotransmitters: norepinephrine and dopamine. It stops them from leaving the brain quickly, so that their effects can be felt for longer. This makes it useful for treating depression and helping with smoking cessation. When combined with naltrexone in the drug Contrave, bupropion is thought to work on the brain's appetite regulation pathways, reducing food intake and increasing energy expenditure.

When to interrupt dosage

The suggested measure of Wellbutrin is contingent upon the determined condition, for example, Depressive Bipolar Disorder, Depression and Disease. The amount as well changes according to the technique of delivery (e.g. Tablet, extended release or Tablet, film coated, extended release) presented in the table below.
Condition
Dosage
Administration
Obesity
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Reducing diet
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Seasonal Affective Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Mood Disorders
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoking Cessation
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Attention Deficit Hyperactivity Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoke
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Depression
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit

Warnings

Wellbutrin Contraindications
Condition
Risk Level
Notes
Bulimia Nervosa
Do Not Combine
ethanol
Do Not Combine
Hypertensive disease
Do Not Combine
Anorexia Nervosa
Do Not Combine
abrupt cessation of barbiturates
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Epilepsy
Do Not Combine
abrupt cessation of antiepileptic drugs
Do Not Combine
Benzodiazepines
Do Not Combine
Pulse Frequency
Do Not Combine
Anorexia Nervosa
Do Not Combine
Anorexia Nervosa
Do Not Combine
There are 20 known major drug interactions with Wellbutrin.
Common Wellbutrin Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Bupropion.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Bupropion.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Bupropion.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Bupropion.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Bupropion.
Wellbutrin Toxicity & Overdose RiskSymptoms of an overdose on this drug may include seizures, seeing and hearing things that are not real, passing out, rapid heartbeat, and heart failure.

Wellbutrin Novel Uses: Which Conditions Have a Clinical Trial Featuring Wellbutrin?

Currently, there are 490 active trials examining the effectiveness of Wellbutrin in treating Attention Deficit Hyperactivity Disorder, Depression and aiding Smoking Cessation.
Condition
Clinical Trials
Trial Phases
Smoking Cessation
104 Actively Recruiting
Early Phase 1, Phase 4, Not Applicable, Phase 3, Phase 2, Phase 1
Attention Deficit Hyperactivity Disorder
63 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2
Obesity
45 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1
Depression
212 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1
Mood Disorders
15 Actively Recruiting
Early Phase 1, Phase 2, Phase 4, Not Applicable, Phase 1, Phase 3
Seasonal Affective Disorder
0 Actively Recruiting
Smoke
0 Actively Recruiting
Reducing diet
0 Actively Recruiting

Patient Q&A Section about wellbutrin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the mental side effects of Wellbutrin?

"Bupropion may cause people to feel agitated, irritable, or display other abnormal behaviors. It may also cause people to have suicidal thoughts or tendencies, or to become more depressed."

Answered by AI

What does Wellbutrin do to you?

"Bupropion is used to treat depression by restoring the balance of certain natural chemicals in your brain."

Answered by AI

What are the most common side effects of Wellbutrin?

"First week or two: headaches, dry mouth, nausea, dizziness, insomnia, constipation, sore throat, fast heartbeat. Other common side effects: abdominal pain, anxiety."

Answered by AI

What does Wellbutrin treat best?

"Bupropion is a medication used to treat depression. It is available under the brand names Aplenzin, Wellbutrin, Wellbutrin SR, and Wellbutrin XL."

Answered by AI

What does Wellbutrin do for you?

"Loss of interest or pleasure in activities.

Bupropion is an antidepressant medication that affects the brain. It is approved to treat major depressive disorder, seasonal affective disorder, and to help people quit smoking. Symptoms of depression include feeling sad, empty, or tearful, and loss of interest or pleasure in activities."

Answered by AI

What is the downside of Wellbutrin?

"Side effects that are commonly experienced by people who take WELLBUTRIN include feeling agitated, having a dry mouth, trouble sleeping, headaches/migraines, nausea/vomiting, constipation, trembling, feeling dizzy, sweating a lot, blurry vision, having a fast heart rate, feeling confused, being hostile, and having problems with hearing."

Answered by AI

Clinical Trials for Wellbutrin

Image of St. Jude Children's Research Hospital in Memphis, United States.

