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What is Vraylar
CariprazineThe Generic name of this drug
Treatment SummaryCariprazine is a medication used to treat schizophrenia and bipolar disorder. It works by activating dopamine receptors in the brain to reduce symptoms of these conditions. Cariprazine is different from other antipsychotic medications because it specifically targets certain dopamine receptors. It was approved by the FDA in 2015 and can also be used as an additional treatment for major depressive disorder.
Vraylaris the brand name
Vraylar Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Vraylar
Cariprazine
2015
6
Effectiveness
How Vraylar Affects PatientsCariprazine is an antipsychotic drug that has been used to reduce symptoms of schizophrenia and bipolar I disorder in clinical trials. Studies have also found it to be effective in treating anxiety and low mood. It works by binding to dopamine receptors, though it does so in a way that causes fewer side effects (such as restlessness and tremors) than other antipsychotics. Additionally, it has an effect on serotonin receptors that helps reduce the risk of side effects even further. However, there is still a risk of side effects with cariprazine, such as akathisia, extrapyramidal disorder, restlessness
How Vraylar works in the bodyCariprazine is a drug used to treat schizophrenia and bipolar disorder. It works by targeting dopamine receptors, which are involved in reward processing and motivation. Specifically, it binds to dopamine D2 and D3 receptors, which are associated with positive and negative symptoms of schizophrenia. It also binds to other receptors in the body, which have been linked to pro-cognitive and antidepressant effects. These effects help reduce the symptoms of schizophrenia and bipolar disorder.
When to interrupt dosage
The suggested measure of Vraylar is contingent upon the diagnosed affliction, for instance Bipolar Disorder, Acute Coryza and Schizophrenia. The amount of dosage is contingent upon the procedure of delivery featured in the table beneath.Condition
Dosage
Administration
Schizophrenia
, 1.5 mg, 3.0 mg, 4.5 mg, 6.0 mg
, Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Kit - Oral, Kit, Capsule - Oral, Capsule
Bipolar Disorder
, 1.5 mg, 3.0 mg, 4.5 mg, 6.0 mg
, Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Kit - Oral, Kit, Capsule - Oral, Capsule
Mental Depression
, 1.5 mg, 3.0 mg, 4.5 mg, 6.0 mg
, Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Kit - Oral, Kit, Capsule - Oral, Capsule
Bipolar Disorder
, 1.5 mg, 3.0 mg, 4.5 mg, 6.0 mg
, Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Kit - Oral, Kit, Capsule - Oral, Capsule
Warnings
Vraylar ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Cariprazine may interact with Pulse Frequency
Common Vraylar Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Major
Cariprazine may increase the antipsychotic activities of Amisulpride.
Azelastine
Major
Cariprazine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of adverse effects can be increased when Cariprazine is combined with Deutetrabenazine.
Ethanol
Major
Cariprazine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Cariprazine may increase the serotonergic activities of Methylene blue.
Vraylar Toxicity & Overdose RiskIn one case, a patient accidentally took a high dose of cariprazine (48 mg/day) and experienced dizziness and drowsiness. They fully recovered the same day. There is no specific antidote for overdose, so medical supervision and monitoring is recommended. It is also possible that multiple drugs were involved in the overdose.
Vraylar Novel Uses: Which Conditions Have a Clinical Trial Featuring Vraylar?
171 active trials are at present assessing the capability of Vraylar to manage Bipolar Disorder, Bipolar Disorder Type I and Schizophrenia.Condition
Clinical Trials
Trial Phases
Bipolar Disorder
0 Actively Recruiting
Mental Depression
3 Actively Recruiting
Not Applicable
Bipolar Disorder
1 Actively Recruiting
Phase 4
Schizophrenia
174 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Vraylar Reviews: What are patients saying about Vraylar?
5Patient Review
7/22/2022 This medicine has been an absolute game-changer for me. If you're struggling with bipolar depression, I cannot recommend this highly enough. Finally, I feel free from negative thoughts and am able to lead a happy life.
5Patient Review
7/3/2022 This treatment was amazing and it really gave me my life back. I would encourage anyone struggling to not give up hope because there are options out there that can help you.
