What is Vimovo
EsomeprazoleThe Generic name of this drug
Treatment SummaryEsomeprazole, commonly known by its brand name Nexium, is a medication that reduces the amount of acid produced in the stomach. It is used to treat gastroesophageal reflux disease (GERD), stomach ulcers, and other conditions related to overproduction of stomach acid. It can also be prescribed in quadruple regimens to treat infections caused by the bacteria H. pylori. Esomeprazole is similar to other proton pump inhibitors (PPIs) such as omeprazole, lansoprazole, pantoprazole and rabeprazole. It works by binding
Nexiumis the brand name
Vimovo Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nexium
Esomeprazole
2001
347
Approved as Treatment by the FDA
Esomeprazole, otherwise called Nexium, is approved by the FDA for 3 uses including Heartburn and Helicobacter Pylori Infection .Heartburn
Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Amoxicillin
Heartburn
Helps manage Gastro-esophageal Reflux Disease (GERD)
Effectiveness
How Vimovo Affects PatientsEsomeprazole is a drug used to treat Gastroesophageal Reflux Disease (GERD), erosive esophagitis, and prevent duodenal ulcer recurrence. It works by blocking the enzyme in the stomach that produces acid. This reduces the amount of acid in the stomach, preventing symptoms of GERD and protecting the stomach from ulcers. Esomeprazole is similar to other drugs in its class, but it does not have anticholinergic or antihistamine side effects. Taking esomeprazole long-term can be associated with potential risks,
How Vimovo works in the bodyEsomeprazole is used to reduce the amount of stomach acid produced. It does this by binding to proteins on the surface of cells in the stomach, called (H+, K+)-ATPase enzymes. This binding prevents the last step in the production of stomach acid and reduces both the normal and extra production that can occur due to triggers like stress or spicy foods. The binding of esomeprazole to the (H+, K+)-ATPase enzyme is permanent, so the effects can last for more than 24 hours.
When to interrupt dosage
The advisable amount of Vimovo is contingent upon the diagnosed circumstance, including Curling Ulcer, Hemorrhage and Critical Illness. The magnitude of dosage differs, as per the approach of delivery (e.g. Tablet, delayed release or Injection, powder, lyophilized, for solution - Intravenous) denoted in the table beneath.Condition
Dosage
Administration
prophylaxis of Stress Ulcers
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Helicobacter Pylori Infection
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Erosive Esophagitis
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
previous gastric or duodenal ulcer
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Hemorrhage
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Heartburn
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Zollinger-Ellison Syndrome
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Stress Ulcers
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
antibacterial therapy
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
maintenance of healing Erosive esophagitis
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
NSAID Associated Gastric Ulcers
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Hemorrhage
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Critical Illness
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Heartburn
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Curling Ulcer
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Peptic Ulcer
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Gastric ulcer
40.0 mg, 49.3 mg, 24.65 mg, 5.0 mg, 10.0 mg, , 20.0 mg, 20.0 mg/mL, 40.0 mg/mL, 2.5 mg
Tablet, delayed release, Injection, powder, lyophilized, for solution - Intravenous, Capsule, delayed release - Oral, Granule, delayed release, For suspension - Oral, Granule, delayed release - Oral, , Tablet, delayed release - Oral, Oral, Injection - Intravenous, Tablet - Oral, Kit, Capsule, delayed release, Granule, for suspension, extended release, Intravenous, Capsule, coated pellets, Injection, powder, lyophilized, for solution, Capsule, Granule, for suspension, extended release - Oral, Tablet, film coated - Oral, Capsule, delayed release pellets, Injection, Capsule, delayed release pellets - Oral, Tablet, film coated, Capsule, coated pellets - Oral, Kit - Oral, For suspension, Capsule - Oral, Tablet
Warnings
Vimovo ContraindicationsCondition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
Common Vimovo Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Esomeprazole.
Atazanavir
Major
Esomeprazole can cause a decrease in the absorption of Atazanavir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Esomeprazole.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Esomeprazole.
Infigratinib
Major
The serum concentration of Infigratinib can be decreased when it is combined with Esomeprazole.
Vimovo Toxicity & Overdose RiskCommon side effects of overdoses on this drug include blurry vision, confusion, tiredness, dry mouth, feeling flushed, headaches, nausea, a rapid heartbeat, and sweating.
Vimovo Novel Uses: Which Conditions Have a Clinical Trial Featuring Vimovo?
