Vesicare

Enlarged Prostate, Overactive Bladder Syndrome, moderate to severe symptoms + 2 more
Treatment
2 FDA approvals
20 Active Studies for Vesicare

What is Vesicare

SolifenacinThe Generic name of this drug
Treatment SummarySolifenacin is a medication used to treat an overactive bladder and its associated symptoms, such as urinary incontinence, urgency, and frequency. It is taken once daily and was approved by the FDA in 2004.
VESIcareis the brand name
image of different drug pills on a surface
Vesicare Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
VESIcare
Solifenacin
2005
95

Approved as Treatment by the FDA

Solifenacin, commonly known as VESIcare, is approved by the FDA for 2 uses which include Overactive Bladder Syndrome (OABS) and Overactive Bladder Syndrome .
Overactive Bladder Syndrome (OABS)
Overactive Bladder Syndrome

Effectiveness

How Vesicare Affects PatientsSolifenacin is a drug designed to help treat an overactive bladder by blocking certain receptors in the bladder. It only needs to be taken once a day and can produce long-lasting effects. However, this drug can also cause serious allergic reactions like angioedema and anaphylaxis, so patients should be aware of this risk.
How Vesicare works in the bodySolifenacin blocks certain receptors in the bladder, which prevents muscle contractions. These receptors, called muscarinic receptors, control the contraction of the detrusor muscle and smooth muscle in the bladder. Solifenacin has the highest affinity for M3, M1, and M2 muscarinic receptors. About 80% of the muscarinic receptors in the bladder are M2, and 20% are M3. By blocking these receptors, Solifenacin stops the muscles from contracting.

When to interrupt dosage

The amount of Vesicare is contingent upon the diagnosed disorder, including tamsulosin, Enlarged Prostate and Overactive Bladder Syndrome. The measure of dosage is detailed in the table below, correlating with the technique of delivery.
Condition
Dosage
Administration
Enlarged Prostate
10.0 mg, , 5.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Tablet, coated - Oral, Tablet, film coated, extended release, Tablet, coated, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension
Overactive Bladder Syndrome
10.0 mg, , 5.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Tablet, coated - Oral, Tablet, film coated, extended release, Tablet, coated, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension
moderate to severe symptoms
10.0 mg, , 5.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Tablet, coated - Oral, Tablet, film coated, extended release, Tablet, coated, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension
inadequate response to monotherapy
10.0 mg, , 5.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Tablet, coated - Oral, Tablet, film coated, extended release, Tablet, coated, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension
tamsulosin
10.0 mg, , 5.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Tablet, coated - Oral, Tablet, film coated, extended release, Tablet, coated, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension

Warnings

Vesicare Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Solifenacin may interact with Pulse Frequency
Gastric Retention
Do Not Combine
Urinary Retention
Do Not Combine
uncontrolled narrow-angle glaucoma
Do Not Combine
There are 20 known major drug interactions with Vesicare.
Common Vesicare Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Solifenacin is combined with Aclidinium.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Solifenacin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Solifenacin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Solifenacin.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Solifenacin is combined with Cimetropium.
Vesicare Toxicity & Overdose RiskThe toxic dose of Solifenacin has not been established. Signs of overdose include extreme anticholinergic symptoms, changes in mental state, and decreased alertness. If someone overdoses on Solifenacin, they should be given a gastric lavage and monitored with an ECG.
image of a doctor in a lab doing drug, clinical research

Vesicare Novel Uses: Which Conditions Have a Clinical Trial Featuring Vesicare?

53 active studies are investigating the potential of Vesicare in providing an adequate response to monotherapy, tamsulosin and Enlarged Prostate treatment.
Condition
Clinical Trials
Trial Phases
inadequate response to monotherapy
0 Actively Recruiting
Overactive Bladder Syndrome
29 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 1, Phase 2
Enlarged Prostate
16 Actively Recruiting
Not Applicable, Phase 2
tamsulosin
0 Actively Recruiting
moderate to severe symptoms
0 Actively Recruiting

Vesicare Reviews: What are patients saying about Vesicare?