5Patient Review
9/10/2022 Vrylar has the strange side effect of making me a morning person. I go to bed just fine, but then I wake up feeling great and full of energy between 5 and 7am. This is even with taking Seroquel at night. I would rate this medication 10 out of 10.
5Patient Review
10/26/2022 I had wonderful results from this medication, however the cost is quite high. I was only able to try it because my nurse practitioner gave me some samples, but now that I need to buy it myself it's quite out of reach. If anyone has any suggestions for dealing with the cost, please let me know.
5Patient Review
7/25/2022 Vraylar has been an absolute godsend. It's drastically decreased the severity and frequency of my hallucinations, both visual and auditory. Additionally, it's helped to lessen delusions and other symptoms so that I can live a relatively normal life again.
3.7Patient Review
7/24/2022 I've tried a lot of different medications, and Vraylar is by far the best one for my depression. However, I have experienced some intense side effects like nausea and headaches. Hoping that these go away with time!
3.7Patient Review
7/25/2022 This medication really helped to improve my mood. I felt less anxious and more even-keeled. Everything seemed brighter and easier to handle.
3.3Patient Review
8/17/2021 I've been taking this for a few weeks now. It's not as effective at controlling my symptoms as Olanzapine was, but the weight gain and lethargy from Olanzapine were too much. I don't sleep well and Vraylar isn't much help for that. It took a few days for the drug to take effect but when it did it works well enough. Good thing is insurance covered the cost otherwise I would not have been able to afford.
3.3Patient Review
8/14/2022 At first, this treatment was working well for me. But then my anxiety started to get worse and now I'm feeling really nervous all the time.
3Patient Review
4/4/2022 I gained 10 lbs while on this medication, and I was always hungry. Additionally, I experienced erectile dysfunction and low interest in sex. However, I think it did help with my delusions when I first started taking it. But the side effects were too much for me to handle.
3Patient Review
11/3/2022 After six weeks of taking Vraylar, I'm done. The constant flu-like symptoms were really getting me down--I was constantly tired and had no appetite. Abilify worked better for me.
2.3Patient Review
9/10/2022 At first, I thought this medicine was amazing. But then I started putting on a lot of weight very quickly, developed diabetes, and started to feel very apathetic from low dopamine levels. If you can, get off this medication as soon as possible.
1Patient Review
9/1/2022 Vraylar caused me so much anxiety and panic that it was honestly terrible. I had to stop taking the medicine because the feeling were just too intense and unbearable. It's a shame, too, because I know it works for some people.
Patient Q&A Section about vraylar
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What symptoms does Vraylar treat?
"The goal of this medication is to improve overall depressive and manic symptoms, as well as to treat mixed episodes— when an individual experiences symptoms of both depression and mania at the same time."
Answered by AI
What are the main side effects of Vraylar?
"The following are extrapyramidal symptoms: muscle spasms, muscle rigidity, tremor, and jerking movements. Agitation, indigestion, nausea, vomiting, sleepiness, and restlessness are also common. Weight gain is a possibility."
Answered by AI
What conditions does Vraylar treat?
"Vraylar is a drug that is approved to treat mixed or manic episodes of bipolar I disorder. The drug is also approved to treat schizophrenia, as well as bipolar depression in bipolar I disorder."
Answered by AI
Is Vraylar a mood stabilizer or antipsychotic?
"The medication Vraylar can be used as an antipsychotic or an antidepressant depending on the diagnosis. If you are prescribed Vraylar, your doctor will closely monitor you for any suicidal thoughts or behaviors."
Answered by AI
What is the drug Vraylar used for?
"Cariprazine is a medication that affects the brain in order to treat schizophrenia. It is also known as a second-generation antipsychotic (SGA) or atypical antipsychotic. Cariprazine rebalances dopamine and serotonin in order to improve thinking, mood, and behavior."
Answered by AI
How does Vraylar make u feel?
"The most common side effects of VRAYLAR include difficulty moving or slow movements, tremors, uncontrolled body movements, restlessness, sleepiness, nausea, vomiting, and indigestion."
Answered by AI