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What is Urso 250
Ursodeoxycholic acidThe Generic name of this drug
Treatment SummaryUrsodeoxycholic acid is a bile acid found naturally in bears. It is used to treat gallstones and helps to alter the composition of bile. Ursodeoxycholic acid is used as a medication to promote the flow of bile from the gallbladder.
Actigallis the brand name
Urso 250 Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Actigall
Ursodeoxycholic acid
1987
100
Approved as Treatment by the FDA
Ursodeoxycholic acid, otherwise known as Actigall, is approved by the FDA for 2 uses which include Cholelithiasis and obese experiencing rapid weight loss .Cholelithiasis
obese experiencing rapid weight loss
Effectiveness
How Urso 250 Affects PatientsUrsodiol (also known as ursodeoxycholic acid) is a type of acid made by bacteria in the intestine. It helps digest fat and regulates cholesterol levels by slowing down the rate at which cholesterol is absorbed. It also breaks down micelles, which are clusters of cholesterol. Doctors use ursodeoxycholic acid to help dissolve gallstones without surgery.
How Urso 250 works in the bodyUrsodeoxycholic acid helps reduce elevated liver enzyme levels by improving the flow of bile and protecting liver cells. We aren't sure exactly how it works, but it appears to reduce the amount of cholesterol in bile, allowing cholesterol-based gallstones to dissolve. It also prevents cholesterol from forming in the first place.
When to interrupt dosage
The proposed dosage of Urso 250 is contingent upon the determined disorder, which includes Primary Biliary Cholangitis, Cholelithiasis and obese experiencing swift weight loss. The measure of dosage varies, in accordance with the administration strategy featured in the table below.Condition
Dosage
Administration
obese experiencing rapid weight loss
, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental
Cholelithiasis
, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental
Primary Biliary Cholangitis
, 300.0 mg, 250.0 mg, 500.0 mg, 0.0002 mg/mg, 10.0 mg, 200.0 mg, 400.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Dental, Paste, Paste - Dental
Warnings
Urso 250 ContraindicationsCondition
Risk Level
Notes
Cholangitis
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ursodeoxycholic Acid may interact with Pulse Frequency
Pancreatitis
Do Not Combine
biliary gastrointestinal fistula
Do Not Combine
Calcinosis
Do Not Combine
Bile duct structure
Do Not Combine
radiopaque stones
Do Not Combine
radiolucent bile pigment stones
Do Not Combine
Cholecystitis
Do Not Combine
Common Urso 250 Drug Interactions
Drug Name
Risk Level
Description
Capmatinib
Major
The serum concentration of Capmatinib can be decreased when it is combined with Ursodeoxycholic acid.
Rimegepant
Major
The metabolism of Rimegepant can be increased when combined with Ursodeoxycholic acid.
Astemizole
Moderate
Ursodeoxycholic acid may decrease the excretion rate of Astemizole which could result in a higher serum level.
Atazanavir
Moderate
Ursodeoxycholic acid may decrease the excretion rate of Atazanavir which could result in a higher serum level.
Atenolol
Moderate
Ursodeoxycholic acid may decrease the excretion rate of Atenolol which could result in a higher serum level.
Urso 250 Toxicity & Overdose RiskUrsodeoxycholic acid overdose has not been reported. Patients on doses of 16-20mg/kg/day have not exhibited any symptoms in studies lasting 6-37 months. The toxic dose in rats is greater than 5000mg/kg and in mice it is greater than 7500mg/kg. If an overdose occurs, it is likely that the patient will experience diarrhea, which should be treated with symptom relief.
Urso 250 Novel Uses: Which Conditions Have a Clinical Trial Featuring Urso 250?
Thirteen active clinical trials are investigating the potential of Urso 250 to treat Primary Biliary Cholangitis, Cholelithiasis and those obese individuals undergoing rapid weight loss.Condition
Clinical Trials
Trial Phases
Primary Biliary Cholangitis
13 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable
Cholelithiasis
0 Actively Recruiting
obese experiencing rapid weight loss
0 Actively Recruiting
Urso 250 Reviews: What are patients saying about Urso 250?
5Patient Review
3/27/2011 I've been on URSO for almost 20 years now. A couple years ago, my pharmacy gave me a generic brand, and within days I was having severe headaches that progressed to nausea and depression. I couldn't get out of bed. Thankfully, I stopped taking them after just three weeks. Within 12 hours I started feeling better and by the next day I was back to normal. Now I only take the brand name URSO.
5Patient Review
7/1/2010 This drug has been keeping me alive for seven years and I am very grateful for it.
5Patient Review
9/17/2009 I've been on Urso for nine years and they recently switched me to the generic Ursodol. About four days into taking it, I started experiencing a lot of heartburn. Could this be a side effect of the generic?
5Patient Review
8/15/20085Patient Review
8/1/2009 I have Primary Sclerosing Cholangitis and this is the medication I use. In the ten years I've been taking it (2000mg/day), I have never had a bad reaction or side effect. On top of that, my liver functions always improve when my doctor increases my dosage.
5Patient Review
12/13/2009 I'm seeing results from this treatment, which is great!
2.3Patient Review
10/12/2010 So far, no negative side effects from taking this medication preventatively for gallstones. I've had great results and would recommend to others who have had bypass surgery or are facing a similar situation.
2.3Patient Review
1/14/2011 I've had a hard time finding a doctor to treat my PBC in the Palm Beach County, Florida area. My URSO therapy of 1500 mg per day leads to diarrhea and abdominal pain. I just want take the URSO and get on with my life, but being housebound and lack of a proactive doctor has me at a loss. Any suggestions?
Patient Q&A Section about urso 250
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Can Urso be taken on empty stomach?
"If you're unsure if you can break the tablet in half, talk to your doctor. If you are able to break the tablet in half, use the other half of the tablet for your next dose, as instructed by your doctor."
Answered by AI
What is Urso used for?
"Ursodiol is a medication used to treat various conditions related to the gallbladder or liver. These include dissolving certain types of gallstones, preventing gallstones from forming in obese patients who are losing weight rapidly, and treating a certain type of liver disease called primary biliary cholangitis."
Answered by AI
What does Urso do for the liver?
"Ursodiol decreases the production of cholesterol and dissolves cholesterol to prevent stones from forming. Additionally, ursodiol decreases the levels of toxic bile acids that accumulate in primary biliary cirrhosis."
Answered by AI
What is Urso Forte used for?
"Urso Forte tablets are used to treat primary biliary cirrhosis, an autoimmune disorder that causes progressive destruction of the bile ducts in your liver. Urso Forte may also be used to treat other conditions not listed in this medication guide."
Answered by AI