5Patient Review
7/12/2016
Vesicare for Overactive Bladder
Vesicare has been a total godsend. It's only been one week, but I already feel so much better. No more running to the bathroom every half hour! The heartburn is manageable too.
5Patient Review
2/1/2022
Vesicare for Overactive Bladder
I really appreciate this medication, as it's helped me a lot with my OAB. The dry mouth is definitely a downside, but it's manageable. I'm hoping to be on this forever!
5Patient Review
6/8/2016
Vesicare for Overactive Bladder
I had some heartburn for the first few days, but it's gone now and I'm sleeping so much better!
5Patient Review
6/10/2016
Vesicare for Frequent Urination
I was paying only $10 a month for this medication, but it suddenly shot up to $700 with insurance. I don't know what I'm going to do.
4.3Patient Review
4/7/2020
Vesicare for Overactive Bladder
Worked great, though I stopped taking it due to dry mouth. However, an unlisted side effect is edema. My feet and ankles started swelling as a result of taking this medication.
4Patient Review
9/24/2017
Vesicare for Overactive Bladder
I started with a low dosage of 5mg and it helped a little bit. I then increased my dosage to 10mg and saw better results; however, there are some negative side effects that come with this increase such as difficulty urinating and heartburn. I'm considering going back to the lower dose of 5mg.
4Patient Review
5/18/2018
Vesicare for Overactive Bladder
I started taking Vesicare in 2011 and it worked great for 4 years. Then, suddenly, it stopped working. I had no side effects while on the medication and loved it, so I'm wondering if there's a chance that it would start working again if I began taking it once more.
4Patient Review
10/25/2021
Vesicare for Overactive Bladder
This worked well for OAB however, the side effects that I experienced were not worth it. Sinus pressure, eye pressure and blurry vision, ear fullness, dizziness, moodiness, forgetfulness. I am hoping this will be out of my system soon.
3.7Patient Review
3/12/2016
Vesicare for Overactive Bladder
I had a lot of side effects while taking this medication, including swelling of my face and tongue, indigestion, constipation, and severe stomach and neck pain. I stopped taking it immediately after just three days.
3.7Patient Review
3/7/2016
Vesicare for Overactive Bladder
I experienced some facial swelling, itching, and dryness after taking this medication. Additionally, I had some cramping in my stomach.
3.3Patient Review
1/30/2017
Vesicare for Needing to Urinate Immediately
While this successfully curbed my urgency to urinate, the side effects were really tough to deal with. I had a dry mouth, constipation for two days then diarrhea for one day on a repeat cycle. When my urine became cloudy and started smelling strange, I stopped taking the medication. Thankfully, there was no infection detected--I can only assume it was the drug that caused these issues.
2.3Patient Review
5/27/2016
Vesicare for Frequent Urination
I felt incredibly exhausted and weak while using this treatment. I had to stop after only four days.
2Patient Review
2/24/2016
Vesicare for Frequent Urination
I'm a 70-year-old man who tried this while travelling on the transsiberian railway. For me, it was useless - no change in peeing frequency - and blood appeared in my stools after 2 weeks. I stopped taking it then, and returned to normal.
2Patient Review
1/16/2016
Vesicare for Needing to Urinate Immediately
Unfortunately, the Vesicare didn't do much for my OAB. I was really hoping it would help more than it did.
1.7Patient Review
3/1/2020
Vesicare for Overactive Bladder
It gave me really bad pain during sex.
1Patient Review
9/6/2019
Vesicare for Overactive Bladder
I week after starting this medication, I was unable to urinate. This created a very uncomfortable situation that led me to stop taking the medication entirely.
1Patient Review
1/24/2020
Vesicare for Urine Leakage When there is a Strong Desire to Void
Since switching from Vesicare to the generic brand, my incontinence has come back.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about vesicare

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is VESIcare prescribed for?

"Solifenacin is a medication used to treat overactive bladder, a condition where the muscles in the bladder contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination."

Answered by AI

How long should you use VESIcare?

"Is it safe to take this medication for an extended period of time? It is generally not recommended to take solifenacin for longer than necessary. Your doctor will check every 6 to 12 months to see if continued treatment is still required. There is a potential increased risk of confusion and dementia with long-term use of solifenacin, but more research needs to be done in this area."

Answered by AI

Should you take VESIcare in the morning or at night?

"It is best to take the tablet at the same time each day to help you remember to take your doses regularly. You can take solifenacin either before or after meals. Swallow the tablet whole with a drink of water - do not chew or crush it before you swallow."

Answered by AI

What are the side effects of the drug VESIcare?

"If you experience any of these side effects, which include dry mouth, constipation, drowsiness, stomach upset, blurred vision, dry eyes, headache, or unusual tiredness/weakness, you should tell your doctor or pharmacist."

