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What is Vesicare
SolifenacinThe Generic name of this drug
Treatment SummarySolifenacin is a medication used to treat an overactive bladder and its associated symptoms, such as urinary incontinence, urgency, and frequency. It is taken once daily and was approved by the FDA in 2004.
VESIcareis the brand name
Vesicare Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
VESIcare
Solifenacin
2005
95
Approved as Treatment by the FDA
Solifenacin, commonly known as VESIcare, is approved by the FDA for 1 uses which include Overactive Bladder Syndrome .Overactive Bladder Syndrome
Effectiveness
How Vesicare Affects PatientsSolifenacin is a drug designed to help treat an overactive bladder by blocking certain receptors in the bladder. It only needs to be taken once a day and can produce long-lasting effects. However, this drug can also cause serious allergic reactions like angioedema and anaphylaxis, so patients should be aware of this risk.
How Vesicare works in the bodySolifenacin blocks certain receptors in the bladder, which prevents muscle contractions. These receptors, called muscarinic receptors, control the contraction of the detrusor muscle and smooth muscle in the bladder. Solifenacin has the highest affinity for M3, M1, and M2 muscarinic receptors. About 80% of the muscarinic receptors in the bladder are M2, and 20% are M3. By blocking these receptors, Solifenacin stops the muscles from contracting.
When to interrupt dosage
The amount of Vesicare is contingent upon the diagnosed disorder, including tamsulosin, Enlarged Prostate and Overactive Bladder Syndrome. The measure of dosage is detailed in the table below, correlating with the technique of delivery.Condition
Dosage
Administration
tamsulosin
10.0 mg, , 5.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Tablet, coated - Oral, Tablet, film coated, extended release, Tablet, coated, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension
Enlarged Prostate
10.0 mg, , 5.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Tablet, coated - Oral, Tablet, film coated, extended release, Tablet, coated, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension
Overactive Bladder Syndrome
10.0 mg, , 5.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Tablet, coated - Oral, Tablet, film coated, extended release, Tablet, coated, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension
moderate to severe symptoms
10.0 mg, , 5.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Tablet, coated - Oral, Tablet, film coated, extended release, Tablet, coated, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension
inadequate response to monotherapy
10.0 mg, , 5.0 mg, 1.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Tablet, coated - Oral, Tablet, film coated, extended release, Tablet, coated, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension
Warnings
Vesicare ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Solifenacin may interact with Pulse Frequency
Gastric Retention
Do Not Combine
Urinary Retention
Do Not Combine
uncontrolled narrow-angle glaucoma
Do Not Combine
Common Vesicare Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Solifenacin is combined with Aclidinium.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Solifenacin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Solifenacin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Solifenacin.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Solifenacin is combined with Cimetropium.
Vesicare Toxicity & Overdose RiskThe toxic dose of Solifenacin has not been established. Signs of overdose include extreme anticholinergic symptoms, changes in mental state, and decreased alertness. If someone overdoses on Solifenacin, they should be given a gastric lavage and monitored with an ECG.
Vesicare Novel Uses: Which Conditions Have a Clinical Trial Featuring Vesicare?
53 active studies are investigating the potential of Vesicare in providing an adequate response to monotherapy, tamsulosin and Enlarged Prostate treatment.Condition
Clinical Trials
Trial Phases
tamsulosin
0 Actively Recruiting
moderate to severe symptoms
0 Actively Recruiting
inadequate response to monotherapy
0 Actively Recruiting
Enlarged Prostate
21 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3
Overactive Bladder Syndrome
32 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2
Vesicare Reviews: What are patients saying about Vesicare?
5Patient Review
7/12/2016 Vesicare has been a total godsend. It's only been one week, but I already feel so much better. No more running to the bathroom every half hour! The heartburn is manageable too.
5Patient Review
2/1/2022 I really appreciate this medication, as it's helped me a lot with my OAB. The dry mouth is definitely a downside, but it's manageable. I'm hoping to be on this forever!
5Patient Review
6/8/2016 I had some heartburn for the first few days, but it's gone now and I'm sleeping so much better!
5Patient Review
6/10/2016 I was paying only $10 a month for this medication, but it suddenly shot up to $700 with insurance. I don't know what I'm going to do.
4.3Patient Review
4/7/2020 Worked great, though I stopped taking it due to dry mouth. However, an unlisted side effect is edema. My feet and ankles started swelling as a result of taking this medication.
4Patient Review
9/24/2017 I started with a low dosage of 5mg and it helped a little bit. I then increased my dosage to 10mg and saw better results; however, there are some negative side effects that come with this increase such as difficulty urinating and heartburn. I'm considering going back to the lower dose of 5mg.
4Patient Review
5/18/2018 I started taking Vesicare in 2011 and it worked great for 4 years. Then, suddenly, it stopped working. I had no side effects while on the medication and loved it, so I'm wondering if there's a chance that it would start working again if I began taking it once more.
4Patient Review
10/25/2021 This worked well for OAB however, the side effects that I experienced were not worth it. Sinus pressure, eye pressure and blurry vision, ear fullness, dizziness, moodiness, forgetfulness. I am hoping this will be out of my system soon.
3.7Patient Review
3/12/2016 I had a lot of side effects while taking this medication, including swelling of my face and tongue, indigestion, constipation, and severe stomach and neck pain. I stopped taking it immediately after just three days.
3.7Patient Review
3/7/2016 I experienced some facial swelling, itching, and dryness after taking this medication. Additionally, I had some cramping in my stomach.
3.3Patient Review
1/30/2017 While this successfully curbed my urgency to urinate, the side effects were really tough to deal with. I had a dry mouth, constipation for two days then diarrhea for one day on a repeat cycle. When my urine became cloudy and started smelling strange, I stopped taking the medication. Thankfully, there was no infection detected--I can only assume it was the drug that caused these issues.
2.3Patient Review
5/27/2016 I felt incredibly exhausted and weak while using this treatment. I had to stop after only four days.
2Patient Review
2/24/2016 I'm a 70-year-old man who tried this while travelling on the transsiberian railway. For me, it was useless - no change in peeing frequency - and blood appeared in my stools after 2 weeks. I stopped taking it then, and returned to normal.
2Patient Review
1/16/2016 Unfortunately, the Vesicare didn't do much for my OAB. I was really hoping it would help more than it did.
1.7Patient Review
3/1/2020 It gave me really bad pain during sex.
1Patient Review
9/6/2019 I week after starting this medication, I was unable to urinate. This created a very uncomfortable situation that led me to stop taking the medication entirely.
1Patient Review
1/24/2020 Since switching from Vesicare to the generic brand, my incontinence has come back.
Patient Q&A Section about vesicare
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is VESIcare prescribed for?
"Solifenacin is a medication used to treat overactive bladder, a condition where the muscles in the bladder contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination."
Answered by AI
How long should you use VESIcare?
"Is it safe to take this medication for an extended period of time? It is generally not recommended to take solifenacin for longer than necessary. Your doctor will check every 6 to 12 months to see if continued treatment is still required. There is a potential increased risk of confusion and dementia with long-term use of solifenacin, but more research needs to be done in this area."
Answered by AI
Should you take VESIcare in the morning or at night?
"It is best to take the tablet at the same time each day to help you remember to take your doses regularly. You can take solifenacin either before or after meals. Swallow the tablet whole with a drink of water - do not chew or crush it before you swallow."
Answered by AI
What are the side effects of the drug VESIcare?
"If you experience any of these side effects, which include dry mouth, constipation, drowsiness, stomach upset, blurred vision, dry eyes, headache, or unusual tiredness/weakness, you should tell your doctor or pharmacist."
Answered by AI