Vesicare

Enlarged Prostate, Overactive Bladder Syndrome, moderate to severe symptoms + 2 more

Treatment

2 FDA approvals

20 Active Studies for Vesicare

Treatment for

Enlarged Prostate

What is Vesicare

SolifenacinThe Generic name of this drug

Treatment SummarySolifenacin is a medication used to treat an overactive bladder and its associated symptoms, such as urinary incontinence, urgency, and frequency. It is taken once daily and was approved by the FDA in 2004.

VESIcareis the brand name

image of different drug pills on a surface

Vesicare Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

VESIcare

Solifenacin

2005

Approved as Treatment by the FDA

Solifenacin, commonly known as VESIcare, is approved by the FDA for 2 uses which include Overactive Bladder Syndrome (OABS) and Overactive Bladder Syndrome .

Overactive Bladder Syndrome (OABS)

Overactive Bladder Syndrome

Effectiveness

How Vesicare Affects PatientsSolifenacin is a drug designed to help treat an overactive bladder by blocking certain receptors in the bladder. It only needs to be taken once a day and can produce long-lasting effects. However, this drug can also cause serious allergic reactions like angioedema and anaphylaxis, so patients should be aware of this risk.

How Vesicare works in the bodySolifenacin blocks certain receptors in the bladder, which prevents muscle contractions. These receptors, called muscarinic receptors, control the contraction of the detrusor muscle and smooth muscle in the bladder. Solifenacin has the highest affinity for M3, M1, and M2 muscarinic receptors. About 80% of the muscarinic receptors in the bladder are M2, and 20% are M3. By blocking these receptors, Solifenacin stops the muscles from contracting.

When to interrupt dosage

The amount of Vesicare is contingent upon the diagnosed disorder, including tamsulosin, Enlarged Prostate and Overactive Bladder Syndrome. The measure of dosage is detailed in the table below, correlating with the technique of delivery.

Condition

Dosage

Administration

Enlarged Prostate

10.0 mg, , 5.0 mg, 1.0 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Tablet, coated - Oral, Tablet, film coated, extended release, Tablet, coated, Tablet, film coated, extended release - Oral, Suspension - Oral, Suspension

Overactive Bladder Syndrome

10.0 mg, , 5.0 mg, 1.0 mg/mL

moderate to severe symptoms

10.0 mg, , 5.0 mg, 1.0 mg/mL

inadequate response to monotherapy

10.0 mg, , 5.0 mg, 1.0 mg/mL

tamsulosin

10.0 mg, , 5.0 mg, 1.0 mg/mL

Warnings

Vesicare Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Solifenacin may interact with Pulse Frequency

Gastric Retention

Do Not Combine

Urinary Retention

Do Not Combine

uncontrolled narrow-angle glaucoma

Do Not Combine

There are 20 known major drug interactions with Vesicare.

Common Vesicare Drug Interactions

Drug Name

Risk Level

Description

Aclidinium

Major

The risk or severity of adverse effects can be increased when Solifenacin is combined with Aclidinium.

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Solifenacin.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Solifenacin.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Solifenacin.

Cimetropium

Major

The risk or severity of adverse effects can be increased when Solifenacin is combined with Cimetropium.

Vesicare Toxicity & Overdose RiskThe toxic dose of Solifenacin has not been established. Signs of overdose include extreme anticholinergic symptoms, changes in mental state, and decreased alertness. If someone overdoses on Solifenacin, they should be given a gastric lavage and monitored with an ECG.

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Vesicare Novel Uses: Which Conditions Have a Clinical Trial Featuring Vesicare?

53 active studies are investigating the potential of Vesicare in providing an adequate response to monotherapy, tamsulosin and Enlarged Prostate treatment.

Condition

Clinical Trials

Trial Phases

inadequate response to monotherapy

0 Actively Recruiting

Overactive Bladder Syndrome

36 Actively Recruiting

Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2

Enlarged Prostate

21 Actively Recruiting

Not Applicable, Phase 4, Phase 2

tamsulosin

0 Actively Recruiting

moderate to severe symptoms

0 Actively Recruiting

Vesicare Reviews: What are patients saying about Vesicare?

5Patient Review

7/12/2016

Vesicare for Overactive Bladder

Vesicare has been a total godsend. It's only been one week, but I already feel so much better. No more running to the bathroom every half hour! The heartburn is manageable too.

5Patient Review

2/1/2022

Vesicare for Overactive Bladder

I really appreciate this medication, as it's helped me a lot with my OAB. The dry mouth is definitely a downside, but it's manageable. I'm hoping to be on this forever!

5Patient Review

6/8/2016

Vesicare for Overactive Bladder

I had some heartburn for the first few days, but it's gone now and I'm sleeping so much better!

5Patient Review

6/10/2016

Vesicare for Frequent Urination

I was paying only $10 a month for this medication, but it suddenly shot up to $700 with insurance. I don't know what I'm going to do.

4.3Patient Review

4/7/2020

Vesicare for Overactive Bladder

Worked great, though I stopped taking it due to dry mouth. However, an unlisted side effect is edema. My feet and ankles started swelling as a result of taking this medication.

View All Reviews

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Patient Q&A Section about vesicare

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is VESIcare prescribed for?

"Solifenacin is a medication used to treat overactive bladder, a condition where the muscles in the bladder contract uncontrollably and cause frequent urination, urgent need to urinate, and inability to control urination."

Answered by AI

How long should you use VESIcare?

"Is it safe to take this medication for an extended period of time? It is generally not recommended to take solifenacin for longer than necessary. Your doctor will check every 6 to 12 months to see if continued treatment is still required. There is a potential increased risk of confusion and dementia with long-term use of solifenacin, but more research needs to be done in this area."

Answered by AI

Should you take VESIcare in the morning or at night?

"It is best to take the tablet at the same time each day to help you remember to take your doses regularly. You can take solifenacin either before or after meals. Swallow the tablet whole with a drink of water - do not chew or crush it before you swallow."

Answered by AI

What are the side effects of the drug VESIcare?

"If you experience any of these side effects, which include dry mouth, constipation, drowsiness, stomach upset, blurred vision, dry eyes, headache, or unusual tiredness/weakness, you should tell your doctor or pharmacist."

Answered by AI

Clinical Trials for Vesicare

Have you considered Vesicare clinical trials? We made a collection of clinical trials featuring Vesicare, we think they might fit your search criteria.

Have you considered Vesicare clinical trials? We made a collection of clinical trials featuring Vesicare, we think they might fit your search criteria.