Answered by AI

Clinical Trials for Vesicare

Image of Stanford Medicine Department of Obstetrics & Gynecology in Palo Alto, United States.

Detrusor Nerve Radiofrequency Ablation for Overactive Bladder

22 - 80
Female
Palo Alto, CA
The goal of this clinical trial is to learn if a vaginal radiofrequency (RF) device called MORPHEUSV works to treat overactive bladder (OAB) in women. Researchers also want to learn how safe the device is for this indication. This study will include women ages 22 to 80 who have had OAB symptoms for at least 6 months. The main questions it aims to answer are: Does the MORPHEUSV device lower the number of daily episodes of accidental urine leakage caused by urgency? Does it work better than a sham (placebo) treatment? Researchers will compare the MORPHEUSV device to a sham treatment to see how well it reduces symptoms of overactive bladder. Participants will: 1) Receive one session of either the MORPHEUSV or sham treatment. 2) Track their symptoms using a diary and questionnaires 3) Return for three to six follow-up visits over 12 months. This study is being conducted at multiple clinics in the United States.
Waitlist Available
Device
Stanford Medicine Department of Obstetrics & Gynecology (+10 Sites)Mickey Karram, MDInMode MD Ltd.
Have you considered Vesicare clinical trials? We made a collection of clinical trials featuring Vesicare, we think they might fit your search criteria.Go to Trials
Have you considered Vesicare clinical trials? We made a collection of clinical trials featuring Vesicare, we think they might fit your search criteria.Go to Trials
Image of Centre Hospitalier de l'université de Montréal (CHUM) in Montréal, Canada.

Optilume vs Rezum for Enlarged Prostate

18+
Male
Montréal, Canada
Lower urinary symptoms (LUTS) affect older men and their frequency and severity increase with age. According to Berry et al., the histological diagnosis of benign prostatic hyperplasia (BPH) increases from 25% in the group age between 40 to 49 years to 80% in the group age between 70 to 79 years (1). However, this hyperplasia can lead to a bladder outlet obstruction (BOO) secondary to benign prostatic enlargement (BPE), causing storage and voiding symptoms, associated with a considerable impairment of the quality of life (2). Surgical therapy of BPH has continuously evolved in recent years. The current gold standard for the endoscopic treatment of BPH is the transurethral resection of the prostate (TURP). Other innovative techniques were developed including Urolift, transurethral laser enucleation (holmium, thulium) and Aquablation therapy. One of the latest technologies for the management of BPH are Optilume BPH Catheter System (Optilume®, Urotronic Inc, Minneapolis, USA) and Rezum Water Vapor Therapy (Rezum System, Bostocn Scientific, Marlborough, MA). The purpose of the present study is to compare between patient experience, symptom relief and functional improvement when using the Optilume BPH Catheter System (Optilume®, Urotronic Inc, Minneapolis, USA) and Rezum Water Vapor Therapy (Rezum System, Boston Scientific, Marlborough, MA).
Recruiting
Has No Placebo
Centre Hospitalier de l'université de Montréal (CHUM) (+1 Sites)Naeem Bhojani, MD
Image of UConn Health in Farmington, United States.

MitoQ for Lower Urinary Tract Symptoms

50 - 75
Female
Farmington, CT
The goal of this clinical trial is to test the effect of a supplement called MitoQ (mitoquinol mesylate) on bladder symptoms such as urgency and frequency in women 50 years and older who have the metabolic syndrome. The main questions it aims to answer are: * Is the study design feasible and acceptable to participants? * Do participants taking the study drug get any improvement to their bladder symptoms compared to participants taking a placebo (a look-alike substance that contains no drug)? Participants will take 2 capsules of the study drug every morning for 4 months, answer many questions about their health including questions about their bladder health, perform physical and cognitive testing, give blood and urine samples, collect urine over 24 hour periods 3 times over the 4 months of the study, complete 3 day bladder diaries about how much they drink and void, undergo electrocardiograms, have their vitals and measurements (weight, height, waist circumference) taken, participate in 4 visits to the clinical research area and participate in many phone calls of varying length. Researchers will compare participants who were taking capsules containing MitoQ and participants taking capsules not containing MitoQ to see if MitoQ improves their bladder symptoms (urgency, frequency, nocturia, incontinence, etc.)
Phase 2
Recruiting
UConn HealthIman M Al-Naggar, PhD
Have you considered Vesicare clinical trials? We made a collection of clinical trials featuring Vesicare, we think they might fit your search criteria.Go to Trials
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security