Methylphenidate for Sickle Cell Disease

8 - 17
All Sexes
Memphis, TN
The purpose of this study is to determine if patients with sickle cell disease (SCD) can consistently take a drug called Methylphenidate (MPH) daily, once a day for 4 weeks to help with any thinking, attention or schoolwork problems and if they have any side effects. The study will assess any thinking or attention problems participants may have both before taking this drug and after. Additionally, the study will assess the decision-making process of the caregiver that may influence using this drug or not. Primary Objective: • Assess the feasibility, acceptability, and adherence to MPH treatment in children with SCD and EF deficits. Secondary Objective: • Evaluate neurobehavioral and safety outcomes following MPH treatment. Exploratory Objective: • Evaluate decision-making and determinants influencing methylphenidate utilization among parents.
Phase 1
Recruiting
St. Jude Children's Research HospitalAndrew Heitzer, PhD
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Image of Detroit Recovery Project in Detroit, United States.

Peer-Delivered Behavioral Activation for Depression

18+
All Sexes
Detroit, MI
Low-income individuals have limited access to evidence-based interventions for mental health. Peer recovery specialists, individuals in recovery from mental health and/or substance use problems, have the potential to increase access to evidence-based interventions for individuals from low-resource communities, particularly when trained and supervised in models that are acceptable and feasible in these communities. This study will examine the effectiveness and implementation potential of a peer-delivered evidence-based intervention (Behavioral Activation) among individuals receiving services from a community-based treatment setting providing integrated physical and behavioral healthcare.
Waitlist Available
Has No Placebo
Detroit Recovery Project
Have you considered Wellbutrin clinical trials? We made a collection of clinical trials featuring Wellbutrin, we think they might fit your search criteria.Go to Trials
Image of UCSD Interventional Psychiatry in San Diego, United States.

Transcranial Direct Current Stimulation for Depression

18 - 85
All Sexes
San Diego, CA
The investigators propose a single-arm, open-label study to evaluate the effectiveness, safety, tolerability and feasibility of at-home transcranial direct current stimulation (tDCS) as a treatment for depression, particularly in cases where patients have not responded well to traditional therapies. Treatment will be delivered over a 2-week period with daily weekday treatments i.e., five tDCS sessions, each lasting 20 minutes, spaced by approximately 20-minute inter-session intervals, for a total of three hours a day. Participants will self-administer treatment at home under direct remote supervision. Pre- and post- treatment neurophysiological biomarkers sessions will also be carried out. The study aims to examine changes in mood, brain activity, and related clinical outcomes before, during, and after treatment, with the goal to provide more information that can be used for future studies.
Recruiting
Has No Placebo
UCSD Interventional Psychiatry
Image of Dr. Vince Clinical Research in Overland Park, United States.

ATI-1013 for Smoking Cessation

23 - 59
All Sexes
Overland Park, KS
This study is a first-in-human clinical trial of drug ATI-1013, in healthy adult cigarette smokers. The main questions it aims to answer are to learn about the safety of drug ATI-1013, how long drug ATI-1013 remains within the body, does drug ATI-1013 trigger an immune response, and the effects of drug ATI-1013 on nicotine levels within the body. The clinical trial will compare drug ATI-1013 to a placebo (a look-alike substance that contains no drug) to see if drug ATI-1013 has comparable safety. Participants will have a Screening visit (Day -28 to -3) and will be admitted on Day -2. Each participant will receive one intravenous (IV) infusion of ATI-1013 or placebo (Day 1). Participants will remain in-clinic for at least 48 hours post-dose and return for follow-up visits on Days 7, 21, 42, 56, and 84, with telephone check-ins on Days 5, 14, 28, and 70. Participants will keep a diary of their cigarette use and smoking behaviors.
Phase 1
Recruiting
Dr. Vince Clinical ResearchMatthew Kalnik, PhDAntidote Therapeutics, Inc
Image of UCSF Nancy Friend Pritzker Psychiatry Building in San Francisco, United States.

Trigeminal Nerve Stimulation for ADHD in Children with Autism

7 - 14
All Sexes
San Francisco, CA
The goal of this clinical trial is to learn if external trigeminal nerve stimulation (eTNS) works to treat ADHD symptoms in children on the autism spectrum (ASD). It will also learn about the efficacy and tolerability of the eTNS device. The main questions it aims to answer are: * Does eTNS reduce ADHD symptoms? * Does eTNS improve core and associated features of ASD? Participation spans 8-12 weeks and includes: * 4-5 in-person visits * 4 brief virtual check-ins * Nightly use of the eTNS device with a small sticky patch applied to child's forehead * Randomized assignment (those who start with the sham device may try the active device later)
Recruiting
Device
UCSF Nancy Friend Pritzker Psychiatry Building
Have you considered Wellbutrin clinical trials? We made a collection of clinical trials featuring Wellbutrin, we think they might fit your search criteria.Go to Trials
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