26 active clinical trials are currently assessing the utility of Vimovo in addressing previous gastric or duodenal ulcer, Stomach Ulcer and Peptic Ulcer.Condition
Clinical Trials
Trial Phases
Heartburn
11 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Early Phase 1
Zollinger-Ellison Syndrome
0 Actively Recruiting
maintenance of healing Erosive esophagitis
0 Actively Recruiting
antibacterial therapy
0 Actively Recruiting
Hemorrhage
0 Actively Recruiting
Peptic Ulcer
2 Actively Recruiting
Not Applicable, Phase 4
previous gastric or duodenal ulcer
0 Actively Recruiting
Heartburn
3 Actively Recruiting
Phase 3, Not Applicable
prophylaxis of Stress Ulcers
0 Actively Recruiting
Curling Ulcer
0 Actively Recruiting
Gastric ulcer
0 Actively Recruiting
Stress Ulcers
0 Actively Recruiting
NSAID Associated Gastric Ulcers
0 Actively Recruiting
Critical Illness
2 Actively Recruiting
Not Applicable, Early Phase 1
Helicobacter Pylori Infection
0 Actively Recruiting
Hemorrhage
1 Actively Recruiting
Phase 4
Erosive Esophagitis
4 Actively Recruiting
Phase 2, Phase 3
Vimovo Reviews: What are patients saying about Vimovo?
5Patient Review
12/29/2019 I don't understand why people are so uneducated about their medications. Naprosyn Sodium is the same drug as Alleve, and the side effects come from IT. The other drug is simply to try to reduce the harsh effects of Naprosyn Sodium on your G I tract. It's not a separate medication, but a combination of two drugs.
5Patient Review
10/4/2016 I've been taking this treatment for around a week to help with my hip pain. While it does work well, I have noticed some concerning side effects like dizziness and heart palpitations. Not sure if I'll be able to take it long-term.
4Patient Review
11/2/2016 Vimovo has done wonders for my arthritis pain. I was previously taking four Aleve pills per day, plus four Nexium pills (all over the counter at the recommended dosage), but now I only need to take two Vimovo pills and I'm good to go. No more stomach burn or nausea, and a lot fewer pills!
3.7Patient Review
4/17/2018 I started taking Vimovo because I developed ulcers from Naproxin. I was on it for over a year, and only realized how much it impacted my mood once I stopped taking it. It did help with my Fibro pain and back issues, but the cost was too high.
3.7Patient Review
3/20/2019 Worked well until an unfortunate side effect developed.
3Patient Review
10/16/2015 I was prescribed this for an infection in my jaw that caused it to click when I opened my mouth. After four days of taking the medication as directed, I experienced extreme drowsiness, muscle pain, headaches, and neck pain. I also had trouble eating and felt nauseous most of the time. This was by far the worst experience I've ever had with a medication and would not recommend it to anyone.
2.3Patient Review
5/7/2018 I've been struggling with Achilles tendinitis for over half a year now and have tried many different treatments to no avail. My doctor prescribed Vimovo, but after taking it I experienced severe pain in my abdomen and was unable to sleep. I'll be discontinuing use of this medication and instead stick to Advil and Turmeric.
2.3Patient Review
4/9/2019 Unfortunately, this treatment gave me really severe diarrhea and stomach pain. It also killed my appetite. I had to stop taking it after a month.
2Patient Review
9/24/20152Patient Review
1/21/2020 I was prescribed this medication to help with my rheumatoid arthritis. Unfortunately, I saw zero difference after taking it as directed; might as well have eaten Smarties.
1Patient Review
8/28/2017 I had such terrible reactions to this medicine- vomiting, diarrhea, and numbness in my extremities. I think it might have also been causing problems with my liver or gallbladder because I was vomiting green bile.
1Patient Review
5/12/2019 While this medication did help my arthritis pain, it also caused severe and permanent damage to the lining of my stomach after just six months. I had to be hospitalized as a result and was diagnosed with chronic microscopic colitis. If there were any way to take legal action against the manufacturer of this drug, I would.
Patient Q&A Section about vimovo
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When should I take vimovo?
"Vimovo is typically taken twice per day, at least 30 minutes before a meal. Follow directions on the prescription label and read all medication guides or instruction sheets. Use the medicine as directed. Swallow the tablet whole and do not crush, chew, or break it."
Answered by AI
Is vimovo the same as ibuprofen?
"The drugs Vimovo and Ibuprofen both contain NSAIDs. Vimovo also contains a proton pump inhibitor. There are various brand names for ibuprofen, such as Advil and Motrin. Motrin (Ibuprofen) can be bought OTC or as a generic."
Answered by AI
What is vimovo pills used for?
"This medication falls under the NSAID category and is used to treat various forms of arthritis. The active ingredients in this medication are esomeprazole and naproxen. This medication carries a high risk for stomach bleeding and ulcers, and should be used with caution in patients with a history of gastric ulcers."
Answered by AI
Is vimovo a painkiller?
"Esomeprazole is a medicine that reduces the amount of acid produced in your stomach.
If you are suffering from pain and need an anti-inflammatory painkiller, Vimovo may be a good option for you as it also provides stomach protection. Vimovo 500mg/20mg modified release tablets contain naproxen and esomeprazole as active ingredients. Naproxen is a powerful anti-inflammatory painkiller (also known as an NSAID) that can be used to treat various painful conditions. Esomeprazole is a medicine designed to reduce the amount of acid produced in your stomach."
Answered by AI